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Conserved domains on  [gi|297742065|emb|CBI33852|]
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unnamed protein product, partial [Vitis vinifera]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 23-361 0e+00

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


:

Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 520.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065  23 LGLVKVTEARSKE-GGIPKVVDRWGEPDSSKCILAASIDDRKSGPLLAIAREGGLIEILNPLNGHPCLSISNIIDNGPEP 101
Cdd:cd22857    1 LGLVKVVEARGKQeEAAPKVVDRWGGPDKSKAVQALSIADRESEPLLAVARKNGTVEVLDPENGDLLASFSDSEPATKLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 102 GDDAIVGLHLFkkqnldlssrSHTLLTCTTKGnaSMRSVELTSshaDSTSSVSSrTWNVCASGNILCSQVDGNENYALFG 181
Cdd:cd22857   81 EEDHFVGLHLF----------SGTLLTCTSKG--SLRSTKLPD---DSTASSSP-TAWVCLGGNLLCMRVDPNENYFAFG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 182 GKGVEVNVWDL-EQGTKIWTAKSPPKNSLGLFTPTWFTSATFLSKDDHRKFVAGTNSHQVRLYDISAQRRPVISFDFRET 260
Cdd:cd22857  145 GKEVELNVWDLeEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDHRKIVTGTGYHQVRLYDTRAQRRPVVSVDFGET 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 261 PIKAVAEDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKCSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVLSAV 340
Cdd:cd22857  225 PIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGGSIRSIARHPELPLIASCGLDRYLRIWDTETRQLLSKV 304

                        330       340
                 ....*....|....*....|.
gi 297742065 341 FLKQPLTNVVFDSNFAEEEVP 361
Cdd:cd22857  305 YLKQRLTAVVFDSSFSPEEEA 325
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 23-361 0e+00

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 520.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065  23 LGLVKVTEARSKE-GGIPKVVDRWGEPDSSKCILAASIDDRKSGPLLAIAREGGLIEILNPLNGHPCLSISNIIDNGPEP 101
Cdd:cd22857    1 LGLVKVVEARGKQeEAAPKVVDRWGGPDKSKAVQALSIADRESEPLLAVARKNGTVEVLDPENGDLLASFSDSEPATKLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 102 GDDAIVGLHLFkkqnldlssrSHTLLTCTTKGnaSMRSVELTSshaDSTSSVSSrTWNVCASGNILCSQVDGNENYALFG 181
Cdd:cd22857   81 EEDHFVGLHLF----------SGTLLTCTSKG--SLRSTKLPD---DSTASSSP-TAWVCLGGNLLCMRVDPNENYFAFG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 182 GKGVEVNVWDL-EQGTKIWTAKSPPKNSLGLFTPTWFTSATFLSKDDHRKFVAGTNSHQVRLYDISAQRRPVISFDFRET 260
Cdd:cd22857  145 GKEVELNVWDLeEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDHRKIVTGTGYHQVRLYDTRAQRRPVVSVDFGET 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 261 PIKAVAEDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKCSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVLSAV 340
Cdd:cd22857  225 PIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGGSIRSIARHPELPLIASCGLDRYLRIWDTETRQLLSKV 304

                        330       340
                 ....*....|....*....|.
gi 297742065 341 FLKQPLTNVVFDSNFAEEEVP 361
Cdd:cd22857  305 YLKQRLTAVVFDSSFSPEEEA 325
WD40 COG2319
WD40 repeat [General function prediction only];
187-337 1.40e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 187 VNVWDLEQGTKIWTAKSPPKnslglftptWFTSATFLSkdDHRKFVAGTNSHQVRLYDIsAQRRPVISFDFRETPIKAVA 266
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTG---------AVRSVAFSP--DGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVA 253

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297742065 267 EDQDGYTIYIGNGSGDLASVDMRTGKLLGcFLGKCSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVL 337
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLR-TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 290-330 7.49e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 7.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 297742065   290 TGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWD 330
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 23-361 0e+00

