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Conserved domains on  [gi|29341718|gb|AAO79504|]
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conserved hypothetical protein [Bacteroides thetaiotaomicron VPI-5482]

Protein Classification

lactonase family protein( domain architecture ID 12104453)

lactonase family protein similar to marine flavobacterium Formosa agariphila 6-phosphogluconolactonase, which may be involved in ulvan degradation, and an enzyme responsible for extracellular lactonase activity in the thermophilic ascomycete Thermothelomyces thermophilus (also known as Myceliophthora thermophila), the latter enzyme catalyzes the hydrolysis of glucono-delta-lactone and cellobiono-delta-lactone

CATH:  2.130.10.10
EC:  3.1.1.-
Gene Ontology:  GO:0052689
SCOP:  4000933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 37-377 1.59e-148

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


:

Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 423.56  E-value: 1.59e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718    37 TMIVGTYTSGDSKGLYSFRFNEENGTATALSE-AEVENPSYLVPSADGKFIYAVSEFsNEQAAANAFAFNKEEGTFRLLN 115
Cdd:pfam10282   1 TLYVGTYTKGDSKGIYVLTLDTETGALTLLGLvAEVGNPSYLALSPDGRTLYAVNEE-GDQGGVAAFRIDPDSGALTLLN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   116 TQKTGGEDPCYIIT--NGSNVVTANYSGGSISVFPIDKDGSLLPASEVVKFKGSGADKERQEKPHLHCVRITPDGKYLFA 193
Cdd:pfam10282  80 QVPTGGASPCHLSVdpDGRFLFVANYHGGSVSVFPLDADGSLGELSQVVQHEGSGPPPERQESPHPHSVDLTPDGKFLVV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   194 DDLGTDQIHKFivnpnaKADNEDVFLKEgsPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYN--DGELKEIQ 271
Cdd:pfam10282 160 PDLGTDRVRVY------KLDAGGGKLTP--PASVQTPPGSGPRHLAFHPNGKYAYVVNELSSTVTVFEYDpaTGTFEELQ 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   272 ---TIAADTVGAKGSGDIHISPDGKFLYASNRLkADGLAIFSIHPENGMLTKVGYQLT-GIHPRNFIITPNGKYLLVACR 347
Cdd:pfam10282 232 tvsTLPEGFTGTNGAAAIRVSPDGKFLYVSNRG-HDSIAVFAVDEAGGTLTLVERVSTeGDFPRDFNIDPDGKFLVVANQ 310

                         330       340       350
                  ....*....|....*....|....*....|
gi 29341718   348 DSNVIQVYERDTDTGLLTDIRKDIKVDKPV 377
Cdd:pfam10282 311 DSDNVTVFRRDPETGKLTLLGKDIEVPEPV 340
 
Name Accession Description Interval E-value
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 37-377 1.59e-148

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 423.56  E-value: 1.59e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718    37 TMIVGTYTSGDSKGLYSFRFNEENGTATALSE-AEVENPSYLVPSADGKFIYAVSEFsNEQAAANAFAFNKEEGTFRLLN 115
Cdd:pfam10282   1 TLYVGTYTKGDSKGIYVLTLDTETGALTLLGLvAEVGNPSYLALSPDGRTLYAVNEE-GDQGGVAAFRIDPDSGALTLLN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   116 TQKTGGEDPCYIIT--NGSNVVTANYSGGSISVFPIDKDGSLLPASEVVKFKGSGADKERQEKPHLHCVRITPDGKYLFA 193
Cdd:pfam10282  80 QVPTGGASPCHLSVdpDGRFLFVANYHGGSVSVFPLDADGSLGELSQVVQHEGSGPPPERQESPHPHSVDLTPDGKFLVV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   194 DDLGTDQIHKFivnpnaKADNEDVFLKEgsPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYN--DGELKEIQ 271
Cdd:pfam10282 160 PDLGTDRVRVY------KLDAGGGKLTP--PASVQTPPGSGPRHLAFHPNGKYAYVVNELSSTVTVFEYDpaTGTFEELQ 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   272 ---TIAADTVGAKGSGDIHISPDGKFLYASNRLkADGLAIFSIHPENGMLTKVGYQLT-GIHPRNFIITPNGKYLLVACR 347
Cdd:pfam10282 232 tvsTLPEGFTGTNGAAAIRVSPDGKFLYVSNRG-HDSIAVFAVDEAGGTLTLVERVSTeGDFPRDFNIDPDGKFLVVANQ 310

