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Conserved domains on  [gi|300591907|emb|CBV31068|]
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unnamed protein product [Rattus norvegicus]

Protein Classification

squalene_cyclas family protein( domain architecture ID 11493165)

squalene_cyclas family protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
 77-722 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


:

Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 1011.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907   77 GALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPaGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTA 156
Cdd:TIGR01787   1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  157 LSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQ 236
Cdd:TIGR01787  80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  237 VYLPMSYCYATRLSASEDPlvqslRQELYVEDyASIdwPAQKNNVCPDDMYTPHSWLLHVVYGLLNL-YERFHSTSLRKW 315
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  316 AIQLLYEHVAADDrftkciSIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTnGSQTWDTSFAVQ 395
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  396 ALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHK-GGFPFSTLDCGW-IVADCTAEALKAVLLLQERcp 473
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQED-- 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  474 sitEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFReyfpdHR 553
Cdd:TIGR01787 383 ---EHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAFG-----HR 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  554 ATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVAQACHFLLSRQMADGGWGED 633
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  634 FESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFN-KSCAISYTNYRNIF 712
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611

                         650
                  ....*....|
gi 300591907  713 PIWALGRFSS 722
Cdd:TIGR01787 612 PLWALGRYRQ 621
 
Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
 77-722 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 1011.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907   77 GALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPaGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTA 156
Cdd:TIGR01787   1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  157 LSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQ 236
Cdd:TIGR01787  80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  237 VYLPMSYCYATRLSASEDPlvqslRQELYVEDyASIdwPAQKNNVCPDDMYTPHSWLLHVVYGLLNL-YERFHSTSLRKW 315
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  316 AIQLLYEHVAADDrftkciSIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTnGSQTWDTSFAVQ 395
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  396 ALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHK-GGFPFSTLDCGW-IVADCTAEALKAVLLLQERcp 473
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQED-- 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  474 sitEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFReyfpdHR 553
Cdd:TIGR01787 383 ---EHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAFG-----HR 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  554 ATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVAQACHFLLSRQMADGGWGED 633
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  634 FESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFN-KSCAISYTNYRNIF 712
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611

                         650
                  ....*....|
gi 300591907  713 PIWALGRFSS 722
Cdd:TIGR01787 612 PLWALGRYRQ 621
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
 78-720 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 918.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  78 ALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTAL 157
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 158 SYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQV 237
Cdd:cd02892   81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 238 YLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVcpDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAI 317
Cdd:cd02892  161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 318 QLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQAL 397
Cdd:cd02892  239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 398 LEAGAHrrPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQErCPSITE 477
Cdd:cd02892  319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQE-LPPFGE 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 478 HVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRAtEI 557
Cdd:cd02892  396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHRR-EI 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 558 RETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVAQACHFLLSRQMADGGWGEDFESC 637
Cdd:cd02892  475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 638 EQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWAL 717
Cdd:cd02892  552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631


                 ...
gi 300591907 718 GRF 720
Cdd:cd02892  632 GRY 634
PLN03012 PLN03012
Camelliol C synthase
 72-725 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 596.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  72 QTAHEGALNGVTFYAKLQAEDGHW----AGDYGGPLFLLPGLLITCHIAHIpLPAGYREEMVRYLRSVQLPNGGWGLHIE 147
Cdd:PLN03012  93 EIATNALRKGIHFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIE 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 148 DKSTVFGTALSYVSLRILGIGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFP 224
Cdd:PLN03012 172 GHSTMFCTTLNYICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFP 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 225 AHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLY 304
Cdd:PLN03012 252 IHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIF 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 305 -ERF-----HSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWsVDGPSSPAFQEHVSRIKDYLWLGLDGMK 378
Cdd:PLN03012 332 aEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMK 410

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 379 MQgTNGSQTWDTSFAVQALLeaGAHRRPEFLPCLQKAHEFLRLSQVPDN-NPDYQKYYRHMHKGGFPFSTLDCGWIVADC 457
Cdd:PLN03012 411 MQ-SFGSQLWDSGFALQALL--ASNLSNEIPDVLRRGHDFIKNSQVGENpSGDFKNMYRHISKGAWTFSDRDHGWQASDC 487

