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Conserved domains on  [gi|28373094|ref|NP_778205|]
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alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform b [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-216 6.67e-162

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23977:

Pssm-ID: 480271  Cd Length: 228  Bit Score: 445.85  E-value: 6.67e-162
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGR 80
Cdd:cd23977  13 MLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWGPERNMDRDGGGK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  81 TYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCREKSH 160
Cdd:cd23977  93 TYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYGMVSDSYCRNKNH 172

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373094 161 PSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR 216
Cdd:cd23977 173 SSVPYHYYEKGRLDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
 
Name Accession Description Interval E-value
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 1-216 6.67e-162

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 445.85  E-value: 6.67e-162
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGR 80
Cdd:cd23977  13 MLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWGPERNMDRDGGGK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  81 TYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCREKSH 160
Cdd:cd23977  93 TYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYGMVSDSYCRNKNH 172

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373094 161 PSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR 216
Cdd:cd23977 173 SSVPYHYYEKGRLDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 2-205 1.27e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 97.29  E-value: 1.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094     2 LGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNY--------------SHYFqKARDTLYM-V 66
Cdd:pfam00777  56 RGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprdpfvefvLVPF-KGRDLLWLpA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094    67 WGQGRHMDRVLggRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQdetgKNRRQSGSFLSTGWFTMILALELCEEIVV 146
Cdd:pfam00777 135 FLTKGNVSRSL--RVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWL----RSHGLKGRRPSTGLLMLSLALHLCDEVSL 208

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 28373094   147 YGmvsdsYCREKSHPSVPYHYFEKGRldecqMYLAHEQAPrsaHRFITEKAVFSRWAKK 205
Cdd:pfam00777 209 YG-----FGPFLDSRGNSHHYYDNVL-----MKKGGFYGV---HDMPFEFKLLQKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 1-216 6.67e-162

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 445.85  E-value: 6.67e-162
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGR 80
Cdd:cd23977  13 MLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWGPERNMDRDGGGK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  81 TYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCREKSH 160
Cdd:cd23977  93 TYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYGMVSDSYCRNKNH 172

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373094 161 PSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR 216
Cdd:cd23977 173 SSVPYHYYEKGRLDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 1-213 2.88e-123

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 348.08  E-value: 2.88e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRN-YSHYFQKARDTLYMVWGQGRHMDRVLGG 79
Cdd:cd23965  13 LLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNaILLLAGTRAPTVVVFWGPETKMNKDGAG 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  80 RtYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCREKS 159
Cdd:cd23965  93 K-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVYGMVPENYCREHP 171

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 28373094 160 HPSVPYHYFEKGRLDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHP 213
Cdd:cd23965 172 NSKVPYHYYEPGGLKECTYYNYHENALKGGHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 1-215 4.06e-102

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 294.53  E-value: 4.06e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGR 80
Cdd:cd23975  13 MVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWGPFRNMRKDGKGI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  81 TYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCREKSH 160
Cdd:cd23975  93 VYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYGMINDTYCKTEGY 172

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 28373094 161 PSVPYHYFEKGRlDECQMYLAHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSW 215
Cdd:cd23975 173 RKVPYHYYEPGR-DECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 1-216 2.87e-82

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 245.16  E-value: 2.87e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGR 80
Cdd:cd23976  27 LTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLNVSQGTVFIFWGPSNYMRRDGKGL 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  81 TYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCREKSH 160
Cdd:cd23976 107 VYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTMIIALELCDRINVYGMVPPDFCRDPNH 186

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28373094 161 PSVPYHYFEKGRLDECQMYLAHEQAPR-SAHRFITEKAVFSRWAKKRPIVFAHPSWR 216
Cdd:cd23976 187 PSVPYHYYEPSGPDECTMYISHERGRKgSHHRFITEKRVFANWARTFNIHFYQPDWK 243
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 1-215 1.63e-81

