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Conserved domains on  [gi|298712456|emb|CBJ33230|]
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conserved unknown protein [Ectocarpus siliculosus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-422 7.84e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 285.38  E-value: 7.84e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 105 KGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWNFS 184
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 185 EGgaggaECLKTLRGHDHNVSCVAWVpPAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDDGEMLASCGN 264
Cdd:cd00200   82 TG-----ECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 265 DHSVKVWSVHSGQCLHDLREHTHVVESIAFAPESAEralatavgsegggggegavrrrfVASGSRDKTVKLWNASVGHCL 344
Cdd:cd00200  156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK-----------------------LLSSSSDGTIKLWDLSTGKCL 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 298712456 345 MTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLEdAHGHLVTALAMHKTSPIVVSGGVDGELHVWE 422
Cdd:cd00200  213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-422 7.84e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 285.38  E-value: 7.84e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 105 KGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWNFS 184
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 185 EGgaggaECLKTLRGHDHNVSCVAWVpPAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDDGEMLASCGN 264
Cdd:cd00200   82 TG-----ECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 265 DHSVKVWSVHSGQCLHDLREHTHVVESIAFAPESAEralatavgsegggggegavrrrfVASGSRDKTVKLWNASVGHCL 344
Cdd:cd00200  156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK-----------------------LLSSSSDGTIKLWDLSTGKCL 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 298712456 345 MTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLEdAHGHLVTALAMHKTSPIVVSGGVDGELHVWE 422
Cdd:cd00200  213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
99-424 2.85e-92

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 285.65  E-value: 2.85e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456  99 LPRAPAKGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTI 178
Cdd:COG2319  107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 179 KIWNFSEGgaggaECLKTLRGHDHNVSCVAWVPpAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDDGEM 258
Cdd:COG2319  187 RLWDLATG-----KLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 259 LASCGNDHSVKVWSVHSGQCLHDLREHTHVVESIAFAPESaeralatavgsegggggegavrrRFVASGSRDKTVKLWNA 338
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-----------------------KLLASGSDDGTVRLWDL 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 339 SVGHCLMTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLEdAHGHLVTALAMHKTSPIVVSGGVDGEL 418
Cdd:COG2319  318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTV 396


                 ....*.
gi 298712456 419 HVWELS 424
Cdd:COG2319  397 RLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 143-182 8.98e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 8.98e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 298712456   143 TGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWN 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
144-182 1.00e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 1.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 298712456  144 GECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWN 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 125-288 1.15e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 125 SVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAF-SPDGQRLASCAADTTIKIWNFSEGGAGGAecLKTlrghDHN 203
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGT--IKT----KAN 619

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 204 VSCVAWVPPAGDTLVSCSRDQTIKLWE---AATGFCtrTLKGDSEWVRRVALSDDGEMLAScGNDHSVKVWSVH---SG- 276
Cdd:PLN00181 620 ICCVQFPSESGRSLAFGSADHKVYYYDlrnPKLPLC--TMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDLSmsiSGi 696

                        170
                 ....*....|....
gi 298712456 277 --QCLHDLREHTHV 288
Cdd:PLN00181 697 neTPLHSFMGHTNV 710
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-422 7.84e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 285.38  E-value: 7.84e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 105 KGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWNFS 184
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 185 EGgaggaECLKTLRGHDHNVSCVAWVpPAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDDGEMLASCGN 264
Cdd:cd00200   82 TG-----ECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 265 DHSVKVWSVHSGQCLHDLREHTHVVESIAFAPESAEralatavgsegggggegavrrrfVASGSRDKTVKLWNASVGHCL 344
Cdd:cd00200  156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK-----------------------LLSSSSDGTIKLWDLSTGKCL 212

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 298712456 345 MTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLEdAHGHLVTALAMHKTSPIVVSGGVDGELHVWE 422
Cdd:cd00200  213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
99-424 2.85e-92