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 458 TAEALKAVLLLQERCPSITEhvPR---ERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVEC 534
Cdd:PLN03012 488 TAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNEC 565

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 535 TSAVMQALRHFREYFPDHRATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVA 614
Cdd:PLN03012 566 TSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIR 642

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 615 QACHFLLSRQMADGGWGEDFESCEQRRYVQSAG--SQVHSTCWALLGLM----AVRHPdiSAQERGIRCLLGKQLPNGDW 688
Cdd:PLN03012 643 KGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGeiSNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDF 720

                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 300591907 689 PQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYP 725
Cdd:PLN03012 721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVP 757
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
73-724 0e+00

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 560.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  73 TAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTV 152
Cdd:COG1657   19 SLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 153 FGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWC 232
Cdd:COG1657   99 STTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSY 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 233 HCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVEDYASIDWPAQKNNvcpddMYTPHSWLLHVVYGLLNLYERFHSTSL 312
Cdd:COG1657  179 WARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPR-----DRSPWSRFFLALDRLLRAYERLPPKPL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 313 RKWAIQLLYEHVA----ADDRFtkcISIGP-ISKTVNMLiRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGtNGSQT 387
Cdd:COG1657  252 RRRALRKAEDWILerleGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPV 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 388 WDTSFAVQALLEAGahrRPEFLPCLQKAHEFLRLSQVPDnNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLL 467
Cdd:COG1657  327 WDTALAVQALQEAG---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLR 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 468 LQERcpsiTEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEvFGdIMIDYTYVECTSAVMQALRHFre 547
Cdd:COG1657  403 LRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLGQL-- 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 548 yfpdhRATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHiyqnRTACAEVAQACHFLLSRQMAD 627
Cdd:COG1657  475 -----GLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGV----DPDDPAIRRAVAWLLSIQNAD 545

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 628 GGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGV-FNKSCAISYT 706
Cdd:COG1657  546 GGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYH 625

                        650
                 ....*....|....*...
gi 300591907 707 NYRNIFPIWALGRFSSLY 724
Cdd:COG1657  626 LYRQYFPLWALARYRNLR 643
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
 385-720 3.46e-49

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 175.60  E-value: 3.46e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  385 SQTWDTSFAVQALLEAGAhrrPEFLPCLQKAHEFLRLSQVPDNNpDYQKYYRHMHKGGFPFSTLDCGWIVADCTAealkA 464
Cdd:pfam13243   2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVKG-DWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  465 VLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 542
Cdd:pfam13243  74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  543 RHFrEYFPDHrateirETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHiyqnRTACAEVAQACHFLLS 622
Cdd:pfam13243 150 GQL-GYPDDH------PVAARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGE----DHNRPYIRKAVDWLKS 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  623 RQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGV-FNKSC 701
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPRVF 298

                         330
                  ....*....|....*....
gi 300591907  702 AISYTNYRNIFPIWALGRF 720
Cdd:pfam13243 299 YLKYHGYRNYFPLWALARY 317
 
Name Accession Description Interval E-value
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
 77-722 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 1011.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907   77 GALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPaGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTA 156
Cdd:TIGR01787   1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  157 LSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQ 236
Cdd:TIGR01787  80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  237 VYLPMSYCYATRLSASEDPlvqslRQELYVEDyASIdwPAQKNNVCPDDMYTPHSWLLHVVYGLLNL-YERFHSTSLRKW 315
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  316 AIQLLYEHVAADDrftkciSIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTnGSQTWDTSFAVQ 395
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  396 ALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHK-GGFPFSTLDCGW-IVADCTAEALKAVLLLQERcp 473
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQED-- 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  474 sitEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFReyfpdHR 553
Cdd:TIGR01787 383 ---EHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAFG-----HR 454

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  554 ATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVAQACHFLLSRQMADGGWGED 633
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  634 FESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFN-KSCAISYTNYRNIF 712
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611

                         650
                  ....*....|
gi 300591907  713 PIWALGRFSS 722
Cdd:TIGR01787 612 PLWALGRYRQ 621
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
 78-720 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 918.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  78 ALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTAL 157
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 158 SYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQV 237
Cdd:cd02892   81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 238 YLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVcpDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAI 317
Cdd:cd02892  161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDL--YDYRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 318 QLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQAL 397
Cdd:cd02892  239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 398 LEAGAHrrPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQErCPSITE 477
Cdd:cd02892  319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQE-LPPFGE 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 478 HVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRAtEI 557
Cdd:cd02892  396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHRR-EI 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 558 RETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVAQACHFLLSRQMADGGWGEDFESC 637
Cdd:cd02892  475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 638 EQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWAL 717
Cdd:cd02892  552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631


                 ...
gi 300591907 718 GRF 720
Cdd:cd02892  632 GRY 634
osq_cycl TIGR03463
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ...
 86-720 0e+00

2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.