                         330       340       350
                  ....*....|....*....|....*....|
gi 29341718   348 DSNVIQVYERDTDTGLLTDIRKDIKVDKPV 377
Cdd:pfam10282 311 DSDNVTVFRRDPETGKLTLLGKDIEVPEPV 340
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
35-382 9.99e-145

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 414.30  E-value: 9.99e-145
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  35 DLTMIVGTYTSGDSKGLYSFRFNEENGTATALSE-AEVENPSYLVPSADGKFIYAVSE--------FSNEqaaanafafn 105
Cdd:COG2706   7 STFVYVGTYTSGESEGIYVFRLDTATGELTLLGLvAALGNPSFLALSPDGRFLYAVNEvddggvsaFRID---------- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 106 KEEGTFRLLNTQKTGGEDPCYIIT--NGSNVVTANYSGGSISVFPIDKDGSLLPASEVVKFKGSGADKERQEKPHLHCVR 183
Cdd:COG2706  77 PADGTLTLLNTVSSGGASPCHLSVdpDGRFLFVANYGGGSVSVFPIDADGSLGEPVQVIQHEGSGPNPERQEGPHAHSVV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 184 ITPDGKYLFADDLGTDQIHKFIVNPNAKAdnedvfLKEgsPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYN 263
Cdd:COG2706 157 FDPDGRFLYVPDLGTDRIYVYRLDPATGK------LPE--PPEVSLPPGSGPRHLAFHPNGRFAYVINELDSTVSVYAYD 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 264 --DGELKEIQTIAA---DTVGAKGSGDIHISPDGKFLYASNRLkADGLAIFSIHPENGMLTKVGYQLT-GIHPRNFIITP 337
Cdd:COG2706 229 aaTGTLTLIQTVSTlpeDFTGENWAADIHISPDGRFLYVSNRG-HNSIAVFAIDADGGKLTLVGHVPTgGKWPRDFAIDP 307

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 29341718 338 NGKYLLVACRDSNVIQVYERDTDTGLLTDIRKDIKVDKPVCIKFV 382
Cdd:COG2706 308 DGRFLLVANQKSDNITVFRIDADTGKLTPTGRSVPVPSPVCVAFL 352
PRK11028 PRK11028
6-phosphogluconolactonase; Provisional
 124-367 1.10e-52

6-phosphogluconolactonase; Provisional


Pssm-ID: 182912 [Multi-domain]  Cd Length: 330  Bit Score: 177.84  E-value: 1.10e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  124 PCYIITN--GSNVVTANYSGGSISVFPIDKDGSLLPASEVVKfkgsgadkerqEKPHLHCVRITPDGKYLFADDLGTDQI 201
Cdd:PRK11028  82 PTHISTDhqGRFLFSASYNANCVSVSPLDKDGIPVAPIQIIE-----------GLEGCHSANIDPDNRTLWVPCLKEDRI 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  202 HKFIVNpnakadnEDVFLKEGSPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYND--GELKEIQTI---AAD 276
Cdd:PRK11028 151 RLFTLS-------DDGHLVAQEPAEVTTVEGAGPRHMVFHPNQQYAYCVNELNSSVDVWQLKDphGEIECVQTLdmmPAD 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  277 TVGAKGSGDIHISPDGKFLYASNRLkADGLAIFSIHPENGMLTKVGYQLTGIHPRNFIITPNGKYLLVACRDSNVIQVYE 356
Cdd:PRK11028 224 FSDTRWAADIHITPDGRHLYACDRT-ASLISVFSVSEDGSVLSFEGHQPTETQPRGFNIDHSGKYLIAAGQKSHHISVYE 302

