NCBI Conserved Domain Search

Conserved domains on [gi|289577057|ref|NP_666524|]

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olfactory receptor 464 [Mus musculus]

Protein Classification

olfactory receptor 4D-like( domain architecture ID 11610407)

olfactory receptor (OR) 4D-like such as human olfactory receptor 4D9 and related proteins in other mammals; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-291

4.66e-156

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 436.77 E-value: 4.66e-156

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15936   82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15936  162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                        250       260
                 ....*....|....*....|....*.
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15936  242 PMDKAVSVLYTVITPMLNPMIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-291

4.66e-156

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 436.77 E-value: 4.66e-156

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15936   82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15936  162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                        250       260
                 ....*....|....*....|....*.
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15936  242 PMDKAVSVLYTVITPMLNPMIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-301

3.23e-34

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 126.08 E-value: 3.23e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057   31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLRLACT 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  191 DTSLLE----FLMISNSGMlvliWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVV-----SMIFIPCIYIYSR 260
Cdd:pfam13853 161 DIKVNNiyglFVVTSTFGI----DSLLIVLSYGLILrTVLGIASREGRLKALNTCGSHVCAVlafytPMIGLSMVHRFGH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 289577057  261 PFTPFpLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKRL 301
Cdd:pfam13853 237 NVPPL-LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-168

1.14e-04

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 43.23 E-value: 1.14e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILImITVTFDPRLDMPMYFLLRNLAVIDLSYsTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIV-IYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSGLYYI 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWvggfahsIVQLSLMLPLPF 168
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW-------IISIIETTPILF 175

Name

Accession

Description

Interval

E-value

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-291

4.66e-156

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 436.77 E-value: 4.66e-156

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15936   82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15936  162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                        250       260
                 ....*....|....*....|....*.
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15936  242 PMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

9.18e-138

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 390.41 E-value: 9.18e-138

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

25-291

8.24e-127

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 362.69 E-value: 8.24e-127

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 289577057 265 FPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-291

2.91e-116

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 335.99 E-value: 2.91e-116

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd13954    2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd13954   82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP--F 262
Cdd:cd13954  162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIIStILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPssS 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd13954  242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-291

1.69e-112

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 326.31 E-value: 1.69e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                        250       260
                 ....*....|....*....|....*.
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15937  242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-291

1.04e-111

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 324.39 E-value: 1.04e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15940    2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15940   82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15940  162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                        250       260
                 ....*....|....*....|....*.
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15940  242 SEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-298

1.84e-109

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 319.02 E-value: 1.84e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15225    2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15225   82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15225  162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIIStILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15225  242 YSPetDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-291

1.71e-108

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 316.43 E-value: 1.71e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15938    2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15938   82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGqaRRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15938  162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIRSTEG--RRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                        250       260
                 ....*....|....*....|....*.
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15938  240 PVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-291

3.90e-108

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 315.60 E-value: 3.90e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15230    2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15230   82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15230  162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILItILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15230  242 YSLdqDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-291

4.89e-106

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 310.16 E-value: 4.89e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRL-DMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                        250       260
                 ....*....|....*....|....*..
gi 289577057 265 FPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15935  242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

26-298

6.21e-103

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 302.65 E-value: 6.21e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15231    2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15231   82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15231  162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIIStILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 265 FPLDKA--VSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15231  242 YSLDKDtlISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-294

6.85e-102

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 300.39 E-value: 6.85e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  12 FILLGFSQTQELQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKT 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  92 ISYQGCMAQIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGP 171
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 172 NVLDNFYCDVPQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMI 250
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILAtILRMRSAEGRHKAFSTCASHLTAVTLF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 289577057 251 FIPCIYIYSRPFTPFPL--DKAVSISYTVLTPMLNPMIYTLRNQEM 294
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEV 286

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-291

1.43e-100

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 296.32 E-value: 1.43e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15912    2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15912   82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT- 263
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIIStILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQs 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 264 -PFPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15912  242 sSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-298

3.09e-99

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 292.96 E-value: 3.09e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15229    2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15229   82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYT-VILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP--F 262
Cdd:cd15229  162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIhIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPnsA 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15229  242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-298

4.64e-99

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 292.59 E-value: 4.64e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  24 QKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFF 103
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQ 183
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 184 VLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPF 262
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAaVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 289577057 263 TPFPLDKA--VSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15235  241 SSYSADKDrvATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-300

2.64e-98

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 290.75 E-value: 2.64e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15419    2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP-FT 263
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILStILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgAV 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 289577057 264 PFP-LDKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15419  242 SSPeQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-301

3.82e-97

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 288.49 E-value: 3.82e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  11 EFILLGFSQTQELQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTK 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  91 TISYQGCMAQIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCG 170
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 171 PNVLDNFYCDVPQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSM 249
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSaILRIHSSEGRRKAFSTCASHLMAVTI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 289577057 250 IFIPCIYIYSRPFTPFPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKRL 301
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-291

1.95e-96

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 285.89 E-value: 1.95e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15227    2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15227   82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP--F 262
Cdd:cd15227  162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFsTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPpsD 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15227  242 SPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

25-291

1.15e-95

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 283.78 E-value: 1.15e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15237   81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15237  161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILaTILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 289577057 264 PFP--LDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15237  241 THSpdQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-291

2.98e-95

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 282.84 E-value: 2.98e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15911    2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15911   82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVM-LRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15911  162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTN 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 265 FPLD--KAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15911  242 TSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-300

3.41e-95

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 282.99 E-value: 3.41e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15417    2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15417   82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIIStILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15417  242 HSQdqDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-298

8.77e-95

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 281.75 E-value: 8.77e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15421    2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP--- 261
Cdd:cd15421  162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLtVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPgsy 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 262 FTPfPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15421  242 HSP-EQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-298

9.46e-95

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 281.64 E-value: 9.46e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFF-HKTKTISYQGCMAQIFFF 104
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15916   82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15916  162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVrAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 289577057 264 PFPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15916  242 KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-301

2.95e-94

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 281.08 E-value: 2.95e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  12 FILLGFSQTQELQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKT 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  92 ISYQGCMAQIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGP 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 172 NVLDNFYCDVPQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMI 250
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVtILRIRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057 251 FIPCIYIYSRPFTPFPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKRL 301
Cdd:cd15410  241 HGTILFMYCRPSSSYSLdtDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

27-300

6.95e-93

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 276.89 E-value: 6.95e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15411    3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15411   83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15411  163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILsTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 266 PL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15411  243 SLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-291

8.06e-93

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 276.41 E-value: 8.06e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLsLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15431  161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVaVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                        250       260
                 ....*....|....*....|....*....
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15431  241 SSSdqDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-298

2.34e-92

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 275.46 E-value: 2.34e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15228    2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVIsILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 289577057 265 FPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15228  242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-291

1.87e-90

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 270.67 E-value: 1.87e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15232    2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15232   82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15232  162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRsILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15232  242 YSPekDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-291

6.55e-90

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 269.11 E-value: 6.55e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15947    3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15947   83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15947  163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIArAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                        250       260
                 ....*....|....*....|....*...
gi 289577057 266 PLD--KAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15947  243 SQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

25-291

1.89e-89

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 267.94 E-value: 1.89e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15918    1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15918   81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYT-VILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15918  161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVrIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 289577057 264 PFP--LDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15918  241 SHSasKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-300

4.38e-88

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 265.04 E-value: 4.38e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15409   82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15409  162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILfTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 289577057 265 FPLDKA--VSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15409  242 YALDQDmmDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-298

5.95e-88

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 264.57 E-value: 5.95e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15420    2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15420   82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15420  162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAaILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 265 FP--LDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15420  242 NSaeQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

27-291

2.51e-87

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 262.63 E-value: 2.51e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15915   83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL--VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15915  163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIIsfLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                        250       260
                 ....*....|....*....|....*....
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15915  243 DSLeqDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-298