Pssm-ID: 274591 [Multi-domain]  Cd Length: 634  Bit Score: 609.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907   86 AKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTALSYVSLRIL 165
Cdd:TIGR03463   2 AALQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  166 GIGPDDPDLVRARNILH-KKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMSYC 244
Cdd:TIGR03463  82 GLGKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  245 YATRLSASE-DPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEH 323
Cdd:TIGR03463 162 SGRGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQ 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  324 VAADDRFTKCISIGPISKTVNMLIRWSVDgPSSPAFQEHVSRIKDYLWLGLD-GMKMQGTNGSQTWDTSFAVQALLEAGA 402
Cdd:TIGR03463 242 ILAEDEATHYICIGPINGLLNCLAIFAHD-PDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALGE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  403 ----HRRpeflpCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQER-CPSITE 477
Cdd:TIGR03463 321 ldeeAKH-----ALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELgDNRISE 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  478 HVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATEI 557
Cdd:TIGR03463 396 ALGAARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPDAKI 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  558 RETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGhiyqNRTACAEVAQACHFLLSRQMADGGWGEDFESC 637
Cdd:TIGR03463 476 DAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAG----AEPADMALQAAAAFLLEKQRADGAWGEHVESC 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  638 EQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWAL 717
Cdd:TIGR03463 552 LEARWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWAL 631


                  ...
gi 300591907  718 GRF 720
Cdd:TIGR03463 632 ARC 634
PLN03012 PLN03012
Camelliol C synthase
 72-725 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 596.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  72 QTAHEGALNGVTFYAKLQAEDGHW----AGDYGGPLFLLPGLLITCHIAHIpLPAGYREEMVRYLRSVQLPNGGWGLHIE 147
Cdd:PLN03012  93 EIATNALRKGIHFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIE 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 148 DKSTVFGTALSYVSLRILGIGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFP 224
Cdd:PLN03012 172 GHSTMFCTTLNYICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFP 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 225 AHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLY 304
Cdd:PLN03012 252 IHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIF 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 305 -ERF-----HSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWsVDGPSSPAFQEHVSRIKDYLWLGLDGMK 378
Cdd:PLN03012 332 aEPFlacwpFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMK 410

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 379 MQgTNGSQTWDTSFAVQALLeaGAHRRPEFLPCLQKAHEFLRLSQVPDN-NPDYQKYYRHMHKGGFPFSTLDCGWIVADC 457
Cdd:PLN03012 411 MQ-SFGSQLWDSGFALQALL--ASNLSNEIPDVLRRGHDFIKNSQVGENpSGDFKNMYRHISKGAWTFSDRDHGWQASDC 487

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 458 TAEALKAVLLLQERCPSITEhvPR---ERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVEC 534
Cdd:PLN03012 488 TAEGFKCCLLFSMIAPDIVG--PKmdpEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNEC 565

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 535 TSAVMQALRHFREYFPDHRATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVA 614
Cdd:PLN03012 566 TSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIR 642

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 615 QACHFLLSRQMADGGWGEDFESCEQRRYVQSAG--SQVHSTCWALLGLM----AVRHPdiSAQERGIRCLLGKQLPNGDW 688
Cdd:PLN03012 643 KGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGeiSNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDF 720

                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 300591907 689 PQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYP 725
Cdd:PLN03012 721 PQQEATGAFLKNCLLHYAAYRNIFPLWALAEYRARVP 757
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
73-724 0e+00

