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Conserved domains on  [gi|296475872|tpg|DAA17987|]
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TPA: NLR family, apoptosis inhibitory protein [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 767-873 9.25e-51

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


:

Pssm-ID: 436120  Cd Length: 106  Bit Score: 174.39  E-value: 9.25e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   767 EDQDLGLHYLKRINSTLMVIYPYANFLNCvSRHPSTKAGPKIVSHLLLLVDNKETLENISENDDYLKHHPEISEVMQFFR 846
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 296475872   847 LIWQLSPQNYLSLASKHLLALAIRIAY 873
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 465-619 5.16e-34

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 128.58  E-value: 5.16e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   465 SVMCVEGEAGSGKTILLKKIAHLWASGRCPLLnrFRLVFCLSLGSTRPEQ---GLASVIRDQLLETKLSVTEmgLRNIIQ 541
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   542 QLKNQVLFLLDDYKEMCSVPQ----------VIARMIQKKHLSRTCLVITVRTNRAKNIRRYLDT--IIEIKAFPFYNTI 609
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 296475872   610 SILRKLFPGD 619
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 163-229 2.27e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


:

Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.46  E-value: 2.27e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296475872   163 RLESFKNWPFYAQGT-SPRELSAAGFVFTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQ 229
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 283-348 1.26e-27

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


:

Pssm-ID: 237989  Cd Length: 69  Bit Score: 106.97  E-value: 1.26e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296475872  283 LQSFKSWHPSYPVGAAALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFPNCQFLQS 348
Cdd:cd00022     4 LKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 4.82e-20

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


:

Pssm-ID: 459891  Cd Length: 68  Bit Score: 85.02  E-value: 4.82e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296475872    63 RLKTFVTY--NTFRSWTSQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
451-767 6.66e-18

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 89.86  E-value: 6.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  451 QEPVVLPEVFANLNSVMCVEGEAGSGKTILLKKIAHLWASGRCPLLNrfRLVFCLSLGSTRPEQGLASVIRDQLLETKLS 530
Cdd:COG5635   167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAED--PIPILIELRDLAEEASLEDLLAEALEKRGGE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  531 VTEmglrNIIQQLKN-QVLFLLDDYKEMcSVPQVIARMIQK-----KHLSRTCLVITVRTNRAKNIRRYLDTIIEIKAFP 604
Cdd:COG5635   245 PED----ALERLLRNgRLLLLLDGLDEV-PDEADRDEVLNQlrrflERYPKARVIITSRPEGYDSSELEGFEVLELAPLS 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  605 FYNTISILRKLFPGDLTRLRKLMVDFGMNQTWQGIQKTPLFVAAVrASWLQNRFHRSFDSVAVFESYMECLFLKHKTEAD 684
Cdd:COG5635   320 DEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLL-ALLLRERGELPDTRAELYEQFVELLLERWDEQRG 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  685 LLKATVSS-------CGDLALKGFFSSCFEFSDEDLieagigeEEDLAMYLMSKFTAQRL---------------RPVYQ 742
Cdd:COG5635   399 LTIYRELSreelrelLSELALAMQENGRTEFAREEL-------EEILREYLGRRKDAEALldelllrtgllvergEGRYS 471

                         330       340
                  ....*....|....*....|....*
gi 296475872  743 FLNPAFQEFLAGMRLTELLDSDRQE 767
Cdd:COG5635   472 FAHRSFQEYLAARALVEELDEELLE 496
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 767-873 9.25e-51

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 174.39  E-value: 9.25e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   767 EDQDLGLHYLKRINSTLMVIYPYANFLNCvSRHPSTKAGPKIVSHLLLLVDNKETLENISENDDYLKHHPEISEVMQFFR 846
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 296475872   847 LIWQLSPQNYLSLASKHLLALAIRIAY 873
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 465-619 5.16e-34

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 128.58  E-value: 5.16e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   465 SVMCVEGEAGSGKTILLKKIAHLWASGRCPLLnrFRLVFCLSLGSTRPEQ---GLASVIRDQLLETKLSVTEmgLRNIIQ 541
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   542 QLKNQVLFLLDDYKEMCSVPQ----------VIARMIQKKHLSRTCLVITVRTNRAKNIRRYLDT--IIEIKAFPFYNTI 609
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 296475872   610 SILRKLFPGD 619
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 163-229 2.27e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.46  E-value: 2.27e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296475872   163 RLESFKNWPFYAQGT-SPRELSAAGFVFTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQ 229
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 160-230 4.30e-32

