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Conserved domains on  [gi|28374396|gb|AAH45763|]
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SDK2 protein, partial [Homo sapiens]

Protein Classification

FN3 domain-containing protein( domain architecture ID 11510106)

FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 783-876 2.44e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 75.61  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  783 APRNVVVHGATATQLDVTWEPPPLDsqNGDIQGYKIYFWEAQRGNlTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 862
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 28374396  863 AGDGPRSTPTQGQT 876
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
364-698 2.56e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  364 QTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 443
Cdd:COG3401  116 EVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  444 KYVL-----YEVQVLAFTRIGDGSPShPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNgiILAYQItHRlnT 518
Cdd:COG3401  196 GGDIepgttYYYRVAATDTGGESAPS-NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRV-YR--S 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  519 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSrpMVQQEDVRARSVLLSW 598
Cdd:COG3401  270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSITLSW 347

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  599 EPGSDglSPVRYYTIQTRELPSGRWALHSASVshNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 678
Cdd:COG3401  348 TASSD--ADVTGYNVYRSTSGGGTYTKIAETV--TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASG 423

                        330       340
                 ....*....|....*....|
gi 28374396  679 EAPTILSVTPHTTTSVLIRW 698
Cdd:COG3401  424 ESLTASVDAVPLTDVAGATA 443
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
136-513 3.37e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.43  E-value: 3.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  136 ALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVtlqfrpGYDGKTSISRWLVEAQVGVVGEGE 215
Cdd:COG3401  104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGA------NASGTTASSVAGAGVVVSPDTSAT 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  216 EWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPpdMAPANVSLRTASETSLWLRWMP 295
Cdd:COG3401  178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP--SAPTGLTATADTPGSVTLSWDP 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  296 lpemeyNGNPESVGYKIKYSRSDGHGKTlshVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESV 374
Cdd:COG3401  256 ------VTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTP 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  375 PSSgPTNVSALATTSSSMLVRWSEVPEADrnglVLGYKVmYKEKDSDTQPRfWLVEGNSSRSAQLTGLGKYVLYEVQVLA 454
Cdd:COG3401  327 PAA-PSGLTATAVGSSSITLSWTASSDAD----VTGYNV-YRSTSGGGTYT-KIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28374396  455 FTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQIT 513
Cdd:COG3401  400 VDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
720-1082 7.71e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 7.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  720 LLYEGLRGFMLRGINNPGATWAELTYLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 799
Cdd:COG3401   67 LGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  800 TWEP-PPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY----TAYMVSVAAFNAAGDGPRSTPTQG 874
Cdd:COG3401  147 LYGVdGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDiepgTTYYYRVAATDTGGESAPSNEVSV 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  875 QTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNgiLEGYRlVYEPCSPVDGVSKIVTvdVKGNSplwLKVKDLAEGVTY 954
Cdd:COG3401  227 TTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYR-VYRSNSGDGPFTKVAT--VTTTS---YTDTGLTNGTTY 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  955 RFRIRAKTFTYGPEIEANV--TTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPgkGPITRYVIEARPSDEGLWDIlikd 1032
Cdd:COG3401  299 YYRVTAVDAAGNESAPSNVvsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADVTGYNVYRSTSGGGTYTK---- 372

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 28374396 1033 IPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1082
Cdd:COG3401  373 IAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 71-159 1.45e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396   71 PGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSK 150
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                 ....*....
gi 28374396  151 GQGQVSAST 159
Cdd:cd00063   81 GESPPSESV 89
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 783-876 2.44e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 75.61  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  783 APRNVVVHGATATQLDVTWEPPPLDsqNGDIQGYKIYFWEAQRGNlTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 862
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 28374396  863 AGDGPRSTPTQGQT 876
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
364-698 2.56e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  364 QTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 443
Cdd:COG3401  116 EVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  444 KYVL-----YEVQVLAFTRIGDGSPShPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNgiILAYQItHRlnT 518
Cdd:COG3401  196 GGDIepgttYYYRVAATDTGGESAPS-NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRV-YR--S 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  519 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSrpMVQQEDVRARSVLLSW 598
Cdd:COG3401  270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSITLSW 347

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  599 EPGSDglSPVRYYTIQTRELPSGRWALHSASVshNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 678
Cdd:COG3401  348 TASSD--ADVTGYNVYRSTSGGGTYTKIAETV--TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASG 423

