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Conserved domains on  [gi|301601602|ref|NP_619732|]
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testis anion transporter 1 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11660 super family cl46980
putative transporter; Provisional
 78-479 1.15e-63

putative transporter; Provisional


The actual alignment was detected with superfamily member TIGR00815:

Pssm-ID: 481320 [Multi-domain]  Cd Length: 552  Bit Score: 224.13  E-value: 1.15e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602   78 PFLEWMCMYRLKdWLLGDLLAGISVGLVQVPQGLTLSLLARQliPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSAL 157
Cdd:TIGR00815   1 PVLRWLRKYRLK-KFKGDLMAGLTVGILLIPQAIAYAKLAGL--PPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  158 L----------------INVLKVSPFNNG--QLVMGSF------------VKNEFSAPS----------YLMGYN----- 192
Cdd:TIGR00815  78 LgslvqreglqglfddyIRLAFTATLLAGifQVIMGLLrlgflieylshaVLVGFTAGAaitiglsqlkGLLGLSifvkt 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  193 KSLSVVATT----------TFLTG----------------------------IIQIIGFTVIAnKISMATETSQTLIDMI 234
Cdd:TIGR00815 158 DILGVVISTwaslhqnnwcTLVIGllfllfllatkelgkrnkkllwapapapLLVVVLATLIV-TIGLHDSQGVSIVGHI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  235 P--YSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIAR 312
Cdd:TIGR00815 237 PqgLSFFPPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  313 TIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNViPYLETISNLPSLWRQDQYDCALWMMTFSSS 392
Cdd:TIGR00815 317 TAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAA-VGLIDIRELYLLWKADKMDFVVWLGTFLGV 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  393 IFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKE 472
Cdd:TIGR00815 396 VFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKW 475


                  ....*..
gi 301601602  473 VDMVKVP 479
Cdd:TIGR00815 476 LETLELD 482
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 614-671 8.11e-11

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


:

Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 59.56  E-value: 8.11e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 301601602 614 PSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFD 671
Cdd:cd07042   39 PPLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLD 96
Trypan_PARP super family cl42451
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 768-818 9.33e-10

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


The actual alignment was detected with superfamily member pfam05887:

Pssm-ID: 368653  Cd Length: 134  Bit Score: 57.49  E-value: 9.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301601602  768 GLDLDLDRELEPEMEPKAETETK----------TQTEMEPQPETEPEMEPNPKSRPRAHTF 818
Cdd:pfam05887  56 GTDPEPEPEPEPEPEPEPEPEPEpepepepepePEPEPEPEPEPEPEPEPEPEPEPGAATL 116
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
 78-479 1.15e-63

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 224.13  E-value: 1.15e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602   78 PFLEWMCMYRLKdWLLGDLLAGISVGLVQVPQGLTLSLLARQliPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSAL 157
Cdd:TIGR00815   1 PVLRWLRKYRLK-KFKGDLMAGLTVGILLIPQAIAYAKLAGL--PPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  158 L----------------INVLKVSPFNNG--QLVMGSF------------VKNEFSAPS----------YLMGYN----- 192
Cdd:TIGR00815  78 LgslvqreglqglfddyIRLAFTATLLAGifQVIMGLLrlgflieylshaVLVGFTAGAaitiglsqlkGLLGLSifvkt 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  193 KSLSVVATT----------TFLTG----------------------------IIQIIGFTVIAnKISMATETSQTLIDMI 234
Cdd:TIGR00815 158 DILGVVISTwaslhqnnwcTLVIGllfllfllatkelgkrnkkllwapapapLLVVVLATLIV-TIGLHDSQGVSIVGHI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  235 P--YSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIAR 312
Cdd:TIGR00815 237 PqgLSFFPPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  313 TIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNViPYLETISNLPSLWRQDQYDCALWMMTFSSS 392
Cdd:TIGR00815 317 TAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAA-VGLIDIRELYLLWKADKMDFVVWLGTFLGV 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  393 IFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKE 472
Cdd:TIGR00815 396 VFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKW 475


