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Conserved domains on  [gi|297143584|gb|ADI00342|]
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pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit [[Bacillus] selenitireducens MLS10]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11867 super family cl36073
2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed
 1-281 2.15e-119

2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed


The actual alignment was detected with superfamily member PRK11867:

Pssm-ID: 237006 [Multi-domain]  Cd Length: 286  Bit Score: 343.36  E-value: 2.15e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   1 MATMKDLRGDVST-WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMG 79
Cdd:PRK11867   5 MLTAKDFRNDQEPrWCPGCGDGSILAALQRALAELGLDPENVAVVSGIGCSGRLPGYINTYGFHTIHGRALAIATGLKLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  80 NPDLKVIASGGDGDGYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIV 159
Cdd:PRK11867  85 NPDLTVIVVTGDGDALAIGGNHFIHALRRNIDITYILFNNQIYGLTKGQYSPTSPVGFVTKTTPYGSIEPPFNPVELALG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 160 NGATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKENLVSIEAPfETRDE-----AISAIREN 234
Cdd:PRK11867 165 AGATFVARGFDSDVKQLTELIKAAINHKGFSFVEILQPCPTFNNVNTFDWFKERLVKVHDA-EGYDPtnalaAMKTLEEG 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 297143584 235 NGLVTGILYEESRDDFQTKlgtkfdMQSLESGPMDEELLKKVQKKFE 281
Cdd:PRK11867 244 DPIPTGIFYQVERPTYEEA------VRAQIEGPLALQDLLMGGDTWT 284
 
Name Accession Description Interval E-value
PRK11867 PRK11867
2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed
 1-281 2.15e-119

2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed


Pssm-ID: 237006 [Multi-domain]  Cd Length: 286  Bit Score: 343.36  E-value: 2.15e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   1 MATMKDLRGDVST-WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMG 79
Cdd:PRK11867   5 MLTAKDFRNDQEPrWCPGCGDGSILAALQRALAELGLDPENVAVVSGIGCSGRLPGYINTYGFHTIHGRALAIATGLKLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  80 NPDLKVIASGGDGDGYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIV 159
Cdd:PRK11867  85 NPDLTVIVVTGDGDALAIGGNHFIHALRRNIDITYILFNNQIYGLTKGQYSPTSPVGFVTKTTPYGSIEPPFNPVELALG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 160 NGATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKENLVSIEAPfETRDE-----AISAIREN 234
Cdd:PRK11867 165 AGATFVARGFDSDVKQLTELIKAAINHKGFSFVEILQPCPTFNNVNTFDWFKERLVKVHDA-EGYDPtnalaAMKTLEEG 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 297143584 235 NGLVTGILYEESRDDFQTKlgtkfdMQSLESGPMDEELLKKVQKKFE 281
Cdd:PRK11867 244 DPIPTGIFYQVERPTYEEA------VRAQIEGPLALQDLLMGGDTWT 284
TPP_OGFOR cd03375
Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) ...
 14-201 5.30e-97

Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA. In the reductive tricarboxylic acid cycle found in the anaerobic autotroph Hydrogenobacter thermophilus, OGFOR catalyzes the reductive carboxylation of succinyl-CoA to produce 2-oxoglutarate. Thauera aromatica OGFOR has been shown to provide reduced ferredoxin to benzoyl-CoA reductase, a key enzyme in the anaerobic metabolism of aromatic compounds. OGFOR is dependent on TPP and a divalent metal cation for activity.


Pssm-ID: 239470 [Multi-domain]  Cd Length: 193  Bit Score: 282.88  E-value: 5.30e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:cd03375    1 WCPGCGDGSILKALAKALAELGIDPEKVVVVSGIGCSSRLPYYFNTYGFHTLHGRALAVATGVKLANPDLTVIVVSGDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:cd03375   81 LAAIGGNHFIHAARRNIDITVIVHNNQIYGLTKGQASPTTPEGFKTKTTPYGNIEEPFNPLALALAAGATFVARGFSGDI 160

