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Conserved domains on  [gi|300153927|gb|EFJ20564|]
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hypothetical protein SELMODRAFT_177006 [Selaginella moellendorffii]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
108-285 2.43e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 108 IWDDHQGRCIGEL-AFRSEVRGVKLRRD-RIVVI--LEHKIYVYNFVDLKLLHQIETIANGKGLCALSPSSTTpiLACpG 183
Cdd:COG2319  146 LWDLATGKLLRTLtGHSGAVTSVAFSPDgKLLASgsDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL--LAS-G 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 184 LHKGQVRV-EHYGLRKTKFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRRGADRaqIFSIAFSPN 262
Cdd:COG2319  223 SADGTVRLwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG--VNSVAFSPD 299

                        170       180
                 ....*....|....*....|...
gi 300153927 263 AQWLAVSSDKGTVHVFRLKGPSP 285
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLATGKL 322
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
108-285 2.43e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 108 IWDDHQGRCIGEL-AFRSEVRGVKLRRD-RIVVI--LEHKIYVYNFVDLKLLHQIETIANGKGLCALSPSSTTpiLACpG 183
Cdd:COG2319  146 LWDLATGKLLRTLtGHSGAVTSVAFSPDgKLLASgsDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL--LAS-G 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 184 LHKGQVRV-EHYGLRKTKFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRRGADRaqIFSIAFSPN 262
Cdd:COG2319  223 SADGTVRLwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG--VNSVAFSPD 299

                        170       180
                 ....*....|....*....|...
gi 300153927 263 AQWLAVSSDKGTVHVFRLKGPSP 285
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-286 9.80e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 9.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 108 IWDDHQGRCIGELA-FRSEVRGVKLRRD-RIVV--ILEHKIYVYNFVDLKLLHQIETIanGKGLCALSPSSTTPILACpG 183
Cdd:cd00200   77 LWDLETGECVRTLTgHTSYVSSVAFSPDgRILSssSRDKTIKVWDVETGKCLTTLRGH--TDWVNSVAFSPDGTFVAS-S 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 184 LHKGQVRV-EHYGLRKTKFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRrgADRAQIFSIAFSPN 262
Cdd:cd00200  154 SQDGTIKLwDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNSVAFSPD 230

                        170       180
                 ....*....|....*....|....
gi 300153927 263 AQWLAVSSDKGTVHVFRLKGPSPS 286
Cdd:cd00200  231 GYLLASGSEDGTIRVWDLRTGECV 254
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-278 6.91e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.91e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 300153927   238 DGTRLQELRrgADRAQIFSIAFSPNAQWLAVSSDKGTVHVF 278
Cdd:smart00320   1 SGELLKTLK--GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
108-285 2.43e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 108 IWDDHQGRCIGEL-AFRSEVRGVKLRRD-RIVVI--LEHKIYVYNFVDLKLLHQIETIANGKGLCALSPSSTTpiLACpG 183
Cdd:COG2319  146 LWDLATGKLLRTLtGHSGAVTSVAFSPDgKLLASgsDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL--LAS-G 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 184 LHKGQVRV-EHYGLRKTKFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRRGADRaqIFSIAFSPN 262
Cdd:COG2319  223 SADGTVRLwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG--VNSVAFSPD 299

                        170       180
                 ....*....|....*....|...
gi 300153927 263 AQWLAVSSDKGTVHVFRLKGPSP 285
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
106-285 9.31e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 9.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 106 VMIWDDHQGRCIGEL-AFRSEVRGVKLRRD--RIVVILEHK-IYVYNFVDLKLLHQIETIANGKGLCALSPSSTTpiLAC 181
Cdd:COG2319  102 VRLWDLATGLLLRTLtGHTGAVRSVAFSPDgkTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--LAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 182 pGLHKGQVRV-EHYGLRKTKFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRrgADRAQIFSIAFS 260
Cdd:COG2319  180 -GSDDGTVRLwDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLT--GHSGSVRSVAFS 255