                  ....*..
gi 301601602  473 VDMVKVP 479
Cdd:TIGR00815 476 LETLELD 482
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
 92-388 8.12e-44

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 163.19  E-value: 8.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602   92 LLGDLLAGISVGLVQVPQGLTLSLLARqlIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSF----FLVSALLINVLKVSPF 167
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAG--LPPIYGLYSSFVPGFVYALFGTSRHLAIGPVavlsLMVGAAIAKLAAKDPE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  168 NNG-------------QLVMG----SFVKNEFSAP------------------SYLMGYN----------------KSLS 196
Cdd:pfam00916  79 LGIalaftltflagiiQLALGllrlGFLVTFLSHAvisgfmggaaivillsqlKVLLGLTnfsgpgyvvsvlqslfTNLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  197 VVATTTFLTG----------------------------IIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDF-- 246
Cdd:pfam00916 159 KVNLATLVLGllvlvillftkelgkkykklfwipapapLVAVVLATLVSAIFDLLRRYGVKIVGEIPSGLPPFSLPKFsw 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  247 SLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFA 326
Cdd:pfam00916 239 SLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATGAFSRSAVNIKAGAKTPLS 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301601602  327 SLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPyLETISNLPSLWRQDQYDCALWMMT 388
Cdd:pfam00916 319 GIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKG-LIDYRELKHLWRLSKLDFLIWLAT 379
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 89-478 7.79e-39

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 152.18  E-value: 7.79e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  89 KDWLLGDLLAGISVGLVQVPQGLTLSLLARqlIPPlnIA--YAAFCSSVIYVIFGSCHQMSIGSfflVSALLinvlkvsp 166
Cdd:COG0659    4 RSNLRGDLLAGLTVALVALPLALAFAIAAG--LPP--EAglYAAIVGGIVYALFGGSRLLISGP---TAALA-------- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 167 fnngqLVMGSFVKNefsapsylMGynkSLSVVATTTFLTGIIQII-------------------GFT-----VIA----- 217
Cdd:COG0659   69 -----VVVAAAVAP--------LG---SLALLLAATLLAGVLQLLlgllrlgrlarfiprpvivGFLagiaiLIIlgqlp 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 218 ----------NKISMATETSQTLIDMIPYSFLL----------------------------------------------- 240
Cdd:COG0659  133 hllglpapggSFLEKLAALLAALGEINPPTLALglltlaillllprllkripgplvavvlgtllvwllgldvatvgeips 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 241 ----PVTPDFSL--LPKIILQAFSlslvssfllIFL---------GKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCV 305
Cdd:COG0659  213 glpsFSLPDFSLetLRALLPPALT---------IALvgsieslltARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLP 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 306 FTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLEtISNLPSLWRQDQYDCALW 385
Cdd:COG0659  284 VTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAILIVVGIGLID-WRSFRRLWRAPRSDFLVM 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 386 MMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLgQIPNTnIYRSINDYREIITIPGVKIFQCCSSITFVNVYYL 465
Cdd:COG0659  363 LVTFLVTVFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVL-RVPGT-HFRNVERHPEAETGPGVLVYRLDGPLFFGNAERL 440

                        490
                 ....*....|...
gi 301601602 466 KHKLLKEVDMVKV 478
Cdd:COG0659  441 KERLDALAPDPRV 453
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 614-671 8.11e-11

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 59.56  E-value: 8.11e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 301601602 614 PSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFD 671
Cdd:cd07042   39 PPLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLD 96
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 768-818 9.33e-10

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 57.49  E-value: 9.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301601602  768 GLDLDLDRELEPEMEPKAETETK----------TQTEMEPQPETEPEMEPNPKSRPRAHTF 818
Cdd:pfam05887  56 GTDPEPEPEPEPEPEPEPEPEPEpepepepepePEPEPEPEPEPEPEPEPEPEPEPGAATL 116
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 614-686 1.13e-07