                        250
                 ....*....|.
gi 29341718  357 RDTDTGLLTDI 367
Cdd:PRK11028 303 IDGETGLLTEL 313
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 110-376 4.93e-04

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 41.94  E-value: 4.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 110 TFRLLNTQKTGGEDPCYIITNGSNVVTANYSGGSIsVFPIDKDGSLLpaseVVKFKGSGADK---ERQEKPHLHCVRITP 186
Cdd:cd20718 131 TLEPLKVIPTTGVNDDGIIESRVGAILETPPGPYF-LVALKDAGSVW----VIDYSDPDGNKvtdIGNIGRPLHDAFLDP 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 187 DGKYlfaddlgtdqihkFIVNPNAkadnEDVF----LKEGSPASyKVEAGSGPrHL---TFAPNGSYAYL--INELSGTV 257
Cdd:cd20718 206 DGRY-------------FIVASQG----SNTMwvldLKTGKVVA-RIPTGKTP-HPgpgATWGRKGVTATphLGEGIVTV 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 258 IAFEYNDgELKEIQT---------------IAADTV-GAKGSGDIHISpDGKFLYASNRLkADGLAIFSIHPEngmltkv 321
Cdd:cd20718 267 WDLDTWK-PVKYIPTpgpgrfvrthpsspyVWADTVfGPENADEIYVI-DKETLKVVKTL-IPKPGKRALHPE------- 336

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 29341718 322 gyqltgihprnfiITPNGKYLLVACRDSNVIQVYerDTDTGlltDIRKDIKVDKP 376
Cdd:cd20718 337 -------------FTRDGKYVYVSVWDGGEVVVY--DAETL---ELVKRIPAETP 373
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 247-361 5.96e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 41.56  E-value: 5.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   247 AYLINELSGTVIAFeynDGE-LKEIQTIAadtVGAKGSGdIHISPDGKFLY--ASnrlkaDGLAIFSIHPENGMLTKvgy 323
Cdd:TIGR03866  13 AYVSNEKDNTISVI---DTAtLKVTRTFP---VGQRPRG-ITFSKDGKLLYvcAS-----DSDTIQVIDPATGEVLH--- 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 29341718   324 QL-TGIHPRNFIITPNGKYLLVACRDSNVIQVYerDTDT 361
Cdd:TIGR03866  78 TLpSGPDPEQFALHPNGKILYIANEDDALVTVI--DIET 114
 
Name Accession Description Interval E-value
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 37-377 1.59e-148

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 423.56  E-value: 1.59e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718    37 TMIVGTYTSGDSKGLYSFRFNEENGTATALSE-AEVENPSYLVPSADGKFIYAVSEFsNEQAAANAFAFNKEEGTFRLLN 115
Cdd:pfam10282   1 TLYVGTYTKGDSKGIYVLTLDTETGALTLLGLvAEVGNPSYLALSPDGRTLYAVNEE-GDQGGVAAFRIDPDSGALTLLN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   116 TQKTGGEDPCYIIT--NGSNVVTANYSGGSISVFPIDKDGSLLPASEVVKFKGSGADKERQEKPHLHCVRITPDGKYLFA 193
Cdd:pfam10282  80 QVPTGGASPCHLSVdpDGRFLFVANYHGGSVSVFPLDADGSLGELSQVVQHEGSGPPPERQESPHPHSVDLTPDGKFLVV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   194 DDLGTDQIHKFivnpnaKADNEDVFLKEgsPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYN--DGELKEIQ 271
Cdd:pfam10282 160 PDLGTDRVRVY------KLDAGGGKLTP--PASVQTPPGSGPRHLAFHPNGKYAYVVNELSSTVTVFEYDpaTGTFEELQ 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   272 ---TIAADTVGAKGSGDIHISPDGKFLYASNRLkADGLAIFSIHPENGMLTKVGYQLT-GIHPRNFIITPNGKYLLVACR 347
Cdd:pfam10282 232 tvsTLPEGFTGTNGAAAIRVSPDGKFLYVSNRG-HDSIAVFAVDEAGGTLTLVERVSTeGDFPRDFNIDPDGKFLVVANQ 310

