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Conserved domains on  [gi|295321561]
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Chain T, Cytochrome c oxidase subunit 6A2

Protein Classification

cytochrome c oxidase subunit VIa family protein( domain architecture ID 10097106)

cytochrome c oxidase subunit VIa (COXVIa) family protein such as yeast cytochrome c oxidase polypeptide VIa (also known as Cox13p and Cox6ap) which is a component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_c_Oxidase_VIa cd00925
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 1-83 1.93e-40

Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate.


:

Pssm-ID: 238465 [Multi-domain]  Cd Length: 86  Bit Score: 127.87  E-value: 1.93e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295321561  1 ASAAKGDHGG*GARTWRFLTFGLALPSVALCTLNSWLHSGHR---ERPAFIPYHHLRIRTKPFSWGDGNHTFFHNPRVNP 77
Cdd:cd00925   1 ETAAKGEHAAGTSELWKKISFYVALPAVALCMLNAYLKHKEHeehERPEFVEYEHLNIRTKPFPWGDGNKTLFHNPHVNA 80


                ....*.
gi 295321561 78 LPTGYE 83
Cdd:cd00925  81 LPTGYE 86
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIa cd00925
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 1-83 1.93e-40

Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate.


Pssm-ID: 238465 [Multi-domain]  Cd Length: 86  Bit Score: 127.87  E-value: 1.93e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295321561  1 ASAAKGDHGG*GARTWRFLTFGLALPSVALCTLNSWLHSGHR---ERPAFIPYHHLRIRTKPFSWGDGNHTFFHNPRVNP 77
Cdd:cd00925   1 ETAAKGEHAAGTSELWKKISFYVALPAVALCMLNAYLKHKEHeehERPEFVEYEHLNIRTKPFPWGDGNKTLFHNPHVNA 80


                ....*.
gi 295321561 78 LPTGYE 83
Cdd:cd00925  81 LPTGYE 86
COX6A pfam02046
Cytochrome c oxidase subunit VIa;
3-76 3.90e-13

Cytochrome c oxidase subunit VIa;


Pssm-ID: 426579 [Multi-domain]  Cd Length: 112  Bit Score: 59.25  E-value: 3.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295321561    3 AAKGDHGG*GARTWRFLTFGLALPSVALCTLNSWL----HSGHRE----RPAFIPYHHLRIRTKPFSWGDGNHTFFHNPR 74
Cdd:pfam02046  28 EAVKEHAAGTTDLWRKISYYVAIPALILAGINAYNleneHWEHWEhlppLEERTEYPYQNIRTKNFFWGDGDKTLFWNDK 107


                  ..
gi 295321561   75 VN 76
Cdd:pfam02046 108 VN 109
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_VIa cd00925
Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 1-83 1.93e-40

Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIa is expressed in two tissue-specific isoforms in mammals but not fish. VIa-H is the heart and skeletal muscle isoform; VIa-L is the liver or non-muscle isoform. Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate.


Pssm-ID: 238465 [Multi-domain]  Cd Length: 86  Bit Score: 127.87  E-value: 1.93e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295321561  1 ASAAKGDHGG*GARTWRFLTFGLALPSVALCTLNSWLHSGHR---ERPAFIPYHHLRIRTKPFSWGDGNHTFFHNPRVNP 77
Cdd:cd00925   1 ETAAKGEHAAGTSELWKKISFYVALPAVALCMLNAYLKHKEHeehERPEFVEYEHLNIRTKPFPWGDGNKTLFHNPHVNA 80


                ....*.
gi 295321561 78 LPTGYE 83
Cdd:cd00925  81 LPTGYE 86
COX6A pfam02046
Cytochrome c oxidase subunit VIa;
3-76 3.90e-13

Cytochrome c oxidase subunit VIa;


Pssm-ID: 426579 [Multi-domain]  Cd Length: 112  Bit Score: 59.25  E-value: 3.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295321561    3 AAKGDHGG*GARTWRFLTFGLALPSVALCTLNSWL----HSGHRE----RPAFIPYHHLRIRTKPFSWGDGNHTFFHNPR 74
Cdd:pfam02046  28 EAVKEHAAGTTDLWRKISYYVAIPALILAGINAYNleneHWEHWEhlppLEERTEYPYQNIRTKNFFWGDGDKTLFWNDK 107


                  ..
gi 295321561   75 VN 76
Cdd:pfam02046 108 VN 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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