3.35e-86

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 260.03 E-value: 3.35e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15429   83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPF-TP 264
Cdd:cd15429  163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISaILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRsGS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 289577057 265 FPL-DKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15429  243 SALqEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-301

8.66e-86

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 259.72 E-value: 8.66e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  12 FILLGFSQTQELQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKT 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  92 ISYQGCMAQIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGP 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 172 NVLDNFYCDVPQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMI 250
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVaILRMRSAEGRRKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057 251 FIPCIYIYSRPFTPFPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKRL 301
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLdqDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

27-300

9.01e-86

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 258.88 E-value: 9.01e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15415    3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15415   83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15415  163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFaILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 266 PLD--KAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15415  243 SLEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-291

1.33e-85

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 258.37 E-value: 1.33e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15224    2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15224   82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP--F 262
Cdd:cd15224  162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIIsTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPkaI 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15224  242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-300

3.05e-85

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 258.14 E-value: 3.05e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  12 FILLGFSQTQELQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKT 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  92 ISYQGCMAQIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGP 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 172 NVLDNFYCDVPQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMI 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIItVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 289577057 251 FIPCIYIYSRPFTPFPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-298

1.16e-84

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 255.82 E-value: 1.16e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSaILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15942  243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-300

3.13e-83

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 252.73 E-value: 3.13e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15414    2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15414   82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15414  162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIaILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15414  242 SSLdlDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRR 279

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

27-300

1.10e-82

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 251.13 E-value: 1.10e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15416    3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15416   83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15416  163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIaILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 266 PLD--KAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15416  243 SMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

25-298

2.69e-82

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 250.09 E-value: 2.69e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15432  161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVrAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 264 PFPLD--KAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15432  241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

24-301

1.48e-81

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 248.16 E-value: 1.48e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  24 QKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFF 103
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQ 183
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 184 VLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPF 262
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAaILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 289577057 263 TPFPL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKRL 301
Cdd:cd15418  241 SSHTPdrDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

27-300

1.96e-81

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 248.01 E-value: 1.96e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15413    3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15413   83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT-- 263
Cdd:cd15413  163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSaILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSsh 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 264 PFPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15413  243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-300

9.40e-81

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 246.16 E-value: 9.40e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIaILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 289577057 264 --PFPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15412  241 eeSVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

25-298

5.30e-79

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 241.52 E-value: 5.30e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15434    1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15434   81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15434  161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIArAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 264 PFPLD--KAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15434  241 SVSQDqgKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

16-301

1.34e-77

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 238.42 E-value: 1.34e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  16 GFSQTQELQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQ 95
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  96 GCMAQIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLD 175
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 176 NFYCDVPQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPC 254
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSsILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 289577057 255 IYIYSRPFTPFPLD--KAVSISYTVLTPMLNPMIYTLRNQEMQAAMKRL 301
Cdd:cd15406  241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-298

1.82e-77

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 237.82 E-value: 1.82e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRL-DMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKT-KTISYQGCMAQIFF 103
Cdd:cd15941    2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLhGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQ 183
Cdd:cd15941   82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 184 VLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPF 262
Cdd:cd15941  162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVaAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15941  242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-298

3.08e-77

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 237.09 E-value: 3.08e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIY-SRPFT 263
Cdd:cd15234  162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVsSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYiSSAVT 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 264 PFPLDKAV-SISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15234  242 HSSRKTAVaSVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-298

8.11e-77

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 236.23 E-value: 8.11e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYT-VILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 265 FP--LDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15233  242 YSsdKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-291

1.69e-76

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 234.96 E-value: 1.69e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15914    2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15914   82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYT-VILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15914  162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVkIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 265 FPL--DKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15914  242 YSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-298

6.85e-76

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 233.86 E-value: 6.85e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15424    2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15424   82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15424  162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILaSVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 265 FP--LDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15424  242 STpdRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-291

8.40e-76

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 233.36 E-value: 8.40e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15913    2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15913   82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYT-VILVMLRSHSGQARRKAASTCTTHIIVVSMIF--IPCIYIYSRPF 262
Cdd:cd15913  162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTlVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYgsVMVMYVSPGSG 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15913  242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-298

6.71e-74

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 228.52 E-value: 6.71e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15428    2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15428   82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYT-VILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP--F 262
Cdd:cd15428  162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTrIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15428  242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-291

1.02e-73

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 228.02 E-value: 1.02e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15430    1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15430  161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILStILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 289577057 264 P--FPLDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15430  241 KnaQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

27-300

2.70e-73

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 227.30 E-value: 2.70e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15407    3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15407   83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFItILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 266 PL--DKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKR 300
Cdd:cd15407  243 SMdtDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-291

4.38e-73

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 226.21 E-value: 4.38e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15946    2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15946   82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15946  162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFkAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                        250       260
                 ....*....|....*....|....*....
gi 289577057 265 FP--LDKAVSISYTVLTPMLNPMIYTLRN 291
Cdd:cd15946  242 YSpeRDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-298

3.77e-71

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 221.52 E-value: 3.77e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15405    3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd15405   83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILV-MLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTPF 265
Cdd:cd15405  163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSnILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 289577057 266 PLD--KAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15405  243 SVNqgKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

26-298

5.22e-71

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 221.18 E-value: 5.22e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15236    2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15236   82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVI-LVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRP-FT 263
Cdd:cd15236  162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIaATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPsSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 264 PFPL-DKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15236  242 NSSDkDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

25-298

8.76e-66

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 207.72 E-value: 8.76e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15433    1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQV 184
Cdd:cd15433   81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 LRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFT 263
Cdd:cd15433  161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAhAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 289577057 264 PFPLD--KAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15433  241 RYSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-298

4.20e-55

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 180.57 E-value: 4.20e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15223    2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15223   82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVV-----SMIFIPCIYIYS 259
Cdd:cd15223  162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILrAVLRLASGEARSKALNTCGSHLIVIlffytAVLVSSLTYRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 289577057 260 RPFTPFpLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15223  242 KTIPPD-VHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

31-294

3.53e-48

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 162.58 E-value: 3.53e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15950    7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLRLACT 190
Cdd:cd15950   87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 191 DTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIY-IYSRPF---TPF 265
Cdd:cd15950  167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILrAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQRFgqgVPP 246

                        250       260
                 ....*....|....*....|....*....
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRNQEM 294
Cdd:cd15950  247 HTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-294

1.08e-46

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 158.61 E-value: 1.08e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd15917    5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAhSIVQLSLMLP-LPFCGPNVLDNFYCDVPQVLRL 187
Cdd:cd15917   85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVA-LIIPLPLLVRrLPYCGSNVISHSYCEHMAVVKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 188 ACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIY-IYSRPF--- 262
Cdd:cd15917  164 ACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILrAVLQLPSKEARLKALSTCGSHICVILIFYTPALFsFLTHRFghh 243

                        250       260       270
                 ....*....|....*....|....*....|..
gi 289577057 263 TPFPLDKAVSISYTVLTPMLNPMIYTLRNQEM 294
Cdd:cd15917  244 VPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

31-293

8.87e-45

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 153.60 E-value: 8.87e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLRLACT 190
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 191 DTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIY-IYSRPFTPFpLD 268
Cdd:cd15221  167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILrAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFsFLTHRFGRH-IP 245

                        250       260
                 ....*....|....*....|....*....
gi 289577057 269 KAVSIS----YTVLTPMLNPMIYTLRNQE 293
Cdd:cd15221  246 RHVHILlanlYVLVPPMLNPIVYGVKTKQ 274

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

31-294

1.04e-44

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 153.30 E-value: 1.04e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLRLACT 190
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 191 DTSL-LEFLMISNSGMlvLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIY-SRPF---TP 264
Cdd:cd15952  167 SIRInIIYGLFAISVL--VLDVILIALSYVLILrAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFlTHRFghnIP 244

                        250       260       270
                 ....*....|....*....|....*....|
gi 289577057 265 FPLDKAVSISYTVLTPMLNPMIYTLRNQEM 294
Cdd:cd15952  245 RYIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