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 560.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  73 TAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTV 152
Cdd:COG1657   19 SLLDAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 153 FGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWC 232
Cdd:COG1657   99 STTVKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSY 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 233 HCRQVYLPMSYCYATRLSASEDPLVqsLRQELYVEDYASIDWPAQKNNvcpddMYTPHSWLLHVVYGLLNLYERFHSTSL 312
Cdd:COG1657  179 WARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDYYFPAPR-----DRSPWSRFFLALDRLLRAYERLPPKPL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 313 RKWAIQLLYEHVA----ADDRFtkcISIGP-ISKTVNMLiRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGtNGSQT 387
Cdd:COG1657  252 RRRALRKAEDWILerleGDGGL---GGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPV 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 388 WDTSFAVQALLEAGahrRPEFLPCLQKAHEFLRLSQVPDnNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLL 467
Cdd:COG1657  327 WDTALAVQALQEAG---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLR 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 468 LQERcpsiTEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEvFGdIMIDYTYVECTSAVMQALRHFre 547
Cdd:COG1657  403 LRLP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLGQL-- 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 548 yfpdhRATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHiyqnRTACAEVAQACHFLLSRQMAD 627
Cdd:COG1657  475 -----GLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGV----DPDDPAIRRAVAWLLSIQNAD 545

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 628 GGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGV-FNKSCAISYT 706
Cdd:COG1657  546 GGWGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYH 625

                        650
                 ....*....|....*...
gi 300591907 707 NYRNIFPIWALGRFSSLY 724
Cdd:COG1657  626 LYRQYFPLWALARYRNLR 643
PLN02993 PLN02993
lupeol synthase
 72-720 0e+00

lupeol synthase


Pssm-ID: 215537 [Multi-domain]  Cd Length: 763  Bit Score: 560.30  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  72 QTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPG----LLITCHIAHIpLPAGYREEMVRYLRSVQLPNGGWGLHIE 147
Cdd:PLN02993  93 ETATNALRRGVSFFSALQASDGHWPGEITGPLFFLPPlvfcLYITGHLEEV-FDAEHRKEMLRHIYCHQNEDGGWGLHIE 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 148 DKSTVFGTALSYVSLRILGIGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFP 224
Cdd:PLN02993 172 SKSVMFCTVLNYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMPPEIWLLPSFLP 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 225 AHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLY 304
Cdd:PLN02993 252 IHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQDLIWDTLHNF 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 305 ERFHSTS------LRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWsVDGPSSPAFQEHVSRIKDYLWLGLDGMK 378
Cdd:PLN02993 332 VEPFLTRwplnklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDYMWVAEDGMK 410

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 379 MQgTNGSQTWDTSFAVQALLeaGAHRRPEFLPCLQKAHEFLRLSQVPDN-NPDYQKYYRHMHKGGFPFSTLDCGWIVADC 457
Cdd:PLN02993 411 MQ-SFGSQLWDTGFAIQALL--ASDLSDETDDVLRRGHNYIKKSQVRENpSGDFKSMYRHISKGAWTLSDRDHGWQVSDC 487

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 458 TAEALKAVLLLQERCPSIT-EHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTS 536
Cdd:PLN02993 488 TAEALKCCMLLSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVEREYVECTS 567

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 537 AVMQALRHFREYFPDHRATEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNrtaCAEVAQA 616
Cdd:PLN02993 568 AVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND---CLAMRKG 644

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 617 CHFLLSRQMADGGWGEDFESCEQRRYVQSAG--SQVHSTCWALLGLMAVRHP--DISAQERGIRCLLGKQLPNGDWPQEN 692
Cdd:PLN02993 645 VHFLLTIQRDDGGWGESYLSCPEQRYIPLEGnrSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQLENGDFPQQE 724

                        650       660
                 ....*....|....*....|....*...
gi 300591907 693 ISGVFNKSCAISYTNYRNIFPIWALGRF 720
Cdd:PLN02993 725 ILGAFMNTCMLHYATYRNTFPLWALAEY 752
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
 385-720 3.19e-168

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 487.11  E-value: 3.19e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 385 SQTWDTSFAVQALLEAGahRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKA 464
Cdd:cd02889   23 SQVWDTALALQALLEAG--LAPEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 465 VLLLQERCPSiTEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELlnPSEVFGDIMIDYTYVECTSAVMQALRH 544
Cdd:cd02889  101 LLRLQKKPPD-GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 545 FREYFPDHRAtEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIyqnrTACAEVAQACHFLLSRQ 624
Cdd:cd02889  178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED----ENSPYVRKACDWLLSKQ 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 625 MADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAIS 704
Cdd:cd02889  253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332