                         330       340       350
                  ....*....|....*....|....*....|
gi 29341718   348 DSNVIQVYERDTDTGLLTDIRKDIKVDKPV 377
Cdd:pfam10282 311 DSDNVTVFRRDPETGKLTLLGKDIEVPEPV 340
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
35-382 9.99e-145

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 414.30  E-value: 9.99e-145
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  35 DLTMIVGTYTSGDSKGLYSFRFNEENGTATALSE-AEVENPSYLVPSADGKFIYAVSE--------FSNEqaaanafafn 105
Cdd:COG2706   7 STFVYVGTYTSGESEGIYVFRLDTATGELTLLGLvAALGNPSFLALSPDGRFLYAVNEvddggvsaFRID---------- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 106 KEEGTFRLLNTQKTGGEDPCYIIT--NGSNVVTANYSGGSISVFPIDKDGSLLPASEVVKFKGSGADKERQEKPHLHCVR 183
Cdd:COG2706  77 PADGTLTLLNTVSSGGASPCHLSVdpDGRFLFVANYGGGSVSVFPIDADGSLGEPVQVIQHEGSGPNPERQEGPHAHSVV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 184 ITPDGKYLFADDLGTDQIHKFIVNPNAKAdnedvfLKEgsPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYN 263
Cdd:COG2706 157 FDPDGRFLYVPDLGTDRIYVYRLDPATGK------LPE--PPEVSLPPGSGPRHLAFHPNGRFAYVINELDSTVSVYAYD 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 264 --DGELKEIQTIAA---DTVGAKGSGDIHISPDGKFLYASNRLkADGLAIFSIHPENGMLTKVGYQLT-GIHPRNFIITP 337
Cdd:COG2706 229 aaTGTLTLIQTVSTlpeDFTGENWAADIHISPDGRFLYVSNRG-HNSIAVFAIDADGGKLTLVGHVPTgGKWPRDFAIDP 307

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 29341718 338 NGKYLLVACRDSNVIQVYERDTDTGLLTDIRKDIKVDKPVCIKFV 382
Cdd:COG2706 308 DGRFLLVANQKSDNITVFRIDADTGKLTPTGRSVPVPSPVCVAFL 352
PRK11028 PRK11028
6-phosphogluconolactonase; Provisional
 124-367 1.10e-52

6-phosphogluconolactonase; Provisional


Pssm-ID: 182912 [Multi-domain]  Cd Length: 330  Bit Score: 177.84  E-value: 1.10e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  124 PCYIITN--GSNVVTANYSGGSISVFPIDKDGSLLPASEVVKfkgsgadkerqEKPHLHCVRITPDGKYLFADDLGTDQI 201
Cdd:PRK11028  82 PTHISTDhqGRFLFSASYNANCVSVSPLDKDGIPVAPIQIIE-----------GLEGCHSANIDPDNRTLWVPCLKEDRI 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  202 HKFIVNpnakadnEDVFLKEGSPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYND--GELKEIQTI---AAD 276
Cdd:PRK11028 151 RLFTLS-------DDGHLVAQEPAEVTTVEGAGPRHMVFHPNQQYAYCVNELNSSVDVWQLKDphGEIECVQTLdmmPAD 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  277 TVGAKGSGDIHISPDGKFLYASNRLkADGLAIFSIHPENGMLTKVGYQLTGIHPRNFIITPNGKYLLVACRDSNVIQVYE 356
Cdd:PRK11028 224 FSDTRWAADIHITPDGRHLYACDRT-ASLISVFSVSEDGSVLSFEGHQPTETQPRGFNIDHSGKYLIAAGQKSHHISVYE 302

                        250
                 ....*....|.
gi 29341718  357 RDTDTGLLTDI 367
Cdd:PRK11028 303 IDGETGLLTEL 313
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
186-362 1.20e-14