27-293

5.89e-42

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 146.11 E-value: 5.89e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15222    3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAhSIVQLSLML-PLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd15222   83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVL-LLLPLPFLLkRLPFCHSNVLSHSYCLHQDVM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSLLE----FLMISNSGMlvliWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCI----- 255
Cdd:cd15222  162 KLACSDTRVNSiyglFVVLSTMGL----DSLLILLSYVLILkTVLGIASREERLKALNTCVSHICAVLIFYVPMIglsmv 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 289577057 256 YIYSRPFTPFpLDKAVSISYTVLTPMLNPMIYTLRNQE 293
Cdd:cd15222  238 HRFGKHASPL-VHVLMANVYLLVPPVLNPIIYSVKTKQ 274

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-293

2.90e-41

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 144.41 E-value: 2.90e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15951    7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLRLACT 190
Cdd:cd15951   87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 191 DTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIY-SRPF---TPF 265
Cdd:cd15951  167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILrAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFlTHRFghnVPP 246

                        250       260
                 ....*....|....*....|....*...
gi 289577057 266 PLDKAVSISYTVLTPMLNPMIYTLRNQE 293
Cdd:cd15951  247 HVHILIANVYLLVPPMLNPIIYGVRTKQ 274

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

31-293

7.80e-40

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 140.48 E-value: 7.80e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCV--GLVvaswvgGFAHSIVqlsLMLP-------LPFCGPNVLDNFYCDV 181
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAklGLV------GLIRGVL---LILPlplllsrLPFCANRIIPHTYCEH 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 182 PQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPciYIYSR 260
Cdd:cd15953  158 MAVVKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIrAVLRLSSKKARQKALNTCTAHICVILMSYTP--ALFSF 235

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 289577057 261 PFTPFPLDKAVSIS------YTVLTPMLNPMIYTLRNQE 293
Cdd:cd15953  236 LTHRFGQGIAPHIHiilanlYLLVPPMLNPIIYGVKTKE 274

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

31-295

4.01e-36

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 131.18 E-value: 4.01e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLvvaswvgGFAHSIVQLSLMLPLPF-------CGPNVLDNFYCDVPQ 183
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKI-------GLAALARAVTLMTPLPFllrrlpyCRSHVIAHCYCEHMA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 184 VLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPC-----IYI 257
Cdd:cd15948  161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILrAVLSLASKEEQLKAFGTCGSHICAILVFYTPVvlsstMHR 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 289577057 258 YSRPFTPFpLDKAVSISYTVLTPMLNPMIYTLRNQEMQ 295
Cdd:cd15948  241 FARHVAPH-VHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-295

4.35e-36

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 131.44 E-value: 4.35e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  10 SEFILLGFSQTQELQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKT 89
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  90 KTISYQGCMAQIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHsIVQLSLMLP-LPF 168
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLY-ISPLPLLVRrLPW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 169 CGPNVLDNFYCDVPQVLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVV 247
Cdd:cd15949  161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILrVVQRLATSEARLKTFGTCVSHVCAI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057 248 SMIFIPC-----IYIYSRPFTPfPLDKAVSISYTVLTPMLNPMIYTLRNQEMQ 295
Cdd:cd15949  241 LAFYVPIavsslIHRFGQNVPP-PTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-301

3.23e-34

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 126.08 E-value: 3.23e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057   31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLRLACT 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  191 DTSLLE----FLMISNSGMlvliWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVV-----SMIFIPCIYIYSR 260
Cdd:pfam13853 161 DIKVNNiyglFVVTSTFGI----DSLLIVLSYGLILrTVLGIASREGRLKALNTCGSHVCAVlafytPMIGLSMVHRFGH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 289577057  261 PFTPFpLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAMKRL 301
Cdd:pfam13853 237 NVPPL-LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

27-294

3.60e-33

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 123.05 E-value: 3.60e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15956    3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMnTKLCV---GLVVAswVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQ 183
Cdd:cd15956   83 FSAMESGVLVAMALDRFVAICNPLHYATIL-TLEVVakaGLLLA--LRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 184 VLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIY---- 258
Cdd:cd15956  160 VVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVkTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVlmhr 239

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 289577057 259 SRPFTPFPLDKAVSISYTVLTPMLNPMIYTLRNQEM 294
Cdd:cd15956  240 FGHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

31-294

2.67e-30

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 115.69 E-value: 2.67e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLRLACT 190
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 191 DTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIY-IYSRPFTPFPLD 268
Cdd:cd15954  167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILrAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFtFFAHRFGGHHIT 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 289577057 269 KAVSIS----YTVLTPMLNPMIYTLRNQEM 294
Cdd:cd15954  247 PHIHIImanlYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

31-294

3.34e-26

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 104.47 E-value: 3.34e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLM-LPLPFCGPNVLDNFYCDVPQVLRLAC 189
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIkLRLHHFRSTVISHSYCEHMAVVKLAA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 190 TDTSLLEFLMISNSGMLVLIWFLLLLISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYI-----YSRPFT 263
Cdd:cd15955  167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFrAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSffahrFGHHVA 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 289577057 264 PFpLDKAVSISYTVLTPMLNPMIYTLRNQEM 294
Cdd:cd15955  247 PY-VHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-287

4.01e-26

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 103.92 E-value: 4.01e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057   41 GNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVD-FFHKTKTISYQGCMAQIFFFHLLGGGTVFFLSVMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  120 YDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVldnFYCDVPQVlrlacTDTSLLEFLM 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNV---TVCFIDFP-----EDLSKPVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  200 ISNSGMLVLIWFLLLLISYTVILVMLRSHSG--------QARRKAASTCTTHIIVVS--------MIFIPCIYIYSRPFT 263
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASkqkssertQRRRKALKTLAVVVVVFIlcwlpyhiVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 289577057  264 PFPLDKAVSISYTVLTPMLNPMIY 287
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-291

3.30e-20

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 88.11 E-value: 3.30e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLMLPLPFCGPNVLDNFYCDVPQVLR 186
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 187 LACTDTSLLEFLmisnsgmlvliWFLLLLISYTVILVMLRSHSGQARRKAASTC-----------TTHIIVVSMIFIPC- 254
Cdd:cd00637  161 YTIFLFVLLFLL-----------PLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSrrrrrrrerkvTKTLLIVVVVFLLCw 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 289577057 255 -------IYIYSRPFTPFPLDKAVSISY--TVLTPMLNPMIYTLRN 291
Cdd:cd00637  230 lpyfillLLDVFGPDPSPLPRILYFLALllAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-298

4.81e-18

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 81.84 E-value: 4.81e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIvqLSLMLPLPFCGPNVLDNFYCDVPQVL 185
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL--PPLVGWRDETQPSVVDCECEFTPNKI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACtdTSLLEF-----LMIsnsgmlvliwfllllISYTVILVMLRSHsgqarRKAASTctthIIVVSMIFIPC------ 254
Cdd:cd14967  159 YVLV--SSVISFfipllIMI---------------VLYARIFRVARRE-----LKAAKT----LAIIVGAFLLCwlpffi 212

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 289577057 255 ---IYIYSRPFTPFPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd14967  213 iylVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

29-157

4.73e-11

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 62.22 E-value: 4.73e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTImNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd14969   85 LVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLFWAL 132

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

29-298

1.59e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 60.77 E-value: 1.59e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLsYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADL-LAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFahsivqlsLMLPLPFCGPNVLDnfyCDVPQVLRLA 188
Cdd:cd14972   82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSV--------LLALLPVLGWNCVL---CDQESCSPLG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 189 CTDT-SLLEFLMISNSGMLVLIWFLlllisYTVILVMLRSHSGQARRKAASTCTTH----------IIVVSMIFIPC--- 254
Cdd:cd14972  151 PGLPkSYLVLILVFFFIALVIIVFL-----YVRIFWCLWRHANAIAARQEAAVPAQpstsrklaktVVIVLGVFLVCwlp 225

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 289577057 255 --IYIYSRPFTPFPLDKAVSISYT----VLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd14972  226 llILLVLDVLCPSVCDIQAVFYYFlvlaLLNSAINPIIYAFRLKEMRRAV 275