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 520.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065  23 LGLVKVTEARSKE-GGIPKVVDRWGEPDSSKCILAASIDDRKSGPLLAIAREGGLIEILNPLNGHPCLSISNIIDNGPEP 101
Cdd:cd22857    1 LGLVKVVEARGKQeEAAPKVVDRWGGPDKSKAVQALSIADRESEPLLAVARKNGTVEVLDPENGDLLASFSDSEPATKLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 102 GDDAIVGLHLFkkqnldlssrSHTLLTCTTKGnaSMRSVELTSshaDSTSSVSSrTWNVCASGNILCSQVDGNENYALFG 181
Cdd:cd22857   81 EEDHFVGLHLF----------SGTLLTCTSKG--SLRSTKLPD---DSTASSSP-TAWVCLGGNLLCMRVDPNENYFAFG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 182 GKGVEVNVWDL-EQGTKIWTAKSPPKNSLGLFTPTWFTSATFLSKDDHRKFVAGTNSHQVRLYDISAQRRPVISFDFRET 260
Cdd:cd22857  145 GKEVELNVWDLeEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDHRKIVTGTGYHQVRLYDTRAQRRPVVSVDFGET 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 261 PIKAVAEDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKCSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVLSAV 340
Cdd:cd22857  225 PIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGGSIRSIARHPELPLIASCGLDRYLRIWDTETRQLLSKV 304

                        330       340
                 ....*....|....*....|.
gi 297742065 341 FLKQPLTNVVFDSNFAEEEVP 361
Cdd:cd22857  305 YLKQRLTAVVFDSSFSPEEEA 325
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 24-357 2.33e-130

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 378.51  E-value: 2.33e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065  24 GLVKVTEAR------SKEGGIPKVVDRWGEPDSSKCILAASIDDRkSGPLLAIAREGGLIEI--LNPLNGHPCLSISNII 95
Cdd:cd22850    1 GSLKEVVCNrgtdtsVQDAAQPKVVETHLSEGLSNAVQRLSLVDR-SDPLLLVARRNGNGEVyvLSPVDGELFELLSSIE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065  96 DNGPEPGDDAIVGLHLFkkqnldlssRSHTLLTCTTKGnASMRSVELTSSHADSTSSVSSrtwnVCASGNILCSQVDG-N 174
Cdd:cd22850   80 GLTRSKEEDKFVGLHLL---------RSLGLLTCATKS-GLLHIIDLEDSKKDSLEVKAP----LTLPGFLSAFRVNPtD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 175 ENYALFGGKGVEVNVWDLEQG----TKIWTAKSPPKNSLGLFTPTWFTSATFLSKDDHR--KFVAGTNSHQVRLYDISAQ 248
Cdd:cd22850  146 EGVFAYGGKENDLKLWDLEKDflklKQIWKAKNVKNDRLDLRVPVWITAITFLPPDDHRkfKFVTGTRYGQVRLYDTSAG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 249 RRPVisfdFRETPIKAVAEDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKCSGSIRSIARHPEL--PVIASCGLDSYL 326
Cdd:cd22850  226 RRPV----FSEKPIKKPEEDLDGHTVYVGDTSGDLALIDIRTGKLLGRLLGKYGGSITGAVRHPELfdPYLASGGLDRYL 301

                        330       340       350
                 ....*....|....*....|....*....|..
gi 297742065 327 RFWDIKTRKVLSAVFL-KQPLTNVVFDSNFAE 357
Cdd:cd22850  302 RVFDIETRELLAKVYLgKQILTVVVLDDEEEE 333
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
 48-384 2.10e-24

