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Conserved domains on  [gi|299527984|gb|ADJ26452|]
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Site-specific DNA-methyltransferase (adenine-specific) [Dehalogenimonas lykanthroporepellens BL-DC-9]

Protein Classification

adenine-specific methyltransferase EcoRI family protein( domain architecture ID 10614878)

adenine-specific methyltransferase EcoRI family protein similar to Escherichia coli EcoRI that recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EcoRI_methylase pfam13651
Adenine-specific methyltransferase EcoRI; This methylase recognizes the double-stranded ...
 37-402 0e+00

Adenine-specific methyltransferase EcoRI; This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.


:

Pssm-ID: 404530  Cd Length: 343  Bit Score: 521.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984   37 LSAAKAAKQDEFYTQYVDIQKEIEAYlefdPNTFRGKVVYCNCDDPFESNFFKYFAANFNKLGLKKLITTSYDGSPIAGQ 116
Cdd:pfam13651   1 LNKAKKAKKDEFYTQLSDIERELRHY----PNHFKDKVVLCNCDDPRESNFFKYFALNFNYLGLKKLIATCYNGSPIAGQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  117 LNLFPEYNEgngKRQKPKAVAFIIDHVKDEDGDGAANVTDVslflkrnkaARIALKGNdqypgGDFRSPECLAFLKETDI 196
Cdd:pfam13651  77 ELQDFSLFS---DEDKKKAYKLEYTGVKDTNGDGAIDLEDI---------QILPLKGD-----GDFRSAECIELLKQADI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  197 VVTNPPFSLFREYVAQLMEYGKKFVIIGPKSAITYKEIFPLIKESKLWLGSGFANGNAYFSIPTHACREFADGVYDET-T 275
Cdd:pfam13651 140 VVTNPPFSLFREYVAQLVEYDKKFLIIGNQNAITYKEIFPLIKENKLWLGYGFGSGDMGFIVPDDYELYATRCFVDEDgQ 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  276 GLVKFRNVGWFTNLDHGRRHEKLPLMTmadnlKFSKHKeikgkaaYARYDNYDAIEVPFTDAIPNDYEGIMGVPITFLDK 355
Cdd:pfam13651 220 KYIRVKGVCWFTNLDIGKRHEDLVLYK-----RYNEEE-------YPKYDNYDAIEVNKTDDIPCDYDGIMGVPITFLDK 287

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 299527984  356 YNPEQFEIIGLAAGNIRGLAGI---------PSATGKDGPYMDGKLKYGRILIRHR 402
Cdd:pfam13651 288 YNPDQFEIIGLRAGQYAGAAGTgtnkyglskHGADRKKDPRVNGKRPYFRILIRNK 343
 
Name Accession Description Interval E-value
EcoRI_methylase pfam13651
Adenine-specific methyltransferase EcoRI; This methylase recognizes the double-stranded ...
 37-402 0e+00

Adenine-specific methyltransferase EcoRI; This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.


Pssm-ID: 404530  Cd Length: 343  Bit Score: 521.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984   37 LSAAKAAKQDEFYTQYVDIQKEIEAYlefdPNTFRGKVVYCNCDDPFESNFFKYFAANFNKLGLKKLITTSYDGSPIAGQ 116
Cdd:pfam13651   1 LNKAKKAKKDEFYTQLSDIERELRHY----PNHFKDKVVLCNCDDPRESNFFKYFALNFNYLGLKKLIATCYNGSPIAGQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  117 LNLFPEYNEgngKRQKPKAVAFIIDHVKDEDGDGAANVTDVslflkrnkaARIALKGNdqypgGDFRSPECLAFLKETDI 196
Cdd:pfam13651  77 ELQDFSLFS---DEDKKKAYKLEYTGVKDTNGDGAIDLEDI---------QILPLKGD-----GDFRSAECIELLKQADI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  197 VVTNPPFSLFREYVAQLMEYGKKFVIIGPKSAITYKEIFPLIKESKLWLGSGFANGNAYFSIPTHACREFADGVYDET-T 275
Cdd:pfam13651 140 VVTNPPFSLFREYVAQLVEYDKKFLIIGNQNAITYKEIFPLIKENKLWLGYGFGSGDMGFIVPDDYELYATRCFVDEDgQ 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  276 GLVKFRNVGWFTNLDHGRRHEKLPLMTmadnlKFSKHKeikgkaaYARYDNYDAIEVPFTDAIPNDYEGIMGVPITFLDK 355
Cdd:pfam13651 220 KYIRVKGVCWFTNLDIGKRHEDLVLYK-----RYNEEE-------YPKYDNYDAIEVNKTDDIPCDYDGIMGVPITFLDK 287

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 299527984  356 YNPEQFEIIGLAAGNIRGLAGI---------PSATGKDGPYMDGKLKYGRILIRHR 402
Cdd:pfam13651 288 YNPDQFEIIGLRAGQYAGAAGTgtnkyglskHGADRKKDPRVNGKRPYFRILIRNK 343
 
Name Accession Description Interval E-value
EcoRI_methylase pfam13651
Adenine-specific methyltransferase EcoRI; This methylase recognizes the double-stranded ...
 37-402 0e+00

Adenine-specific methyltransferase EcoRI; This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.


Pssm-ID: 404530  Cd Length: 343  Bit Score: 521.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984   37 LSAAKAAKQDEFYTQYVDIQKEIEAYlefdPNTFRGKVVYCNCDDPFESNFFKYFAANFNKLGLKKLITTSYDGSPIAGQ 116
Cdd:pfam13651   1 LNKAKKAKKDEFYTQLSDIERELRHY----PNHFKDKVVLCNCDDPRESNFFKYFALNFNYLGLKKLIATCYNGSPIAGQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  117 LNLFPEYNEgngKRQKPKAVAFIIDHVKDEDGDGAANVTDVslflkrnkaARIALKGNdqypgGDFRSPECLAFLKETDI 196
Cdd:pfam13651  77 ELQDFSLFS---DEDKKKAYKLEYTGVKDTNGDGAIDLEDI---------QILPLKGD-----GDFRSAECIELLKQADI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  197 VVTNPPFSLFREYVAQLMEYGKKFVIIGPKSAITYKEIFPLIKESKLWLGSGFANGNAYFSIPTHACREFADGVYDET-T 275
Cdd:pfam13651 140 VVTNPPFSLFREYVAQLVEYDKKFLIIGNQNAITYKEIFPLIKENKLWLGYGFGSGDMGFIVPDDYELYATRCFVDEDgQ 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299527984  276 GLVKFRNVGWFTNLDHGRRHEKLPLMTmadnlKFSKHKeikgkaaYARYDNYDAIEVPFTDAIPNDYEGIMGVPITFLDK 355
Cdd:pfam13651 220 KYIRVKGVCWFTNLDIGKRHEDLVLYK-----RYNEEE-------YPKYDNYDAIEVNKTDDIPCDYDGIMGVPITFLDK 287

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 299527984  356 YNPEQFEIIGLAAGNIRGLAGI---------PSATGKDGPYMDGKLKYGRILIRHR 402
Cdd:pfam13651 288 YNPDQFEIIGLRAGQYAGAAGTgtnkyglskHGADRKKDPRVNGKRPYFRILIRNK 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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