                        170       180
                 ....*....|....*....|....*...
gi 297143584 174 KELSTILKRAIEHRGFSHVNIYSPCVTF 201
Cdd:cd03375  161 KQLKEIIKKAIQHKGFSFVEVLSPCPTF 188
PorB COG1013
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta ...
 3-245 6.60e-94

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440637 [Multi-domain]  Cd Length: 262  Bit Score: 277.80  E-value: 6.60e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   3 TMKD-LRGDVSTWCPGCGHFSVMAGIQKAIVELGyEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNP 81
Cdd:COG1013    3 KKKDlLRTPGHRWCPGCGHGIILRLLLKALDELL-DGDKTVVVSGIGCSSVAPGYFNVPGFHTLHGRAAAVATGIKLANP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  82 DLKVIA------------SggdgdgygiglgHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEY 149
Cdd:COG1013   82 DLTVIVfggdgdtydiggN------------HLIHAARRNEDITYIVYDNEIYGNTGGQRSPTTPLGAKTTTTPYGKPEP 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 150 PVDPITTSIVNGATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPCVTFNKIN---TYDYYKENLVSIEApFETRDE 226
Cdd:COG1013  150 PKDPAEIAAAHGATYVARASVGDPKDLKKKIKKAIEHKGFSFIEVLSPCPTGWGRDpskTIEWAKEGMWPLYE-YDPGEK 228

                        250
                 ....*....|....*....
gi 297143584 227 AISAIRENNGLVTGILYEE 245
Cdd:COG1013  229 LRLTYEPKDKIPVGEFLKN 247
PorB_KorB TIGR02177
2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; A number ...
 14-254 8.93e-90

2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of beta subunits, representing mostly pyruvate and 2-ketoisovalerate specific enzymes.


Pssm-ID: 274015 [Multi-domain]  Cd Length: 287  Bit Score: 268.17  E-value: 8.93e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:TIGR02177   3 WCPGCGDFGILSALQRALAELNLDPEQVVVVSGIGCSAKTPHYVNVNGFHGLHGRALPVATGIKLANPHLKVIVVGGDGD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:TIGR02177  83 LYGIGGNHFVAAGRRNVDITVIVHDNQVYGLTKGQASPTLLKGVKTKSLPYPNIQDPVNPLLLAIALGYTFVARGFSGDV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  174 KELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKENLVSIE---------APFETRDEAISAIRE----NNGLVTG 240
Cdd:TIGR02177 163 AHLKEIIKEAINHKGYALVDILQPCVTYNKINTYEWYRERVYKLDeegydpivrEPEEFEEKAAAAIKKamewGDRIPIG 242

                         250
                  ....*....|....*
gi 297143584  241 ILY-EESRDDFQTKL 254
Cdd:TIGR02177 243 IFYkNENKPTFEERL 257
Oxoac_fdxbeta_Archa NF041171
2-oxoacid:ferredoxin oxidoreductase subunit beta;
14-212 4.43e-82

2-oxoacid:ferredoxin oxidoreductase subunit beta;


Pssm-ID: 469082 [Multi-domain]  Cd Length: 296  Bit Score: 248.70  E-value: 4.43e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:NF041171   5 WCPGCGNFGILTAEQQALAELGLDPKKVVIVSGIGCSGKTPHFVNVSGVHTLHGRAIPFATGIKLANPELEVIVNGGDGD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:NF041171  85 LLGIGAGHFVALGRRNVDITVILHDNGVYGLTKGQASPTLPRGVKTKSLPKPNIQDAVNPIALALASGYTFVARGYAYDV 164

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 297143584 174 KELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKE 212
Cdd:NF041171 165 KHLKELIKAAIKHKGLAFIDVLQPCPTYNDINTKEWYDK 203
TPP_enzyme_C pfam02775
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
46-194 4.17e-24

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;