                        330       340
                 ....*....|....*....|
gi 28374396  679 EAPTILSVTPHTTTSVLIRW 698
Cdd:COG3401  424 ESLTASVDAVPLTDVAGATA 443
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
136-513 3.37e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.43  E-value: 3.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  136 ALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVtlqfrpGYDGKTSISRWLVEAQVGVVGEGE 215
Cdd:COG3401  104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGA------NASGTTASSVAGAGVVVSPDTSAT 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  216 EWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPpdMAPANVSLRTASETSLWLRWMP 295
Cdd:COG3401  178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP--SAPTGLTATADTPGSVTLSWDP 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  296 lpemeyNGNPESVGYKIKYSRSDGHGKTlshVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESV 374
Cdd:COG3401  256 ------VTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTP 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  375 PSSgPTNVSALATTSSSMLVRWSEVPEADrnglVLGYKVmYKEKDSDTQPRfWLVEGNSSRSAQLTGLGKYVLYEVQVLA 454
Cdd:COG3401  327 PAA-PSGLTATAVGSSSITLSWTASSDAD----VTGYNV-YRSTSGGGTYT-KIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28374396  455 FTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQIT 513
Cdd:COG3401  400 VDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 477-570 4.52e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.76  E-value: 4.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  477 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRlNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR 556
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR-EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 28374396  557 KGWGEAAEALVVTT 570
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
720-1082 7.71e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 7.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  720 LLYEGLRGFMLRGINNPGATWAELTYLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 799
Cdd:COG3401   67 LGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  800 TWEP-PPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY----TAYMVSVAAFNAAGDGPRSTPTQG 874
Cdd:COG3401  147 LYGVdGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDiepgTTYYYRVAATDTGGESAPSNEVSV 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  875 QTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNgiLEGYRlVYEPCSPVDGVSKIVTvdVKGNSplwLKVKDLAEGVTY 954
Cdd:COG3401  227 TTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYR-VYRSNSGDGPFTKVAT--VTTTS---YTDTGLTNGTTY 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  955 RFRIRAKTFTYGPEIEANV--TTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPgkGPITRYVIEARPSDEGLWDIlikd 1032
Cdd:COG3401  299 YYRVTAVDAAGNESAPSNVvsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADVTGYNVYRSTSGGGTYTK---- 372

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 28374396 1033 IPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1082
Cdd:COG3401  373 IAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
fn3 pfam00041
Fibronectin type III domain;
783-869 1.28e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 1.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    783 APRNVVVHGATATQLDVTWEPPPldSQNGDIQGYKIYFWEaQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 862
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPP--DGNGPITGYEVEYRP-KNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 28374396    863 AGDGPRS 869
Cdd:pfam00041   79 GGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 275-370 3.57e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 3.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  275 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 354
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPED----DGGPITGYVVEY-REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 28374396  355 NAIGSGPWSQTVVGRT 370
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 71-159 1.45e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396   71 PGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSK 150
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                 ....*....
gi 28374396  151 GQGQVSAST 159
Cdd:cd00063   81 GESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
275-363 1.78e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 1.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    275 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 354
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPD----GNGPITGYEVEY-RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 28374396    355 NAIGSGPWS 363
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 881-962 2.58e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  881 PSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPcspvDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 960
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE----KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRA 76


                 ..
gi 28374396  961 KT 962
Cdd:cd00063   77 VN 78
fn3 pfam00041
Fibronectin type III domain;
72-156 3.69e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 3.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     72 GPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNrTNTRVTHY-LPNVTLEYRVTGLTALTTYTIEVAAMTSK 150
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKN-SGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 28374396    151 GQGQVS 156
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
882-962 2.62e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.59  E-value: 2.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    882 SAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCspvDGVSKIVTVDVKGNSPLwLKVKDLAEGVTYRFRIRAK 961
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK---NSGEPWNEITVPGTTTS-VTLTGLKPGTEYEVRVQAV 76