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 285.65  E-value: 2.85e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456  99 LPRAPAKGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTI 178
Cdd:COG2319  107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 179 KIWNFSEGgaggaECLKTLRGHDHNVSCVAWVPpAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDDGEM 258
Cdd:COG2319  187 RLWDLATG-----KLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 259 LASCGNDHSVKVWSVHSGQCLHDLREHTHVVESIAFAPESaeralatavgsegggggegavrrRFVASGSRDKTVKLWNA 338
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-----------------------KLLASGSDDGTVRLWDL 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 339 SVGHCLMTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLEdAHGHLVTALAMHKTSPIVVSGGVDGEL 418
Cdd:COG2319  318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTV 396


                 ....*.
gi 298712456 419 HVWELS 424
Cdd:COG2319  397 RLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
107-382 2.46e-82

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 259.84  E-value: 2.46e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 107 VLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWNFSEG 186
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 187 gaggaECLKTLRGHDHNVSCVAWvPPAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDDGEMLASCGNDH 266
Cdd:COG2319  237 -----KLLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 267 SVKVWSVHSGQCLHDLREHTHVVESIAFAPESaeralatavgsegggggegavrrRFVASGSRDKTVKLWNASVGHCLMT 346
Cdd:COG2319  311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-----------------------KTLASGSDDGTVRLWDLATGELLRT 367

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 298712456 347 FSVHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKT 382
Cdd:COG2319  368 LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
96-424 5.41e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 240.97  E-value: 5.41e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456  96 DRVLPRAPAKGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAAD 175
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 176 TTIKIWNFSEGgaggaECLKTLRGHDHNVSCVAWVPpAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDD 255
Cdd:COG2319  100 GTVRLWDLATG-----LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 256 GEMLASCGNDHSVKVWSVHSGQCLHDLREHTHVVESIAFAPESaeralatavgsegggggegavrrRFVASGSRDKTVKL 335
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-----------------------KLLASGSADGTVRL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 336 WNASVGHCLMTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLeDAHGHLVTALAMHKTSPIVVSGGVD 415
Cdd:COG2319  231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDD 309


                 ....*....
gi 298712456 416 GELHVWELS 424
Cdd:COG2319  310 GTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 193-424 1.82e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.39  E-value: 1.82e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 193 CLKTLRGHDHNVSCVAWVPPaGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEWVRRVALSDDGEMLASCGNDHSVKVWS 272
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 273 VHSGQCLHDLREHTHVVESIAFAPEsaeralatavgsegggggegavrRRFVASGSRDKTVKLWNASVGHCLMTFSVHEN 352
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPD-----------------------GRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 298712456 353 WVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLEdAHGHLVTALAMHKTSPIVVSGGVDGELHVWELS 424
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 92-272 4.99e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.84  E-value: 4.99e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456  92 AGGSDRV-----LPRAPAKGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDG 166
Cdd:cd00200  110 SSSRDKTikvwdVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 167 QRLASCAADTTIKIWNFSEGgaggaECLKTLRGHDHNVSCVAWvPPAGDTLVSCSRDQTIKLWEAATGFCTRTLKGDSEW 246
Cdd:cd00200  190 EKLLSSSSDGTIKLWDLSTG-----KCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS 263

                        170       180
                 ....*....|....*....|....*.
gi 298712456 247 VRRVALSDDGEMLASCGNDHSVKVWS 272
Cdd:cd00200  264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 143-182 8.98e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 8.98e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 298712456   143 TGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWN 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
144-182 1.00e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 1.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 298712456  144 GECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWN 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 125-288 1.15e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 125 SVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAF-SPDGQRLASCAADTTIKIWNFSEGGAGGAecLKTlrghDHN 203
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGT--IKT----KAN 619

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 204 VSCVAWVPPAGDTLVSCSRDQTIKLWE---AATGFCtrTLKGDSEWVRRVALSDDGEMLAScGNDHSVKVWSVH---SG- 276
Cdd:PLN00181 620 ICCVQFPSESGRSLAFGSADHKVYYYDlrnPKLPLC--TMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDLSmsiSGi 696

