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Conserved domains on  [gi|284172520|ref|NP_940876|]
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olfactomedin-like protein 1 isoform a precursor [Homo sapiens]

Protein Classification

olfactomedin domain-containing protein( domain architecture ID 10490292)

olfactomedin domain-containing protein adopts a five-bladed beta-propeller structure, similar to gliomedin that interacts with neuronal cell adhesion molecules such as neurofascin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OLF pfam02191
Olfactomedin-like domain;
145-395 4.31e-113

Olfactomedin-like domain;


:

Pssm-ID: 460482  Cd Length: 246  Bit Score: 330.65  E-value: 4.31e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  145 LMGIKSLKIVKKMMDTHGSWMKDAVYNSPKVYLL-IGSRNNTVWEFANIRAFMEDNtkpAPRKQILTLSWQGTGQVIYKG 223
Cdd:pfam02191   1 LVSVSKPVTVKLSGGKYGAWMKDPLPPSDKIYVTdRGTSGNTLREYASLDDFKNGS---PSKKYKLPYPWQGTGHVVYNG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  224 FLFFHnQATSNEIIKYNLQKRTVEDRMLLPG-GVGRALVYQHSPSTYIDLAVDEHGLWAIHSGPGTHSHLVLTKIEPGTL 302
Cdd:pfam02191  78 SLYYN-KYNSRNIVKYDLTTRTVAARRVLPGaGYNNRFPYSWGGHTDIDLAVDENGLWVIYATEENEGNIVVSKLDPETL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  303 GVEHSWDTPCRSQDAEASFLLCGVLYVVYStGGQGPHRITCIYDPLgtISEEDLPNLFFPKRPRSHSMIHYNPRDKQLYA 382
Cdd:pfam02191 157 EVEQTWNTSYPKRSAGNAFMVCGVLYAVRS-VNTRREEIFYAFDTY--TGKEEAVSIPFPNRYGKISMLDYNPRDKKLYA 233

                         250
                  ....*....|...
gi 284172520  383 WNEGNQIIYKLQT 395
Cdd:pfam02191 234 WDDGYQVTYPVTF 246
 
Name Accession Description Interval E-value
OLF pfam02191
Olfactomedin-like domain;
145-395 4.31e-113

Olfactomedin-like domain;


Pssm-ID: 460482  Cd Length: 246  Bit Score: 330.65  E-value: 4.31e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  145 LMGIKSLKIVKKMMDTHGSWMKDAVYNSPKVYLL-IGSRNNTVWEFANIRAFMEDNtkpAPRKQILTLSWQGTGQVIYKG 223
Cdd:pfam02191   1 LVSVSKPVTVKLSGGKYGAWMKDPLPPSDKIYVTdRGTSGNTLREYASLDDFKNGS---PSKKYKLPYPWQGTGHVVYNG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  224 FLFFHnQATSNEIIKYNLQKRTVEDRMLLPG-GVGRALVYQHSPSTYIDLAVDEHGLWAIHSGPGTHSHLVLTKIEPGTL 302
Cdd:pfam02191  78 SLYYN-KYNSRNIVKYDLTTRTVAARRVLPGaGYNNRFPYSWGGHTDIDLAVDENGLWVIYATEENEGNIVVSKLDPETL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  303 GVEHSWDTPCRSQDAEASFLLCGVLYVVYStGGQGPHRITCIYDPLgtISEEDLPNLFFPKRPRSHSMIHYNPRDKQLYA 382
Cdd:pfam02191 157 EVEQTWNTSYPKRSAGNAFMVCGVLYAVRS-VNTRREEIFYAFDTY--TGKEEAVSIPFPNRYGKISMLDYNPRDKKLYA 233

                         250
                  ....*....|...
gi 284172520  383 WNEGNQIIYKLQT 395
Cdd:pfam02191 234 WDDGYQVTYPVTF 246
OLF smart00284
Olfactomedin-like domains;
145-393 8.22e-49

Olfactomedin-like domains;