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 50.69  E-value: 1.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 301601602  614 PSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDagitKTQLFLSVHDA 686
Cdd:pfam01740  38 GEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTGLDD----IIKIFPTVAEA 106
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 609-665 1.44e-05

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 44.46  E-value: 1.44e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 301601602 609 DASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFE 665
Cdd:COG1366   32 LEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVARVLE 88
PRK11660 PRK11660
putative transporter; Provisional
 283-358 2.75e-05

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 47.64  E-value: 2.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301601602 283 NSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL 358
Cdd:PRK11660 312 SANSELVGQGLGNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMAALLL 387
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 439-479 6.42e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 37.22  E-value: 6.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 301601602 439 YREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVP 479
Cdd:cd07042    1 YPLAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVDEDPPL 41
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
 78-479 1.15e-63

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 224.13  E-value: 1.15e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602   78 PFLEWMCMYRLKdWLLGDLLAGISVGLVQVPQGLTLSLLARQliPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSAL 157
Cdd:TIGR00815   1 PVLRWLRKYRLK-KFKGDLMAGLTVGILLIPQAIAYAKLAGL--PPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  158 L----------------INVLKVSPFNNG--QLVMGSF------------VKNEFSAPS----------YLMGYN----- 192
Cdd:TIGR00815  78 LgslvqreglqglfddyIRLAFTATLLAGifQVIMGLLrlgflieylshaVLVGFTAGAaitiglsqlkGLLGLSifvkt 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  193 KSLSVVATT----------TFLTG----------------------------IIQIIGFTVIAnKISMATETSQTLIDMI 234
Cdd:TIGR00815 158 DILGVVISTwaslhqnnwcTLVIGllfllfllatkelgkrnkkllwapapapLLVVVLATLIV-TIGLHDSQGVSIVGHI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  235 P--YSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIAR 312
Cdd:TIGR00815 237 PqgLSFFPPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  313 TIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNViPYLETISNLPSLWRQDQYDCALWMMTFSSS 392
Cdd:TIGR00815 317 TAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAA-VGLIDIRELYLLWKADKMDFVVWLGTFLGV 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  393 IFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKE 472
Cdd:TIGR00815 396 VFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKW 475


                  ....*..
gi 301601602  473 VDMVKVP 479
Cdd:TIGR00815 476 LETLELD 482
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
 92-388 8.12e-44

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 163.19  E-value: 8.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602   92 LLGDLLAGISVGLVQVPQGLTLSLLARqlIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSF----FLVSALLINVLKVSPF 167
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAG--LPPIYGLYSSFVPGFVYALFGTSRHLAIGPVavlsLMVGAAIAKLAAKDPE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  168 NNG-------------QLVMG----SFVKNEFSAP------------------SYLMGYN----------------KSLS 196
Cdd:pfam00916  79 LGIalaftltflagiiQLALGllrlGFLVTFLSHAvisgfmggaaivillsqlKVLLGLTnfsgpgyvvsvlqslfTNLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  197 VVATTTFLTG----------------------------IIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDF-- 246
Cdd:pfam00916 159 KVNLATLVLGllvlvillftkelgkkykklfwipapapLVAVVLATLVSAIFDLLRRYGVKIVGEIPSGLPPFSLPKFsw 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  247 SLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFA 326
Cdd:pfam00916 239 SLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATGAFSRSAVNIKAGAKTPLS 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301601602  327 SLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPyLETISNLPSLWRQDQYDCALWMMT 388
Cdd:pfam00916 319 GIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKG-LIDYRELKHLWRLSKLDFLIWLAT 379
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 89-478 7.79e-39

