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Conserved domains on  [gi|296262665|gb|EFH09290|]
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hypothetical protein HMPREF0731_4492, partial [Pseudoroseomonas cervicalis ATCC 49957]

Protein Classification

YncE family protein( domain architecture ID 11465355)

YncE family protein contains repeats resembling the NHL (NCL-1, HT2A and LIN-41) and YVTN-type repeats, similar to DNA-binding beta-propeller protein YncE and Bacillus subtilis uncharacterized protein YwhL

CATH:  2.130.10.10
PubMed:  22120742|10607670
SCOP:  4002745

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
43-261 6.10e-16

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 74.73  E-value: 6.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  43 APGTVSHPRDVVVDQPLGKAYVSATFKPEVVVFRAGTPELAGRVEIASRVRGGTFSAASLSLDAAAHRLYVVSNTTSEVA 122
Cdd:COG3391   14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 123 VIDTRTDTVLKVLPVPGarGSIGVSHDPQTGRIFVAAQGSDNLVVLDGESGAVIADTPVGAGALNVVFDPVRRRAYVSSR 202
Cdd:COG3391   94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANS 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 296262665 203 AAGTVTV-----TDADGKILANLGPAPLANHVAAGRDG-TIFAVDKSANARGEDGDTLLRIRPRS 261
Cdd:COG3391  172 GSNTVSVivsviDTATGKVVATIPVGGGPVGVAVSPDGrRLYVANRGSNTSNGGSNTVSVIDLAT 236
 
Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
43-261 6.10e-16

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 74.73  E-value: 6.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  43 APGTVSHPRDVVVDQPLGKAYVSATFKPEVVVFRAGTPELAGRVEIASRVRGGTFSAASLSLDAAAHRLYVVSNTTSEVA 122
Cdd:COG3391   14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 123 VIDTRTDTVLKVLPVPGarGSIGVSHDPQTGRIFVAAQGSDNLVVLDGESGAVIADTPVGAGALNVVFDPVRRRAYVSSR 202
Cdd:COG3391   94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANS 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 296262665 203 AAGTVTV-----TDADGKILANLGPAPLANHVAAGRDG-TIFAVDKSANARGEDGDTLLRIRPRS 261
Cdd:COG3391  172 GSNTVSVivsviDTATGKVVATIPVGGGPVGVAVSPDGrRLYVANRGSNTSNGGSNTVSVIDLAT 236
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 14-211 4.36e-09

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 55.82  E-value: 4.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665   14 ANGTVWVTNTRQDTVAVYRQADLSLLRQFAPGtvSHPRDVVVDQPLGKAYVSATFKPEVVVFRAGTPELAGrvEIASRVR 93
Cdd:TIGR03866   9 AAETAYVSNEKDNTISVIDTATLKVTRTFPVG--QRPRGITFSKDGKLLYVCASDSDTIQVIDPATGEVLH--TLPSGPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665   94 GGTFSAASLSldaaaHRLYVVSNTTSEVAVIDTRTDTVLKVLPVPGARGSIGVSHDpqtGRIFVAAQGSDNLV-VLDGES 172
Cdd:TIGR03866  85 PEQFALHPNG-----KILYIANEDDALVTVIDIETRKVLAQIDVGVEPEGMAVSPD---GKIVVNTSETTNMAhWIDTAT 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 296262665  173 GAVIADTPVGAGALNVVFDPVRRRAYVSSRAAGTVTVTD 211
Cdd:TIGR03866 157 YEIVDNTLVDARPRFAEFTADGKELWVSSEIGGTVTVID 195
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 157-247 3.22e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.03  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 157 VAAQGSDNLVVLDGESGAVIADTP-------VGAGAL-----NVVFDPVRRRAYVSSRAAGTVTVTDADGKILANLGP-- 222
Cdd:cd14962   62 VAIDANGNLYVSDAELGKVFVFDRdgkflraIGAGALfkrptGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKrg 141

                         90       100       110
                 ....*....|....*....|....*....|
gi 296262665 223 -AP----LANHVAAGRDGTIFAVDkSANAR 247
Cdd:cd14962  142 sGPgefnLPTDLAVDRDGNLYVTD-TMNFR 170
 
