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Conserved domains on  [gi|283837896|ref|NP_001164634|]
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zinc finger MYM-type protein 3 isoform 3 [Homo sapiens]

Protein Classification

heavy metal translocating P-type ATPase( domain architecture ID 10654501)

heavy metal translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 2-304 2.09e-09

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896    2 DPSDFPSPFDPLTLPEKPLAGD----LPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLE---KDPGVLD 74
Cdd:PHA03307   66 EPPTGPPPGPGTEAPANESRSTptwsLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSemlRPVGSPG 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   75 GATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLE-----PLAPDSP 149
Cdd:PHA03307  146 PPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPIsasasSPAPAPG 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  150 ITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAP-----PSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGD 224
Cdd:PHA03307  226 RSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPtriweASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGS 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  225 GLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRAGRSA 304
Cdd:PHA03307  306 GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRP 385
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 446-488 1.36e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.75  E-value: 1.36e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 283837896  446 LKTNCCDQCGAYIYTKtgsPGPELLFHEGQQKRFCNTTCLGAY 488
Cdd:pfam06467   1 LVKATCWFCKKLIKNK---PTVIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 348-389 1.56e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.37  E-value: 1.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 283837896  348 SGKKTCTFCKKEIWNTKDsvVAQTGSGGSFHEFCTSVCLSLY 389
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
311-347 1.19e-04

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.28  E-value: 1.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 283837896   311 CAHCRTPLQKGQTA--YQRKGLPQLFCSSSCLTTFSKKP 347
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 404-440 1.34e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.28  E-value: 1.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 283837896  404 ADATRCSICQKTGEVLHE---VSNGSVVHRLCSDSCFSKF 440
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-304 2.09e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896    2 DPSDFPSPFDPLTLPEKPLAGD----LPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLE---KDPGVLD 74
Cdd:PHA03307   66 EPPTGPPPGPGTEAPANESRSTptwsLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSemlRPVGSPG 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   75 GATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLE-----PLAPDSP 149
Cdd:PHA03307  146 PPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPIsasasSPAPAPG 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  150 ITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAP-----PSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGD 224
Cdd:PHA03307  226 RSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPtriweASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGS 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  225 GLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRAGRSA 304
Cdd:PHA03307  306 GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRP 385
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 446-488 1.36e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.75  E-value: 1.36e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 283837896  446 LKTNCCDQCGAYIYTKtgsPGPELLFHEGQQKRFCNTTCLGAY 488
Cdd:pfam06467   1 LVKATCWFCKKLIKNK---PTVIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 348-389 1.56e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.37  E-value: 1.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 283837896  348 SGKKTCTFCKKEIWNTKDsvVAQTGSGGSFHEFCTSVCLSLY 389
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
451-490 2.02e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 41.59  E-value: 2.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 283837896   451 CDQCGAYIYTKTGspgPELLFHEGQQKRFCNTTCLGAYKK 490
Cdd:smart00746   1 CSFCGKDIYNPGT---GIMVVNDGKVYYFCSSKCLSKFKK 37
TRASH smart00746
metallochaperone-like domain;
311-347 1.19e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.28  E-value: 1.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 283837896   311 CAHCRTPLQKGQTA--YQRKGLPQLFCSSSCLTTFSKKP 347
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 404-440 1.34e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.28  E-value: 1.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 283837896  404 ADATRCSICQKTGEVLHE---VSNGSVVHRLCSDSCFSKF 440
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
353-393 9.52e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 36.97  E-value: 9.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 283837896   353 CTFCKKEIWNTKDSVVAQtgSGGSFHEFCTSVCLSLYEAQQ 393
Cdd:smart00746   1 CSFCGKDIYNPGTGIMVV--NDGKVYYFCSSKCLSKFKKKR 39
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 34-228 3.33e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   34 LLESQTAPTRGWAPPGPSPSSGALDLLD-TPAGlekdpgVLDGATELlglggllykAPSPPEVDHGPEGT----LAWDAG 108
Cdd:pfam05109 448 LPSSTHVPTNLTAPASTGPTVSTADVTSpTPAG------TTSGASPV---------TPSPSPRDNGTESKapdmTSPTSA 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  109 DQTLEPGPGGQTPEVVPPDPgagaNSCSPEglLEPLAPDSPITLQSPHIEEEE---TTSIATARRGSPGQEEELPQGQPQ 185
Cdd:pfam05109 513 VTTPTPNATSPTPAVTTPTP----NATSPT--LGKTSPTSAVTTPTPNATSPTpavTTPTPNATIPTLGKTSPTSAVTTP 586