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 103.84  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065  48 PDSSKCILAASIDDRKS-------GPLLAIAREGGLIEILNpLNGHPCLSISN--IIDNGPEPGD------DAIVGLHLF 112
Cdd:cd22858   32 PFHIETHLTEGLANRVQrilhisdEKLLVARRLNGSVELYD-LSKVPKFDEEEyeLLHSIKGLLDdrskakDKFVSLIVL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 113 KKQNldlssrshTLLTCTTKGNASMRSVEltsshadsTSSVSSRTWNVCASGNIL-CSQVDGNENYAL-FGGKGVEVNVW 190
Cdd:cd22858  111 ESLG--------IILAATKSGLVHIIDLE--------DDLFKIKPHEVKAPLEFIqAFDLNPTDPGVFaYGGKENDLKIV 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 191 DLEQGTK-------IWTAKSPPKNSLGLFTPTWFTSATFL----SKDDHRKFVAGTNSHQVRLYDISAQRRPVISFDFRE 259
Cdd:cd22858  175 ELFSDKKkffklkqIWEAKNVKNDRLDLRVPIWITGILFLkpspSKGFDYKFITVTRYGHLRKYDTTHGRKPIKSYKLLP 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 260 TPIKAVAEDQdgyTIYIGNgSGDLAS-----VDMR--------TGKLLGCFL-GKCSGSIRSIARHPElPVIASCGLDSY 325
Cdd:cd22858  255 KPELTEPLTE---LIISDT-HSLIAKlslitTDSKksvsagdgKGRLLGKYGgGDITGAVSAVDVFED-KYLATGGLDRY 329

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 326 LRFWDIKTRKVLSAVFLKQPLTNVVF-DSNfaEEEVPSSVVDPPTEAQNTNETQESDEEE 384
Cdd:cd22858  330 LRVFDLETRELLAKVYVGSKISSVLLlDDE--DIELPESEKKKKKKKKRKEEEEEEDDEE 387
WD40 COG2319
WD40 repeat [General function prediction only];
187-337 1.40e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 187 VNVWDLEQGTKIWTAKSPPKnslglftptWFTSATFLSkdDHRKFVAGTNSHQVRLYDIsAQRRPVISFDFRETPIKAVA 266
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTG---------AVRSVAFSP--DGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVA 253

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297742065 267 EDQDGYTIYIGNGSGDLASVDMRTGKLLGcFLGKCSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVL 337
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLR-TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-337 9.70e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 9.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 110 HLFKKQNLDLSSRSHTLLTCTTKGNA---SMRSVELTSSHADSTSSVSSRTWNvcASGNILCSqvdgnenyalfGGKGVE 186
Cdd:cd00200   50 HTGPVRDVAASADGTYLASGSSDKTIrlwDLETGECVRTLTGHTSYVSSVAFS--PDGRILSS-----------SSRDKT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 187 VNVWDLEQGTKIWTAKSPPKnslglftptWFTSATFlSKDDhrKFVA-GTNSHQVRLYDISAQRrPVISFDFRETPIKAV 265
Cdd:cd00200  117 IKVWDVETGKCLTTLRGHTD---------WVNSVAF-SPDG--TFVAsSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSV 183

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 297742065 266 AEDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVL 337
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
187-337 5.48e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 5.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 187 VNVWDLEQGTKIWTAKSPPKNSLGL-FTPtwftsatflskdDHRKFVAGTNSHQVRLYDIsAQRRPVISFDFRETPIKAV 265
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVaFSP------------DGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSV 294

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 297742065 266 AEDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVL 337
Cdd:COG2319  295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
187-337 6.97e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 6.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 187 VNVWDLEQGTKIWTAKSPPKnslglftptWFTSATFlSKDDHRkFVAGTNSHQVRLYDIsAQRRPVISFDFRETPIKAVA 266
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSG---------AVTSVAF-SPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297742065 267 EDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVL 337
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281
WD40 COG2319
WD40 repeat [General function prediction only];
187-333 7.90e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 7.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 187 VNVWDLEQGTKIWTAKSPPKnslglftptWFTSATFlSKDDhRKFVAGTNSHQVRLYDIsAQRRPVISFDFRETPIKAVA 266
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSG---------GVNSVAF-SPDG-KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVA 337