Name Accession Description Interval E-value
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
43-261 6.10e-16

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 74.73  E-value: 6.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  43 APGTVSHPRDVVVDQPLGKAYVSATFKPEVVVFRAGTPELAGRVEIASRVRGGTFSAASLSLDAAAHRLYVVSNTTSEVA 122
Cdd:COG3391   14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 123 VIDTRTDTVLKVLPVPGarGSIGVSHDPQTGRIFVAAQGSDNLVVLDGESGAVIADTPVGAGALNVVFDPVRRRAYVSSR 202
Cdd:COG3391   94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANS 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 296262665 203 AAGTVTV-----TDADGKILANLGPAPLANHVAAGRDG-TIFAVDKSANARGEDGDTLLRIRPRS 261
Cdd:COG3391  172 GSNTVSVivsviDTATGKVVATIPVGGGPVGVAVSPDGrRLYVANRGSNTSNGGSNTVSVIDLAT 236
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
9-207 2.26e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 67.80  E-value: 2.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665   9 VGVDDANGTVWVTNTRQDTVAVYRQADLSLLRQFAPGTVSHPRDVVVDQPLGKAYVSATFKPEVVVFRAGTPELAGRVEI 88
Cdd:COG3391   29 GLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  89 ASRVRGGTFsaaslslDAAAHRLYVVSNTTSEVAVIDTRTDTVLKVLPVPgaRGSIGVSHDPQTGRIFVAAQGSDN---- 164
Cdd:COG3391  109 GGGPRGLAV-------DPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG--AGPHGIAVDPDGKRLYVANSGSNTvsvi 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 296262665 165 LVVLDGESGAVIADTPVGAGALNVVFDPVRRRAYVSSRAAGTV 207
Cdd:COG3391  180 VSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTS 222
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 14-211 4.36e-09

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 55.82  E-value: 4.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665   14 ANGTVWVTNTRQDTVAVYRQADLSLLRQFAPGtvSHPRDVVVDQPLGKAYVSATFKPEVVVFRAGTPELAGrvEIASRVR 93
Cdd:TIGR03866   9 AAETAYVSNEKDNTISVIDTATLKVTRTFPVG--QRPRGITFSKDGKLLYVCASDSDTIQVIDPATGEVLH--TLPSGPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665   94 GGTFSAASLSldaaaHRLYVVSNTTSEVAVIDTRTDTVLKVLPVPGARGSIGVSHDpqtGRIFVAAQGSDNLV-VLDGES 172
Cdd:TIGR03866  85 PEQFALHPNG-----KILYIANEDDALVTVIDIETRKVLAQIDVGVEPEGMAVSPD---GKIVVNTSETTNMAhWIDTAT 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 296262665  173 GAVIADTPVGAGALNVVFDPVRRRAYVSSRAAGTVTVTD 211
Cdd:TIGR03866 157 YEIVDNTLVDARPRFAEFTADGKELWVSSEIGGTVTVID 195
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 114-213 1.58e-07

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 51.19  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  114 VSNTTSE-VAVIDTRTDTVLKVLPVpGARG-SIGVSHDPQtgRIFVAAQGSDNLVVLDGESGAVIADTPVGAGALNVVFD 191
Cdd:TIGR03866  15 VSNEKDNtISVIDTATLKVTRTFPV-GQRPrGITFSKDGK--LLYVCASDSDTIQVIDPATGEVLHTLPSGPDPEQFALH 91

                          90       100
                  ....*....|....*....|..
gi 296262665  192 PVRRRAYVSSRAAGTVTVTDAD 213
Cdd:TIGR03866  92 PNGKILYIANEDDALVTVIDIE 113
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
13-180 2.35e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.40  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  13 DANGTVWVTNTRQDTVAVYRQADLSLLRQFAPGTVSHPRDVVVDqPLGKAYVSATFKPEVVVFRAGTpelaGRVEI---- 88
Cdd:COG4257  110 DPDGNLWFTDQGGNRIGRLDPATGEVTEFPLPTGGAGPYGIAVD-PDGNLWVTDFGANAIGRIDPDT----GTLTEyalp 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  89 --ASRVRGGTFSAASlsldaaahRLYVVSNTTSEVAVIDTRTDTVLKVLPVPGARGSIGVSHDPQtGRIFVAAQGSDNLV 166
Cdd:COG4257  185 tpGAGPRGLAVDPDG--------NLWVADTGSGRIGRFDPKTGTVTEYPLPGGGARPYGVAVDGD-GRVWFAESGANRIV 255