Pssm-ID: 460689 [Multi-domain]  Cd Length: 151  Bit Score: 94.96  E-value: 4.17e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   46 GIGCSGK-VSEYIRSN--------GFHTIHGRSLPVAQGVKMGNPDLKVIA-----SggdgdgYGIGLGHFVHASRRNID 111
Cdd:pfam02775   1 DIGCHQMwAAQYYRFRpprryltsGGLGTMGYGLPAAIGAKLARPDRPVVAiagdgG------FQMNLQELATAVRYNLP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  112 MSYIVMDNNIYGLTKGQTSPrsmHGFETKSAAASNKEYPVDPITTSIVNGATFVaqgYSGNIKELSTILKRAIEHRGFSH 191
Cdd:pfam02775  75 ITVVVLNNGGYGMTRGQQTP---FGGGRYSGPSGKILPPVDFAKLAEAYGAKGA---RVESPEELEEALKEALEHDGPAL 148


                  ...
gi 297143584  192 VNI 194
Cdd:pfam02775 149 IDV 151
 
Name Accession Description Interval E-value
PRK11867 PRK11867
2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed
 1-281 2.15e-119

2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed


Pssm-ID: 237006 [Multi-domain]  Cd Length: 286  Bit Score: 343.36  E-value: 2.15e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   1 MATMKDLRGDVST-WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMG 79
Cdd:PRK11867   5 MLTAKDFRNDQEPrWCPGCGDGSILAALQRALAELGLDPENVAVVSGIGCSGRLPGYINTYGFHTIHGRALAIATGLKLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  80 NPDLKVIASGGDGDGYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIV 159
Cdd:PRK11867  85 NPDLTVIVVTGDGDALAIGGNHFIHALRRNIDITYILFNNQIYGLTKGQYSPTSPVGFVTKTTPYGSIEPPFNPVELALG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 160 NGATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKENLVSIEAPfETRDE-----AISAIREN 234
Cdd:PRK11867 165 AGATFVARGFDSDVKQLTELIKAAINHKGFSFVEILQPCPTFNNVNTFDWFKERLVKVHDA-EGYDPtnalaAMKTLEEG 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 297143584 235 NGLVTGILYEESRDDFQTKlgtkfdMQSLESGPMDEELLKKVQKKFE 281
Cdd:PRK11867 244 DPIPTGIFYQVERPTYEEA------VRAQIEGPLALQDLLMGGDTWT 284
PRK05778 PRK05778
2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated
 1-256 7.24e-114

2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated


Pssm-ID: 235604 [Multi-domain]  Cd Length: 301  Bit Score: 329.92  E-value: 7.24e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   1 MATMKDLRGDVSTWCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGN 80
Cdd:PRK05778   7 GLTYLRYDGLPTTWCPGCGNFGILNAIIQALAELGLDPDKVVVVSGIGCSSKIPGYFLSHGLHTLHGRAIAFATGAKLAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  81 PDLKVIASGGDGDGYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVN 160
Cdd:PRK05778  87 PDLEVIVVGGDGDLASIGGGHFIHAGRRNIDITVIVENNGIYGLTKGQASPTTPEGSKTKTAPYGNIEPPIDPCALALAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 161 GATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYD--------YYKENLVSIEAPFET----RDEAI 228
Cdd:PRK05778 167 GATFVARSFAGDVKQLVELIKKAISHKGFAFIDVLSPCVTFNGRNTSTkspaymreYYKKRVYKLKLEEDYdptdRDKAA 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 297143584 229 SAIRE---NNGLVTGILYEESRDDFQTKLGT 256
Cdd:PRK05778 247 EKMLEeelGGKIPIGVFYKNERPTFEERLEK 277
TPP_OGFOR cd03375
Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) ...
 14-201 5.30e-97

Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA. In the reductive tricarboxylic acid cycle found in the anaerobic autotroph Hydrogenobacter thermophilus, OGFOR catalyzes the reductive carboxylation of succinyl-CoA to produce 2-oxoglutarate. Thauera aromatica OGFOR has been shown to provide reduced ferredoxin to benzoyl-CoA reductase, a key enzyme in the anaerobic metabolism of aromatic compounds. OGFOR is dependent on TPP and a divalent metal cation for activity.