                   .
gi 28374396    962 T 962
Cdd:pfam00041   77 N 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 783-866 2.73e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.73e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     783 APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTlflAENSVKLKNLTGYTAYMVSVAAFNA 862
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTP---SSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 28374396     863 AGDG 866
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
379-464 9.31e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 9.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    379 PTNVSALATTSSSMLVRWSevPEADRNGLVLGYKVMYKEKDsDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRI 458
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 28374396    459 GDGSPS 464
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 71-153 4.07e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 4.07e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396      71 PGPVGHLSFSEILDTSLKVSWQEPGEKNGI--LTGYRISWEEYNRTNTRVTHylPNVTLEYRVTGLTALTTYTIEVAAMT 148
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNV--TPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 28374396     149 SKGQG 153
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 275-360 4.76e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 4.76e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     275 APANVSLRTASETSLWLRWMPlPEMEYNGNPEsVGYKIKYSRSDGHGKTLSHVVQDRVerdYTIEDLEEWTEYRVQVQAF 354
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEP-PPDDGITGYI-VGYRVEYREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 28374396     355 NAIGSG 360
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 881-962 9.42e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 9.42e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     881 PSAPSSVKFSELTTTSVNVSWEAPQFPNGilEGYRLVYEPC-SPVDGVSKIVTVDVKGNSplwLKVKDLAEGVTYRFRIR 959
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEyREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVR 75


                    ...
gi 28374396     960 AKT 962
Cdd:smart00060   76 AVN 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 576-660 2.12e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 2.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     576 PQPPSRPMVqqEDVRARSVLLSWEPGSD--GLSPVRYYTIQTRElPSGRWalHSASVSHNASSFIVDRLKPFTSYKFRVK 653
Cdd:smart00060    1 PSPPSNLRV--TDVTSTSVTLSWEPPPDdgITGYIVGYRVEYRE-EGSEW--KEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*..
gi 28374396     654 ATNDIGD 660
Cdd:smart00060   76 AVNGAGE 82
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 783-876 2.44e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 75.61  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  783 APRNVVVHGATATQLDVTWEPPPLDsqNGDIQGYKIYFWEAQRGNlTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 862
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 28374396  863 AGDGPRSTPTQGQT 876
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
364-698 2.56e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  364 QTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG 443
Cdd:COG3401  116 EVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  444 KYVL-----YEVQVLAFTRIGDGSPShPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNgiILAYQItHRlnT 518
Cdd:COG3401  196 GGDIepgttYYYRVAATDTGGESAPS-NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRV-YR--S 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  519 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSrpMVQQEDVRARSVLLSW 598
Cdd:COG3401  270 NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSITLSW 347

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  599 EPGSDglSPVRYYTIQTRELPSGRWALHSASVshNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 678
Cdd:COG3401  348 TASSD--ADVTGYNVYRSTSGGGTYTKIAETV--TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASG 423

                        330       340
                 ....*....|....*....|
gi 28374396  679 EAPTILSVTPHTTTSVLIRW 698
Cdd:COG3401  424 ESLTASVDAVPLTDVAGATA 443
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
136-513 3.37e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.43  E-value: 3.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  136 ALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVtlqfrpGYDGKTSISRWLVEAQVGVVGEGE 215
Cdd:COG3401  104 GGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGA------NASGTTASSVAGAGVVVSPDTSAT 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  216 EWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPpdMAPANVSLRTASETSLWLRWMP 295
Cdd:COG3401  178 AAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP--SAPTGLTATADTPGSVTLSWDP 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  296 lpemeyNGNPESVGYKIKYSRSDGHGKTlshVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESV 374
Cdd:COG3401  256 ------VTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTP 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  375 PSSgPTNVSALATTSSSMLVRWSEVPEADrnglVLGYKVmYKEKDSDTQPRfWLVEGNSSRSAQLTGLGKYVLYEVQVLA 454
Cdd:COG3401  327 PAA-PSGLTATAVGSSSITLSWTASSDAD----VTGYNV-YRSTSGGGTYT-KIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28374396  455 FTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQIT 513
Cdd:COG3401  400 VDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 477-570 4.52e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.76  E-value: 4.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  477 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRlNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR 556
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR-EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 28374396  557 KGWGEAAEALVVTT 570
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
720-1082 7.71e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 7.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  720 LLYEGLRGFMLRGINNPGATWAELTYLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 799
Cdd:COG3401   67 LGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  800 TWEP-PPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY----TAYMVSVAAFNAAGDGPRSTPTQG 874
Cdd:COG3401  147 LYGVdGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDiepgTTYYYRVAATDTGGESAPSNEVSV 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  875 QTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNgiLEGYRlVYEPCSPVDGVSKIVTvdVKGNSplwLKVKDLAEGVTY 954
Cdd:COG3401  227 TTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYR-VYRSNSGDGPFTKVAT--VTTTS---YTDTGLTNGTTY 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  955 RFRIRAKTFTYGPEIEANV--TTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPgkGPITRYVIEARPSDEGLWDIlikd 1032
Cdd:COG3401  299 YYRVTAVDAAGNESAPSNVvsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADVTGYNVYRSTSGGGTYTK---- 372