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 72.80  E-value: 1.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 186 PDGKYLFADDLGTDQIHKFIVNPNAKADnedvflkegspasyKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYNDG 265
Cdd:COG3391  77 ADGRRLYVANSGSGRVSVIDLATGKVVA--------------TIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 266 ELkeIQTIAadtVGaKGSGDIHISPDGKFLYASNRLKADGLAIFS-IHPENGmltKVGYQL-TGIHPRNFIITPNGKYLL 343
Cdd:COG3391 143 KV--VATIP---VG-AGPHGIAVDPDGKRLYVANSGSNTVSVIVSvIDTATG---KVVATIpVGGGPVGVAVSPDGRRLY 213

                       170       180
                ....*....|....*....|....*.
gi 29341718 344 VACRDSN-------VIQVYerDTDTG 362
Cdd:COG3391 214 VANRGSNtsnggsnTVSVI--DLATL 237
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
119-367 3.43e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 51.17  E-value: 3.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 119 TGGEDPCYIITNGS-NVVTANYSGGSISVFPIdKDGSLlpaSEVVKFKGSGAdkerqekphlHCVRITPDGKYLFADdLG 197
Cdd:COG4257  14 APGSGPRDVAVDPDgAVWFTDQGGGRIGRLDP-ATGEF---TEYPLGGGSGP----------HGIAVDPDGNLWFTD-NG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 198 TDQIHKFivNPnakadnedvflKEGSPASYKVEAG-SGPRHLTFAPNGSYaYLINELSGTVIAFEYNDGELKEIqtiaad 276
Cdd:COG4257  79 NNRIGRI--DP-----------KTGEITTFALPGGgSNPHGIAFDPDGNL-WFTDQGGNRIGRLDPATGEVTEF------ 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 277 TVGAKGSG--DIHISPDGKFLYASNRlkADGLAIFSihPENGMLTKVGYQLTGIHPRNFIITPNGKyLLVACRDSNVIQV 354
Cdd:COG4257 139 PLPTGGAGpyGIAVDPDGNLWVTDFG--ANAIGRID--PDTGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTGSGRIGR 213

                       250
                ....*....|...
gi 29341718 355 YerDTDTGLLTDI 367
Cdd:COG4257 214 F--DPKTGTVTEY 224
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
184-379 4.64e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.79  E-value: 4.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 184 ITPDGKYLFADDlGTDQIHKFivNPnakadnedvflKEGSPASYKVEAGSGPRHLTFAPNGSyAYLINELSGTVIAFEYN 263
Cdd:COG4257  24 VDPDGAVWFTDQ-GGGRIGRL--DP-----------ATGEFTEYPLGGGSGPHGIAVDPDGN-LWFTDNGNNRIGRIDPK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 264 DGELKEIQTiaadTVGAKGSGDIHISPDGKfLYASNrlkADGLAIFSIHPENGMLTKVGYQLTGIHPRNFIITPNGKyLL 343
Cdd:COG4257  89 TGEITTFAL----PGGGSNPHGIAFDPDGN-LWFTD---QGGNRIGRLDPATGEVTEFPLPTGGAGPYGIAVDPDGN-LW 159

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 29341718 344 VACRDSNVIQVYerDTDTGLLTDIRKDIKVDKPVCI 379
Cdd:COG4257 160 VTDFGANAIGRI--DPDTGTLTEYALPTPGAGPRGL 193
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
40-272 1.82e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  40 VGTYTSGDSKGLYSFRFNEENGTATALSEAEVENPSYLVPSADGKFIYAVSEFSNeQAAANAFAFNKEEGTFRLlntqkt 119
Cdd:COG3391  36 LLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSG-RVSVIDLATGKVVATIPV------ 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 120 gGEDPCYII--TNGSNVVTANYSGGSISVfpIDkdgslLPASEVVKFKGSGAdkerqeKPHlhCVRITPDGKYLFADDLG 197
Cdd:COG3391 109 -GGGPRGLAvdPDGGRLYVADSGNGRVSV--ID-----TATGKVVATIPVGA------GPH--GIAVDPDGKRLYVANSG 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29341718 198 TDQIHKFIVnpnakadnedVF-LKEGSPASyKVEAGSGPRHLTFAPNGSYAYLINELSGTViafEYNDGELKEIQT 272
Cdd:COG3391 173 SNTVSVIVS----------VIdTATGKVVA-TIPVGGGPVGVAVSPDGRRLYVANRGSNTS---NGGSNTVSVIDL 234
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 220-368 5.33e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 46.20  E-value: 5.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 220 KEGSPASYKVEAGSG-PRHLT----------FAPNGSYaylinelsgtvIAFEYNDGELKEIQTIAAD-------TVGAK 281
Cdd:COG0823   7 RDGNSDIYVVDLDGGePRRLTnspgidtspaWSPDGRR-----------IAFTSDRGGGPQIYVVDADggeprrlTFGGG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 282 GSGDIHISPDGKFLYASNRlKADGLAIFSIHPENGMLTkvgyQLT--GIHPRnfiITPNGKYLLVACRDSNVIQVYERDT 359
Cdd:COG0823  76 YNASPSWSPDGKRLAFVSR-SDGRFDIYVLDLDGGAPR----RLTdgPGSPS---WSPDGRRIVFSSDRGGRPDLYVVDL 147