Pssm-ID: 239470 [Multi-domain]  Cd Length: 193  Bit Score: 282.88  E-value: 5.30e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:cd03375    1 WCPGCGDGSILKALAKALAELGIDPEKVVVVSGIGCSSRLPYYFNTYGFHTLHGRALAVATGVKLANPDLTVIVVSGDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:cd03375   81 LAAIGGNHFIHAARRNIDITVIVHNNQIYGLTKGQASPTTPEGFKTKTTPYGNIEEPFNPLALALAAGATFVARGFSGDI 160

                        170       180
                 ....*....|....*....|....*...
gi 297143584 174 KELSTILKRAIEHRGFSHVNIYSPCVTF 201
Cdd:cd03375  161 KQLKEIIKKAIQHKGFSFVEVLSPCPTF 188
PorB COG1013
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta ...
 3-245 6.60e-94

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440637 [Multi-domain]  Cd Length: 262  Bit Score: 277.80  E-value: 6.60e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   3 TMKD-LRGDVSTWCPGCGHFSVMAGIQKAIVELGyEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNP 81
Cdd:COG1013    3 KKKDlLRTPGHRWCPGCGHGIILRLLLKALDELL-DGDKTVVVSGIGCSSVAPGYFNVPGFHTLHGRAAAVATGIKLANP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  82 DLKVIA------------SggdgdgygiglgHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEY 149
Cdd:COG1013   82 DLTVIVfggdgdtydiggN------------HLIHAARRNEDITYIVYDNEIYGNTGGQRSPTTPLGAKTTTTPYGKPEP 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 150 PVDPITTSIVNGATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPCVTFNKIN---TYDYYKENLVSIEApFETRDE 226
Cdd:COG1013  150 PKDPAEIAAAHGATYVARASVGDPKDLKKKIKKAIEHKGFSFIEVLSPCPTGWGRDpskTIEWAKEGMWPLYE-YDPGEK 228

                        250
                 ....*....|....*....
gi 297143584 227 AISAIRENNGLVTGILYEE 245
Cdd:COG1013  229 LRLTYEPKDKIPVGEFLKN 247
PorB_KorB TIGR02177
2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; A number ...
 14-254 8.93e-90

2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of beta subunits, representing mostly pyruvate and 2-ketoisovalerate specific enzymes.


Pssm-ID: 274015 [Multi-domain]  Cd Length: 287  Bit Score: 268.17  E-value: 8.93e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:TIGR02177   3 WCPGCGDFGILSALQRALAELNLDPEQVVVVSGIGCSAKTPHYVNVNGFHGLHGRALPVATGIKLANPHLKVIVVGGDGD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:TIGR02177  83 LYGIGGNHFVAAGRRNVDITVIVHDNQVYGLTKGQASPTLLKGVKTKSLPYPNIQDPVNPLLLAIALGYTFVARGFSGDV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  174 KELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKENLVSIE---------APFETRDEAISAIRE----NNGLVTG 240
Cdd:TIGR02177 163 AHLKEIIKEAINHKGYALVDILQPCVTYNKINTYEWYRERVYKLDeegydpivrEPEEFEEKAAAAIKKamewGDRIPIG 242

                         250
                  ....*....|....*
gi 297143584  241 ILY-EESRDDFQTKL 254
Cdd:TIGR02177 243 IFYkNENKPTFEERL 257
PRK11866 PRK11866
2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional
 14-218 4.00e-89

2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional


Pssm-ID: 183347 [Multi-domain]  Cd Length: 279  Bit Score: 266.24  E-value: 4.00e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:PRK11866   9 WCPGCGNYGILEALRKALAELGIPPENVVVVSGIGCSSNLPEFLNTYGIHGIHGRVLPIATGVKWANPKLTVIGYGGDGD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:PRK11866  89 GYGIGLGHLPHAARRNVDITYIVSNNQVYGLTTGQASPTTPRGVKTKTTPDGNIEEPFNPIALALAAGATFVARGFSGDV 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 297143584 174 KELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKENLVSIE 218
Cdd:PRK11866 169 KHLKEIIKEAIKHKGFSFIDVLSPCVTFNKLNTYDWFRPRVYKLE 213
Oxoac_fdxbeta_Archa NF041171
2-oxoacid:ferredoxin oxidoreductase subunit beta;
14-212 4.43e-82

2-oxoacid:ferredoxin oxidoreductase subunit beta;