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

26-162

3.00e-09

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 56.98 E-value: 3.00e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVyITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLV-DFFHKTkTISYQGCMAQIFFF 104
Cdd:cd15065    2 IGIFLSLII-VLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVnDLLGYW-LFGETFCNIWISFD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSL 162
Cdd:cd15065   80 VMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHL 137

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-151

3.26e-09

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 56.51 E-value: 3.26e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15329    2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVG 151
Cdd:cd15329   82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLL 127

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

26-232

1.06e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 52.36 E-value: 1.06e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFH-KTKTISYQGCMAQIFFF 104
Cdd:cd14979    2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWqYPWAFGDGGCKLYYFLF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQLSLM----LPLPFCGPnVLDNFYCD 180
Cdd:cd14979   82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMgiqyLNGPLPGP-VPDSAVCT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 289577057 181 VPqvlrlacTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQA 232
Cdd:cd14979  161 LV-------VDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIK 205

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

26-132

2.11e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 51.16 E-value: 2.11e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCvyITTVVGNILIMITVTFDPRL-DMPMYFLLrNLAVIDLSYSTVTSP-KMLVDFFHKTKTISYQGCMAQIFF 103
Cdd:cd15052    4 ALLLLLLV--IATIGGNILVCLAISLEKRLqNVTNYFLM-SLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTL 80

                         90       100
                 ....*....|....*....|....*....
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHY 132
Cdd:cd15052   81 DVLFCTASIMHLCTISLDRYMAIRYPLRT 109

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-297

2.21e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 51.21 E-value: 2.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAhsivqlsLMLPlPFCGPNvlDNFYCDVPQvl 185
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLL-------ITSP-PLVGPS--WHGRRGLGS-- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 rlaCTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRshsgqaRRKAASTCTthiIVVSMiFIPC-----IYIYSR 260
Cdd:cd15061  149 ---CYYTYDKGYRIYSSMGSFFLPLLLMLFVYLRIFRVIAK------ERKTAKTLA---IVVGC-FIVCwlpffIMYLIE 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 289577057 261 PFTPFPLDKAVSISYTVL---TPMLNPMIYTLRNQEMQAA 297
Cdd:cd15061  216 PFCDCQFSEALSTAFTWLgyfNSVINPFIYAFYNKDFRRA 255

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

27-150

2.62e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 51.22 E-value: 2.62e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVY-ITTVVGNILIMITVTFDPRL-DMPMYFLLRNLAVID----LSYSTVTSPKMLVDFFHKTKTIsyqgCMAQ 100
Cdd:cd15104    1 AAGVILAVLsPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADflvgLAIPGLATDELLSDGENTQKVL----CLLR 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 289577057 101 IFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15104   77 MCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWL 126

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

27-156

3.09e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 50.82 E-value: 3.09e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVID-------LSYSTVTSPK---MLVDFFHKTKT-ISYQ 95
Cdd:cd15312    3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDfllgflvMPYSMVRSVEscwYFGDLFCKIHSsLDMM 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 289577057  96 GCMAQIFffHLlgggtvFFLSVmayDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHS 156
Cdd:cd15312   83 LSTTSIF--HL------CFIAV---DRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

26-150

4.25e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 50.21 E-value: 4.25e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15301    2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15301   82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWI 126

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

26-297

4.74e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 50.19 E-value: 4.74e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15063    2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFahsivqlsLMLPLPFCGPNvldnfycDVPQVL 185
Cdd:cd15063   82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF--------VICFPPLVGWN-------DGKDGI 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 186 RLACTDTSL-LEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSMIFIPCIYIYSRPFTP 264
Cdd:cd15063  147 MDYSGSSSLpCTCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRA 226

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 289577057 265 FPLDKAVSISYTV------LTPMLNPMIYTLRNQEMQAA 297
Cdd:cd15063  227 FCEDCIPPLLFSVffwlgyCNSALNPCIYALFSRDFRFA 265

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

34-168

4.84e-07

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 49.96 E-value: 4.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  34 VYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGGTVF 113
Cdd:cd15210   10 FMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLL 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 289577057 114 FLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAhsivqlsLMLPLPF 168
Cdd:cd15210   90 TLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFG-------SFLPLWL 137

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

30-190

5.87e-07

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 50.10 E-value: 5.87e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGG 109
Cdd:cd15336    6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 110 GTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSivqlslmLPlPFCGpnvldnFYCDVPQVLRLAC 189
Cdd:cd15336   86 TSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWS-------LP-PLFG------WSAYVPEGLLTSC 151


                 .
gi 289577057 190 T 190
Cdd:cd15336  152 T 152

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

26-150

6.40e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 49.88 E-value: 6.40e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTvTSPKMLVDFFHKTKTISYQGCmaQIFFF- 104
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMI-KMPIFIYNSFYEGWALGPLGC--QIYAFl 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 289577057 105 -HLLGGGTVFFLSVMAYDRYIAISQPLHyVTIMNTKLCVGLVVASWV 150
Cdd:cd15079   79 gSLSGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWL 124

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

29-169

7.84e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 49.52 E-value: 7.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITT----VVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd14993    1 IVLIVLYVVVfllaLVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAhsivqlsLMLPLPFC 169
Cdd:cd14993   81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAII-------IMLPLLVV 138

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-149

9.66e-07

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 49.16 E-value: 9.66e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVdffhktktISYQGCM-AQIFF- 103
Cdd:cd15314    2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMV--------RSVETCWyFGDLFc 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 289577057 104 -FH-----LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASW 149
Cdd:cd15314   74 kIHssfdiTLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISW 125

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

30-297

1.32e-06

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 48.88 E-value: 1.32e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYIT-TVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSP-KMLVDFFHKTKTISYQGCMAQIFFFHLL 107
Cdd:cd15053    5 LFLLLLPLlTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPfAVYVEVNGGKWYLGPILCDIYIAMDVMC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 108 GGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAhsivqlsLMLPLpFCGPNVLDNfycDVPQVLRL 187
Cdd:cd15053   85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAA-------IACPL-LFGLNNVPY---RDPEECRF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 188 ACTDtslleFLMISNSGMLVLIWFLLLLISYTVILVMLRshsgqaRRKAAST----------CTTHIIVVSMIFIPCIYI 257
Cdd:cd15053  154 YNPD-----FIIYSSISSFYIPCIVMLLLYYRIFRALRR------EKKATKTlaivlgvflfCWLPFFTLNILNAICPKL 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 289577057 258 YSR----PFTPFPLdkAVSISYtvLTPMLNPMIYTLRNQEMQAA 297
Cdd:cd15053  223 QNQschvGPALFSL--TTWLGY--VNSFLNPIIYTIFNIEFRKA 262

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-158

1.72e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 48.70 E-value: 1.72e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYStvtspkMLVDFFHKTKTIS---YQG---CMA 99
Cdd:cd15055    2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVG------LLVMPFSMIRSIEtcwYFGdtfCKL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 289577057 100 QIFFFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIV 158
Cdd:cd15055   76 HSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV 134

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

26-150

1.72e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 48.60 E-value: 1.72e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVID-------LSYSTVTSPK---MLVDFFHKTKT-ISY 94
Cdd:cd15317    2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADfllglcvMPFSMIRTVEtcwYFGDLFCKFHTgLDL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 289577057  95 QGCMAQIFffHLlgggtvFFLSVmayDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15317   82 LLCTTSIF--HL------CFIAI---DRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

32-153

2.65e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 48.01 E-value: 2.65e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  32 LCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPkmlvdfFHKTKTISYQ----GCMAQIFFFHLL 107
Cdd:cd15069    8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIP------FAITISLGFCtdfhSCLFLACFVLVL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 289577057 108 GGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd15069   82 TQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAF 127

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

36-153

3.72e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 47.42 E-value: 3.72e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  36 ITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGGTVFFL 115
Cdd:cd15073   12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLL 91

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 289577057 116 SVMAYDRYIAISQPlHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd15073   92 TVVAVDRYLTICRP-DLGRKMTTNTYTVMILLAWTNAF 128