                        330
                 ....*....|....*.
gi 300591907 705 YTNYRNIFPIWALGRF 720
Cdd:cd02889  333 YHNYRNYFPLWALGRY 348
hopene_cyclase TIGR01507
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ...
 82-723 1.03e-60

squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273661 [Multi-domain]  Cd Length: 635  Bit Score: 215.91  E-value: 1.03e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907   82 VTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHiPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTALSYVS 161
Cdd:TIGR01507  22 VDYLLSCQKDEGYWWGELESNVTIEAEYVLLCHILD-RVDRDRMEKIRNYLLHEQREDGTWALYPGGPGDLSTTVEAYVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  162 LRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPM 241
Cdd:TIGR01507 101 LKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSSWARATVVPL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  242 SYCYATRLSAsedPLVQSLR-QELYVEDYASIDWpaqknnvcpddmYTPHS-WLLHVVYGL---LNLYERFHSTSLRKWA 316
Cdd:TIGR01507 181 SIVCSRKPVF---PLPERARvPELYETDVPKPRR------------RGAKGgTGWGIFDALdraLHGYEKLSVHPFRRAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  317 IQL----LYEHVAADDRFTkcisiGPISKTVNMLIRWSVDG-PSSPAF-QEHVSRIKDYLWLGLDGMKMQGTNgSQTWDT 390
Cdd:TIGR01507 246 EIRaldwLLERQAGDGSWG-----GIQPAMFNALIALKILGmTQHDAFiKLGWEGIDLYGVELDDSWMFQACV-SPVWDT 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  391 SFAVQALLEAGahrRPEFLPCLQKAHEFLRLSQVpDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAvlLLQE 470
Cdd:TIGR01507 320 ALAVLALREAG---LPADHDALVKAGEWLLDKQI-TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDDTAVVVWA--LNGL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  471 RCPSitEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNpsevFGDI--MIDYTYVECTSAVMQALRHFREy 548
Cdd:TIGR01507 394 RLPD--ERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGY- 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  549 fpdhraTEIRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFAcmghIYQNRTACAEVAQACHFLLSRQMADG 628
Cdd:TIGR01507 467 ------DDAWPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALK----AVGIDTREPYIQKALAWLESHQNPDG 536

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  629 GWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGV-FNKSCAISYTN 707
Cdd:TIGR01507 537 GWGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHM 616

                         650
                  ....*....|....*.
gi 300591907  708 YRNIFPIWALGRFSSL 723
Cdd:TIGR01507 617 YRHVFPLLALARYKQA 632
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
 363-720 1.49e-53

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 186.99  E-value: 1.49e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 363 VSRIKDYL--WLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAH--RRPEFLPCLQKAHEFLRLSQVPDnnpdyqkyyrhm 438
Cdd:cd00688    1 IEKHLKYLlrYPYGDGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLSD------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 439 hkGGFPFSTLDcGWIVADCTAEALKAVLLLQErcpsiTEHVPRERLYDAVAVLLSMRNSDGGFATYEtkrggyllellnp 518
Cdd:cd00688   69 --GGFSGWGGN-DYPSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDG------------- 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 519 sEVFGDIMIDYTYVECTSAVMQALRHFREYFPDhrateirETLNQGLDFCRKKQRADGSWeGSWGVCFTYGTWFGLEAFA 598
Cdd:cd00688  128 -PGNHRIGGDESDVRLTAYALIALALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALA 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 599 CMGHIYQNRtacaeVAQACHFLLSRQMADGGWGEdfesceqRRYVQSAGSQVHSTCWALLGLMA-VRHPDISAQERGIRC 677
Cdd:cd00688  199 LLGDLDSPD-----AKKALRWLLSRQRPDGGWGE-------GRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKW 266

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 300591907 678 LLGKQLPNGDWPQENIsgvfnkscaISYTNYRNIFPIWALGRF 720
Cdd:cd00688  267 LLSQQNEDGGFSSKPG---------KSYDTQHTVFALLALSLY 300
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
 385-720 3.46e-49