                        170
                 ....*....|....
gi 296262665 167 VLDGESGAVIADTP 180
Cdd:COG4257  256 RFDPDTELTEYVLP 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
13-261 2.85e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.40  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  13 DANGTVWVTNTRQDTVAVYRQADLSlLRQFAPGTVSHPRDVVVDqPLGKAYVSATFKPEVVVFRAGTpelaGRVEiasRV 92
Cdd:COG4257   25 DPDGAVWFTDQGGGRIGRLDPATGE-FTEYPLGGGSGPHGIAVD-PDGNLWFTDNGNNRIGRIDPKT----GEIT---TF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  93 RGGTFSAASLSLDAAAH-RLYVVSNTTSEVAVIDTRTDTVLKV-LPVPGARGSiGVSHDPQtGRIFVAAQGSDNLVVLDG 170
Cdd:COG4257   96 ALPGGGSNPHGIAFDPDgNLWFTDQGGNRIGRLDPATGEVTEFpLPTGGAGPY-GIAVDPD-GNLWVTDFGANAIGRIDP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 171 ESGAV--IADTPVGAGALNVVFDPvRRRAYVSSRAAGTVTVTD-ADGKI--LANLGPAPLANHVAAGRDGTIFAVDKSAN 245
Cdd:COG4257  174 DTGTLteYALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDpKTGTVteYPLPGGGARPYGVAVDGDGRVWFAESGAN 252

                        250
                 ....*....|....*.
gi 296262665 246 ArgedgdtLLRIRPRS 261
Cdd:COG4257  253 R-------IVRFDPDT 261
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
74-236 3.83e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.69  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  74 VFRAGTPELAGRVEIASRVRGGTFSAASLSLDAAAHRLYVVSNTTSEVAVIDTRTDTVLKVLPVPGARGSIGVSHDPQTG 153
Cdd:COG3391    1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 154 RIFVAAQGSDNLVVLDGESGAVIADTPVGAGALNVVFDPVRRRAYVSSRAAGTVTVTD-ADGKILANLGPAPLANHVAAG 232
Cdd:COG3391   81 RLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDtATGKVVATIPVGAGPHGIAVD 160


                 ....
gi 296262665 233 RDGT 236
Cdd:COG3391  161 PDGK 164
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
43-261 6.71e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.17  E-value: 6.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  43 APGTVSHPRDVVVDqPLGKAYVSATFKPEVVVFRAGTPELAgrveiasRVRGGTFSAASLSLDAAAHRLYVVSNTTSEVA 122
Cdd:COG4257   12 VPAPGSGPRDVAVD-PDGAVWFTDQGGGRIGRLDPATGEFT-------EYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 123 VIDTRTDTVLKVLPVPGARGSIGVSHDPQtGRIFVAAQGSDNLVVLDGESGAVIADT--PVGAGALNVVFDPvRRRAYVS 200
Cdd:COG4257   84 RIDPKTGEITTFALPGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDPATGEVTEFPlpTGGAGPYGIAVDP-DGNLWVT 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296262665 201 SRAAGTV-TVTDADGKILANLGPAPLA--NHVAAGRDGTIFAVDKSANArgedgdtLLRIRPRS 261
Cdd:COG4257  162 DFGANAIgRIDPDTGTLTEYALPTPGAgpRGLAVDPDGNLWVADTGSGR-------IGRFDPKT 218
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
7-164 2.21e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 2.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665   7 YGVGVDDANGTVWVTNTRQDTVAVYRQADLSLLRQFAPGtvSHPRDVVVDQPLGKAYVSATFKPEVVVFragtpelagrv 86
Cdd:COG3391  113 RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG--AGPHGIAVDPDGKRLYVANSGSNTVSVI----------- 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296262665  87 eiasrvrggtfsaaslsldaaahrlyvvsnttseVAVIDTRTDTVLKVLPVPGarGSIGVSHDPQTGRIFVAAQGSDN 164
Cdd:COG3391  180 ----------------------------------VSVIDTATGKVVATIPVGG--GPVGVAVSPDGRRLYVANRGSNT 221
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 157-247 3.22e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.03  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 157 VAAQGSDNLVVLDGESGAVIADTP-------VGAGAL-----NVVFDPVRRRAYVSSRAAGTVTVTDADGKILANLGP-- 222
Cdd:cd14962   62 VAIDANGNLYVSDAELGKVFVFDRdgkflraIGAGALfkrptGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKrg 141

                         90       100       110
                 ....*....|....*....|....*....|
gi 296262665 223 -AP----LANHVAAGRDGTIFAVDkSANAR 247
Cdd:cd14962  142 sGPgefnLPTDLAVDRDGNLYVTD-TMNFR 170
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
149-209 2.93e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 38.35  E-value: 2.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 296262665 149 DPQTGRIFVAAQGSDNLVV--LDGESGAV----IADTPVGAGALNVVFDPVRRRAYVSSRAAGTVTV 209
Cdd:COG2706  158 DPDGRFLYVPDLGTDRIYVyrLDPATGKLpeppEVSLPPGSGPRHLAFHPNGRFAYVINELDSTVSV 224
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 7-247 4.56e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 37.68  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665   7 YGVGVDDaNGTVWVTNTRQDTVAVYRQADLSLLRQ----FAPGTVSHPRDVVVDqPLGKAYVSATFKPEVVVFRAGtpel 82
Cdd:cd05819   11 QGIAVDS-SGNIYVADTGNNRIQVFDPDGNFITSFgsfgSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPD---- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  83 aGRVEIASRVRG---GTFSAASLSLDAAAHRLYVVSNTTSEVAVIDTrTDTVLKVLPVPGA-----RGSIGVSHDPqTGR 154
Cdd:cd05819   85 -GNFLASFGGSGdgdGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDP-DGEFLTTFGSGGSgpgqfNGPTGVAVDS-DGN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 155 IFVAAQGSDNLVVLD--GESGAVIADTPVGAGALN----VVFDPvRRRAYVSSRAAGTVTVTDADGKILANLGPAPLANH 228
Cdd:cd05819  162 IYVADTGNHRIQVFDpdGNFLTTFGSTGTGPGQFNyptgIAVDS-DGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDG 240

                        250       260
                 ....*....|....*....|....*.
gi 296262665 229 -------VAAGRDGTIFAVDkSANAR 247
Cdd:cd05819  241 qfnrpsgLAVDSDGNLYVAD-TGNNR 265
8prop_hemeD1_NirF cd20778
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ...
 120-212 4.92e-03

eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.


Pssm-ID: 467722 [Multi-domain]  Cd Length: 381  Bit Score: 37.65  E-value: 4.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665 120 EVAVIDTRTDTVLKVLPVPGARGSIGVSHDpqtGR-IFVAAQGSDN--LVVLDGESGAVIADTPVGAGALNVVFDPVRRR 196
Cdd:cd20778  262 RVLVYDTNDWKFIKSIPLAGQPVFAVARPD---GRyVWVNFSGPDNdtVQVIDTKTLKVVKTLEPGKRVLHMEFTPRGEA 338

                         90
                 ....*....|....*.
gi 296262665 197 AYVSSRAAGTVTVTDA 212
Cdd:cd20778  339 VYISVNDDNKVVVYDT 354
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 110-211 7.33e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 36.94  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296262665  110 RLYVVSNTTSEVAVIDTRTDTVLKVL--PVPGARGS----IGVSHDPQTGRIFVAAQGSDNLVVLDGESGAVIADTPVGA 183
Cdd:TIGR03866 180 ELWVSSEIGGTVTVIDVATRKVIKKItfAIPGVHPEkvqpVGIKLTKDGKTAFVALGPANRVAVVDAKTYEVLDYLLVGQ 259

                          90       100
                  ....*....|....*....|....*...
gi 296262665  184 GALNVVFDPVRRRAYVSSRAAGTVTVTD 211
Cdd:TIGR03866 260 RVWQLAFTPDESRLLTTNGVSNDVSVID 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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