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 283837896  186 SPNAPpSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTA 228
Cdd:pfam05109 587 TPNAT-SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSA 628
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 106-254 6.12e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 38.98  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896 106 DAGDQTLEPGPGGQTPEVVP-PDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARR-----GSPGQEEEL 179
Cdd:NF040712 182 DEARWLIDPDFGRPLRPLATvPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRrragvEQPEDEPVG 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 283837896 180 PQGQPQSPNAPPSPSVGETLGDGINSSQTKPG----GSSPPAHPSLPGDGLTAKASEKPPERKRSERVRRAEPPKPEVV 254
Cdd:NF040712 262 PGAAPAAEPDEATRDAGEPPAPGAAETPEAAEppapAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVPSWDDVL 340
TRASH smart00746
metallochaperone-like domain;
409-444 7.54e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 34.27  E-value: 7.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 283837896   409 CSICQKTGEVLHEVS---NGSVVHRLCSDSCFSKFRANK 444
Cdd:smart00746   1 CSFCGKDIYNPGTGImvvNDGKVYYFCSSKCLSKFKKKR 39
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-304 2.09e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896    2 DPSDFPSPFDPLTLPEKPLAGD----LPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLE---KDPGVLD 74
Cdd:PHA03307   66 EPPTGPPPGPGTEAPANESRSTptwsLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSemlRPVGSPG 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   75 GATELLGLGGLLYKAPSPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLE-----PLAPDSP 149
Cdd:PHA03307  146 PPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPIsasasSPAPAPG 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  150 ITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAP-----PSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGD 224
Cdd:PHA03307  226 RSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPtriweASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGS 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  225 GLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDSDAMVDDPNDEDFVPFRPRRSPRMSLRSSVSQRAGRSA 304
Cdd:PHA03307  306 GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRP 385
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 446-488 1.36e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.75  E-value: 1.36e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 283837896  446 LKTNCCDQCGAYIYTKtgsPGPELLFHEGQQKRFCNTTCLGAY 488
Cdd:pfam06467   1 LVKATCWFCKKLIKNK---PTVIVLQNDGSVGQFCSQSCLDSY 40
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 348-389 1.56e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 47.37  E-value: 1.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 283837896  348 SGKKTCTFCKKEIWNTKDsvVAQTGSGGSFHEFCTSVCLSLY 389
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPT--VIVLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
451-490 2.02e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 41.59  E-value: 2.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 283837896   451 CDQCGAYIYTKTGspgPELLFHEGQQKRFCNTTCLGAYKK 490
Cdd:smart00746   1 CSFCGKDIYNPGT---GIMVVNDGKVYYFCSSKCLSKFKK 37
PHA03247 PHA03247
large tegument protein UL36; Provisional
 39-261 4.62e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   39 TAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPgvldgatellglggllykAPSPPEVDHGPEGTLAWDAGDQTLEPGPGG 118
Cdd:PHA03247 2677 SSPPQRPRRRAARPTVGSLTSLADPPPPPPTP------------------EPAPHALVSATPLPPGPAAARQASPALPAA 2738

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  119 QTPE------VVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPNAPPS 192
Cdd:PHA03247 2739 PAPPavpagpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  193 PSVGETLGDGINSSQTKPGGSSPPAHP---SLPGDGLTAKA---SEKPPER--------KRSERVRRAepPKPEVVDSTE 258
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPpppSLPLGGSVAPGgdvRRRPPSRspaakpaaPARPPVRRL--ARPAVSRSTE 2896


                  ...
gi 283837896  259 SIP 261
Cdd:PHA03247 2897 SFA 2899
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-260 8.70e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 8.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896    2 DPSDFPSPFDPLTLPEKPLAGDLPvdmefGEDLLESQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLG 81
Cdd:PHA03247 2604 DRGDPRGPAPPSPLPPDTHAPDPP-----PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   82 LGGLLYKAPSPPEVdhGPEGTLAW-DAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEE 160
Cdd:PHA03247 2679 PPQRPRRRAARPTV--GSLTSLADpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPAR 2756

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  161 ETTSIATARRGSPGQEEELPQGQPQSPNAPPSPSVGETLgdgiNSSQTKPGGSSPPAHPSLPGDGLTAKASEKPPERKRS 240
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR----ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT 2832

                         250       260
                  ....*....|....*....|
gi 283837896  241 ERVRRAEPPKPEVVDSTESI 260
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPL 2852
TRASH smart00746
metallochaperone-like domain;
311-347 1.19e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 39.28  E-value: 1.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 283837896   311 CAHCRTPLQKGQTA--YQRKGLPQLFCSSSCLTTFSKKP 347
Cdd:smart00746   1 CSFCGKDIYNPGTGimVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 404-440 1.34e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 39.28  E-value: 1.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 283837896  404 ADATRCSICQKTGEVLHE---VSNGSVVHRLCSDSCFSKF 440
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTvivLQNDGSVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
353-393 9.52e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 36.97  E-value: 9.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 283837896   353 CTFCKKEIWNTKDSVVAQtgSGGSFHEFCTSVCLSLYEAQQ 393
Cdd:smart00746   1 CSFCGKDIYNPGTGIMVV--NDGKVYYFCSSKCLSKFKKKR 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 7-263 2.43e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896    7 PSPFDPLTlPEKPLAGDLPVdmefgedlleSQTAPTRGWAPPGPSPSSGALDLLDTPAGLEKDPGVLDGATELLGLGGLL 86
Cdd:PHA03247 2734 ALPAAPAP-PAVPAGPATPG----------GPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPW 2802