                        170       180
                 ....*....|....*....|....*
gi 300153927 261 PNAQWLAVSSDKGTVHVFRLKGPSP 285
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
106-282 1.18e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 106 VMIWDDHQGRCIGEL-AFRSEVRGVKLRRD-RIVVI--LEHKIYVYNFVDLKLLHQIETIANGKGLCALSPSSTTpiLAC 181
Cdd:COG2319  186 VRLWDLATGKLLRTLtGHTGAVRSVAFSPDgKLLASgsADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL--LAS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 182 pGLHKGQVRVehYGL---RKTKFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRrgADRAQIFSIA 258
Cdd:COG2319  264 -GSADGTVRL--WDLatgELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLT--GHTGAVRSVA 337

                        170       180
                 ....*....|....*....|....
gi 300153927 259 FSPNAQWLAVSSDKGTVHVFRLKG 282
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-286 9.80e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 9.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 108 IWDDHQGRCIGELA-FRSEVRGVKLRRD-RIVV--ILEHKIYVYNFVDLKLLHQIETIanGKGLCALSPSSTTPILACpG 183
Cdd:cd00200   77 LWDLETGECVRTLTgHTSYVSSVAFSPDgRILSssSRDKTIKVWDVETGKCLTTLRGH--TDWVNSVAFSPDGTFVAS-S 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 184 LHKGQVRV-EHYGLRKTKFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRrgADRAQIFSIAFSPN 262
Cdd:cd00200  154 SQDGTIKLwDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNSVAFSPD 230

                        170       180
                 ....*....|....*....|....
gi 300153927 263 AQWLAVSSDKGTVHVFRLKGPSPS 286
Cdd:cd00200  231 GYLLASGSEDGTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
106-282 1.43e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 1.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 106 VMIWDDHQGRCIGELAF-RSEVRGVKLRRD-RIVVI--LEHKIYVYNFVDLKLLHQIETIANGKGLCALSPSSTTpiLAC 181
Cdd:COG2319  228 VRLWDLATGKLLRTLTGhSGSVRSVAFSPDgRLLASgsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL--LAS 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 182 pGLHKGQVRVEHYGLRKT-KFIPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRRGADRaqIFSIAFS 260
Cdd:COG2319  306 -GSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGA--VTSVAFS 381

                        170       180
                 ....*....|....*....|..
gi 300153927 261 PNAQWLAVSSDKGTVHVFRLKG 282
Cdd:COG2319  382 PDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-279 2.03e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 2.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 105 KVMIWDDHQGRCIGELAFRSE-VRGVKLRRDRIVVI---LEHKIYVYNFVDLKLLHQIET-IANGKGLCaLSPSSTTPIL 179
Cdd:cd00200  116 TIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVAsssQDGTIKLWDLRTGKCVATLTGhTGEVNSVA-FSPDGEKLLS 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 180 ACpglHKGQVRVehYGLRKTKFI---PAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRrgADRAQIFS 256
Cdd:cd00200  195 SS---SDGTIKL--WDLSTGKCLgtlRGHENGVNSVAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLS--GHTNSVTS 266

                        170       180
                 ....*....|....*....|...
gi 300153927 257 IAFSPNAQWLAVSSDKGTVHVFR 279
Cdd:cd00200  267 LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
203-281 2.26e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 2.26e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300153927 203 PAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELRRGADRaqIFSIAFSPNAQWLAVSSDKGTVHVFRLK 281
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSADGTVRLWDLA 150
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-288 2.52e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300153927 202 IPAHDSNLACFSLSQDGKLLATASTKGTlIRIFNTMDGTRLQELrRGAdRAQIFSIAFSPNAQWLAVSSDKGTVHVFRLK 281
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTL-KGH-TGPVRDVAASADGTYLASGSSDKTIRLWDLE 81


                 ....*..
gi 300153927 282 GPSPSDE 288
Cdd:cd00200   82 TGECVRT 88
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 213-273 2.15e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.50  E-value: 2.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300153927 213 SLSQDGKLLATASTKGTLIRIFnTM--DGTRLQELRRGAdraqiFSIAFSPNAQWLAVSSDKG 273
Cdd:COG0823   81 SWSPDGKRLAFVSRSDGRFDIY-VLdlDGGAPRRLTDGP-----GSPSWSPDGRRIVFSSDRG 137
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-278 6.91e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.91e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 300153927   238 DGTRLQELRrgADRAQIFSIAFSPNAQWLAVSSDKGTVHVF 278
Cdd:smart00320   1 SGELLKTLK--GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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