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Conserved domains on  [gi|296416424|ref|XP_002837880|]
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uncharacterized protein GSTUM_00005791001 [Tuber melanosporum]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10637820)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0008270|GO:0000981
PubMed:  9290251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 275-696 1.61e-57

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 203.06  E-value: 1.61e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 275 PRRQVGENYVDIFFNQANPQTPILHRPSFEKVFRQACSkieeeggnglpanggaggtsggEKDHQHRADLYFLYMVFAIA 354
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYS----------------------DPSSLSPASLALLLAVLALA 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 355 TAMSSRTEALPERYHASAMLHMD---SLFSSIALTNNRLDGLKGILLLALYSIMRPAAPGVWYVVGAAMRLAIDLGLHQE 431
Cdd:cd12148   59 ALSLPDSELRGESRRSLAERYYEaarQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 432 NPQKAEKmwDPLTVDERRRLWWCTYCLDRQICVYLGRPFGIADEAIETPFPVEEVDGWSDAQQIETGDDDKriRSCRTVS 511
Cdd:cd12148  139 PSSLPGL--SPFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEE--PTSLSFF 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 512 IHIFKIRQIQSEIQQVLYqsvSALPRRFATVEGWRKDVESRLTLWCDSVPK------SRAEMSNCGYNLSFIDLNYQQTR 585
Cdd:cd12148  215 IALIRLARILGRILRLLY---SPRASSPEDSLETILELDAELEEWRASLPPelrldsSSLESPSLLPQRLLLHLLYHLLL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 586 LLLH-------GLCPTVSTPSTEAFEVIADSGSRIIRLYRQLHREKCINY-TWLACHNLFMAGTSYLYALWHSREVRRKT 657
Cdd:cd12148  292 ILLHrpfllrsLSSLSPSSSSAESRRACLEAAREILELLRLLLSSSLLLLlWWFLLYYLFSAALVLLLALLLRPSSSELE 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 296416424 658 TVEQIDfhnLACVDVLGSMIDKCP-AAQGCRDVFESLASA 696
Cdd:cd12148  372 EARSLL---ERALELLERLSERWPrLARRALRLLERLLAR 408
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 65-102 2.25e-11

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 59.30  E-value: 2.25e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 296416424    65 SRSISACNRCRSRKTKCDQLFPNCSSCAKAGVECVGID 102
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSD 38
ZIP_Gal4p-like super family cl22421
Leucine zipper Dimerization domain of Gal4p-like transcription factors; The Gal4p family of ...
 109-127 4.93e-03

Leucine zipper Dimerization domain of Gal4p-like transcription factors; The Gal4p family of transcriptional activators contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. Included in this family are Saccharomyces cerevisiae Gal4p, Hap1p, Put3p, Ppr1p and Sip4p, Neurospora crassa acu-15, and Colletotrichum acutatum Nir1, among others. Gal4p functions in the induction of GAL genes in the presence of galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Hap1p promotes transcription of genes required for respiration and controlling oxidative damage in response to heme. Put3p activates the transcription of the PUT1 and PUT2 genes in the presence of proline, allowing yeast cells to use proline as a nitrogen source. Ppr1p activates transcription of the URA1, URA3, and URA4 genes, which encode enzymes involved in the regulation of pyrimidine levels. Sip4p activates target genes under conditions of glucose deprivation. Acu-15 is involved in regulating acetate utilization while Nir1 plays a role during nitrogen-starvation conditions.


The actual alignment was detected with superfamily member cd14723:

Pssm-ID: 277561  Cd Length: 25  Bit Score: 35.05  E-value: 4.93e-03
                         10
                 ....*....|....*....
gi 296416424 109 VPRSYVDWLEKRVRFLEQE 127
Cdd:cd14723    1 VPRSYVVYLEDRVAELEAQ 19
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 275-696 1.61e-57

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 203.06  E-value: 1.61e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 275 PRRQVGENYVDIFFNQANPQTPILHRPSFEKVFRQACSkieeeggnglpanggaggtsggEKDHQHRADLYFLYMVFAIA 354
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYS----------------------DPSSLSPASLALLLAVLALA 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 355 TAMSSRTEALPERYHASAMLHMD---SLFSSIALTNNRLDGLKGILLLALYSIMRPAAPGVWYVVGAAMRLAIDLGLHQE 431
Cdd:cd12148   59 ALSLPDSELRGESRRSLAERYYEaarQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 432 NPQKAEKmwDPLTVDERRRLWWCTYCLDRQICVYLGRPFGIADEAIETPFPVEEVDGWSDAQQIETGDDDKriRSCRTVS 511
Cdd:cd12148  139 PSSLPGL--SPFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEE--PTSLSFF 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 512 IHIFKIRQIQSEIQQVLYqsvSALPRRFATVEGWRKDVESRLTLWCDSVPK------SRAEMSNCGYNLSFIDLNYQQTR 585
Cdd:cd12148  215 IALIRLARILGRILRLLY---SPRASSPEDSLETILELDAELEEWRASLPPelrldsSSLESPSLLPQRLLLHLLYHLLL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 586 LLLH-------GLCPTVSTPSTEAFEVIADSGSRIIRLYRQLHREKCINY-TWLACHNLFMAGTSYLYALWHSREVRRKT 657
Cdd:cd12148  292 ILLHrpfllrsLSSLSPSSSSAESRRACLEAAREILELLRLLLSSSLLLLlWWFLLYYLFSAALVLLLALLLRPSSSELE 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 296416424 658 TVEQIDfhnLACVDVLGSMIDKCP-AAQGCRDVFESLASA 696
Cdd:cd12148  372 EARSLL---ERALELLERLSERWPrLARRALRLLERLLAR 408
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 284-558 3.02e-34