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 28374396 1033 IPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1082
Cdd:COG3401  373 IAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
fn3 pfam00041
Fibronectin type III domain;
783-869 1.28e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 1.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    783 APRNVVVHGATATQLDVTWEPPPldSQNGDIQGYKIYFWEaQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 862
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPP--DGNGPITGYEVEYRP-KNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 28374396    863 AGDGPRS 869
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
639-975 1.84e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  639 VDRLKPFTSYKFRVKATNDIGDSEFSEESEsLTTLQAAPdEAPTILSVTPHTTTSVLIRWQPPAEDKINgillGFRIrYR 718
Cdd:COG3401  196 GGDIEPGTTYYYRVAATDTGGESAPSNEVS-VTTPTTPP-SAPTGLTATADTPGSVTLSWDPVTESDAT----GYRV-YR 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  719 ELLYEGlrGFMLrgINNPGATWAELTYLNKHRRYEIRMSVYNAVG-EGPSSPPQEVFVGEAVPtAAPRNVVVHGATATQL 797
Cdd:COG3401  269 SNSGDG--PFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP-AAPSGLTATAVGSSSI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  798 DVTWEPppldSQNGDIQGYKIYFWEAQRGNLTERVKTlfLAENSVKLKNLTGYTAYMVSVAAFNAAGD-GPRSTPTQGQT 876
Cdd:COG3401  344 TLSWTA----SSDADVTGYNVYRSTSGGGTYTKIAET--VTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATT 417

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  877 QQAAPSAPssvkfselTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 956
Cdd:COG3401  418 ASAASGES--------LTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANL 489

                        330
                 ....*....|....*....
gi 28374396  957 RIRAKTFTYGPEIEANVTT 975
Cdd:COG3401  490 SVTTGSLVGGSGASSVTNS 508
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 275-370 3.57e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 3.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  275 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 354
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPED----DGGPITGYVVEY-REKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 28374396  355 NAIGSGPWSQTVVGRT 370
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 576-660 8.57e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 8.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  576 PQPPSRPMVqqEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSaSVSHNASSFIVDRLKPFTSYKFRVKAT 655
Cdd:cd00063    1 PSPPTNLRV--TDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAV 77


                 ....*
gi 28374396  656 NDIGD 660
Cdd:cd00063   78 NGGGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 71-159 1.45e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396   71 PGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSK 150
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80


                 ....*....
gi 28374396  151 GQGQVSAST 159
Cdd:cd00063   81 GESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
275-363 1.78e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 1.78e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    275 APANVSLRTASETSLWLRWMPLPEmeynGNPESVGYKIKYsRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 354
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPD----GNGPITGYEVEY-RPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 28374396    355 NAIGSGPWS 363
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 881-962 2.58e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  881 PSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPcspvDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 960
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE----KGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRA 76


                 ..
gi 28374396  961 KT 962
Cdd:cd00063   77 VN 78
fn3 pfam00041
Fibronectin type III domain;
72-156 3.69e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 3.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     72 GPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNrTNTRVTHY-LPNVTLEYRVTGLTALTTYTIEVAAMTSK 150
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKN-SGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 28374396    151 GQGQVS 156
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
882-962 2.62e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.59  E-value: 2.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    882 SAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCspvDGVSKIVTVDVKGNSPLwLKVKDLAEGVTYRFRIRAK 961
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPK---NSGEPWNEITVPGTTTS-VTLTGLKPGTEYEVRVQAV 76


                   .
gi 28374396    962 T 962
Cdd:pfam00041   77 N 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 783-866 2.73e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 2.73e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     783 APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTlflAENSVKLKNLTGYTAYMVSVAAFNA 862
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTP---SSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 28374396     863 AGDG 866
Cdd:smart00060   80 AGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
31-391 2.77e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.19  E-value: 2.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396   31 VGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNgiLTGYRI---- 106
Cdd:COG3401  193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVyrsn 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  107 ----SWEEYNRTNTrvthylpnvtLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGP 182
Cdd:COG3401  271 sgdgPFTKVATVTT----------TSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGS 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  183 RSVTLQFRPGYDGKtsISRWLVEaqVGVVGEGeEWLLIHQLSNEPdarSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPS 262
Cdd:COG3401  341 SSITLSWTASSDAD--VTGYNVY--RSTSGGG-TYTKIAETVTTT---SYTDTGLTPGTTYYYKVTAVDAAGNESAPSEE 412

