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Conserved domains on  [gi|28839604|gb|AAH47897|]
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PSMD1 protein, partial [Homo sapiens]

Protein Classification

26S proteasome non-ATPase regulatory subunit 1( domain architecture ID 1001948)

26S proteasome non-ATPase regulatory subunit 1 (PSMD1), also known as RPN2, is a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome which plays a critical role in the recognition of ubiquitinated protein substrates by the proteasome and is involved in the ATP-dependent unfolding and translocation of these substrates into the proteasome core for degradation

Gene Ontology:  GO:0043161|GO:0005838

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPN2 super family cl34911
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-836 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5116:

Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 840.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116   3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116  83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116 161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116 240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116 274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116 352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116 431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116 511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116 591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLK 796
Cdd:COG5116 671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQA 750

                       810       820       830       840
                ....*....|....*....|....*....|....*....|
gi 28839604 797 MPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSIT 836
Cdd:COG5116 751 IPKFCFNEDLEEEEFEYPRMYEEASGKSVRKVNTAVLSTT 790
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-836 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 840.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116   3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116  83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116 161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116 240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116 274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116 352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116 431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116 511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116 591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLK 796
Cdd:COG5116 671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQA 750

                       810       820       830       840
                ....*....|....*....|....*....|....*....|
gi 28839604 797 MPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSIT 836
Cdd:COG5116 751 IPKFCFNEDLEEEEFEYPRMYEEASGKSVRKVNTAVLSTT 790
RPN2_C pfam18004
26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found ...
 786-836 2.29e-17

26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteriztic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae, this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain.


Pssm-ID: 465613 [Multi-domain]  Cd Length: 159  Bit Score: 79.93  E-value: 2.29e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28839604   786 TCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSIT 836
Cdd:pfam18004   1 TAIIGLNKDLKMPKFEFNSNAKPSLFAYPPETEEKKEKAPEKVATAVLSTT 51
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-836 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 840.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116   3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116  83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116 161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116 240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116 274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116 352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116 431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116 511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116 591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLK 796
Cdd:COG5116 671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQA 750

                       810       820       830       840
                ....*....|....*....|....*....|....*....|
gi 28839604 797 MPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSIT 836
Cdd:COG5116 751 IPKFCFNEDLEEEEFEYPRMYEEASGKSVRKVNTAVLSTT 790
RPN1 COG5110
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 373-800 1.06e-25

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227441 [Multi-domain]  Cd Length: 881  Bit Score: 113.87  E-value: 1.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 373 NSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSpgsaYQEGGGLYALGLIH-A 451
Cdd:COG5110 368 NDPINLGYENDSLIPLDDEWIYKCKVPGLISAFASIGVIESWNSDKGLETLDKYLYADES----YRKAGALLGIGLSGlR 443

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 452 NHG-GDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEA--AGLALGLVMLGSKNAQA 528
Cdd:COG5110 444 VFEeRPPALALLSNYLQSSSSKHVIAAILGLGAAFSGTQAEEVLELLQPIMFSTDSPIEVVffASLTLGSVFVGTCNGDL 523

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 529 IEDMV-------GYAQETQhekILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRR 601
Cdd:COG5110 524 TSLILqtfvergKIESETQ---WFRFLALGLASLFYGRKDQVDDVEETIMAIEGALSKHEEILVKGCQYVGTGDVLVIQS 600

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 602 LLHVAVSDVNDDVRR--AAVES---LGFILFRTPEQCPSVVSLLSESY-----NPHVRYGAAMALGICCAGTGNKEAINL 671
Cdd:COG5110 601 LLHVKDEFTGDTLKNeeALIESlalLGCALIAMGEDIGSEMVLRHFSHsmhygSSHIRSVLPLAYGILSPSNPQMNVFDT 680

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 672 LEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVnqFRQLYSKVindkHDDVMAKFGAILAQGILDAGGHNVTISLQSR 751
Cdd:COG5110 681 LERSSHDGDLNVIINTIFAMGLIGAGTLNARLAQL--LRQLASYY----YKESKALFVLRIAQGLLSLGKGTMTISPLYF 754

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28839604 752 TGHTHMPSVVGVLVFTQFWFW----FPL--SH----FLSLAYTPTCVIGLNKDLKMPKV 800
Cdd:COG5110 755 DKTTLMPKNTAGLFTTVFMLLdssiFPLvsSHalmyFLLCQIRPQKYVTLSEKGEPIKV 813
RPN2_C pfam18004
26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found ...
 786-836 2.29e-17

26S proteasome regulatory subunit RPN2 C-terminal domain; This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating interactions with the ubiquitin-binding subunit Rpn13. Futhermore, the extreme C-terminal 20 or 21 residues of Rpn2 (926-945 or 925-945) of S. cerevisiae, were shown to be equally effective at binding Rpn13. Multiple sequence alignments indicate that Rpn2 orthologs are highly conserved in this C-terminal region and share characteriztic acidic, aromatic, and proline residues, suggesting a common function. In the structure of Rpn2 from S. cerevisiae, this region is exposed and disordered, and is thus accessible for associating with Rpn13. The Rpn2 binding surface of human Rpn13 has been mapped by nuclear magnetic resonance titration to one surface of its Pru domain.


