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Conserved domains on  [gi|292659004|gb|ADE34392|]
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ORF47R [Turbot reddish body iridovirus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF super family cl00116
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 1-113 6.27e-34

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


The actual alignment was detected with superfamily member PHA02661:

Pssm-ID: 444701  Cd Length: 146  Bit Score: 114.72  E-value: 6.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004   1 MKCTALLLlAIVAVAWAGNTV------------LESIMESSCQPRPTKVQLSS------YSMYIPACTYVPRCGGCCSgD 62
Cdd:PHA02661   8 QFAVALLL-CMYNVPWCFSGStgsssasslsswLDTSDKSSCQPRDTVVQLSDeypgntNDRYNPRCVTVRRCGGCCN-D 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 292659004  63 EATTCRPTATGTVNVTAFKLVFR-----TTQQVVLSVVTHTACACKFKRA-----YLRGPR 113
Cdd:PHA02661  86 ESQICTPTETSNVTVTVMLTSVSgstgaTSNFQTISVEEHTKCKCEFKTTpppttTTREPR 146
 
Name Accession Description Interval E-value
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 1-113 6.27e-34

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 114.72  E-value: 6.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004   1 MKCTALLLlAIVAVAWAGNTV------------LESIMESSCQPRPTKVQLSS------YSMYIPACTYVPRCGGCCSgD 62
Cdd:PHA02661   8 QFAVALLL-CMYNVPWCFSGStgsssasslsswLDTSDKSSCQPRDTVVQLSDeypgntNDRYNPRCVTVRRCGGCCN-D 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 292659004  63 EATTCRPTATGTVNVTAFKLVFR-----TTQQVVLSVVTHTACACKFKRA-----YLRGPR 113
Cdd:PHA02661  86 ESQICTPTETSNVTVTVMLTSVSgstgaTSNFQTISVEEHTKCKCEFKTTpppttTTREPR 146
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 28-105 7.72e-19

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 74.33  E-value: 7.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004  28 SSCQPRPTKVQLSSYS------MYIPACTYVPRCGGCCsGDEATTCRPTATGTVNVTAFKL---VFRTTQQVVLSVVTHT 98
Cdd:cd00135    1 SSCKPRETLVEISEELpdetntIFKPPCVEVKRCGGCC-NDESLECVPTETSNVTMQVLKIspkRKPRSKLVEISFEEHT 79


                 ....*..
gi 292659004  99 ACACKFK 105
Cdd:cd00135   80 ECECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
30-102 3.69e-11

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 54.60  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004   30 CQPRPTKVQLSS------YSMYIPACTYVPRCGGCCsGDEATTCRPTATGTVNVTAFKLVFRTTQQ----VVLSVVTHTA 99
Cdd:pfam00341   1 CKPRETLVEIRRelpdetNAFFKPSCVEVQRCSGCC-NDEGLECVPTETHNVTMQVLKIEYAPRRPspelVEVSFEEHVQ 79


                  ...
gi 292659004  100 CAC 102
Cdd:pfam00341  80 CEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 28-102 8.29e-10

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 51.27  E-value: 8.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004    28 SSCQPRPTKVQLSSY------SMYIPACTYVPRCGGCCsGDEATTCRPTATGTVNVTAFKLVFRTTQQVV-LSVVTHTAC 100
Cdd:smart00141   1 SQCKPRETVVEVSREypdetnFLFKPPCVTVKRCGGCC-NDEGLECVPTETSNVTMQLLEISRPLSQHLVeVSFEEHTKC 79


                   ..
gi 292659004   101 AC 102
Cdd:smart00141  80 EC 81
 
Name Accession Description Interval E-value
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 1-113 6.27e-34

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 114.72  E-value: 6.27e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004   1 MKCTALLLlAIVAVAWAGNTV------------LESIMESSCQPRPTKVQLSS------YSMYIPACTYVPRCGGCCSgD 62
Cdd:PHA02661   8 QFAVALLL-CMYNVPWCFSGStgsssasslsswLDTSDKSSCQPRDTVVQLSDeypgntNDRYNPRCVTVRRCGGCCN-D 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 292659004  63 EATTCRPTATGTVNVTAFKLVFR-----TTQQVVLSVVTHTACACKFKRA-----YLRGPR 113
Cdd:PHA02661  86 ESQICTPTETSNVTVTVMLTSVSgstgaTSNFQTISVEEHTKCKCEFKTTpppttTTREPR 146
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 28-105 7.72e-19

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 74.33  E-value: 7.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004  28 SSCQPRPTKVQLSSYS------MYIPACTYVPRCGGCCsGDEATTCRPTATGTVNVTAFKL---VFRTTQQVVLSVVTHT 98
Cdd:cd00135    1 SSCKPRETLVEISEELpdetntIFKPPCVEVKRCGGCC-NDESLECVPTETSNVTMQVLKIspkRKPRSKLVEISFEEHT 79


                 ....*..
gi 292659004  99 ACACKFK 105
Cdd:cd00135   80 ECECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
30-102 3.69e-11

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 54.60  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004   30 CQPRPTKVQLSS------YSMYIPACTYVPRCGGCCsGDEATTCRPTATGTVNVTAFKLVFRTTQQ----VVLSVVTHTA 99
Cdd:pfam00341   1 CKPRETLVEIRRelpdetNAFFKPSCVEVQRCSGCC-NDEGLECVPTETHNVTMQVLKIEYAPRRPspelVEVSFEEHVQ 79


                  ...
gi 292659004  100 CAC 102
Cdd:pfam00341  80 CEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 28-102 8.29e-10

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 51.27  E-value: 8.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292659004    28 SSCQPRPTKVQLSSY------SMYIPACTYVPRCGGCCsGDEATTCRPTATGTVNVTAFKLVFRTTQQVV-LSVVTHTAC 100
Cdd:smart00141   1 SQCKPRETVVEVSREypdetnFLFKPPCVTVKRCGGCC-NDEGLECVPTETSNVTMQLLEISRPLSQHLVeVSFEEHTKC 79


                   ..
gi 292659004   101 AC 102
Cdd:smart00141  80 EC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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