Pssm-ID: 469082 [Multi-domain]  Cd Length: 296  Bit Score: 248.70  E-value: 4.43e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:NF041171   5 WCPGCGNFGILTAEQQALAELGLDPKKVVIVSGIGCSGKTPHFVNVSGVHTLHGRAIPFATGIKLANPELEVIVNGGDGD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:NF041171  85 LLGIGAGHFVALGRRNVDITVILHDNGVYGLTKGQASPTLPRGVKTKSLPKPNIQDAVNPIALALASGYTFVARGYAYDV 164

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 297143584 174 KELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKE 212
Cdd:NF041171 165 KHLKELIKAAIKHKGLAFIDVLQPCPTYNDINTKEWYDK 203
PRK11869 PRK11869
2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional
 10-254 5.15e-77

2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional


Pssm-ID: 183349 [Multi-domain]  Cd Length: 280  Bit Score: 235.45  E-value: 5.15e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  10 DVStWCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASG 89
Cdd:PRK11869   7 DIA-WCPGCGNFGIRNALMKALSELNLKPRQVVIVSGIGQAAKMPHYINVNGFHTLHGRAIPAATAVKATNPELTVIAEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  90 GDGDGYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGY 169
Cdd:PRK11869  86 GDGDMYAEGGNHLIHAIRRNPDITVLVHNNQVYGLTKGQASPTTLKGFKTPTQPWGVFEEPFNPIALAIALDASFVARTF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 170 SGNIKELSTILKRAIEHRGFSHVNIYSPCVTFNKINTYDYYKENLVSIEA--PFEtRDEAISAIRENNGLVTGILYEESR 247
Cdd:PRK11869 166 SGDIEETKEILKEAIKHKGLAIVDIFQPCVSFNKVNTYQWYRENTYYLKDhdPTD-RELAFKRALETEKLPLGIFYINEK 244


                 ....*..
gi 297143584 248 DDFQTKL 254
Cdd:PRK11869 245 PTFEELV 251
oorB PRK09628
2-oxoglutarate ferredoxin oxidoreductase subunit beta;
14-245 1.48e-49

2-oxoglutarate ferredoxin oxidoreductase subunit beta;


Pssm-ID: 182003 [Multi-domain]  Cd Length: 277  Bit Score: 164.90  E-value: 1.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  14 WCPGCGHFSVMAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGFHTIHGRSLPVAQGVKMGNPDLKVIASGGDGD 93
Cdd:PRK09628  18 WCWGCGDGVILKSIIRAIDKLGWNMDDVCVVSGIGCSGRFSSYVNCNTVHTTHGRAVAYATGIKLANPDKHVIVVSGDGD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  94 GYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNI 173
Cdd:PRK09628  98 GLAIGGNHTIHGCRRNIDLNFILINNFIYGLTNSQTSPTTPKGMWTVTAQYGNIDPTFDACKLATAAGASFVARESVIDP 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 297143584 174 KELSTILKRAIEHRGFSHVNIYSPC-VTFNKINTYDYYKENLVSIEAPF--ETRDEAISAIRENNGLVTGILYEE 245
Cdd:PRK09628 178 QKLEKLLVKGFSHKGFSFFDVFSNChINLGRKNKMGEAVQMLKWIESRTvsKRKFDALSPEERVGKFPTGILKHD 252
TPP_enzyme_C pfam02775
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
46-194 4.17e-24

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;


Pssm-ID: 460689 [Multi-domain]  Cd Length: 151  Bit Score: 94.96  E-value: 4.17e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584   46 GIGCSGK-VSEYIRSN--------GFHTIHGRSLPVAQGVKMGNPDLKVIA-----SggdgdgYGIGLGHFVHASRRNID 111
Cdd:pfam02775   1 DIGCHQMwAAQYYRFRpprryltsGGLGTMGYGLPAAIGAKLARPDRPVVAiagdgG------FQMNLQELATAVRYNLP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  112 MSYIVMDNNIYGLTKGQTSPrsmHGFETKSAAASNKEYPVDPITTSIVNGATFVaqgYSGNIKELSTILKRAIEHRGFSH 191
Cdd:pfam02775  75 ITVVVLNNGGYGMTRGQQTP---FGGGRYSGPSGKILPPVDFAKLAEAYGAKGA---RVESPEELEEALKEALEHDGPAL 148