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 119.73  E-value: 4.30e-32
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296475872    160 EKARLESFKNWPFYAQgTSPRELSAAGFVFTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQS 230
Cdd:smart00238    2 EEARLKTFQNWPYNSK-CTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 161-230 5.22e-31

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 116.60  E-value: 5.22e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  161 KARLESFKNWPFYAQgTSPRELSAAGFVFTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQS 230
Cdd:cd00022     1 EARLKTFKNWPISLK-VTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 283-348 1.26e-27

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 106.97  E-value: 1.26e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296475872  283 LQSFKSWHPSYPVGAAALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFPNCQFLQS 348
Cdd:cd00022     4 LKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 278-348 4.06e-26

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 102.78  E-value: 4.06e-26
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296475872    278 NEELLLQSFKSWHPSYPVGAAALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFPNCQFLQS 348
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 283-347 3.26e-25

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 100.04  E-value: 3.26e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296475872   283 LQSFKSWHPSYPVGAA--ALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFPNCQFLQ 347
Cdd:pfam00653    2 LATFENWPHSNKSPPTpeELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 4.82e-20

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 85.02  E-value: 4.82e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296475872    63 RLKTFVTY--NTFRSWTSQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.13e-19

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 84.24  E-value: 1.13e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 296475872   61 AKRLKTFVTYNTFRSWTSQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFLLG 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 59-129 4.02e-19

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 82.75  E-value: 4.02e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296475872     59 SEAKRLKTFVTYNTFRSWTSQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFLLG 129
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
451-767 6.66e-18

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 89.86  E-value: 6.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  451 QEPVVLPEVFANLNSVMCVEGEAGSGKTILLKKIAHLWASGRCPLLNrfRLVFCLSLGSTRPEQGLASVIRDQLLETKLS 530
Cdd:COG5635   167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAED--PIPILIELRDLAEEASLEDLLAEALEKRGGE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  531 VTEmglrNIIQQLKN-QVLFLLDDYKEMcSVPQVIARMIQK-----KHLSRTCLVITVRTNRAKNIRRYLDTIIEIKAFP 604
Cdd:COG5635   245 PED----ALERLLRNgRLLLLLDGLDEV-PDEADRDEVLNQlrrflERYPKARVIITSRPEGYDSSELEGFEVLELAPLS 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  605 FYNTISILRKLFPGDLTRLRKLMVDFGMNQTWQGIQKTPLFVAAVrASWLQNRFHRSFDSVAVFESYMECLFLKHKTEAD 684
Cdd:COG5635   320 DEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLL-ALLLRERGELPDTRAELYEQFVELLLERWDEQRG 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  685 LLKATVSS-------CGDLALKGFFSSCFEFSDEDLieagigeEEDLAMYLMSKFTAQRL---------------RPVYQ 742
Cdd:COG5635   399 LTIYRELSreelrelLSELALAMQENGRTEFAREEL-------EEILREYLGRRKDAEALldelllrtgllvergEGRYS 471

                         330       340
                  ....*....|....*....|....*
gi 296475872  743 FLNPAFQEFLAGMRLTELLDSDRQE 767
Cdd:COG5635   472 FAHRSFQEYLAARALVEELDEELLE 496
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 688-743 2.00e-03

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 37.54  E-value: 2.00e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 296475872   688 ATVSSCGDLALKGFFSSCFEFSDEDLIEAGIgEEEDLAMYLMSKFTAQRL--RPVYQF 743
Cdd:pfam17779    1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGL-DESDLSSGLLTEILQKDLgcEKVYSF 57
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 767-873 9.25e-51

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 174.39  E-value: 9.25e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   767 EDQDLGLHYLKRINSTLMVIYPYANFLNCvSRHPSTKAGPKIVSHLLLLVDNKETLENISENDDYLKHHPEISEVMQFFR 846
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 296475872   847 LIWQLSPQNYLSLASKHLLALAIRIAY 873
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 465-619 5.16e-34