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  263 RKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLE 342
Cdd:COG3401  413 VSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVT 492

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 28374396  343 EWteyrvQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSS 391
Cdd:COG3401  493 TG-----SLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPV 536
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 377-466 5.60e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 5.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  377 SGPTNVSALATTSSSMLVRWSevPEADRNGLVLGYKVMYKEKDSDtQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFT 456
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|
gi 28374396  457 RIGDGSPSHP 466
Cdd:cd00063   79 GGGESPPSES 88
fn3 pfam00041
Fibronectin type III domain;
379-464 9.31e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 9.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    379 PTNVSALATTSSSMLVRWSevPEADRNGLVLGYKVMYKEKDsDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRI 458
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 28374396    459 GDGSPS 464
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
989-1069 3.09e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 3.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    989 IIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIkDIPKEVSSYTFSMdiLKPGVSYDFRVIAVNDYGFGTP 1068
Cdd:pfam00041    8 VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI-TVPGTTTSVTLTG--LKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 28374396   1069 S 1069
Cdd:pfam00041   85 S 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
50-419 3.14e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.72  E-value: 3.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396   50 FTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEY 129
Cdd:COG3401  115 DEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVD 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  130 RVTGLTALTTYTIEVAAMTSKGQGQVSaSTISSGVPPELPGPPTNLGISNIGPRSVTLQFRP-------GYDgktsISRW 202
Cdd:COG3401  195 GGGDIEPGTTYYYRVAATDTGGESAPS-NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvtesdatGYR----VYRS 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  203 LVeaqvgvvgEGEEWLLIHQLSNepdaRSMEVPDLNPFTCYSFRMRQVNIVG-TSPPSQPSrKIQTLQAPPDmAPANVSL 281
Cdd:COG3401  270 NS--------GDGPFTKVATVTT----TSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVV-SVTTDLTPPA-APSGLTA 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  282 RTASETSLWLRWmplpemEYNGNPESVGYKIKysRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SG 360
Cdd:COG3401  336 TAVGSSSITLSW------TASSDADVTGYNVY--RSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnES 407

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28374396  361 PWSQTVVGRTRESVPSSGPTNVSALATTSSSmlVRWSEVPEADRNGLVLGYKVMYKEKD 419
Cdd:COG3401  408 APSEEVSATTASAASGESLTASVDAVPLTDV--AGATAAASAASNPGVSAAVLADGGDT 464
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 679-773 3.97e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 3.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  679 EAPTILSVTPHTTTSVLIRWQPPAEDkiNGILLGFRIRYRELLYEGLRGFmlrGINNPGATWAELTYLNKHRRYEIRMSV 758
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEV---EVTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*
gi 28374396  759 YNAVGEGPSSPPQEV 773
Cdd:cd00063   77 VNGGGESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 71-153 4.07e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 4.07e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396      71 PGPVGHLSFSEILDTSLKVSWQEPGEKNGI--LTGYRISWEEYNRTNTRVTHylPNVTLEYRVTGLTALTTYTIEVAAMT 148
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNV--TPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 28374396     149 SKGQG 153
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 275-360 4.76e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 4.76e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     275 APANVSLRTASETSLWLRWMPlPEMEYNGNPEsVGYKIKYSRSDGHGKTLSHVVQDRVerdYTIEDLEEWTEYRVQVQAF 354
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEP-PPDDGITGYI-VGYRVEYREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 28374396     355 NAIGSG 360
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 994-1073 4.78e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 4.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  994 SSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKdipKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 1073
Cdd:cd00063   14 STSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEV---TPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 881-962 9.42e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 9.42e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     881 PSAPSSVKFSELTTTSVNVSWEAPQFPNGilEGYRLVYEPC-SPVDGVSKIVTVDVKGNSplwLKVKDLAEGVTYRFRIR 959
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEyREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVR 75