Pssm-ID: 465613 [Multi-domain]  Cd Length: 159  Bit Score: 79.93  E-value: 2.29e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28839604   786 TCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSIT 836
Cdd:pfam18004   1 TAIIGLNKDLKMPKFEFNSNAKPSLFAYPPETEEKKEKAPEKVATAVLSTT 51
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 599-690 9.30e-13

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 64.67  E-value: 9.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604   599 IRRLLHVAVSDVNDDVRRAAVESLGfiLFRTPEQCPSVVSLLSESyNPHVRYGAAMALGIccagTGNKEAINLLEPM-TN 677
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALG--RIGDPEAVPALLELLKDE-DPAVRRAAAEALGK----IGDPEALPALLELlRD 73

                          90
                  ....*....|...
gi 28839604   678 DPVNYVRQGALIA 690
Cdd:pfam13646  74 DDDDVVRAAAAEA 86
HEAT COG1413
HEAT repeat [General function prediction only];
545-690 1.85e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 65.42  E-value: 1.85e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 545 LRGLAVGiALVMYGRMEEADALIESLcRDKDPILRRSGMYTVAMAycgsGNNKAIRRLLHvAVSDVNDDVRRAAVESLGF 624
Cdd:COG1413   1 VRRAAAR-ALGRLGDPAAVPALIAAL-ADEDPDVRAAAARALGRL----GDPRAVPALLE-ALKDPDPEVRAAAAEALGR 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28839604 625 IlfRTPEQCPSVVSLLSESyNPHVRYGAAMALGiccaGTGNKEAINLLEPMTNDPVNYVRQGALIA 690
Cdd:COG1413  74 I--GDPEAVPALIAALKDE-DPEVRRAAAEALG----RLGDPAAVPALLEALKDPDWEVRRAAARA 132
HEAT COG1413
HEAT repeat [General function prediction only];
510-657 1.02e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 60.41  E-value: 1.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 510 EAAGLALGLVmlgsKNAQAIEDMVGYAQETQHEkiLRGLAVgIALVMYGRMEEADALIESLcRDKDPILRRSgmytVAMA 589
Cdd:COG1413   3 RAAARALGRL----GDPAAVPALIAALADEDPD--VRAAAA-RALGRLGDPRAVPALLEAL-KDPDPEVRAA----AAEA 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28839604 590 YCGSGNNKAIRRLLHvAVSDVNDDVRRAAVESLGFIlfRTPEQCPSVVSLLSESyNPHVRYGAAMALG 657
Cdd:COG1413  71 LGRIGDPEAVPALIA-ALKDEDPEVRRAAAEALGRL--GDPAAVPALLEALKDP-DWEVRRAAARALG 134
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 563-657 2.09e-10

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 57.73  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604   563 ADALIESLCRDKDPILRRsgmyTVAMAyCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFIlfRTPEQCPSVVSLLSE 642
Cdd:pfam13646   1 LPALLQALLRDPDPEVRA----AAIRA-LGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKI--GDPEALPALLELLRD 73

                          90
                  ....*....|....*
gi 28839604   643 SYNPHVRYGAAMALG 657
Cdd:pfam13646  74 DDDDVVRAAAAEALA 88
PC_rep pfam01851
Proteasome/cyclosome repeat;
651-685 7.04e-07

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 46.26  E-value: 7.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 28839604   651 GAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQ 685
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
HEAT COG1413
HEAT repeat [General function prediction only];
614-694 6.65e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.55  E-value: 6.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28839604 614 VRRAAVESLGFIlfRTPEQCPSVVSLLSESyNPHVRYGAAMALGiccaGTGNKEAINLLEPMTNDPVNYVRQGALIASAL 693
Cdd:COG1413   1 VRRAAARALGRL--GDPAAVPALIAALADE-DPDVRAAAARALG----RLGDPRAVPALLEALKDPDPEVRAAAAEALGR 73


                .
gi 28839604 694 I 694
Cdd:COG1413  74 I 74
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 545-623 1.38e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.17  E-value: 1.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28839604   545 LRGLAVgIALVMYGRMEEADALIEsLCRDKDPILRRsgmyTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLG 623
Cdd:pfam13646  16 VRAAAI-RALGRIGDPEAVPALLE-LLKDEDPAVRR----AAAEALGKIGDPEALPALLELLRDDDDDVVRAAAAEALA 88
PC_rep pfam01851
Proteasome/cyclosome repeat;
511-544 1.75e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 39.33  E-value: 1.75e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 28839604   511 AAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKI 544
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESR 34
PC_rep pfam01851
Proteasome/cyclosome repeat;
476-510 7.48e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 37.78  E-value: 7.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 28839604   476 GGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGE 510
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
PC_rep pfam01851
Proteasome/cyclosome repeat;
441-474 7.94e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 37.40  E-value: 7.94e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 28839604   441 GGLYALGLIHANHG-GDIIDYLLNQLKNASNDIVR 474
Cdd:pfam01851   1 GAALALGLIHAGSGnEEALDLLLPYLSDTSAESRA 35
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 646-690 1.75e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 37.35  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28839604   646 PHVRYGAAMALGICCAGTGN------KEAINLLEPMTNDPVNYVRQGALIA 690
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDllapavPELLPALLPLLNDDSDLVREAAAWA 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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