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Conserved domains on  [gi|29171740|ref|NP_003704|]
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phospholipid phosphatase 3 [Homo sapiens]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 125-271 2.88e-67

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 207.10  E-value: 2.88e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSeGYIQNYR----CRGDDSKVQEARKSFFSGHA 200
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCS-LDHQYIAdctcCTGDPDLIREARLSFPSGHA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29171740 201 SFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:cd03384  80 SLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 125-271 2.88e-67

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 207.10  E-value: 2.88e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSeGYIQNYR----CRGDDSKVQEARKSFFSGHA 200
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCS-LDHQYIAdctcCTGDPDLIREARLSFPSGHA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29171740 201 SFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:cd03384  80 SLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
134-271 3.65e-32

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 115.52  E-value: 3.65e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740    134 LFGCAISQSFTDIAKVSIGRLRPHFLSvcnpdfsqincsegyIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLY 213
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLS---------------IGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 29171740    214 LQARFTWRgarllrpLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:smart00014  66 LPARAGRK-------LLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
 49-273 4.68e-21

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 91.14  E-value: 4.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740   49 LPFLIIET--STIKPYHRgFYCND--ESIKYPLKTgetiNDAVLCAVGIVIAILAIITGEFYriYYLKKSrstiqnpyVA 124
Cdd:PLN02250  30 LLLVVIEVvlNVIEPFHR-FVGKDmlTDLSYPLQD----NTIPFWAVPLIAILLPFAVILVY--YFIRRD--------VY 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDfsQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSM 204
Cdd:PLN02250  95 DLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPD--GKGVFHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSF 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171740  205 YTMLYLVLYLQAR---FTWRGaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA--CCIVFF 273
Cdd:PLN02250 173 AGLGFLSLYLSGKirvFDRRG-HVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVAsfCYLQFF 245
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 132-274 7.91e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 7.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740   132 CFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQIncsegyiqnyrcrgddSKVQEARKSFFSGHASFSMYTMLYLV 211
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAP----------------STLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171740   212 LYLQARFTWrgarlLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFV 274
Cdd:pfam01569  65 LLLRRLRKI-----VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 194-274 2.93e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 58.51  E-value: 2.93e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 194 SFFSGHASFSMytMLYLVLYLqarftwrgaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFF 273
Cdd:COG0671 118 SFPSGHAAAAF--ALALVLAL---------LLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186


                .
gi 29171740 274 V 274
Cdd:COG0671 187 L 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 125-271 2.88e-67

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 207.10  E-value: 2.88e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSeGYIQNYR----CRGDDSKVQEARKSFFSGHA 200
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCS-LDHQYIAdctcCTGDPDLIREARLSFPSGHA 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29171740 201 SFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:cd03384  80 SLSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 72-272 9.31e-37

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 130.03  E-value: 9.31e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  72 SIKYPLKTGETINDAVLCAVGIVIAILAIItgefyrIYYLKKSRStIQNPYVAALykqvgCFLFGCAISQSFTDIAKVSI 151
Cdd:cd03390   2 SISYPFAESETVPTWLLVIISVGIPLLVII------LISLFFRRS-LWDLHTSLL-----GLLLSVSLNGVITNVLKNYA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 152 GRLRPHFLSVCNPDfsQINCSEGYIQNYRCR-GDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTW--RGARLLRP 228
Cdd:cd03390  70 GRPRPDFLARCFPD--GGTPSDTLVGIDICCtGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIfdPRGSSWRL 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 29171740 229 LLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVF 272
Cdd:cd03390 148 LLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYR 191
acidPPc smart00014
Acid phosphatase homologues;
134-271 3.65e-32

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 115.52  E-value: 3.65e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740    134 LFGCAISQSFTDIAKVSIGRLRPHFLSvcnpdfsqincsegyIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLY 213
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLS---------------IGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 29171740    214 LQARFTWRgarllrpLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIV 271
Cdd:smart00014  66 LPARAGRK-------LLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 130-268 8.09e-24