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297742065 267 EDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWDIKT 333
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-354 1.35e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 163 SGNILCSQVDGNENYALFGGKGVEVNVWDLEQGTKIWTaksppknsLGLFTPTWFtSATFLskDDHRKFVAGTNSHQVRL 242
Cdd:cd00200   51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT--------LTGHTSYVS-SVAFS--PDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 243 YDIsAQRRPVISFDFRETPIKAVAEDQDGYTIYignGSGDLASV---DMRTGKLLGCFLGKcSGSIRSIARHPELPVIAS 319
Cdd:cd00200  120 WDV-ETGKCLTTLRGHTDWVNSVAFSPDGTFVA---SSSQDGTIklwDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLS 194

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 297742065 320 CGLDSYLRFWDIKTRKVLsAVFL--KQPLTNVVFDSN 354
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCL-GTLRghENGVNSVAFSPD 230
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-337 8.22e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 8.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 163 SGNILCSQVDGNENYALFGGKGVEVNVWDLEQGTKIWTAKSPPKnslglftptWFTSATFLSkdDHRKFVAGTNSHQVRL 242
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---------PVRDVAASA--DGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 243 YDISaQRRPVISFDFRETPIKAVAEDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKcSGSIRSIARHPELPVIASCGL 322
Cdd:cd00200   78 WDLE-TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQ 155

                        170
                 ....*....|....*
gi 297742065 323 DSYLRFWDIKTRKVL 337
Cdd:cd00200  156 DGTIKLWDLRTGKCV 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-330 1.01e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 187 VNVWDLEQGTKIWTAKSPPKnslglftptWFTSATFLskDDHRKFVAGTNSHQVRLYDISAQRrPVISFDFRETPIKAVA 266
Cdd:cd00200  159 IKLWDLRTGKCVATLTGHTG---------EVNSVAFS--PDGEKLLSSSSDGTIKLWDLSTGK-CLGTLRGHENGVNSVA 226

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297742065 267 EDQDGYTIYIGNGSGDLASVDMRTGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWD 330
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
190-337 1.26e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 190 WDLEQGTKIWTAKSPPKNSLGLFTPTWFTSATFLSkdDHRKFVAGTNSHQVRLYDISAQRRPVISFDFREtPIKAVAEDQ 269
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP--DGRLLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSP 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 297742065 270 DGYTIYIGNGSGDLASVDMRTGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVL 337
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
223-295 4.32e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 4.32e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 297742065 223 LSKDDHRKFVAGTNSHQVRLYDIsAQRRPVISFDFRETPIkAVAEDQDGYTIYIGNGSGDLASV-----DMRTGKLLG 295
Cdd:COG3391  117 VDPDGGRLYVADSGNGRVSVIDT-ATGKVVATIPVGAGPH-GIAVDPDGKRLYVANSGSNTVSVivsviDTATGKVVA 192
WD40 COG2319
WD40 repeat [General function prediction only];
209-337 1.18e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 209 LGLFTPTWFTSATFLSKDDHRKFVAGTNSHQVRLYDISAQRRPvISFDFRETPIKAVAEDQDGYTIYIGNGSGDLASVDM 288
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 297742065 289 RTGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWDIKTRKVL 337
Cdd:COG2319  108 ATGLLLRTLTGH-TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
177-295 6.42e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297742065 177 YALFGGKGVEVNVWDLEQGTKIWTAKSPPKNSLGLFTPTWFTSATFLSKDDHRK-FVAGTNSHQVRLYDIsAQRRPVISF 255
Cdd:COG3391   28 LGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRlYVANSGSGRVSVIDL-ATGKVVATI 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 297742065 256 DFRETPIkAVAEDQDGYTIYIGN-GSGDLASVDMRTGKLLG 295
Cdd:COG3391  107 PVGGGPR-GLAVDPDGGRLYVADsGNGRVSVIDTATGKVVA 146
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 290-330 7.49e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 7.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 297742065   290 TGKLLGCFLGKcSGSIRSIARHPELPVIASCGLDSYLRFWD 330
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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