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   87 YKAPsPPEVDHGPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAPDS---------PITLQSPHI 157
Cdd:PHA03247 2803 DPAD-PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRrrppsrspaAKPAAPARP 2881

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  158 EEEETTSIATARRGSPGQEEELPQGQPQSPNAPPSPSVGETL--GDGINSSQTKPGGSSPPAHPSLPGDGLTAKASEKPP 235
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ 2961

                         250       260
                  ....*....|....*....|....*...
gi 283837896  236 ERKRSERVRRAEPPKPEVVDSTESIPVS 263
Cdd:PHA03247 2962 PWLGALVPGRVAVPRFRVPQPAPSREAP 2989
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 88-274 3.13e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  88 KAPSPPEVDH--GPEGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEGLLEPLAP--DSPITLQSPHIEEEETT 163
Cdd:PRK07764 605 SSGPPEEAARpaAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGgdGWPAKAGGAAPAAPPPA 684

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896 164 SIATARRGSPGQEEelPQGQPQSPNAPPSPSVGETLGDGINSSQT-------KPGGSSPPAHPSLPGDGLTAKASEKPPe 236
Cdd:PRK07764 685 PAPAAPAAPAGAAP--AQPAPAPAATPPAGQADDPAAQPPQAAQGasapspaADDPVPLPPEPDDPPDPAGAPAQPPPP- 761

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 283837896 237 rkRSERVRRAEPPKPEVVDSTESiPVSDEDSDAMVDDP 274
Cdd:PRK07764 762 --PAPAPAAAPAAAPPPSPPSEE-EEMAEDDAPSMDDE 796
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 34-228 3.33e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.28  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   34 LLESQTAPTRGWAPPGPSPSSGALDLLD-TPAGlekdpgVLDGATELlglggllykAPSPPEVDHGPEGT----LAWDAG 108
Cdd:pfam05109 448 LPSSTHVPTNLTAPASTGPTVSTADVTSpTPAG------TTSGASPV---------TPSPSPRDNGTESKapdmTSPTSA 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  109 DQTLEPGPGGQTPEVVPPDPgagaNSCSPEglLEPLAPDSPITLQSPHIEEEE---TTSIATARRGSPGQEEELPQGQPQ 185
Cdd:pfam05109 513 VTTPTPNATSPTPAVTTPTP----NATSPT--LGKTSPTSAVTTPTPNATSPTpavTTPTPNATIPTLGKTSPTSAVTTP 586

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 283837896  186 SPNAPpSPSVGETLGDGINSSQTKPGGSSPPAHPSLPGDGLTA 228
Cdd:pfam05109 587 TPNAT-SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSA 628
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-261 4.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 4.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896    3 PSDFPSPFDPLTLPEKPLAGDLPVDMEFGEDLLESQTAPTRGWAPPGP-SPSSGALDLLDTPAGLEKDPgvldgateLLG 81
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvLAPAAALPPAASPAGPLPPP--------TSA 2834

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896   82 LGGLLYKAPSPPEVDHGPEGTLAwdAGDQTLEPGPGGQTPEVV-----PPDPGAGANSCSPEGLLEPLAPDSPITLQSPH 156
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVA--PGGDVRRRPPSRSPAAKPaaparPPVRRLARPAVSRSTESFALPPDQPERPPQPQ 2912

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896  157 IEEEETTSiatarrgSPGQEEELPQGQPQSPNAPPSPSvgetlgdginSSQTKPGGSSPPAhPSLPGDGLTAKAsekpPE 236
Cdd:PHA03247 2913 APPPPQPQ-------PQPPPPPQPQPPPPPPPRPQPPL----------APTTDPAGAGEPS-GAVPQPWLGALV----PG 2970

                         250       260
                  ....*....|....*....|....*
gi 283837896  237 RKRSERvRRAEPPKPEVVDSTESIP 261
Cdd:PHA03247 2971 RVAVPR-FRVPQPAPSREAPASSTP 2994
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 106-254 6.12e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 38.98  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283837896 106 DAGDQTLEPGPGGQTPEVVP-PDPGAGANSCSPEGLLEPLAPDSPITLQSPHIEEEETTSIATARR-----GSPGQEEEL 179
Cdd:NF040712 182 DEARWLIDPDFGRPLRPLATvPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRrragvEQPEDEPVG 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 283837896 180 PQGQPQSPNAPPSPSVGETLGDGINSSQTKPG----GSSPPAHPSLPGDGLTAKASEKPPERKRSERVRRAEPPKPEVV 254
Cdd:NF040712 262 PGAAPAAEPDEATRDAGEPPAPGAAETPEAAEppapAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVPSWDDVL 340
TRASH smart00746
metallochaperone-like domain;
409-444 7.54e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 34.27  E-value: 7.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 283837896   409 CSICQKTGEVLHEVS---NGSVVHRLCSDSCFSKFRANK 444
Cdd:smart00746   1 CSFCGKDIYNPGTGImvvNDGKVYYFCSSKCLSKFKKKR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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