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Conserved domains on  [gi|28610149|ref|NP_786943|]
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interleukin-6 receptor subunit beta isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 26-112 4.26e-38

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 130.44  E-value: 4.26e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149    26 DPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNI 105
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80


                  ....*..
gi 28610149   106 LTFGQLE 112
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 222-321 4.18e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 4.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149 222 PNPPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTrsSFTVQDLKPFTEYVFRIRC 301
Cdd:cd00063   1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRA 76

                        90       100
                ....*....|....*....|
gi 28610149 302 MKEDGkgyWSDWSEEASGIT 321
Cdd:cd00063  77 VNGGG---ESPPSESVTVTT 93
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 121-215 2.56e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 42.79  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149   121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCkAKRDTPTS-------CTVDYSTVY-FV 192
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKEC-PLYSTSGAnstrlfiCFFPKNDVSlFV 81

                          90       100
                  ....*....|....*....|...
gi 28610149   193 NIEVWVEAENALGKVTSDHINFD 215
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 26-112 4.26e-38

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 130.44  E-value: 4.26e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149    26 DPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNI 105
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80


                  ....*..
gi 28610149   106 LTFGQLE 112
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 222-321 4.18e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 4.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149 222 PNPPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTrsSFTVQDLKPFTEYVFRIRC 301
Cdd:cd00063   1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRA 76

                        90       100
                ....*....|....*....|
gi 28610149 302 MKEDGkgyWSDWSEEASGIT 321
Cdd:cd00063  77 VNGGG---ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
224-311 1.00e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149   224 PPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQipPEDTASTRSSFTVQDLKPFTEYVFRIRCMK 303
Cdd:pfam00041   2 APSNLTVTDVTS-TSLT-VSWTPPPDGNGPITGYEVEYRPKNSGEPWN--EITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ....*...
gi 28610149   304 EDGKGYWS 311
Cdd:pfam00041  78 GGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 222-308 1.07e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149    222 PNPPHNLSVINSEelSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC 301
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 28610149    302 MKEDGKG 308
Cdd:smart00060  77 VNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
222-321 8.39e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.47  E-value: 8.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149 222 PNPPHNLSVINseELSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIppedTASTRSSFTVQDLKPFTEYVFRIRC 301
Cdd:COG3401 233 PSAPTGLTATA--DTPGSVTLSWDPVTESDAT--GYRVYRSNSGDGPFTKV----ATVTTTSYTDTGLTNGTTYYYRVTA 304

                        90       100
                ....*....|....*....|
gi 28610149 302 MKEDGKGywSDWSEEASGIT 321
Cdd:COG3401 305 VDAAGNE--SAPSNVVSVTT 322
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 121-215 2.56e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 42.79  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149   121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCkAKRDTPTS-------CTVDYSTVY-FV 192
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKEC-PLYSTSGAnstrlfiCFFPKNDVSlFV 81

                          90       100
                  ....*....|....*....|...
gi 28610149   193 NIEVWVEAENALGKVTSDHINFD 215
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 26-112 4.26e-38

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 130.44  E-value: 4.26e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149    26 DPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNI 105
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80


                  ....*..
gi 28610149   106 LTFGQLE 112
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 222-321 4.18e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 4.18e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149 222 PNPPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTrsSFTVQDLKPFTEYVFRIRC 301
Cdd:cd00063   1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRA 76

                        90       100
                ....*....|....*....|
gi 28610149 302 MKEDGkgyWSDWSEEASGIT 321
Cdd:cd00063  77 VNGGG---ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
224-311 1.00e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 1.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149   224 PPHNLSVINSEElSSILkLTWTNPSIKSVIILKYNIQYRTKDASTWSQipPEDTASTRSSFTVQDLKPFTEYVFRIRCMK 303
Cdd:pfam00041   2 APSNLTVTDVTS-TSLT-VSWTPPPDGNGPITGYEVEYRPKNSGEPWN--EITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ....*...
gi 28610149   304 EDGKGYWS 311
Cdd:pfam00041  78 GGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 222-308 1.07e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149    222 PNPPHNLSVINSEelSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC 301
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 28610149    302 MKEDGKG 308
Cdd:smart00060  77 VNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
222-321 8.39e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.47  E-value: 8.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149 222 PNPPHNLSVINseELSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIppedTASTRSSFTVQDLKPFTEYVFRIRC 301
Cdd:COG3401 233 PSAPTGLTATA--DTPGSVTLSWDPVTESDAT--GYRVYRSNSGDGPFTKV----ATVTTTSYTDTGLTNGTTYYYRVTA 304

                        90       100
                ....*....|....*....|
gi 28610149 302 MKEDGKGywSDWSEEASGIT 321
Cdd:COG3401 305 VDAAGNE--SAPSNVVSVTT 322
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
221-322 1.34e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 1.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149 221 KPNPPHNLSVINSeeLSSILKLTWTNPSIKSVIilKYNIQYRTKDASTWSQIppeDTASTRSSFTVQDLKPFTEYVFRIR 300
Cdd:COG3401 326 PPAAPSGLTATAV--GSSSITLSWTASSDADVT--GYNVYRSTSGGGTYTKI---AETVTTTSYTDTGLTPGTTYYYKVT 398

                        90       100
                ....*....|....*....|..
gi 28610149 301 CMkeDGKGYWSDWSEEASGITY 322
Cdd:COG3401 399 AV--DAAGNESAPSEEVSATTA 418
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 121-215 2.56e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 42.79  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149   121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCkAKRDTPTS-------CTVDYSTVY-FV 192
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKEC-PLYSTSGAnstrlfiCFFPKNDVSlFV 81

                          90       100
                  ....*....|....*....|...
gi 28610149   193 NIEVWVEAENALGKVTSDHINFD 215
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 131-216 1.03e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 40.86  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149   131 NLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWAT-HKFADCKA-KRDTPTSC-------TVDYSTVYFVNIEVWVeaE 201
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPlGPVLQCQYyIRDDGTRIgcqfddlEGLSSSFHQVYICVNG--S 78

                          90
                  ....*....|....*
gi 28610149   202 NALGKVTSDHINFDP 216
Cdd:pfam09240  79 SSAGPIRSSDQTFQL 93
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 242-313 3.85e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 36.23  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28610149   242 LTW-TNPSIKSVIIlkyniQYRTKDASTWSQIPPEDTASTRS--------SFTVQDLKPFTEYVFRIRcmkeDGKGYWSD 312
Cdd:pfam16656  17 VSWvTPSAVTSPVV-----QYGTSSSALTSTATATSSTYTTGdggtgyihRATLTGLEPGTTYYYRVG----DDNGGWSE 87


                  .
gi 28610149   313 W 313
Cdd:pfam16656  88 V 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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