                  ...
gi 297143584  192 VNI 194
Cdd:pfam02775 149 IDV 151
TPP_PFOR cd02018
Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) ...
 15-206 1.58e-15

Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea, anaerobic bacteria and eukaryotes that lack mitochondria (and therefore pyruvate dehydrogenase) use PFOR to oxidatively decarboxylate pyruvate, with ferredoxin or flavodoxin as the electron acceptor. PFORs can be homodimeric, heterodimeric, or heterotetrameric, depending on the organism. These enzymes are dependent on TPP and a divalent metal cation as cofactors.


Pssm-ID: 238976 [Multi-domain]  Cd Length: 237  Bit Score: 74.06  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  15 CPGCGHfsvmAGIQKAIVELGYEPHEFAIISGIGCSGKVSEYIRSNGF--HTIH---GRSLPVAQGVKMG---------- 79
Cdd:cd02018    8 CAGCGE----VTAVRVVLAALPAPEDTVIANSTGCSSVYASTAPFNSWavPWVNslfEDANAVASGLKRGlkarfpkdre 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  80 ---NPDLKVIASGGDGdgYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITT 156
Cdd:cd02018   84 ldkKKDVVVIGGDGAT--YDIGFGALSHSLFRGEDITVIVLDNEVYSNTGGQRSGATPLGADSKMAPAGKKEDKKDLVLI 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 297143584 157 SIVNGATFVAQGYSGNIKELSTILKRAI-EHRGFSHVNIYSPCVTFNKINT 206
Cdd:cd02018  162 AATHGCVYVARLSPALKKHFLKVVKEAIsRTDGPTFIHAYTPCITEWGIGS 212
PFO_beta_C pfam12367
Pyruvate ferredoxin oxidoreductase beta subunit C terminal; This domain family is found in ...
 198-255 8.54e-15

Pyruvate ferredoxin oxidoreductase beta subunit C terminal; This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length. The family is found in association with pfam02775. There are two completely conserved residues (A and G) that may be functionally important. PFO is involved in carbon dioxide fixation via a reductive TCA cycle. It forms a heterodimer (alpha/beta). The beta subunit has binding motifs for Fe-S clusters and thiamine pyrophosphate.


Pssm-ID: 463551 [Multi-domain]  Cd Length: 62  Bit Score: 67.52  E-value: 8.54e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297143584  198 CVTFNKINTYDYYKENLVSIEAPFET--RDEAISAIREN-NGLVTGILYEESRDDFQTKLG 255
Cdd:pfam12367   1 CVTFNKVNTYDWYKERVYKLDEDHDPtdREAAMEKALEWgDRIPIGIFYKEERPTFEERLP 61
TPP_IOR_alpha cd02008
Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of ...
 15-198 3.64e-06

Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the transamination of aromatic amino acids, to the corresponding aryl acetyl-CoA.


Pssm-ID: 238966 [Multi-domain]  Cd Length: 178  Bit Score: 46.12  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  15 CPGCGH---FSVMAGIQKAIVelgyephefaIISG-IGCS--GKVSEYIRSNGFhTIHGRSLPVAQGVKMGNPDLKVIA- 87
Cdd:cd02008    7 CPGCPHrpsFYALRKAFKKDS----------IVSGdIGCYtlGALPPLNAIDTC-TCMGASIGVAIGMAKASEDKKVVAv 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  88 ---SGgdgdgygiglghFVH--------ASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSaaasnkeyPVDPITT 156
Cdd:cd02008   76 igdST------------FFHsgilglinAVYNKANITVVILDNRTTAMTGGQPHPGTGKTLTEPT--------TVIDIEA 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 297143584 157 SI-VNGATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPC 198
Cdd:cd02008  136 LVrAIGVKRVVVVDPYDLKAIREELKEALAVPGVSVIIAKRPC 178
TPP_enzymes cd00568
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
 23-188 1.39e-05

Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.