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

30-150

5.72e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 47.10 E-value: 5.72e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQ--------I 101
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 289577057 102 FFFHLLGggTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15103   86 ICSSLLA--SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWV 132

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

26-153

6.12e-06

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 46.91 E-value: 6.12e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15048    2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd15048   82 TLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAF 129

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

33-149

6.76e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 47.07 E-value: 6.76e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  33 CVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTI-SYQGCMAQIFFFHLLGGGT 111
Cdd:cd15005    9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHS 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 289577057 112 VFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASW 149
Cdd:cd15005   89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

26-171

7.88e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 46.47 E-value: 7.88e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVdfFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15068    2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFahsIVQLSLMLPLPFCGP 171
Cdd:cd15068   80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF---AIGLTPMLGWNNCGQ 142

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

39-150

9.26e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 46.42 E-value: 9.26e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  39 VVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPkmlvdfFHKTKTISYQGCMAQIF------FFHLLGGGTV 112
Cdd:cd15326   15 IVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP------FSATLEILGYWVFGRIFcdiwaaVDVLCCTASI 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 289577057 113 FFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15326   89 LSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWV 126

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

29-150

1.00e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 46.31 E-value: 1.00e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQG--------CMAQ 100
Cdd:cd15350    5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDS 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 289577057 101 IFFFHLLggGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15350   85 LFCLSLL--GSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWT 132

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

32-170

1.62e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 45.69 E-value: 1.62e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  32 LCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTK-TISYQGCMAQIFFFHLLGGG 110
Cdd:cd15304    8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLFSTA 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVggfahsiVQLSLMLPLPFCG 170
Cdd:cd15304   88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWT-------ISVGISMPIPVFG 140

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

27-150

1.67e-05

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 45.54 E-value: 1.67e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15209    3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15209   83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWL 126

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

29-157

2.53e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 44.93 E-value: 2.53e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTfDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQI-----FF 103
Cdd:cd14978    5 YVLPVICIFGIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd14978   84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNL 137

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

26-130

2.64e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 45.19 E-value: 2.64e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15202    2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                         90       100
                 ....*....|....*....|....*
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPL 130
Cdd:cd15202   82 CSVHVSAYTLTAIAVDRYQAIMHPL 106

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

26-150

2.86e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 44.74 E-value: 2.86e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15012   81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL 125

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

27-150

2.93e-05

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 44.90 E-value: 2.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:cd15401    3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15401   83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWV 126

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

25-298

3.10e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 44.77 E-value: 3.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15102    1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLgGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLcVGLVVASWVggfahsivqLSLML-PLPFCGPNVLDNFYcDVPQ 183
Cdd:cd15102   81 VAL-SASVFSLLAIAIERHLTMAKMKPYGASKTSRV-LLLIGACWL---------ISLLLgGLPILGWNCLGALD-ACST 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 184 VLRLACTDTSLleFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSmIFIPCiyiYSRPFT 263
Cdd:cd15102  149 VLPLYSKHYVL--FCVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLL-VFIAC---WGPLFI 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 289577057 264 PFPLDKAVS-------------ISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15102  223 LLLLDVACPvktcpilykadwfLALAVLNSALNPIIYTLRSRELRRAV 270

7tmA_P2Y1-like

cd15168

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...

26-292

4.07e-05

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).

Pssm-ID: 341329 [Multi-domain] Cd Length: 284 Bit Score: 44.23 E-value: 4.07e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTvTSPKMLVDFFHKTKTISYQG-CMAQIFFF 104
Cdd:cd15168    2 FLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLL-SLPFLIYYYANGDHWIFGDFmCKLVRFLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVggfahsIVQLSLMLPLPFCGPNVLDNfycdvpqv 184
Cdd:cd15168   81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWI------LVLLQLLPILFFATTGRKNN-------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 185 lRLACTDTSLLEFL---MISNSGMLVLIWFLLLLIS----YTVILVMLRSHSGQA----RRKAASTCTTHIIVVSMIFIP 253
Cdd:cd15168  147 -RTTCYDTTSPEELndyVIYSMVLTGLGFLLPLLIIlacyGLIVRALIRKLGEGVtsalRRKSIRLVIIVLALFAVCFLP 225

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057 254 -----CIYIYSR---PFTPFPLDKAVSISYTVLTPM------LNPMIYTLRNQ 292
Cdd:cd15168  226 fhvtrTINLAARllsGTASCATLNGIYVAYKVTRPLaslnscLNPLLYFLAGD 278

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

36-157

4.24e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 44.24 E-value: 4.24e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  36 ITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGGTVFFL 115
Cdd:cd15064   12 LATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 289577057 116 SVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15064   92 CVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL 133

7tmA_Mel1A

cd15402

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

33-150

4.56e-05

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320524 [Multi-domain] Cd Length: 279 Bit Score: 44.12 E-value: 4.56e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  33 CVYITTVV----GNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd15402    5 CILIFTIVvdilGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15402   85 IGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWV 126

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

26-297

4.75e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 43.96 E-value: 4.75e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITV-TFDPRLDMPMYFLLrNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15060    2 VTTILLSVIIAFTIVGNILVILSVfTYRPLRIVQNFFIV-SLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVggfahsivqLSLMLPLP--FCGPNVLDNFYCDVP 182
Cdd:cd15060   81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWA---------LSALISVPplIGWNDWPENFTETTP 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 183 qvlrlaCTDTSLLEFLMISNSGmlvlIWFLLLLISYTVILVMLRSHSGQarRKAASTCTTHIIVVSMIFIPCIYIYS-RP 261
Cdd:cd15060  152 ------CTLTEEKGYVIYSSSG----SFFIPLLIMTIVYVKIFIATSKE--RRAARTLGIIMGVFVVCWLPFFLMYViLP 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 289577057 262 FTPF-PLDKAVSISYTVL---TPMLNPMIYTLRNQEMQAA 297
Cdd:cd15060  220 FCETcSPSAKVVNFITWLgyvNSALNPVIYTIFNLDFRRA 259

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

26-150

5.23e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 43.88 E-value: 5.23e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITtVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSP---------------KMLVDFFHktk 90
Cdd:cd15067    2 LGVVLSLFCLVT-VAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfsilhemtggywlfgRDWCDVWH--- 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  91 TISYQGCMAQIfffhllgggtvFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15067   78 SFDVLASTASI-----------LNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

23-150

5.41e-05

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 44.06 E-value: 5.41e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  23 LQKLLFVVFLCvyiTTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIF 102
Cdd:cd15215    1 IRSVLIVIFLC---ASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 289577057 103 FFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15215   78 LMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWI 125

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

30-157

6.14e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 43.75 E-value: 6.14e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYI-TTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKmlvdffhkTKTISYQGCMAQIFFFH--- 105
Cdd:cd15327    5 VFLAIFIlMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPF--------SATLEVLGFWAFGRVFCdiw 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 289577057 106 -----LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15327   77 aavdvLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISI 133

7tmA_P2Y1-like

cd15967

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...