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 152.18  E-value: 7.79e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  89 KDWLLGDLLAGISVGLVQVPQGLTLSLLARqlIPPlnIA--YAAFCSSVIYVIFGSCHQMSIGSfflVSALLinvlkvsp 166
Cdd:COG0659    4 RSNLRGDLLAGLTVALVALPLALAFAIAAG--LPP--EAglYAAIVGGIVYALFGGSRLLISGP---TAALA-------- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 167 fnngqLVMGSFVKNefsapsylMGynkSLSVVATTTFLTGIIQII-------------------GFT-----VIA----- 217
Cdd:COG0659   69 -----VVVAAAVAP--------LG---SLALLLAATLLAGVLQLLlgllrlgrlarfiprpvivGFLagiaiLIIlgqlp 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 218 ----------NKISMATETSQTLIDMIPYSFLL----------------------------------------------- 240
Cdd:COG0659  133 hllglpapggSFLEKLAALLAALGEINPPTLALglltlaillllprllkripgplvavvlgtllvwllgldvatvgeips 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 241 ----PVTPDFSL--LPKIILQAFSlslvssfllIFL---------GKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCV 305
Cdd:COG0659  213 glpsFSLPDFSLetLRALLPPALT---------IALvgsieslltARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLP 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 306 FTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLEtISNLPSLWRQDQYDCALW 385
Cdd:COG0659  284 VTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAILIVVGIGLID-WRSFRRLWRAPRSDFLVM 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602 386 MMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLgQIPNTnIYRSINDYREIITIPGVKIFQCCSSITFVNVYYL 465
Cdd:COG0659  363 LVTFLVTVFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVL-RVPGT-HFRNVERHPEAETGPGVLVYRLDGPLFFGNAERL 440

                        490
                 ....*....|...
gi 301601602 466 KHKLLKEVDMVKV 478
Cdd:COG0659  441 KERLDALAPDPRV 453
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 614-671 8.11e-11

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 59.56  E-value: 8.11e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 301601602 614 PSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFD 671
Cdd:cd07042   39 PPLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLD 96
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 768-818 9.33e-10

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 57.49  E-value: 9.33e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 301601602  768 GLDLDLDRELEPEMEPKAETETK----------TQTEMEPQPETEPEMEPNPKSRPRAHTF 818
Cdd:pfam05887  56 GTDPEPEPEPEPEPEPEPEPEPEpepepepepePEPEPEPEPEPEPEPEPEPEPEPGAATL 116
NESP55 pfam06390
Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian ...
 770-861 1.00e-08

Neuroendocrine-specific golgi protein P55 (NESP55); This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins.


Pssm-ID: 115071 [Multi-domain]  Cd Length: 261  Bit Score: 57.18  E-value: 1.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301601602  770 DLDLDRELEPEMEPKAETETKTQTEMEPQ--PETEPEMEPNPKsrpRAHTFPQQrywPMYHPSMASTQSQTQTRTWSVER 847
Cdd:pfam06390 113 DTETDSETEPESDIESETEFETEPETEPDtaPTTEPETEPEDE---PGPVVPKG---ATFHQSLTERLHALKLQSADASP 186

                          90
                  ....*....|....
gi 301601602  848 RRHPMDSYSPEGNS 861
Cdd:pfam06390 187 RRAPPSTQEPESAR 200
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 614-686 1.13e-07

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 50.69  E-value: 1.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 301601602  614 PSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDagitKTQLFLSVHDA 686
Cdd:pfam01740  38 GEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTGLDD----IIKIFPTVAEA 106
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 609-665 1.44e-05

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 44.46  E-value: 1.44e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 301601602 609 DASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFE 665
Cdd:COG1366   32 LEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVARVLE 88
PRK11660 PRK11660
putative transporter; Provisional
 283-358 2.75e-05

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 47.64  E-value: 2.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301601602 283 NSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL 358
Cdd:PRK11660 312 SANSELVGQGLGNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMAALLL 387
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 609-665 1.40e-04

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 41.74  E-value: 1.40e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 301601602 609 DASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFE 665
Cdd:cd07043   31 EELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVRRVLE 87
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 439-479 6.42e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 37.22  E-value: 6.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 301601602 439 YREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVP 479
Cdd:cd07042    1 YPLAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVDEDPPL 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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