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 132.23  E-value: 3.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424  284 VDIFFNQANPQTPILHRPSFEKVFRQACSKIEEEggnglpanggaggtsggekdhqhrADLYFLYMVFAIATAMSS---R 360
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRDYFELFSSPSNY------------------------ASPLLLLAILALGALFSEsptA 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424  361 TEALPERYHASAMLHMDSLFSSIALTN-----NRLDGLKGILLLALYSIMRPAAPGVWYVVGAAMRLAIDLGLHQE--NP 433
Cdd:pfam04082  57 RSSSSLTDEAADGIHFFLRALILIHEDfsspsSSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRDpsYV 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424  434 QKAEKMWdPLTVDERRRLWWCTYCLDRQICVYLGRPFGIADEAIETPFPVEEVDGWSDAQQIETGDDDKRIRSCRTVSIH 513
Cdd:pfam04082 137 SPSWKLW-IEEAELRRRLFWACFYLDRLISLILGRPPLLSDSDIDLPLPCDDDDLWESDSADEVTLPLISLESKSIKPPL 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 296416424  514 -IFKIRQIQSEIQQVLYQSVSALPRR-FATVEGWRKDVESRLTLWCD 558
Cdd:pfam04082 216 fLIKLSKILSKILGSLLSIRSTLDQRdLQLKLSWVRELERALDNWRK 262
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 397-487 4.22e-24

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 97.14  E-value: 4.22e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424   397 LLLALYSIMRPAAPGVWYVVGAAMRLAIDLGLHQENPqkaekMWDPLTVDERRRLWWCTYCLDRQICVYLGRPFGIADEA 476
Cdd:smart00906   8 LLLALLSLYLGGRDAAWMLLGLAIRLAQALGLHRDPS-----NSDLEERERRRRRFWWLYILDRLLSLSLGRPPLIDDDD 82

                           90
                   ....*....|.
gi 296416424   477 IETPFPVEEVD 487
Cdd:smart00906  83 IDVPLPSDLDD 93
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 65-102 2.25e-11

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 59.30  E-value: 2.25e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 296416424    65 SRSISACNRCRSRKTKCDQLFPNCSSCAKAGVECVGID 102
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSD 38
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 66-99 5.47e-11

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 58.06  E-value: 5.47e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 296416424  66 RSISACNRCRSRKTKCDQLFPNCSSCAKAGVECV 99
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECT 34
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
70-99 9.16e-11

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 57.31  E-value: 9.16e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 296416424   70 ACNRCRSRKTKCDQLFPNCSSCAKAGVECV 99
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECT 31
ZIP_Ppr1 cd14723
Leucine zipper Dimerization coil of Ppr1-like transcription factors; Ppr1/Ppr1p activates ...
 109-127 4.93e-03

Leucine zipper Dimerization coil of Ppr1-like transcription factors; Ppr1/Ppr1p activates transcription of the URA1, URA3, and URA4 genes, which encode enzymes involved in the regulation of pyrimidine levels. Also included in this subfamily is Colletotrichum acutatum Nir1 which plays a role during nitrogen-starvation conditions. Proteins in this subfamily are members of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271240  Cd Length: 25  Bit Score: 35.05  E-value: 4.93e-03
                         10
                 ....*....|....*....
gi 296416424 109 VPRSYVDWLEKRVRFLEQE 127
Cdd:cd14723    1 VPRSYVVYLEDRVAELEAQ 19
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 275-696 1.61e-57

