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Conserved domains on  [gi|289577061|ref|NP_001166161|]
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zinc finger protein 573 isoform 3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
28-89 3.24e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 3.24e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 289577061    28 VTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSLGGHsISKPVVVDLLERGKEPWM 89
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ-VPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-521 1.44e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 160 RPYECKECGKNFRSGYQLTLHQRFHTGEKPYECT--ECGKNFRSGYQLTVHQRFHTGEKTYECRQ--------------- 222
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 223 -CGKAFIYASHIVQH-------------ERIHTGGKPYECQECGRAFSQG----------------------GHLRIHQR 266
Cdd:COG5048  112 sSSSNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 267 VHTGEKPYKCKECGKTFSRRSNlveHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPYECKECGKGY------- 339
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPS---SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslpta 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 340 --TTASYFLLHQRIHKG-GKPYECKECKKTFTLYRNLTRHQN--IHTGEKLfeckqcgktyttgsklfqhqkthtgeKPY 414
Cdd:COG5048  269 ssQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESL--------------------------KPF 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 415 ECKE--CGKAFSLYGYLKQHQKIHTGMKHFECKECKKTFTLYRNLT-------RHQNIHTGKKLFEC--QECGKAYSTGS 483
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDS 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 289577061 484 NLIQHRKTHTGEKP--YKCKECGKTFSLHGYLNQHQKIHT 521
Cdd:COG5048  403 NLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
442-664 4.21e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 442 FECKECKKTFTLYRNLTRHQNIHTGKKLFEC--QECGKAYSTGSNLIQHRKTHTGEKPYKCK----------------EC 503
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 504 GKTFSLHGYLNQH---QKIHTGMKPYECKVC--------------------------------RKTFTFYRNLTLHQSIH 548
Cdd:COG5048  114 SSNSNDNNLLSSHslpPSSRDPQLPDLLSISnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 549 TDEKPFECKECGKTFRR-------------SSHLTAHQSIHADKKPY---------------ECKECGKAFKMYGYLTQH 600
Cdd:COG5048  194 TSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLSPKSLlsqspsslsssdsssSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 289577061 601 QKIHTG-------GKPYECKECGKAFSRASNLVQHER--IHTGE--KPYVC--KQCGKTFRYGSALKAHQRIHRSIK 664
Cdd:COG5048  274 SPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
28-89 3.24e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 3.24e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 289577061    28 VTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSLGGHsISKPVVVDLLERGKEPWM 89
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ-VPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-68 2.69e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 95.62  E-value: 2.69e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289577061   27 LVTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSLG 68
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-67 3.39e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.83  E-value: 3.39e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 289577061  28 VTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSL 67
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-521 1.44e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 160 RPYECKECGKNFRSGYQLTLHQRFHTGEKPYECT--ECGKNFRSGYQLTVHQRFHTGEKTYECRQ--------------- 222
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 223 -CGKAFIYASHIVQH-------------ERIHTGGKPYECQECGRAFSQG----------------------GHLRIHQR 266
Cdd:COG5048  112 sSSSNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 267 VHTGEKPYKCKECGKTFSRRSNlveHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPYECKECGKGY------- 339
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPS---SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslpta 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 340 --TTASYFLLHQRIHKG-GKPYECKECKKTFTLYRNLTRHQN--IHTGEKLfeckqcgktyttgsklfqhqkthtgeKPY 414
Cdd:COG5048  269 ssQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESL--------------------------KPF 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 415 ECKE--CGKAFSLYGYLKQHQKIHTGMKHFECKECKKTFTLYRNLT-------RHQNIHTGKKLFEC--QECGKAYSTGS 483
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDS 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 289577061 484 NLIQHRKTHTGEKP--YKCKECGKTFSLHGYLNQHQKIHT 521
Cdd:COG5048  403 NLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
442-664 4.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 442 FECKECKKTFTLYRNLTRHQNIHTGKKLFEC--QECGKAYSTGSNLIQHRKTHTGEKPYKCK----------------EC 503
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 504 GKTFSLHGYLNQH---QKIHTGMKPYECKVC--------------------------------RKTFTFYRNLTLHQSIH 548
Cdd:COG5048  114 SSNSNDNNLLSSHslpPSSRDPQLPDLLSISnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 549 TDEKPFECKECGKTFRR-------------SSHLTAHQSIHADKKPY---------------ECKECGKAFKMYGYLTQH 600
Cdd:COG5048  194 TSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLSPKSLlsqspsslsssdsssSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 289577061 601 QKIHTG-------GKPYECKECGKAFSRASNLVQHER--IHTGE--KPYVC--KQCGKTFRYGSALKAHQRIHRSIK 664
Cdd:COG5048  274 SPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-285 4.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 289577061  260 HLRIHQRVHTGEKPYKCKECGKTFSR 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 6.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 289577061  624 NLVQHERIHTGEKPYVCKQCGKTFRY 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
28-89 3.24e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 3.24e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 289577061    28 VTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSLGGHsISKPVVVDLLERGKEPWM 89
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ-VPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-68 2.69e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 95.62  E-value: 2.69e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289577061   27 LVTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSLG 68