25-157

7.11e-05

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 320633 [Multi-domain] Cd Length: 281 Bit Score: 43.53 E-value: 7.11e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYsTVTSPKMLVDFFHKTKTISYQG-CMAQIFF 103
Cdd:cd15967    1 QFLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLY-LLTLPFLVVYYLKGRKWIFGQVfCKITRFC 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15967   80 FNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSL 133

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

25-170

1.00e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 43.09 E-value: 1.00e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15083    1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVggfaHSIVqlsLMLPlPFCG 170
Cdd:cd15083   81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWL----YSLL---WVLP-PLFG 138

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

26-157

1.03e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 43.25 E-value: 1.03e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYIT-TVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPkmlvdfFHKTKTISYQGCMAQIF-- 102
Cdd:cd15062    1 IVVGVALGAFILfAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP------FSATLEVLGYWAFGRIFcd 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 289577057 103 ----FFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15062   75 vwaaVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISI 133

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

26-150

1.04e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 43.25 E-value: 1.04e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15056    2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAIS-QPLHYVtiMNTKLCVGLVVASWV 150
Cdd:cd15056   82 LLTTASIMHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWV 125

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

26-157

1.08e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 42.96 E-value: 1.08e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPkmlvdfFHKTKTISYQGCMAQIF--- 102
Cdd:cd15325    2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP------FSAIFEILGYWAFGRVFcni 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 289577057 103 ---FFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15325   76 waaVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI 133

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

32-170

1.12e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 42.97 E-value: 1.12e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  32 LCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTK-TISYQGCMAQIFFFHLLGGG 110
Cdd:cd15305    8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFSTA 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 111 TVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVggfahsiVQLSLMLPLPFCG 170
Cdd:cd15305   88 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWT-------ISIGISMPIPVIG 140

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-168

1.14e-04

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 43.23 E-value: 1.14e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILImITVTFDPRLDMPMYFLLRNLAVIDLSYsTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHL 106
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIV-IYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSGLYYI 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 289577057 107 LGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWvggfahsIVQLSLMLPLPF 168
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW-------IISIIETTPILF 175

7tmA_S1PR1_Edg1

cd15346

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...

25-297

1.16e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320468 [Multi-domain] Cd Length: 277 Bit Score: 42.94 E-value: 1.16e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15346    1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLgGGTVFFLSVMAYDRYIA-ISQPLHYVTimNTKLCVGLVVASWVggfahsivqLSLML-PLPFCGPNVLDNfycdvp 182
Cdd:cd15346   81 VAL-SASVFSLLAIAIERYITmLKMKLHNGS--NSFRSFLLISACWV---------ISLILgGLPIMGWNCISA------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 183 qvLRLACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHS------------GQARRKAASTCTTHIIVVSmI 250
Cdd:cd15346  143 --LSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSrrltfrknirkaSRSSEKSMALLKTVIIVLS-V 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 251 FIPCiyiYSRPFTPFPLD-----KAVSISY--------TVLTPMLNPMIYTLRNQEMQAA 297
Cdd:cd15346  220 FIAC---WAPLFILLLLDvgckvKTCSILFkaeyflvlAVLNSATNPIIYTLTNKEMRRA 276

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

26-131

1.33e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 43.05 E-value: 1.33e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFF-HKTKTISYQGCMAQIFFF 104
Cdd:cd14997    2 LVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWaREPWLLGEFMCKLVPFVE 81

                         90       100
                 ....*....|....*....|....*..
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLH 131
Cdd:cd14997   82 LTVAHASVLTILAISFERYYAICHPLQ 108

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

29-163

1.76e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 42.63 E-value: 1.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRL-DMPMYFLLrNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLL 107
Cdd:cd15307    5 LLALVLVLGTAAGNILVCLAIAWERRLqNVTNYFLM-SLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLF 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 289577057 108 GGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIvQLSLM 163
Cdd:cd15307   84 CTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL-PLSLM 138

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

26-265

2.01e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 42.25 E-value: 2.01e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYsTVTSPKMLVDFFHKTKTISYQG-CMAQIFFF 104
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNGGWWPFGDFlCRLTGLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI-VQLSLMLPLPFCGPNVLDNFYCDVPQ 183
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVpLLLLRSTIAKENNSTTCFEFLSEWLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 184 VLRLACTDTSLLEFLMIsnsgmlvliwFLLLLISYTVILVMLRSHSGQARRKAAST-CTTHIIVVSMIFIPCiyiysrpF 262
Cdd:cd14982  161 SAAPIVLIALVVGFLIP----------LLIILVCYSLIIRALRRRSKQSQKSVRKRkALRMILIVLAVFLVC-------F 223


                 ...
gi 289577057 263 TPF 265
Cdd:cd14982  224 LPY 226

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

34-160

2.18e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 42.36 E-value: 2.18e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  34 VYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVT-SPKMLVDFFHK-------TKTISYqgcmAQIFFFH 105
Cdd:cd14986   10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTvLTQIIWEATGEwvagdvlCRIVKY----LQVVGLF 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 289577057 106 LlgggTVFFLSVMAYDRYIAISQPLHyvTIMNTKLCVGLVVASWVGGFAHSIVQL 160
Cdd:cd14986   86 A----STYILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQL 134

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

26-157

2.84e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 41.89 E-value: 2.84e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCvyitTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15330    6 FLGTLILC----AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15330   82 LCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISI 133

7tmA_P2Y1

cd15377

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

27-149

3.40e-04

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).

Pssm-ID: 341350 [Multi-domain] Cd Length: 289 Bit Score: 41.43 E-value: 3.40e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYsTVTSPKMLVDFFHKTKTISYQG-CMAQIFFFH 105
Cdd:cd15377    3 LPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLY-VLTLPALIFYYFNKTDWIFGDAmCKLQRFIFH 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASW 149
Cdd:cd15377   82 VNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVW 125

7tmA_HCAR-like

cd14991

hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...

25-287

3.88e-04

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).

Pssm-ID: 320122 [Multi-domain] Cd Length: 280 Bit Score: 41.28 E-value: 3.88e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYstVTSPKMLVDFF--HKTKTISYQGCMAQIF 102
Cdd:cd14991    1 SILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLL--LICLPFRIDYYlrGEHWIFGEAWCRVNLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 103 FFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVggfahsiVQLSLMLPLpfcgpnVLDNFYCDVP 182
Cdd:cd14991   79 MLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWA-------LVLLLTLPL------LLSTLLTVNS 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 183 QVLR----LACTDTS----------LLEFLMisnsgmlvlIWFLLLLISYTVILVMLRSHS--GQAR-RKAASTCTTHII 245
Cdd:cd14991  146 NKSSchsfSSYTKPSlsirwhnalfLLEFFL---------PLGLIVFCSVRIACNLRIRQSlgKQARvQRAIRLVFLVVI 216

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057 246 VVSMIFIPCIY--IYSRPFTPFPLDKA---------VSISYTVLTPMLNPMIY 287
Cdd:cd14991  217 VFVLCFLPSIIagLLALVFKNLGSCRClnsvaqlfhISLAFTYLNSALDPVIY 269

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

36-153

4.42e-04

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 41.11 E-value: 4.42e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  36 ITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGGTVFFL 115
Cdd:cd15297   12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNL 91

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 289577057 116 SVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd15297   92 LIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSF 129

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

26-150

4.46e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 41.38 E-value: 4.46e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVID-------LSYSTVTSPKMLVDFFHKTKTISYqgCM 98
Cdd:cd15316    2 ILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADflvgvtvMPFSTVRSVESCWYFGESFCTFHT--CC 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 289577057  99 AQIFFFhllggGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15316   80 DVSFCY-----ASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWI 126

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

23-149

4.59e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 41.47 E-value: 4.59e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  23 LQKLLFVVFLCVyitTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTK-TISYQGC---- 97
Cdd:cd15217    2 VKLVLLGLIICV---SLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCkiva 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057  98 -MAQIFFFHllgggTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASW 149
Cdd:cd15217   79 fMAVLFCFH-----AAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVW 126

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

29-150

4.74e-04

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 41.13 E-value: 4.74e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWI 126

7tmA_mAChR_M4

cd15298

muscarinic acetylcholine receptor subtype M4, member of the class A family of ...