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 203.06  E-value: 1.61e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 275 PRRQVGENYVDIFFNQANPQTPILHRPSFEKVFRQACSkieeeggnglpanggaggtsggEKDHQHRADLYFLYMVFAIA 354
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYS----------------------DPSSLSPASLALLLAVLALA 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 355 TAMSSRTEALPERYHASAMLHMD---SLFSSIALTNNRLDGLKGILLLALYSIMRPAAPGVWYVVGAAMRLAIDLGLHQE 431
Cdd:cd12148   59 ALSLPDSELRGESRRSLAERYYEaarQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRD 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 432 NPQKAEKmwDPLTVDERRRLWWCTYCLDRQICVYLGRPFGIADEAIETPFPVEEVDGWSDAQQIETGDDDKriRSCRTVS 511
Cdd:cd12148  139 PSSLPGL--SPFERELRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEE--PTSLSFF 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 512 IHIFKIRQIQSEIQQVLYqsvSALPRRFATVEGWRKDVESRLTLWCDSVPK------SRAEMSNCGYNLSFIDLNYQQTR 585
Cdd:cd12148  215 IALIRLARILGRILRLLY---SPRASSPEDSLETILELDAELEEWRASLPPelrldsSSLESPSLLPQRLLLHLLYHLLL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424 586 LLLH-------GLCPTVSTPSTEAFEVIADSGSRIIRLYRQLHREKCINY-TWLACHNLFMAGTSYLYALWHSREVRRKT 657
Cdd:cd12148  292 ILLHrpfllrsLSSLSPSSSSAESRRACLEAAREILELLRLLLSSSLLLLlWWFLLYYLFSAALVLLLALLLRPSSSELE 371

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 296416424 658 TVEQIDfhnLACVDVLGSMIDKCP-AAQGCRDVFESLASA 696
Cdd:cd12148  372 EARSLL---ERALELLERLSERWPrLARRALRLLERLLAR 408
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 284-558 3.02e-34

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 132.23  E-value: 3.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424  284 VDIFFNQANPQTPILHRPSFEKVFRQACSKIEEEggnglpanggaggtsggekdhqhrADLYFLYMVFAIATAMSS---R 360
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRDYFELFSSPSNY------------------------ASPLLLLAILALGALFSEsptA 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424  361 TEALPERYHASAMLHMDSLFSSIALTN-----NRLDGLKGILLLALYSIMRPAAPGVWYVVGAAMRLAIDLGLHQE--NP 433
Cdd:pfam04082  57 RSSSSLTDEAADGIHFFLRALILIHEDfsspsSSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRDpsYV 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424  434 QKAEKMWdPLTVDERRRLWWCTYCLDRQICVYLGRPFGIADEAIETPFPVEEVDGWSDAQQIETGDDDKRIRSCRTVSIH 513
Cdd:pfam04082 137 SPSWKLW-IEEAELRRRLFWACFYLDRLISLILGRPPLLSDSDIDLPLPCDDDDLWESDSADEVTLPLISLESKSIKPPL 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 296416424  514 -IFKIRQIQSEIQQVLYQSVSALPRR-FATVEGWRKDVESRLTLWCD 558
Cdd:pfam04082 216 fLIKLSKILSKILGSLLSIRSTLDQRdLQLKLSWVRELERALDNWRK 262
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 397-487 4.22e-24

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 97.14  E-value: 4.22e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296416424   397 LLLALYSIMRPAAPGVWYVVGAAMRLAIDLGLHQENPqkaekMWDPLTVDERRRLWWCTYCLDRQICVYLGRPFGIADEA 476
Cdd:smart00906   8 LLLALLSLYLGGRDAAWMLLGLAIRLAQALGLHRDPS-----NSDLEERERRRRRFWWLYILDRLLSLSLGRPPLIDDDD 82

                           90
                   ....*....|.
gi 296416424   477 IETPFPVEEVD 487
Cdd:smart00906  83 IDVPLPSDLDD 93
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 65-102 2.25e-11

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 59.30  E-value: 2.25e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 296416424    65 SRSISACNRCRSRKTKCDQLFPNCSSCAKAGVECVGID 102
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSD 38
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 66-99 5.47e-11

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 58.06  E-value: 5.47e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 296416424  66 RSISACNRCRSRKTKCDQLFPNCSSCAKAGVECV 99
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECT 34
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
70-99 9.16e-11

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 57.31  E-value: 9.16e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 296416424   70 ACNRCRSRKTKCDQLFPNCSSCAKAGVECV 99
Cdd:pfam00172   2 ACDNCRKRKVKCDGKKPACSRCIKNGLECT 31
ZIP_Ppr1 cd14723
Leucine zipper Dimerization coil of Ppr1-like transcription factors; Ppr1/Ppr1p activates ...
 109-127 4.93e-03

Leucine zipper Dimerization coil of Ppr1-like transcription factors; Ppr1/Ppr1p activates transcription of the URA1, URA3, and URA4 genes, which encode enzymes involved in the regulation of pyrimidine levels. Also included in this subfamily is Colletotrichum acutatum Nir1 which plays a role during nitrogen-starvation conditions. Proteins in this subfamily are members of the Gal4p family of transcriptional activators which contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271240  Cd Length: 25  Bit Score: 35.05  E-value: 4.93e-03
                         10
                 ....*....|....*....
gi 296416424 109 VPRSYVDWLEKRVRFLEQE 127
Cdd:cd14723    1 VPRSYVVYLEDRVAELEAQ 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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