                        170
                 ....*....|....
gi 298712456 277 --QCLHDLREHTHV 288
Cdd:PLN00181 697 neTPLHSFMGHTNV 710
WD40 pfam00400
WD domain, G-beta repeat;
192-230 1.53e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.53e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 298712456  192 ECLKTLRGHDHNVSCVAWvPPAGDTLVSCSRDQTIKLWE 230
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-230 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.54e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 298712456   192 ECLKTLRGHDHNVSCVAWVpPAGDTLVSCSRDQTIKLWE 230
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 154-427 2.25e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 154 TNVVQSVAFSPDGQRLASCAADTTIKIWnfseggaggaEClktlrghdhnvscvawvppagDTLVSCSRDQTIKLWEAA- 232
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIF----------EC---------------------ESIIKDGRDIHYPVVELAs 531

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 233 ----TGFCtrtlkgdseWVRRVAlsddgEMLASCGNDHSVKVWSVHSGQCLHDLREHTHVVESIAFApeSAERALatavg 308
Cdd:PLN00181 532 rsklSGIC---------WNSYIK-----SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS--SADPTL----- 590

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 309 segggggegavrrrfVASGSRDKTVKLWNASVGHCLMTFSVHENWvrCVLVHPS--GAFVLSASDDRSVRAFDVKTGRCA 386
Cdd:PLN00181 591 ---------------LASGSDDGSVKLWSINQGVSIGTIKTKANI--CCVQFPSesGRSLAFGSADHKVYYYDLRNPKLP 653

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 298712456 387 rkledahghLVTALAMHKT--------SPIVVSGGVDGELHVWELSLTM 427
Cdd:PLN00181 654 ---------LCTMIGHSKTvsyvrfvdSSTLVSSSTDNTLKLWDLSMSI 693
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 233-272 2.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 298712456   233 TGFCTRTLKGDSEWVRRVALSDDGEMLASCGNDHSVKVWS 272
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 107-140 4.07e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.07e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 298712456   107 VLTGHRNPVTCVALHPLYSVVASSSEDATVKVWD 140
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 108-231 4.76e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.20  E-value: 4.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 108 LTGHRNPVTCVALHP-LYSVVASSSEDATVKVWDYETGECERTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWNFSEG 186
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 298712456 187 ----GAGGAECLKTLRghdhnvsCVaWVPPAgDTLVS--CSRDQT--IKLWEA 231
Cdd:PTZ00421 201 tivsSVEAHASAKSQR-------CL-WAKRK-DLIITlgCSKSQQrqIMLWDT 244
PTZ00421 PTZ00421
coronin; Provisional
 150-270 8.26e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.43  E-value: 8.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 150 LKGHTNVVQSVAFSP-DGQRLASCAADTTIKIWNFSEGG--AGGAECLKTLRGHDHNVSCVAWVPPAGDTLVSCSRDQTI 226
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 298712456 227 KLWEAATGFCTRTLKGDSEWVRRVALSDDGEMLASCGNDHSVKV 270
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
106-140 8.53e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 8.53e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 298712456  106 GVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWD 140
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
341-379 2.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 298712456  341 GHCLMTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFD 379
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 341-379 2.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 298712456   341 GHCLMTFSVHENWVRCVLVHPSGAFVLSASDDRSVRAFD 379
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
234-272 3.08e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 298712456  234 GFCTRTLKGDSEWVRRVALSDDGEMLASCGNDHSVKVWS 272
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 150-230 2.36e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.87  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 150 LKGHTNVVQSVAFSP-DGQRLASCAADTTIKIWNFSEGGAGGAE-----CLktLRGHDHNVSCVAWVPPAGDTLVSCSRD 223
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVKEikdpqCI--LKGHKKKISIIDWNPMNYYIMCSSGFD 147


                 ....*..
gi 298712456 224 QTIKLWE 230
Cdd:PTZ00420 148 SFVNIWD 154
WD40 COG2319
WD40 repeat [General function prediction only];
92-143 2.45e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 2.45e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 298712456  92 AGGSDRV-----LPRAPAKGVLTGHRNPVTCVALHPLYSVVASSSEDATVKVWDYET 143
Cdd:COG2319  347 SGSDDGTvrlwdLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 101-182 2.97e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 101 RAPAKGVLTGHRNPVTCVALHPLYS-VVASSSEDATVKVWDY--------ETGECERTLKGHTNVVQSVAFSP-DGQRLA 170
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPmNYYIMC 142