                       170
                ....*....|.
gi 29341718 360 DTGL--LTDIR 368
Cdd:COG0823 148 DGRKrrLTPAS 158
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
241-383 5.68e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 5.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 241 APNGSYAYLINELSGTVIAFEYNDGELKEIQTIAADTVGAKGSGDIHISPDGKFLYASNRlkaDGLAIFSIHPENGmlTK 320
Cdd:COG3391  28 LGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANS---GSGRVSVIDLATG--KV 102

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29341718 321 VGYQLTGIHPRNFIITPNGKYLLVACRDSNVIQVYerDTDTGlltDIRKDIKV-DKPVCIKFVP 383
Cdd:COG3391 103 VATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVI--DTATG---KVVATIPVgAGPHGIAVDP 161
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 110-376 4.93e-04

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 41.94  E-value: 4.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 110 TFRLLNTQKTGGEDPCYIITNGSNVVTANYSGGSIsVFPIDKDGSLLpaseVVKFKGSGADK---ERQEKPHLHCVRITP 186
Cdd:cd20718 131 TLEPLKVIPTTGVNDDGIIESRVGAILETPPGPYF-LVALKDAGSVW----VIDYSDPDGNKvtdIGNIGRPLHDAFLDP 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 187 DGKYlfaddlgtdqihkFIVNPNAkadnEDVF----LKEGSPASyKVEAGSGPrHL---TFAPNGSYAYL--INELSGTV 257
Cdd:cd20718 206 DGRY-------------FIVASQG----SNTMwvldLKTGKVVA-RIPTGKTP-HPgpgATWGRKGVTATphLGEGIVTV 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 258 IAFEYNDgELKEIQT---------------IAADTV-GAKGSGDIHISpDGKFLYASNRLkADGLAIFSIHPEngmltkv 321
Cdd:cd20718 267 WDLDTWK-PVKYIPTpgpgrfvrthpsspyVWADTVfGPENADEIYVI-DKETLKVVKTL-IPKPGKRALHPE------- 336

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 29341718 322 gyqltgihprnfiITPNGKYLLVACRDSNVIQVYerDTDTGlltDIRKDIKVDKP 376
Cdd:cd20718 337 -------------FTRDGKYVYVSVWDGGEVVVY--DAETL---ELVKRIPAETP 373
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 247-361 5.96e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 41.56  E-value: 5.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718   247 AYLINELSGTVIAFeynDGE-LKEIQTIAadtVGAKGSGdIHISPDGKFLY--ASnrlkaDGLAIFSIHPENGMLTKvgy 323
Cdd:TIGR03866  13 AYVSNEKDNTISVI---DTAtLKVTRTFP---VGQRPRG-ITFSKDGKLLYvcAS-----DSDTIQVIDPATGEVLH--- 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 29341718   324 QL-TGIHPRNFIITPNGKYLLVACRDSNVIQVYerDTDT 361
Cdd:TIGR03866  78 TLpSGPDPEQFALHPNGKILYIANEDDALVTVI--DIET 114
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 258-366 8.02e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.66  E-value: 8.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 258 IAFEYNDGELKEIQTIAAD-------TVGAKGSGDIHISPDGKFL-YASNRlkADGLAIFSIHPENGMLTkvgyQLTGIH 329
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDLDggeprrlTNSPGIDTSPAWSPDGRRIaFTSDR--GGGPQIYVVDADGGEPR----RLTFGG 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 29341718 330 PRNF--IITPNGKYLLVACRDSNVIQVYERDTDTG---LLTD 366
Cdd:COG0823  75 GYNAspSWSPDGKRLAFVSRSDGRFDIYVLDLDGGaprRLTD 116
YliI COG2133
Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];
223-300 8.38e-04