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 242.45  E-value: 1.63e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARDTLYMVWGQGRHMDRVLGGR 80
Cdd:cd23978  13 LLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWGPPNKMQKDGKSN 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  81 TYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCREKSH 160
Cdd:cd23978  93 LFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYGMVPPNYCSKRPT 172

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28373094 161 P-SVPYHYFEKGRLDECQMYLAHEQAPR-SAHRFITEKAVFSRWAKKRPIVFAHPSW 215
Cdd:cd23978 173 PkKMPYHYYEPKGPDECVTYIQNEHGRRgNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-202 1.66e-40

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 136.72  E-value: 1.66e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQ--KARDTLYMVWGQGRHmdrvlg 78
Cdd:cd19952  10 LLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHplPLEEEVVLILSRAAA------ 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  79 gRTYRTLLQLTRMYPGLQVY--TFTERMMAYCDQIFQDETGKNrRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSYcr 156
Cdd:cd19952  84 -ADFKRLKRRKKRHDNAVLLltDPAPDLLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDLYGFGVDSG-- 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 28373094 157 ekSHPSVPYHYFEKGRldecqmylahEQAPRSAHRFITEKAVFSRW 202
Cdd:cd19952 160 --HAPKVPYHYYDLVE----------AEEGTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 2-205 1.27e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 97.29  E-value: 1.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094     2 LGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNY--------------SHYFqKARDTLYM-V 66
Cdd:pfam00777  56 RGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNlgfshprdpfvefvLVPF-KGRDLLWLpA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094    67 WGQGRHMDRVLggRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQdetgKNRRQSGSFLSTGWFTMILALELCEEIVV 146
Cdd:pfam00777 135 FLTKGNVSRSL--RVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWL----RSHGLKGRRPSTGLLMLSLALHLCDEVSL 208

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 28373094   147 YGmvsdsYCREKSHPSVPYHYFEKGRldecqMYLAHEQAPrsaHRFITEKAVFSRWAKK 205
Cdd:pfam00777 209 YG-----FGPFLDSRGNSHHYYDNVL-----MKKGGFYGV---HDMPFEFKLLQKLHKE 254
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 2-195 6.20e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 85.01  E-value: 6.20e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   2 LGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLrvvshTSV-PLLLRNYSHYFQKARDTLYMVwgqgRHMDRVLGG- 79
Cdd:cd23963  76 LGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNL-----TTLnPSILKRRYNSLKKNRDRDKFL----NRLKEYNGSi 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  80 ---------RTYRTLLQLTRMYpglqVYTFTERMMAYCDQIFQDETGK--NRRQSGSFLSTGWFTMILALELCEEIVVYG 148
Cdd:cd23963 147 lwypkfsfkSSTNLLLKAARAL----KKNGLNLTVVYSNPEHFLAVQKfwKRRGLEKRPSTGLYLVSLALTFCDEIHLYG 222

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 28373094 149 ---MVSDSYCREkshpsVPYHYFEKGRLDEcqmylaheqaPRSAHRFITE 195
Cdd:cd23963 223 fwpFPTDPNGRP-----VPYHYYDDLSPST----------KNKVHNMPEE 257
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 1-182 7.85e-18

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 79.24  E-value: 7.85e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTsvpLLLRNYSHYFQKA--RDTLYMVWGQGRHmDRVLG 78
Cdd:cd23968  57 LLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ---ILSKPEFNFLTDPlyRNVTLLVWDPSSY-NVNLE 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  79 GRTYRT-------LLQLTRMYPGLQVYTFTERMMAYCDQIFQDETgKNRRQSGSfLSTGWFTMILALELCEEIVVYGMVs 151
Cdd:cd23968 133 KWYKKPdfdffpnYIKYRRRHPEEPFYLIDPRFLWRLWDILQEYT-PEKIKPNP-PSSGFIGIVLMLHLCDWVDVYEYV- 209