36-153

5.20e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341344 [Multi-domain] Cd Length: 262 Bit Score: 40.77 E-value: 5.20e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  36 ITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGGTVFFL 115
Cdd:cd15298   12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 289577057 116 SVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd15298   92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSF 129

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

28-153

6.35e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 40.70 E-value: 6.35e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  28 FVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPkmLVDFFHKTKTISYQGCMAQIFFFHLL 107
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 289577057 108 GGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd14968   82 TQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSF 127

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

32-131

6.37e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 40.59 E-value: 6.37e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  32 LCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVD-FFHKTKTISYQGCMAQIFFFHLLGGG 110
Cdd:cd15306    8 LMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTiLFEAMWPLPLVLCPIWLFLDVLFSTA 87

                         90       100
                 ....*....|....*....|.
gi 289577057 111 TVFFLSVMAYDRYIAISQPLH 131
Cdd:cd15306   88 SIMHLCAISLDRYIAIKKPIQ 108

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

23-150

6.49e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 40.55 E-value: 6.49e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  23 LQKLLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVdfFHKTKTISYQGCMAQIF 102
Cdd:cd15333    3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIV--YTVTGTWTLGQVVCDIW 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 289577057 103 FFHLLGGGT--VFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15333   81 LSSDITCCTasILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWV 130

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

28-157

8.96e-04

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 40.34 E-value: 8.96e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  28 FVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLL 107
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057 108 GGGTVFFLSVMAYDRYIAISQPL---HYVTIMNTKLCVGLVvasWVGGFAHSI 157
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMkakSFCTIGRARKVALLI---WILSAILAS 132

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-157

9.38e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 40.14 E-value: 9.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133

7tmA_GPER1

cd14989

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...

27-254

9.40e-04

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320120 [Multi-domain] Cd Length: 276 Bit Score: 40.19 E-value: 9.40e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  27 LFVVFLcvYITTVVGNILIMIT-VTFDPRLDMP-MYFLlrNLAVIDLsystVTSPKMLVDFFH---KTKTISYQgCMAQI 101
Cdd:cd14989    5 LYTIFL--FPIGFIGNILILVVnLSFREKMTIPdLYFV--NLAVADL----ILVADSLIEVFNlneKYYDIAVL-CTFMS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 102 FFFHLLGGGTVFFLSVMAYDRYIAISQPLH---YVTIMNTKLCVGLV----VASWVGGFAhsIVQLSLMLPLPFCgpnvl 174
Cdd:cd14989   76 LFLQINMYSSIFFLTWMSFDRYIALAKVMKsspLRTMQHARLSCGLIwmasISATLLPFT--AVQAQHTGEVHFC----- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 175 dnfYCDVPQVLRLACTDTSLLEFLMISnsgmlvliwfllllISYTVIL-VMLRSHSGQARRKAASTCTTHIIVVSMIFIP 253
Cdd:cd14989  149 ---FADVREIQWLEVTLGFIIPFSIIG--------------LCYSLIVrVLVRAQKHRRLRPRRQKALRMILVVVLVFFI 211


                 .
gi 289577057 254 C 254
Cdd:cd14989  212 C 212

7tmA_LWS_opsin

cd15081

long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...

26-295

1.11e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320209 [Multi-domain] Cd Length: 292 Bit Score: 39.89 E-value: 1.11e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVgnilIMITVTFDpRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15081   19 MIFVVFASVFTNGLV----LVATLKFK-KLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTiMNTKLCVGLVVASWV---GGFAHSIVQLSLMLPLPF---CGPNVLDNfyC 179
Cdd:cd15081   94 VCGITGLWSLTIISWERWVVVCKPFGNIK-FDGKLAIVGIIFSWVwsaVWCAPPIFGWSRYWPHGLktsCGPDVFSG--S 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 180 DVPQVlrlactdTSLLEFLMISnsgmLVLIWFLLLLISYTVILVMLRSHSGQAR-----RKAASTCTTHIIVVSMIFIPC 254
Cdd:cd15081  171 SDPGV-------QSYMIVLMIT----CCIIPLAIIILCYLQVWLAIRAVAQQQKesestQKAEKEVSRMVVVMIFAYCFC 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 289577057 255 IYIYS--------RPFTPF-PLDKAVSISYTVLTPMLNPMIYTLRNQEMQ 295
Cdd:cd15081  240 WGPYTffacfaaaNPGYAFhPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

26-157

1.39e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 39.90 E-value: 1.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFhkTKTISYQGCMAQIFFFh 105
Cdd:cd15203    2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTL--TKNWPFGSILCKLVPS- 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 289577057 106 lLGGGTVFF----LSVMAYDRYIAISQPLHyvTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15203   79 -LQGVSIFVstltLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSL 131

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

30-150

1.43e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 39.49 E-value: 1.43e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPK--MLVDFFHKTKTISYQGC--MAQIF--F 103
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLEtiMIAVLNSGYLVISDQFIqhMDNVFdsM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15352   86 ICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

26-145

1.47e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 39.45 E-value: 1.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVyITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15085    3 LSFLMFLNA-TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVN 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLV 145
Cdd:cd15085   82 YFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLL 121

7tmA_GPR17

cd15161

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...

26-273

1.58e-03

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.

Pssm-ID: 320289 [Multi-domain] Cd Length: 277 Bit Score: 39.69 E-value: 1.58e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVF-LCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFF 104
Cdd:cd15161    1 ILFALFyILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 105 HLLGGGTVFFLSVMAYDRYIAISQPLHYVTI---MNTKLCVGLVvasWVggfahsIVQLSlMLPLPFCGPNVLDNfycDV 181
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIrkpLYAHVVCGFL---WV------IVTVA-MAPLLVSPQTVEVN---NT 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 182 PQVLRLACTDTSLLEFLMISnsgMLVLIWFLLLLISYTVILVMLRSHSgQARRKAASTCTTHIIVVSMIFIPCiyiysrp 261
Cdd:cd15161  148 TVCLQLYREKASRGALVSLA---VAFTIPFVTTVTCYLLIIRSLRTGK-REEKPLKDKAIKMIILVLTIFLIC------- 216

                        250
                 ....*....|..
gi 289577057 262 FTPFPLDKAVSI 273
Cdd:cd15161  217 FVPYHISRYIYI 228

7tmA_SWS2_opsin

cd15077

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...

28-298

1.63e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320205 [Multi-domain] Cd Length: 280 Bit Score: 39.43 E-value: 1.63e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  28 FVVFLcvYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLL 107
Cdd:cd15077    6 FMLFL--VIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 108 GGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGlVVASWVGGFAHSIVQL---SLMLPLPF---CGPN--VLDNFYC 179
Cdd:cd15077   84 GMVSLWSLAVVAFERFLVICKPLGNFTFRGTHAIIG-CIATWVFGLAASLPPLfgwSRYIPEGLqcsCGPDwyTTNNKWN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 180 DVPQVLRLACtdtslleflmisnsgMLVLIWFLLLLISYTVILVMLRSHSGQ-----ARRKAASTCTTHIIVVSMIFIPC 254
Cdd:cd15077  163 NESYVMFLFC---------------FCFGVPLSIIVFSYGRLLLTLRAVAKQqeqsaSTQKAEREVTKMVVVMVLGFLVC 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 289577057 255 --------IYIYSRPFTPFPLDKAVSIS-YTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15077  228 wlpyasfaLWVVTNRGEPFDLRLASIPSvFSKASTVYNPVIYVFMNKQFRSCM 280

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

36-149

1.79e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 39.46 E-value: 1.79e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  36 ITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGGTVFFL 115
Cdd:cd15318   12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 289577057 116 SVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASW 149
Cdd:cd15318   92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGW 125

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

26-158

1.81e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 39.24 E-value: 1.81e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRL-DMPMYFLLrNLAVIDLSYSTVTSPkmLVDFFHKTKTISYQGCMAQIF-- 102
Cdd:cd15051    2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLrNLTNYFIV-SLAVTDLLLGLLVLP--FSAIYELRGEWPLGPVFCNIYis 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 289577057 103 FFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIV 158
Cdd:cd15051   79 LDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFL 134

7tmA_Glyco_hormone_R

cd15136

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...

34-153

1.97e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.

Pssm-ID: 320264 [Multi-domain] Cd Length: 275 Bit Score: 39.12 E-value: 1.97e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  34 VYITTVVGNIL-IMITVTFDPRLDMPmYFLLRNLAVID------LSYSTVTSPKMLVDFFHKTktISYQ---GCMAQIFF 103
Cdd:cd15136   10 VFLLALVGNIIvLLVLLTSRTKLTVP-RFLMCNLAFADfcmgiyLGLLAIVDAKTLGEYYNYA--IDWQtgaGCKTAGFL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 289577057 104 FHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd15136   87 AVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFAL 136

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

25-153

1.98e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 39.16 E-value: 1.98e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  25 KLLFVVFLC--VYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIF 102
Cdd:cd15299    2 QVVLIAFLTgiLALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 289577057 103 FFHLLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGF 153
Cdd:cd15299   82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISF 132

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

30-158

2.92e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 38.62 E-value: 2.92e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQ--------I 101
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQhmdnvidtM 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 289577057 102 FFFHLLGggTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIV 158
Cdd:cd15351   86 ICSSVVS--SLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTL 140

7tmA_GPR6

cd15962

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...