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 94.06  E-value: 8.09e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 130 VGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDfsqincsegyiqnyrcrGDDSKVQEARKSFFSGHASFSMYTMLY 209
Cdd:cd01610   5 ALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFALALF 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 29171740 210 LVLYLqarftwrGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVAC 268
Cdd:cd01610  68 LALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVAL 119
PLN02250 PLN02250
lipid phosphate phosphatase
 49-273 4.68e-21

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 91.14  E-value: 4.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740   49 LPFLIIET--STIKPYHRgFYCND--ESIKYPLKTgetiNDAVLCAVGIVIAILAIITGEFYriYYLKKSrstiqnpyVA 124
Cdd:PLN02250  30 LLLVVIEVvlNVIEPFHR-FVGKDmlTDLSYPLQD----NTIPFWAVPLIAILLPFAVILVY--YFIRRD--------VY 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  125 ALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDfsQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSM 204
Cdd:PLN02250  95 DLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPD--GKGVFHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSF 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171740  205 YTMLYLVLYLQAR---FTWRGaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA--CCIVFF 273
Cdd:PLN02250 173 AGLGFLSLYLSGKirvFDRRG-HVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVAsfCYLQFF 245
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 132-274 7.91e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 7.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740   132 CFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQIncsegyiqnyrcrgddSKVQEARKSFFSGHASFSMYTMLYLV 211
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAP----------------STLPGLGYSFPSGHSATAFALALLLA 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171740   212 LYLQARFTWrgarlLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFV 274
Cdd:pfam01569  65 LLLRRLRKI-----VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02715 PLN02715
lipid phosphate phosphatase
 54-267 5.95e-18

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 82.79  E-value: 5.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740   54 IETSTIKPYHRgfYCNDE---SIKYPLKTgetiNDAVLCAVGIVIAILAIITgefYRIYYLKKSrstiqnpYVAALYKQV 130
Cdd:PLN02715  62 IGLNLISPFYR--YVGKDmmtDLKYPFKD----NTVPIWSVPVYAVLLPIIL---FVCFYLKRR-------CVYDLHHSI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  131 GCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQnyrCRGDDSKVQEARKSFFSGHASFSMYTMLYL 210
Cdd:PLN02715 126 LGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVI---CHGKAAEVKEGHKSFPSGHTSWSFAGLTFL 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  211 VLYLQAR---FTWRGARLLRPLLQFTLiMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA 267
Cdd:PLN02715 203 SLYLSGKikaFNGEGHVAKLCLVIFPL-LAACLVGISRVDDYWHHWQDVFAGALIGILVA 261
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 59-273 1.74e-16

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 78.53  E-value: 1.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740   59 IKPYHRgFYCND--ESIKYPLKTgetiNDAVLCAVGIVIAILAIITgeFYRIYYLKKSrstiqnpyVAALYKQVGCFLFG 136
Cdd:PLN02731  61 IHPFYR-FVGKDmmTDLSYPLKS----NTVPIWSVPVYAMLLPLVI--FIFIYFRRRD--------VYDLHHAVLGLLYS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  137 CAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGyiqNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQA 216
Cdd:PLN02731 126 VLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLG---DVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSG 202

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171740  217 R---FTWRG--ARLLRPLLQftlIMMAFYTGLSRVSDHKHHPSDVLAGFAQG--ALVACCIVFF 273
Cdd:PLN02731 203 KiqaFDGKGhvAKLCIVILP---LLFAALVGISRVDDYWHHWQDVFAGGLLGlaISTICYLQFF 263
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 86-273 2.40e-13

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 67.25  E-value: 2.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  86 AVLCAVGIVIAILAIITGEFYRIYYlkksrstiqnpYVAALYkqvgcFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPD 165
Cdd:cd03392  36 TFLGSPAVLLIIVLLLALLLLLKRR-----------RRAALF-----LLLALLGGGALNTLLKLLVQRPRPPLHLLVPEG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 166 fsqincseGYiqnyrcrgddskvqearkSFFSGHASFSMytMLYLVL-YLQARFTWRgaRLLRPLLQFTLIMMAFYTGLS 244
Cdd:cd03392 100 --------GY------------------SFPSGHAMGAT--VLYGFLaYLLARRLPR--RRVRILLLILAAILILLVGLS 149