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-67 3.39e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.83  E-value: 3.39e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 289577061  28 VTFRDVAIDFSRQEWEYLDPNQRDLYRDVMLENYRNLVSL 67
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-521 1.44e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 160 RPYECKECGKNFRSGYQLTLHQRFHTGEKPYECT--ECGKNFRSGYQLTVHQRFHTGEKTYECRQ--------------- 222
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 223 -CGKAFIYASHIVQH-------------ERIHTGGKPYECQECGRAFSQG----------------------GHLRIHQR 266
Cdd:COG5048  112 sSSSNSNDNNLLSSHslppssrdpqlpdLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 267 VHTGEKPYKCKECGKTFSRRSNlveHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPYECKECGKGY------- 339
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPS---SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslpta 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 340 --TTASYFLLHQRIHKG-GKPYECKECKKTFTLYRNLTRHQN--IHTGEKLfeckqcgktyttgsklfqhqkthtgeKPY 414
Cdd:COG5048  269 ssQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESL--------------------------KPF 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 415 ECKE--CGKAFSLYGYLKQHQKIHTGMKHFECKECKKTFTLYRNLT-------RHQNIHTGKKLFEC--QECGKAYSTGS 483
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDS 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 289577061 484 NLIQHRKTHTGEKP--YKCKECGKTFSLHGYLNQHQKIHT 521
Cdd:COG5048  403 NLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-660 6.11e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 6.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 356 KPYECKECKKTFTLYRNLTRHQNIHTGEKLFEC--KQCGKTYTTGSKLFQHQKTHTGEKPYECK---------------- 417
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 418 ECGKAFSLYGYLKQH---QKIHTGMKHFECkeckkTFTLYRNLTRHQNIHTGKKLFECQE----------CGKAYSTGSN 484
Cdd:COG5048  112 SSSSNSNDNNLLSSHslpPSSRDPQLPDLL-----SISNLRNNPLPGNNSSSVNTPQSNSlhpplpanslSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 485 LIQHRKTHTGEKPYKCKECGKTFSLHGyLNQHQKIHTGMKPYECKVCRKTFTFYRNLTLHQSIHTDEKPFECKECGKTFR 564
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 565 RSSHLTAHQSIHAD-------KKPYECKECGKAFKMYGYLTQHQ--KIHTG--GKPYECKE--CGKAFSRASNLVQHERI 631
Cdd:COG5048  266 PTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350
                 ....*....|....*....|....*....|.
gi 289577061 632 HTGEKPYVCK--QCGKTFRYGSALKAHQRIH 660
Cdd:COG5048  346 HTSISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-628 2.83e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 244 KPYECQECGRAFSQGGHLRIHQRVHTGEKPYKC--KECGKTFSRRSNLVEHGQFHT------------------------ 297
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnnpsdlnskslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 298 -----DEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPYECKECGKGYT-TASYFLLHQRIHKggkpyecKECKKTFTLYR 371
Cdd:COG5048  112 ssssnSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPA-------NSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 372 NLTRHQNIHTGEKLFECKQCGKTYTTGSKLFQHQKTHTGEKPYECKECGKAF--SLYGYLKQHQKIHTgmKHFECKECKK 449
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkSLLSQSPSSLSSSD--SSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 450 TFTLYRNLTRHQNIHTG-------KKLFECQECGKAYSTGSNLIQHRKT--HTGE--KPYKCKE--CGKTFSLHGYLNQH 516
Cdd:COG5048  263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 517 QKIHTGMKPYECKVCRKTFTFYRNLT-------LHQSIHTDEKPFEC--KECGKTFRRSSHLTAHQSIHADKKPYECK-- 585
Cdd:COG5048  343 ILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 289577061 586 ECGKAFKMYGYLTQHQKIHTGGKPYECkECGKAFSRASNLVQH 628
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
442-664 4.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 442 FECKECKKTFTLYRNLTRHQNIHTGKKLFEC--QECGKAYSTGSNLIQHRKTHTGEKPYKCK----------------EC 503
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 504 GKTFSLHGYLNQH---QKIHTGMKPYECKVC--------------------------------RKTFTFYRNLTLHQSIH 548
Cdd:COG5048  114 SSNSNDNNLLSSHslpPSSRDPQLPDLLSISnlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 549 TDEKPFECKECGKTFRR-------------SSHLTAHQSIHADKKPY---------------ECKECGKAFKMYGYLTQH 600
Cdd:COG5048  194 TSIPSSSENSPLSSSYSipssssdqnlensSSSLPLTTNSQLSPKSLlsqspsslsssdsssSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 289577061 601 QKIHTG-------GKPYECKECGKAFSRASNLVQHER--IHTGE--KPYVC--KQCGKTFRYGSALKAHQRIHRSIK 664
Cdd:COG5048  274 SPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 522-602 3.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577061 522 GMKPYECKV--CRKTFTF-----YRNLTLHQSIHTDEKPFECKecgktfrrsshltaHQSIHADKKPYECKECGKAFKMY 594
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNqnglkYHMLHGHQNQKLHENPSPEK--------------MNIFSAKDKPYRCEVCDKRYKNL 411


                 ....*...
gi 289577061 595 GYLTQHQK 602
Cdd:COG5189  412 NGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-285 4.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 289577061  260 HLRIHQRVHTGEKPYKCKECGKTFSR 285
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 6.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 289577061  624 NLVQHERIHTGEKPYVCKQCGKTFRY 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-508 8.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.56e-04
                          10        20
                  ....*....|....*....|....*
gi 289577061  484 NLIQHRKTHTGEKPYKCKECGKTFS 508
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-424 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....
gi 289577061  401 LFQHQKTHTGEKPYECKECGKAFS 424
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
540-612 2.47e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.47e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 289577061 540 NLTLHQSIHTDEKPFECKECGKTFRRSSHLTAHQSIHADKKPYEC--KECGKAFKMYGYLTQHQKIHTGGKPYEC 612
Cdd:COG5048   20 PKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
596-621 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 289577061  596 YLTQHQKIHTGGKPYECKECGKAFSR 621
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 554-576 6.25e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|...
gi 289577061  554 FECKECGKTFRRSSHLTAHQSIH 576
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-536 6.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.73e-03
                          10        20
                  ....*....|....*....|....*
gi 289577061  512 YLNQHQKIHTGMKPYECKVCRKTFT 536
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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