30-298

3.12e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320628 [Multi-domain] Cd Length: 268 Bit Score: 38.76 E-value: 3.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITTVVG-NILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISyqgcMAQIFFFHLLG 108
Cdd:cd15962    5 IMLCISGTVIACeNAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETIS----LITVGFLVASF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTiMNTKLCVGLVVASWVGgfahsiVQLSLMLpLPFCGPNVLDNfYCDVPQVLRLA 188
Cdd:cd15962   81 TASVSSLLAITVDRYLSLYNALTYYS-EKTVLGVHLMLAATWG------VSLCLGL-LPVLGWNCLEE-RASCSIVRPLT 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 189 CTDTSLLE--FLMIsnsgmlvliwFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIV----VSMIFIpCIYIYSRPF 262
Cdd:cd15962  152 KSNVTLLSasFFFI----------FILMLHLYIKICKIVCRHAHQIALQQHFLTASHYVAtkkgVSTLAI-ILGTFGASW 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 289577057 263 TPFPL-------DKAVSISYTVLTP-----MLNPMIYTLRNQEMQAAM 298
Cdd:cd15962  221 LPFAIycvvgdhEYPAVYTYATLLPatynsMINPIIYAYRNQEIQRSM 268

7tmA_S1PR4_Edg6

cd15349

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...

26-298

3.48e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320471 [Multi-domain] Cd Length: 271 Bit Score: 38.61 E-value: 3.48e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLsystVTSPKMLVDFFHKTKTiSYQGCMAQIFF-- 103
Cdd:cd15349    2 ALTVLFICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDL----LTGTSYLVNICLSGER-TFRLTPALWFLre 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 104 ---FHLLGGGTvFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFahsivqlsLMLPLPFCGPNVLdnfyCD 180
Cdd:cd15349   77 gllFTALAAST-FSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAF--------LIGFLPLLGWNCL----CD 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 181 VPQVLR-LACTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSmIFIPC----- 254
Cdd:cd15349  144 FRSCSSlLPLYSKSYILFCLVIFFIILLTIIGLYFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILG-AFMVCwgplf 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 289577057 255 ------IYIYSRPFTPfPLDKAVSISYTVLTPMLNPMIYTLRNQEMQAAM 298
Cdd:cd15349  223 illlvdFFCSSRSCKP-LFGMEWVLALAVLNSAINPLIYSFRSLEVRRAV 271

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

36-153

3.74e-03

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 38.41 E-value: 3.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  36 ITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGGGTVFFL 115
Cdd:cd15074   12 ILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTL 91

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 289577057 116 SVMAYDRYIAISQPLHYVTIMNTKLCVgLVVASWVGGF 153
Cdd:cd15074   92 TAISIYRYLKICHPPYGPKLSRRHVCI-VIVAIWLYAL 128

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

26-169

3.91e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 38.43 E-value: 3.91e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15390    2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHyvTIMNTKLCVGLVVASWVggfahsivqLSLMLPLPFC 169
Cdd:cd15390   82 TTVAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWL---------ASFLLALPQL 134

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

30-160

4.35e-03

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 38.18 E-value: 4.35e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITT-VVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd14992    5 VALVVIILVsVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSV 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSIVQL 160
Cdd:cd14992   85 YASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQL 136

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

26-157

5.26e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 37.71 E-value: 5.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFH 105
Cdd:cd15059    2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 289577057 106 LLGGGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWVGGFAHSI 157
Cdd:cd15059   82 LFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISL 133

7tmA_S1PR3_Edg3

cd15345

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...

29-297

6.60e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320467 [Multi-domain] Cd Length: 270 Bit Score: 37.49 E-value: 6.60e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDfFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd15345    5 IFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYKVNILMS-GKKTFSLSPTQWFLREGSMFVAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVgLVVASWVGGFahsivqlsLMLPLPFCGPNVLDNFYcDVPQVLRLa 188
Cdd:cd15345   84 GASTFSLLAIAIERHLTMIKMRPYDANKRYRVFL-LIGTCWLISV--------LLGALPILGWNCLDNLP-DCSTILPL- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057 189 cTDTSLLEFLMISNSGMLVLIWFLLLLISYTVILVMLRSHSGQARRKAASTCTTHIIVVSmIFIPCiyiYSRPFTPFPLD 268
Cdd:cd15345  153 -YSKKYVAFCISIFIAILVAIVILYARIYILVKSSSRRVTNHRNSERSMALLRTVVIVVG-VFIAC---WSPLFILLLID 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 289577057 269 KAVS-------------ISYTVLTPMLNPMIYTLRNQEMQAA 297
Cdd:cd15345  228 VACEvkqcpilykadwfIALAVLNSAMNPIIYTLASKEMRRA 269

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

30-149

6.89e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 37.58 E-value: 6.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLV-------DFFHKTKTISYQGCMAQIF 102
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVitllngnDTDAQSFTVNIDNVIDSVI 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 289577057 103 FFHLLggGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASW 149
Cdd:cd15353   86 CSSLL--ASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

29-150

7.40e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 37.22 E-value: 7.40e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYitTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd15323    7 VGFLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASWV 150
Cdd:cd15323   85 TSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWL 126

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

30-154

7.85e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 37.40 E-value: 7.85e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  30 VFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGG 109
Cdd:cd15000    5 MFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 289577057 110 GTVFFLSVMAYDRYIAISQPLHY-VTIMNTKLcvgLVVASWVGGFA 154
Cdd:cd15000   85 ASVLALCAVSYDRLTAIVLPSEArLTKRGAKI---VIVITWIVGLL 127

7tmA_NPFFR

cd15207

neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...

26-159

7.95e-03

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.

Pssm-ID: 320335 [Multi-domain] Cd Length: 291 Bit Score: 37.22 E-value: 7.95e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  26 LLFVVFLCVYITTVVGNILIMITVTFDPRL-DMPMYFLLrNLAVIDLSYSTVTSPKMLVDffHKTKTISYQGCMAQIFFF 104
Cdd:cd15207    2 LFIVSYSLIFLLCVVGNVLVCLVVAKNPRMrTVTNYFIL-NLAVSDLLVGVFCMPFTLVD--NILTGWPFGDVMCKLSPL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 289577057 105 hLLG---GGTVFFLSVMAYDRYIAISQPlhYVTIMNTKLCVGLVVASWVGGFAHSIVQ 159
Cdd:cd15207   79 -VQGvsvAASVFTLVAIAVDRYRAVVHP--TEPKLTNRQAFVIIVAIWVLALAIMIPQ 133

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

31-149

8.34e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 37.09 E-value: 8.34e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  31 FLCVYIT-TVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYSTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLGG 109
Cdd:cd15054    6 FLCLIILlTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCS 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 289577057 110 GTVFFLSVMAYDRYIAISQPLHYVTIMNTKLCVGLVVASW 149
Cdd:cd15054   86 ASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAW 125

7tmA_UII-R

cd14999

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...

29-130

9.64e-03

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.

Pssm-ID: 320130 [Multi-domain] Cd Length: 282 Bit Score: 37.04 E-value: 9.64e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577057  29 VVFLCVYITTVVGNILIMITVTFDPRLDMPMYFLLRNLAVIDLSYsTVTSPKMLVDFFHKTKTISYQGCMAQIFFFHLLG 108
Cdd:cd14999    4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLY-LLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTM 82

                         90       100
                 ....*....|....*....|..
gi 289577057 109 GGTVFFLSVMAYDRYIAISQPL 130
Cdd:cd14999   83 HASIFTLTVMSTERYLAVVKPL 104

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01