Pssm-ID: 128580  Cd Length: 255  Bit Score: 166.16  E-value: 8.22e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520   145 LMGIkSLKIVKKMMDTH--GSWMKDAVYNSPKVYL-----LIGSRNNTVWEFANIRAFMedNTKPaPRKQILTLSWQGTG 217
Cdd:smart00284   3 LAGI-SKPVTLQTSWKGksGAWMKDPLWNTTKKSLywympLNTRVLRSVREYSSMSDFQ--MGKN-PTDHPLPHAGQGTG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520   218 QVIYKGFLFFhNQATSNEIIKYNLQKRTVEDRMLLPG-GVGRALVYQHSPSTYIDLAVDEHGLWAIHSGPGTHSHLVLTK 296
Cdd:smart00284  79 VVVYNGSLYF-NKFNSHDICRFDLTTETYQKEPLLNGaGYNNRFPYAWGGFSDIDLAVDENGLWVIYATEQNAGKIVISK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520   297 IEPGTLGVEHSWDTPCRSQDAEASFLLCGVLYVVySTGGQGPHRITCIYDPLGTISEE-DLPnlfFPKRPRSHSMIHYNP 375
Cdd:smart00284 158 LNPATLTIENTWITTYNKRSASNAFMICGILYVT-RSLGSKGEKVFYAYDTNTGKEGHlDIP---FENMYEYISMLDYNP 233

                          250
                   ....*....|....*...
gi 284172520   376 RDKQLYAWNEGNQIIYKL 393
Cdd:smart00284 234 NDRKLYAWNNGHLVHYDI 251
 
Name Accession Description Interval E-value
OLF pfam02191
Olfactomedin-like domain;
145-395 4.31e-113

Olfactomedin-like domain;


Pssm-ID: 460482  Cd Length: 246  Bit Score: 330.65  E-value: 4.31e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  145 LMGIKSLKIVKKMMDTHGSWMKDAVYNSPKVYLL-IGSRNNTVWEFANIRAFMEDNtkpAPRKQILTLSWQGTGQVIYKG 223
Cdd:pfam02191   1 LVSVSKPVTVKLSGGKYGAWMKDPLPPSDKIYVTdRGTSGNTLREYASLDDFKNGS---PSKKYKLPYPWQGTGHVVYNG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  224 FLFFHnQATSNEIIKYNLQKRTVEDRMLLPG-GVGRALVYQHSPSTYIDLAVDEHGLWAIHSGPGTHSHLVLTKIEPGTL 302
Cdd:pfam02191  78 SLYYN-KYNSRNIVKYDLTTRTVAARRVLPGaGYNNRFPYSWGGHTDIDLAVDENGLWVIYATEENEGNIVVSKLDPETL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520  303 GVEHSWDTPCRSQDAEASFLLCGVLYVVYStGGQGPHRITCIYDPLgtISEEDLPNLFFPKRPRSHSMIHYNPRDKQLYA 382
Cdd:pfam02191 157 EVEQTWNTSYPKRSAGNAFMVCGVLYAVRS-VNTRREEIFYAFDTY--TGKEEAVSIPFPNRYGKISMLDYNPRDKKLYA 233

                         250
                  ....*....|...
gi 284172520  383 WNEGNQIIYKLQT 395
Cdd:pfam02191 234 WDDGYQVTYPVTF 246
OLF smart00284
Olfactomedin-like domains;
145-393 8.22e-49

Olfactomedin-like domains;


Pssm-ID: 128580  Cd Length: 255  Bit Score: 166.16  E-value: 8.22e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520   145 LMGIkSLKIVKKMMDTH--GSWMKDAVYNSPKVYL-----LIGSRNNTVWEFANIRAFMedNTKPaPRKQILTLSWQGTG 217
Cdd:smart00284   3 LAGI-SKPVTLQTSWKGksGAWMKDPLWNTTKKSLywympLNTRVLRSVREYSSMSDFQ--MGKN-PTDHPLPHAGQGTG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520   218 QVIYKGFLFFhNQATSNEIIKYNLQKRTVEDRMLLPG-GVGRALVYQHSPSTYIDLAVDEHGLWAIHSGPGTHSHLVLTK 296
Cdd:smart00284  79 VVVYNGSLYF-NKFNSHDICRFDLTTETYQKEPLLNGaGYNNRFPYAWGGFSDIDLAVDENGLWVIYATEQNAGKIVISK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284172520   297 IEPGTLGVEHSWDTPCRSQDAEASFLLCGVLYVVySTGGQGPHRITCIYDPLGTISEE-DLPnlfFPKRPRSHSMIHYNP 375
Cdd:smart00284 158 LNPATLTIENTWITTYNKRSASNAFMICGILYVT-RSLGSKGEKVFYAYDTNTGKEGHlDIP---FENMYEYISMLDYNP 233

                          250
                   ....*....|....*...
gi 284172520   376 RDKQLYAWNEGNQIIYKL 393
Cdd:smart00284 234 NDRKLYAWNNGHLVHYDI 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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