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 128.58  E-value: 5.16e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   465 SVMCVEGEAGSGKTILLKKIAHLWASGRCPLLnrFRLVFCLSLGSTRPEQ---GLASVIRDQLLETKLSVTEmgLRNIIQ 541
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872   542 QLKNQVLFLLDDYKEMCSVPQ----------VIARMIQKKHLSRTCLVITVRTNRAKNIRRYLDT--IIEIKAFPFYNTI 609
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 296475872   610 SILRKLFPGD 619
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 163-229 2.27e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 120.46  E-value: 2.27e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296475872   163 RLESFKNWPFYAQGT-SPRELSAAGFVFTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQ 229
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 160-230 4.30e-32

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 119.73  E-value: 4.30e-32
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296475872    160 EKARLESFKNWPFYAQgTSPRELSAAGFVFTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQS 230
Cdd:smart00238    2 EEARLKTFQNWPYNSK-CTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 161-230 5.22e-31

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 116.60  E-value: 5.22e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  161 KARLESFKNWPFYAQgTSPRELSAAGFVFTGKHDTVQCFSCGGCLGNWEDDDDPWKEHAKWFPKCEFLQS 230
Cdd:cd00022     1 EARLKTFKNWPISLK-VTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 283-348 1.26e-27

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 106.97  E-value: 1.26e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296475872  283 LQSFKSWHPSYPVGAAALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFPNCQFLQS 348
Cdd:cd00022     4 LKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 278-348 4.06e-26

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 102.78  E-value: 4.06e-26
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296475872    278 NEELLLQSFKSWHPSYPVGAAALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFPNCQFLQS 348
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 283-347 3.26e-25

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 100.04  E-value: 3.26e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296475872   283 LQSFKSWHPSYPVGAA--ALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFPNCQFLQ 347
Cdd:pfam00653    2 LATFENWPHSNKSPPTpeELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 4.82e-20

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 85.02  E-value: 4.82e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296475872    63 RLKTFVTY--NTFRSWTSQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-129 1.13e-19

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 84.24  E-value: 1.13e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 296475872   61 AKRLKTFVTYNTFRSWTSQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFLLG 129
Cdd:cd00022     1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 59-129 4.02e-19

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 82.75  E-value: 4.02e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296475872     59 SEAKRLKTFVTYNTFRSWTSQEMAEAGFYLTGTKSGIQCFCCSLILFGTSLQNTPMEHHKKFHPDCEFLLG 129
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
451-767 6.66e-18

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 89.86  E-value: 6.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  451 QEPVVLPEVFANLNSVMCVEGEAGSGKTILLKKIAHLWASGRCPLLNrfRLVFCLSLGSTRPEQGLASVIRDQLLETKLS 530
Cdd:COG5635   167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAED--PIPILIELRDLAEEASLEDLLAEALEKRGGE 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  531 VTEmglrNIIQQLKN-QVLFLLDDYKEMcSVPQVIARMIQK-----KHLSRTCLVITVRTNRAKNIRRYLDTIIEIKAFP 604
Cdd:COG5635   245 PED----ALERLLRNgRLLLLLDGLDEV-PDEADRDEVLNQlrrflERYPKARVIITSRPEGYDSSELEGFEVLELAPLS 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  605 FYNTISILRKLFPGDLTRLRKLMVDFGMNQTWQGIQKTPLFVAAVrASWLQNRFHRSFDSVAVFESYMECLFLKHKTEAD 684
Cdd:COG5635   320 DEQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLL-ALLLRERGELPDTRAELYEQFVELLLERWDEQRG 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296475872  685 LLKATVSS-------CGDLALKGFFSSCFEFSDEDLieagigeEEDLAMYLMSKFTAQRL---------------RPVYQ 742
Cdd:COG5635   399 LTIYRELSreelrelLSELALAMQENGRTEFAREEL-------EEILREYLGRRKDAEALldelllrtgllvergEGRYS 471

                         330       340
                  ....*....|....*....|....*
gi 296475872  743 FLNPAFQEFLAGMRLTELLDSDRQE 767
Cdd:COG5635   472 FAHRSFQEYLAARALVEELDEELLE 496
NOD2_WH pfam17779
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ...
 688-743 2.00e-03

NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.


Pssm-ID: 465501  Cd Length: 57  Bit Score: 37.54  E-value: 2.00e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 296475872   688 ATVSSCGDLALKGFFSSCFEFSDEDLIEAGIgEEEDLAMYLMSKFTAQRL--RPVYQF 743
Cdd:pfam17779    1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGL-DESDLSSGLLTEILQKDLgcEKVYSF 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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