                         90
                 ....*....|..
gi 298712456 171 SCAADTTIKIWN 182
Cdd:PTZ00420 143 SSGFDSFVNIWD 154
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 259-421 5.02e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 5.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456  259 LASCGN-DHSVKVWSVHSGQCLHDLREHTHVVESIAFAPEsaeralatavgsegggggegavrRRFVASGSRDKTVKLWN 337
Cdd:pfam20426  96 LISCGNwENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSD-----------------------GSILATGSYDTTVMVWE 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456  338 ASVG--------------------------HCLMTfsvHENWVRCVLVHPSGAFVLSASDDRSVRAFDVKTGRCARKLED 391
Cdd:pfam20426 153 VLRGrssekrsrntqtefprkdhviaetpfHILCG---HDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRH 229

                         170       180       190
                  ....*....|....*....|....*....|
gi 298712456  392 AHGHLVTALAMHKTSPIVVSGGVDGELHVW 421
Cdd:pfam20426 230 PSGCPLSKLVASRHGRIVLYADDDLSLHLY 259
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 178-424 6.32e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 6.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 178 IKIWNFSEGGAGGAECLKTLRG---HDHNVSCVAWVPPAGDTLVSCSR-DQTIKLWEAATG------------------- 234
Cdd:cd22857    4 VKVVEARGKQEEAAPKVVDRWGgpdKSKAVQALSIADRESEPLLAVARkNGTVEVLDPENGdllasfsdsepatklseed 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 235 -------------FCTRT-------LKGDSEWVRRVALSDDGEMLASC-------------GNDHSVKVWSVhSGQCL-- 279
Cdd:cd22857   84 hfvglhlfsgtllTCTSKgslrstkLPDDSTASSSPTAWVCLGGNLLCmrvdpnenyfafgGKEVELNVWDL-EEKPGki 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456 280 -------HD---LREHTHVVeSIAFAPESAERALATavgsegggggegavrrrfvasGSRDKTVKLWNASVG-HCLMTFS 348
Cdd:cd22857  163 wraknvpNDslgLRVPVWVT-DLTFLSKDDHRKIVT---------------------GTGYHQVRLYDTRAQrRPVVSVD 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 298712456 349 VHENWVRCVLVHPSG--AFVLSASDDrsVRAFDVKTGRCARKLEDAHGHLVTALAMHKTSPIVVSGGVDGELHVWELS 424
Cdd:cd22857  221 FGETPIKAVAEDPDGhtVYVGDTSGD--LASIDLRTGKLLGCFKGKCGGSIRSIARHPELPLIASCGLDRYLRIWDTE 296
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 275-337 8.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.06e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 298712456   275 SGQCLHDLREHTHVVESIAFAPESaeralatavgsegggggegavrrRFVASGSRDKTVKLWN 337
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-----------------------KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
276-337 2.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 298712456  276 GQCLHDLREHTHVVESIAFAPESaeralatavgsegggggegavrrRFVASGSRDKTVKLWN 337
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-----------------------KLLASGSDDGTVKVWD 39
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 150-241 3.20e-03

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 39.75  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298712456  150 LKGHTNVVQSvAFSPDGQRLASCAADTTIKIWNFSEGGAGGAECLKTLRGHD-HNVSCVAWV-----PPAGD----TLVS 219
Cdd:pfam16529 183 IEEHSLLVDA-AFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDgKPLSSLFFLdnhkkPPEVQfwrfAITG 261

                          90       100
                  ....*....|....*....|..
gi 298712456  220 CSRDQTIKLWEAATGFCTRTLK 241
Cdd:pfam16529 262 ADNNSELKLWSCESWTCLQTIR 283
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 137-209 4.74e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 4.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 298712456  137 KVWDyetgeceRTLKGHTNVVQSVAFSPDGQRLASCAADTTIKIWNfSEGGaggaECLKTLRGHDHNVSCVAW 209
Cdd:pfam12894  28 RVWT-------LSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLD-AENG----KIVHHFSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 382-422 6.97e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 298712456   382 TGRCARKLEdAHGHLVTALAMHKTSPIVVSGGVDGELHVWE 422
Cdd:smart00320   1 SGELLKTLK-GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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