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 175.60  E-value: 3.46e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  385 SQTWDTSFAVQALLEAGAhrrPEFLPCLQKAHEFLRLSQVPDNNpDYQKYYRHMHKGGFPFSTLDCGWIVADCTAealkA 464
Cdd:pfam13243   2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLVKG-DWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  465 VLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLnPsevFGDI--MIDYTYVECTSAVMQAL 542
Cdd:pfam13243  74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKI-P---FADHgaLLDPPTADVTARVLEML 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  543 RHFrEYFPDHrateirETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHiyqnRTACAEVAQACHFLLS 622
Cdd:pfam13243 150 GQL-GYPDDH------PVAARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGE----DHNRPYIRKAVDWLKS 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  623 RQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGV-FNKSC 701
Cdd:pfam13243 219 RQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPRVF 298

                         330
                  ....*....|....*....
gi 300591907  702 AISYTNYRNIFPIWALGRF 720
Cdd:pfam13243 299 YLKYHGYRNYFPLWALARY 317
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
 88-318 1.58e-42

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 156.11  E-value: 1.58e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907   88 LQAEDGHWAGDyggplfLLPGLLITCH--IAH---IPLPAGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTALSYVSL 162
Cdd:pfam13249  11 LQHPDGHWVGE------LEANVTITAEyiLLRhflGPDDPELEAKIARYLRSQQREDGGWPLFHGGPGDLSTTVEAYFAL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  163 RILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMS 242
Cdd:pfam13249  85 KLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFNIYKFSSWARTTIVPLL 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300591907  243 YCYATRLSASEDPlvQSLRQELYVEDYASIDWPAQKnnvcpddmYTPHSW--LLHVVYGLLNLYERFHSTSLRKWAIQ 318
Cdd:pfam13249 165 ILSALKPVAPLPP--GIGLDELFVEPPENVRYYPRP--------HRLFSWtnLFLGLDRVLKLYERLPPKPLRRRALR 232
squa_tetra_cyc TIGR04277
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ...
 132-720 8.72e-19

squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.


Pssm-ID: 212000 [Multi-domain]  Cd Length: 624  Bit Score: 90.85  E-value: 8.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  132 LRSVQLPNGGWgLHIEDKSTVFG----TALSYVSLRILGIGPD-DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSW 206
Cdd:TIGR04277  77 LLGSQFEDGSW-EQVEDANIETGqldaTIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPW 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  207 EgintlfpEMWLLPEW-FPAHPSTLWCHCRQVYLPMSYCYATRLSASE------DPLVQSLRqELYvedyasIDWPAQKN 279
Cdd:TIGR04277 156 E-------DLFKIPLFiFKKKGIFKPLYIKDITAQWVYPHLTALAYLQnqriifNVAVADIR-ELW------INKAKKGI 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  280 NVCPDDMYT--PHSWLLHVVYGLLNLYERFhsTSLRKWAIQLLYEHVAADDrFTkcisigpiSKTVNMlirwsvdgpssp 357
Cdd:TIGR04277 222 KHQKKERPSffIDNDLLILMDEIFKLKQPL--GSFGAYTISTLLSLLAFKD-FQ--------GKHPHK------------ 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  358 afqeHVSRIKDYLWLGLDGMKM------QGTNGS----QTWDTSFAVQALLEAGAHRRPEFlPCLQKaheFLRLSQVPDN 427
Cdd:TIGR04277 279 ----HKNEIQDALEDGLDFVEFnyfnfrEAYHGSlddgRWWDTILISWAMLESGEDKEKIF-PIVEN---MLKEGLQPKG 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  428 NPDYQKYYrhmhkgGFPFSTLDCGwivadctaealkavLLLQerCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYET- 506
Cdd:TIGR04277 351 GIEYGYDF------EYAPDADDTG--------------LLLQ--VLSYYGEAFADAIDEGAEFLFSMQNDDGGFPAFDKg 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  507 KRGGYLL--------ELLNPSEVFgdimiDYTYVECTSAVMQALRHFrEYFPDHrateirETLNQGLDFCRKKQRADGSW 578
Cdd:TIGR04277 409 KMEDNLLfkfafkiaGIADSAEIF-----DPSCPDITAHILEGLGEF-GDQANH------DQIQKMIKYFMDTQEKFGSW 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907  579 EGSWGVCFTYGTWFGLEAFACMGHIYQNRTacaeVAQACHFLLSRQMADGGWGEDFESC-EQRRYVQSAGSQVHSTCWAL 657
Cdd:TIGR04277 477 EARWGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLSYnDPEKWNGIGKSTVTQTSWGL 552