                    ...
gi 28374396     960 AKT 962
Cdd:smart00060   76 AVN 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 576-660 2.12e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 2.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     576 PQPPSRPMVqqEDVRARSVLLSWEPGSD--GLSPVRYYTIQTRElPSGRWalHSASVSHNASSFIVDRLKPFTSYKFRVK 653
Cdd:smart00060    1 PSPPSNLRV--TDVTSTSVTLSWEPPPDdgITGYIVGYRVEYRE-EGSEW--KEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*..
gi 28374396     654 ATNDIGD 660
Cdd:smart00060   76 AVNGAGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 377-461 2.20e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 2.20e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     377 SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPrfwLVEGNSSRSAQLTGLGKYVLYEVQVLAFT 456
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKE---VNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 28374396     457 RIGDG 461
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
578-659 4.10e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 4.10e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    578 PPSRpmVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSaSVSHNASSFIVDRLKPFTSYKFRVKATND 657
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEI-TVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ..
gi 28374396    658 IG 659
Cdd:pfam00041   79 GG 80
fn3 pfam00041
Fibronectin type III domain;
170-259 6.82e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 6.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    170 GPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVgvVGEGEEWlliHQLSNEPDARSMEVPDLNPFTCYSFRMRQ 249
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRP--KNSGEPW---NEITVPGTTTSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 28374396    250 VNIVGTSPPS 259
Cdd:pfam00041   76 VNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
478-561 1.10e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 1.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    478 GPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVlAPSARQYTATGLKPESVYLFRITAQTRK 557
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 28374396    558 GWGE 561
Cdd:pfam00041   80 GEGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 477-560 2.02e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 2.02e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     477 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIilAYQITHRLNTTTANTATVEVLA-PSARQYTATGLKPESVYLFRITAQT 555
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVtPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 28374396     556 RKGWG 560
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 680-765 2.27e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 2.27e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     680 APTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGlrgfmLRGINNPGATWAELTYLNKHRRYEIRMSVY 759
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEW-----KEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 28374396     760 NAVGEG 765
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
680-768 2.57e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396    680 APTILSVTPHTTTSVLIRWQPPaeDKINGILLGFRIRYREllyEGLRGFMLRGINNPGATWAELTYLNKHRRYEIRMSVY 759
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRP---KNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 28374396    760 NAVGEGPSS 768
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 169-263 4.63e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 4.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  169 PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLlihqlSNEPDARSMEVPDLNPFTCYSFRMR 248
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVE-----VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*
gi 28374396  249 QVNIVGTSPPSQPSR 263
Cdd:cd00063   76 AVNGGGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 169-256 5.49e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 5.49e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396     169 PGPPTNLGISNIGPRSVTLQFRPGYDGktSISRWLVEAQVGVVGEGEEWlliHQLSNEPDARSMEVPDLNPFTCYSFRMR 248
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDD--GITGYIVGYRVEYREEGSEW---KEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 28374396     249 QVNIVGTS 256
Cdd:smart00060   76 AVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 994-1066 9.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 9.04e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28374396     994 SSAIAIHWS--SGDPGKGPITRYVIEARPSDEGlWdiliKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1066
Cdd:smart00060   14 STSVTLSWEppPDDGITGYIVGYRVEYREEGSE-W----KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
751-960 5.83e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 47.63  E-value: 5.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  751 RYEIRM-----SVYNAV--GEGPSSPPQEVFVGeaVPTAAPRNVVVHGATATQLDVTWEPPPLDSqngdiqGYKIYfWEA 823
Cdd:COG4733  503 TYTITAvqhapEKYAAIdaGAFDDVPPQWPPVN--VTTSESLSVVAQGTAVTTLTVSWDAPAGAV------AYEVE-WRR 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28374396  824 QRGNLTervktlFLAENSVKLKNLTGYTA--YMVSVAAFNAAGD-GPRSTPTQGQTQQ--AAPSAPSSvkfseLTTTS-- 896
Cdd:COG4733  574 DDGNWV------SVPRTSGTSFEVPGIYAgdYEVRVRAINALGVsSAWAASSETTVTGktAPPPAPTG-----LTATGgl 642

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28374396  897 --VNVSWEAPQFPNgiLEGYRLVYEPcSPVDGVSKIVTVDVKGNSPLWlkvKDLAEGVTYRFRIRA 960
Cdd:COG4733  643 ggITLSWSFPVDAD--TLRTEIRYST-TGDWASATVAQALYPGNTYTL---AGLKAGQTYYYRARA 702
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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