                       170       180       190
                ....*....|....*....|....*....|
gi 29171740 245 RVSDHKHHPSDVLAGFAQG-ALVACCIVFF 273
Cdd:cd03392 150 RLYLGVHYPSDVLAGWLLGlAWLALLILLY 179
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 194-274 2.93e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 58.51  E-value: 2.93e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 194 SFFSGHASFSMytMLYLVLYLqarftwrgaRLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFF 273
Cdd:COG0671 118 SFPSGHAAAAF--ALALVLAL---------LLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186


                .
gi 29171740 274 V 274
Cdd:COG0671 187 L 187
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 133-267 1.55e-08

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 51.56  E-value: 1.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 133 FLFGCAISQSFTDIAKVSIGRLRPhflsvcnpdfsqincsEGYIQNYRcrgddskvqearkSFFSGHAS--FSMYTMLyl 210
Cdd:cd03394   8 LAEAAALTAAVTEGLKFAVGRARP----------------DGSNNGYR-------------SFPSGHTAsaFAAATFL-- 56

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 29171740 211 vlylQARFTWRgarlLRPLLQFTLimmAFYTGLSRVSDHKHHPSDVLAGFAQGALVA 267
Cdd:cd03394  57 ----QYRYGWR----WYGIPAYAL---ASLVGASRVVANRHWLSDVLAGAAIGILVG 102
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 90-267 1.23e-07

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 50.78  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740  90 AVGIVIAILAIitgefYRIYYLKKSRSTIQNPYVAALykqvGCFLFGC-AISQSFTDIAKVSIGRLRPHFLsvcnpdfsq 168
Cdd:cd03389  39 IPSLLLFLLFR-----FGDLRGLSAPSRARFPKAAWA----GLFLFATvALSGILVNLLKFIIGRARPKLL--------- 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 169 inCSEGYIQNYRCRGDDskvqeARKSFFSGHAS--FSMYTMLYLvLYLQARFTWRGARLLrpllqftlimmafyTGLSRV 246
Cdd:cd03389 101 --FDDGLYGFDPFHADY-----AFTSFPSGHSAtaGAAAAALAL-LFPRYRWAFILLALL--------------IAFSRV 158

                       170       180
                ....*....|....*....|.
gi 29171740 247 SDHKHHPSDVLAGFAQGALVA 267
Cdd:cd03389 159 IVGAHYPSDVIAGSLLGAVTA 179
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 134-279 4.68e-07

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 49.18  E-value: 4.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171740 134 LFGCAIS---QSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYiqnyrcrgddskvqearkSFFSGHASFSMYTMLYL 210
Cdd:cd03395  60 LVLLAVGfadQLASGFLKPLVARLRPCNALDGVRLVVLGDQGGSY------------------SFASSHAANSFALALFI 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171740 211 VLYLQARFtwrgarllrplLQFTLIMMAFYTGLSRVSDHKHHPSDVLAgfaqGALVACCIVFFVSDLFK 279
Cdd:cd03395 122 WLFFRRGL-----------FSPVLLLWALLVGYSRVYVGVHYPGDVIA----GALIGIISGLLFYLLFS 175
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 194-265 1.82e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 44.23  E-value: 1.82e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171740 194 SFFSGHAS--FSMYTMLYLVLYLqarftwrgARLLRPLLqftlIMMAFYTGLSRVSDHKHHPSDVLAGFAQGAL 265
Cdd:cd03391  92 SFPSGHASraAFVARFLLNHLVL--------AVPLRVLL----VLWATVVGISRVLLGRHHVLDVLAGAFLGYL 153
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 197-267 6.86e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 42.26  E-value: 6.86e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29171740 197 SGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVA 267
Cdd:cd03382  85 SSHSQFMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLG 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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