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300591907  658 LGLMAVR-HPDI--SAQERGIRCLLGK-QLPNGDWPQENISGVFNKSCA-ISYTNYRNIFPIWALGRF 720
Cdd:TIGR04277 553 LALLAVEdHNDQikEAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
125-166 2.49e-08

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 50.20  E-value: 2.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 300591907  125 REEMVRYLRSVQLPNGGWGLHIEDKSTVFGTALSYVSLRILG 166
Cdd:pfam00432   3 KEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
562-601 1.87e-07

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 47.89  E-value: 1.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 300591907  562 NQGLDFCRKKQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 601
Cdd:pfam00432   4 EKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
613-659 3.00e-06

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 44.42  E-value: 3.00e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 300591907  613 VAQACHFLLSRQMADGGWGEDFESCeqrryVQSAGSQVHSTCWALLG 659
Cdd:pfam00432   3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
 556-703 1.75e-04

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 43.93  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 556 EIRETLnqgLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEvaqachFLLSRQMADGGwgedFE 635
Cdd:COG5029   19 DFTDSH---LDYLRASQNPDGGFAGRSGPSDLYSTYYAVRTLALLGESPKWRDRVAD------LLSSLRVEDGG----FA 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 636 SCeqrryVQSAGSQVHSTCWALLGLMAVRHPDISaQERGIRCLLGKQLPNG--DWPQENISGVFNKSCAI 703
Cdd:COG5029   86 KA-----PEGGAGSTYHTYLATLLAELLGRPPPD-PDRLVRFLISQQNDDGgfEISPGRRSDTNPTAAAI 149
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
 121-181 2.77e-04

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 43.16  E-value: 2.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300591907 121 PAGYREEMVRYLRSVQLPNGGWGLHIEDKSTVFGTALSYVSLRILGIGpDDPDLVRARNIL 181
Cdd:COG5029  111 PPPDPDRLVRFLISQQNDDGGFEISPGRRSDTNPTAAAIGALRALGAL-DDPIETKVIRFL 170
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
 465-686 7.92e-04

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 42.00  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 465 VLLLQERCPSITEHVPRERLYDAVAvllSMRNSDGGFATYETkrggyllellnPSEVFgdimidYTYVECTSAVMQALRH 544
Cdd:COG5029    5 VLSRLEGGSSKSTADFTDSHLDYLR---ASQNPDGGFAGRSG-----------PSDLY------STYYAVRTLALLGESP 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 545 FreyfpdhrateIRETLnqgLDFCRKKQRADGSW----EGSWGvcFTYGTWFGLEAFACMGHiyqnrtACAEVAQACHFL 620
Cdd:COG5029   65 K-----------WRDRV---ADLLSSLRVEDGGFakapEGGAG--STYHTYLATLLAELLGR------PPPDPDRLVRFL 122

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300591907 621 LSRQMADGGWGEDFesceqrryvqSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNG 686
Cdd:COG5029  123 ISQQNDDGGFEISP----------GRRSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
AF1543 COG1689
Class II terpene cyclase family protein AF1543 [General function prediction only];
486-577 2.14e-03

Class II terpene cyclase family protein AF1543 [General function prediction only];


Pssm-ID: 441295 [Multi-domain]  Cd Length: 272  Bit Score: 40.48  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300591907 486 DAVAVLLSMRNSDGGFA-----TYETKRGGYLLELL-----NPSEV-------------FGDIMIDYTYVECTSAVMQAL 542
Cdd:COG1689  139 KIREFLLSLRRPDGGFGgkkpnLEDTYWALAALRRLgrdlpPADRViafilacqnedggFSKTPGSYSDLEATYYALRAL 218

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 300591907 543 RHFREYFPDHRATeiretlnqgLDFCRKKQRADGS 577
Cdd:COG1689  219 KLLGEPPKNVDKL---------LEFIASCQNSDGG 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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