Glucose/arabinose dehydrogenase, beta-propeller fold [Carbohydrate transport and metabolism];


Pssm-ID: 441736 [Multi-domain]  Cd Length: 365  Bit Score: 41.07  E-value: 8.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 223 SPASYKVE---AG-SGPRHLTFAPNGSyaYLINELSGTVIAFEYNDGELKEIQTIAADTVGAKGSGDIHISPDgkflYAS 298
Cdd:COG2133  23 LPPGFTVEvvaDGlDHPWGLAFLPDGR--LLVTERAGRIRLLDDDGKLSTPVADLPVFAGGEGGLLGVALDPD----FAT 96


                ..
gi 29341718 299 NR 300
Cdd:COG2133  97 NG 98
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 181-363 9.82e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.65  E-value: 9.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 181 CVRITPDGkYLFADDLGTDQIHKFivnpNAKADNEDVFLK-EGSPASykveagsgprhLTFAPNGSYayLINELSGTVIA 259
Cdd:COG3386  12 GPVWDPDG-RLYWVDIPGGRIHRY----DPDGGAVEVFAEpSGRPNG-----------LAFDPDGRL--LVADHGRGLVR 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 260 FEYNDGELKEIqtiaADTVGAKGSG--DIHISPDGKFlYASN-RLKADGLAIFSIHPeNGMLTKVGYQLT---GIhprnf 333
Cdd:COG3386  74 FDPADGEVTVL----ADEYGKPLNRpnDGVVDPDGRL-YFTDmGEYLPTGALYRVDP-DGSLRVLADGLTfpnGI----- 142

                       170       180       190
                ....*....|....*....|....*....|
gi 29341718 334 IITPNGKYLLVACRDSNVIQVYERDTDTGL 363
Cdd:COG3386 143 AFSPDGRTLYVADTGAGRIYRFDLDADGTL 172
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 236-361 4.27e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.25  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718  236 RHLTFAPNGSYAYLINELSGtviafEYN------DGElKEIQTIAADTVGAKGSgdIHISPDGKFL-YASNRLKadgLAI 308
Cdd:COG4946  346 RLPAWSPDGKSIAYFSDASG-----EYElyiapaDGS-GEPKQLTLGDLGRVFN--PVWSPDGKKIaFTDNRGR---LWV 414

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 29341718  309 FSIhpENGMLTKVGYQLTGIHPRNFIITPNGKYLLVACRDSN---VIQVYERDTDT 361
Cdd:COG4946  415 VDL--ASGKVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPNqlsQIFLYDVETGK 468
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
226-365 6.22e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 38.08  E-value: 6.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29341718 226 SYKV-EAGSGPRHLTFAPNGSyAYLINELSGTVIAFEYNDGELKEIQTiaadtvgAKGSG--DIHISPDGKFLYASNRLK 302
Cdd:COG4257   9 EYPVpAPGSGPRDVAVDPDGA-VWFTDQGGGRIGRLDPATGEFTEYPL-------GGGSGphGIAVDPDGNLWFTDNGNN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29341718 303 adglAIFSIHPENGMLTKVGYQLTGIHPRNFIITPNGKyLLVACRDSNVIQVYerDTDTGLLT 365
Cdd:COG4257  81 ----RIGRIDPKTGEITTFALPGGGSNPHGIAFDPDGN-LWFTDQGGNRIGRL--DPATGEVT 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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