NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|29825827|ref|NP_821170|]
View 

vacuolar protein sorting-associated protein 26B [Mus musculus]

Protein Classification

vacuolar protein sorting-associated protein 26( domain architecture ID 10508368)

vacuolar protein sorting-associated protein 26 (Vps26) plays a role in vesicular protein sorting and is a component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport

CATH:  2.60.40.640
Gene Ontology:  GO:0030904|GO:0006886
PubMed:  16732284|18472259
SCOP:  4004065

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Vps26 pfam03643
Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein ...
6-281 8.11e-167

Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking. In particular, Vps26 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35. This family also contains Down syndrome critical region 3/A.


:

Pssm-ID: 397622 [Multi-domain]  Cd Length: 275  Bit Score: 465.37  E-value: 8.11e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827     6 FGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLSLKNpNKRLEHQGIKIEFIGQIELYYDRGNHHE 85
Cdd:pfam03643   1 FGPPCDIEIKLDNEEERKTVEVKTEDGKKEKNPVYYDGESVSGKVNIRLKD-GKKVEHQGIKIEFIGQIELFYDRGNPHE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827    86 FVSLVKDLARPGEITQSQAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKME 165
Cdd:pfam03643  80 FTSLVRELAPPGELTQNKTFPFEFPLVEKPYESYIGVNVRLRYFLRVTVRRSLTDITKEKDFWVHNFTTYPETNNSIKME 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827   166 VGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAPVRGESIP 245
Cdd:pfam03643 160 VGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMELQLIRRESTGTGPNTFTESETIAKFEIMDGAPVRGESIP 239
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 29825827   246 IRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEE 281
Cdd:pfam03643 240 IRLFLAGYDLTPTMRDVNKKFSVKYFLNLVLVDEED 275
 
Name Accession Description Interval E-value
Vps26 pfam03643
Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein ...
6-281 8.11e-167

Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking. In particular, Vps26 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35. This family also contains Down syndrome critical region 3/A.


Pssm-ID: 397622 [Multi-domain]  Cd Length: 275  Bit Score: 465.37  E-value: 8.11e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827     6 FGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLSLKNpNKRLEHQGIKIEFIGQIELYYDRGNHHE 85
Cdd:pfam03643   1 FGPPCDIEIKLDNEEERKTVEVKTEDGKKEKNPVYYDGESVSGKVNIRLKD-GKKVEHQGIKIEFIGQIELFYDRGNPHE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827    86 FVSLVKDLARPGEITQSQAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKME 165
Cdd:pfam03643  80 FTSLVRELAPPGELTQNKTFPFEFPLVEKPYESYIGVNVRLRYFLRVTVRRSLTDITKEKDFWVHNFTTYPETNNSIKME 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827   166 VGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAPVRGESIP 245
Cdd:pfam03643 160 VGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMELQLIRRESTGTGPNTFTESETIAKFEIMDGAPVRGESIP 239
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 29825827   246 IRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEE 281
Cdd:pfam03643 240 IRLFLAGYDLTPTMRDVNKKFSVKYFLNLVLVDEED 275
 
Name Accession Description Interval E-value
Vps26 pfam03643
Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein ...
6-281 8.11e-167

Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking. In particular, Vps26 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35. This family also contains Down syndrome critical region 3/A.


Pssm-ID: 397622 [Multi-domain]  Cd Length: 275  Bit Score: 465.37  E-value: 8.11e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827     6 FGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLSLKNpNKRLEHQGIKIEFIGQIELYYDRGNHHE 85
Cdd:pfam03643   1 FGPPCDIEIKLDNEEERKTVEVKTEDGKKEKNPVYYDGESVSGKVNIRLKD-GKKVEHQGIKIEFIGQIELFYDRGNPHE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827    86 FVSLVKDLARPGEITQSQAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKME 165
Cdd:pfam03643  80 FTSLVRELAPPGELTQNKTFPFEFPLVEKPYESYIGVNVRLRYFLRVTVRRSLTDITKEKDFWVHNFTTYPETNNSIKME 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29825827   166 VGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAPVRGESIP 245
Cdd:pfam03643 160 VGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMELQLIRRESTGTGPNTFTESETIAKFEIMDGAPVRGESIP 239
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 29825827   246 IRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEE 281
Cdd:pfam03643 240 IRLFLAGYDLTPTMRDVNKKFSVKYFLNLVLVDEED 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH