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Conserved domains on  [gi|295791936|gb|ADG28957|]
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NS4A, partial [Hepacivirus hominis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HCV_NS4a super family cl03067
Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine ...
 4-57 1.20e-11

Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine protease, as it is required in a number of cases as a cofactor of cleavage. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex.


The actual alignment was detected with superfamily member pfam01006:

Pssm-ID: 366414  Cd Length: 55  Bit Score: 53.24  E-value: 1.20e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295791936   4 STWVLAGGVLAAVAAYCLATGCVCIIGRLHINQR-AVVAPDKEVLYEAFDEMEEC 57
Cdd:pfam01006  1 STWVLVGGALAAGAAYCLTTGSVVVVGRWSVNGKpPAVVPDREVLYQQGEEMEEC 55
 
Name Accession Description Interval E-value
HCV_NS4a pfam01006
Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine ...
 4-57 1.20e-11

Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine protease, as it is required in a number of cases as a cofactor of cleavage. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex.


Pssm-ID: 366414  Cd Length: 55  Bit Score: 53.24  E-value: 1.20e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295791936   4 STWVLAGGVLAAVAAYCLATGCVCIIGRLHINQR-AVVAPDKEVLYEAFDEMEEC 57
Cdd:pfam01006  1 STWVLVGGALAAGAAYCLTTGSVVVVGRWSVNGKpPAVVPDREVLYQQGEEMEEC 55
 
Name Accession Description Interval E-value
HCV_NS4a pfam01006
Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine ...
 4-57 1.20e-11

Hepatitis C virus non-structural protein NS4a; NS4a forms an integral part of the NS3 serine protease, as it is required in a number of cases as a cofactor of cleavage. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex.


Pssm-ID: 366414  Cd Length: 55  Bit Score: 53.24  E-value: 1.20e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 295791936   4 STWVLAGGVLAAVAAYCLATGCVCIIGRLHINQR-AVVAPDKEVLYEAFDEMEEC 57
Cdd:pfam01006  1 STWVLVGGALAAGAAYCLTTGSVVVVGRWSVNGKpPAVVPDREVLYQQGEEMEEC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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