Pssm-ID: 238318 [Multi-domain]  Cd Length: 168  Bit Score: 44.55  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  23 VMAGIQKAIvelgyePHEFAIISGIGCSGKVS----EYIRSNGFHTIH-----GRSLPVAQGVKMGNPDLKVIA------ 87
Cdd:cd00568    2 VLAALRAAL------PEDAIVVNDAGNSAYWAyrylPLRRGRRFLTSTgfgamGYGLPAAIGAALAAPDRPVVCiagdgg 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  88 ---SggdgdgygigLGHFVHASRRNIDMSYIVMDNNIYGLTKGQtsprsmHGFETKSAAASNKEYPVDPITtsivngatf 164
Cdd:cd00568   76 fmmT----------GQELATAVRYGLPVIVVVFNNGGYGTIRMH------QEAFYGGRVSGTDLSNPDFAA--------- 130

                        170       180       190
                 ....*....|....*....|....*....|
gi 297143584 165 VAQGYSGN------IKELSTILKRAIEHRG 188
Cdd:cd00568  131 LAEAYGAKgvrvedPEDLEAALAEALAAGG 160
PRK11864 PRK11864
3-methyl-2-oxobutanoate dehydrogenase subunit beta;
105-200 1.19e-04

3-methyl-2-oxobutanoate dehydrogenase subunit beta;


Pssm-ID: 237005 [Multi-domain]  Cd Length: 300  Bit Score: 42.77  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584 105 ASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVDPITTSIVNGATFVAQGYSGNIKELSTILKRAI 184
Cdd:PRK11864 115 AAERNHDILYIMYDNEAYMNTGIQRSSSTPYGAWTTTTPGGKREHKKPVPDIMAAHKVPYVATASIAYPEDFIRKLKKAK 194

                         90
                 ....*....|....*.
gi 297143584 185 EHRGFSHVNIYSPCVT 200
Cdd:PRK11864 195 EIRGFKFIHLLAPCPP 210
PRK06163 PRK06163
hypothetical protein; Provisional
 39-133 2.95e-04

hypothetical protein; Provisional


Pssm-ID: 235721 [Multi-domain]  Cd Length: 202  Bit Score: 40.97  E-value: 2.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  39 HEFAIISGIG-------CSGKvseyiRSNGFHTI--HGRSLPVAQGVKMGNPDLKVIASGGDGDGYGIGLGHFVHASRRN 109
Cdd:PRK06163  28 DEEAVIGGIGntnfdlwAAGQ-----RPQNFYMLgsMGLAFPIALGVALAQPKRRVIALEGDGSLLMQLGALGTIAALAP 102

                         90       100
                 ....*....|....*....|....
gi 297143584 110 IDMSYIVMDNNIYGLTKGQTSPRS 133
Cdd:PRK06163 103 KNLTIIVMDNGVYQITGGQPTLTS 126
PRK11865 PRK11865
pyruvate synthase subunit beta;
15-200 1.76e-03

pyruvate synthase subunit beta;


Pssm-ID: 183346 [Multi-domain]  Cd Length: 299  Bit Score: 39.31  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  15 CPGCGHFSVMAGIQKAIVElgyephEFAIISGIGCSgkvsEYIRSNGFHT------IH---GRSLPVAQGV----KMGNP 81
Cdd:PRK11865  21 CAGCGAAIAMRLALKALGK------NTVIVVATGCL----EVITTPYPETawnvpwIHvafENAAAVASGIeravKALGK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297143584  82 DLKVIASGGDGDGYGIGLGHFVHASRRNIDMSYIVMDNNIYGLTKGQTSPRSMHGFETKSAAASNKEYPVD------PIT 155
Cdd:PRK11865  91 KVNVVAIGGDGGTADIGFQSLSGAMERGHNILYLMYDNEAYMNTGIQRSGSTPFGASTTTSPAGKYSRGEDrpkknmPLI 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 297143584 156 TsIVNGATFVAQGYSGNIKELSTILKRAIEHRGFSHVNIYSPCVT 200
Cdd:PRK11865 171 M-AAHGIPYVATASIGYPEDFMEKVKKAKEVEGPAYIQVLQPCPT 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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