                       170       180       190
                ....*....|....*....|....*....|....*
gi 28373094 152 dsycrekshPSVPY----HYFEKGRLDECQMYLAH 182
Cdd:cd23968 210 ---------PSVRQtdrcHYYDVEKDLACTLGAWH 235
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 1-182 2.87e-14

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 68.47  E-value: 2.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYShyfqkaRDTLYMV---------Wgqgr 71
Cdd:cd23967  14 LKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYD------SDWLLVLvpfksmdllW---- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  72 hMDRVLGGRTYRTLL----QLTRMYPgLQVYTF----------TERMMAYcdQIFQDETGKNRRqsgsflSTGWFTMILA 137
Cdd:cd23967  84 -LQAVIKGKKPNGKGgfwkKIATSVP-KPPKKIrilnpyilqeAAFDLIG--LPMNGKQGKNVP------TTGIIAIVMA 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 28373094 138 LELCEEIVVYGMVSDSycrekSHPSVPYHYFEKGRLDECQMYLAH 182
Cdd:cd23967 154 LHYCDEVDIAGFGYDP-----SDPNAPLHYYDSLTMKAIKRSWTH 193
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 1-172 3.05e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 69.73  E-value: 3.05e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRvvshTSVPLLLRNYSHYFQKARDTL-----------YMVW-- 67
Cdd:cd23970  80 LTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLT----TFNPSILEKYYNNLLTIQDRNnfflslkkldgAILWip 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  68 GQGRHMDRVlggrTYRTLLQLTrmypgLQVYTFTERMMAYCDQIFQDETG--KNRRQSGSFLSTGWFTMILALELCEEIV 145
Cdd:cd23970 156 AFFFHTSAT----VTRTLVDFF-----VEHRGQLKVQLAWPGNIMQHVNRywKTKHLSPKRLSTGILMYTLASAICEEIH 226

                       170       180
                ....*....|....*....|....*..
gi 28373094 146 VYGMVsdSYCREKSHPSVPYHYFEKGR 172
Cdd:cd23970 227 LYGFW--PFGFDPTGTPLPYHYYDKKG 251
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 3-172 3.12e-14

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 69.52  E-value: 3.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   3 GSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARdTLYMVW-------GQGRHmdr 75
Cdd:cd23979  94 GSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFK-TLDLLWitsalstGQIRF--- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  76 vlggrTYRTLLQLTRMYpglqvytfTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSyc 155
Cdd:cd23979 170 -----TYAPVKQFLRVD--------KDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADS-- 234

                       170
                ....*....|....*..
gi 28373094 156 REKSHpsvpyHYFEKGR 172
Cdd:cd23979 235 RGNWH-----HYWENNR 246
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 3-208 6.43e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 69.01  E-value: 6.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   3 GSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHY-FQKA---RDTLYMVWGQGRH----MD 74
Cdd:cd23973  97 GSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRgFKNIpqdKDIKYILFPEGPRdyqwLE 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  75 RVLGGRTYRTlLQLTRMYPglQVY---TFTERMMAYCDQIFQDETgKNRRQSGSFL----------STGWFTMILALELC 141
Cdd:cd23973 177 ALLKNKTIPS-GAYYGRRP--RSYfsgDFTEDKYLVLHPDFLRYV-KNRFLRSKTLkgkywaiyrpTTGAFLLLTALHLC 252

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28373094 142 EEIVVYGMVSDSYCRekshpsVPYHYFEKgRLDECQMYLAHEqaprsahrFITEKAVFSRWAKKRPI 208
Cdd:cd23973 253 DTVSAYGFITEDYRK------YPDHYYDK-KKTKLVFYINHD--------FRLEKKLWKRLHDEKII 304
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 1-147 9.26e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 68.33  E-value: 9.26e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTsvplLLRNYSHYFQKA---RDTLYMVWGQGRHMDRVL 77
Cdd:cd23986  61 ILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPNHHFIDSslyKDVILVAWDPAPYSANLH 136

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28373094  78 GG------RTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSflSTGWFTMILALELCEEIVVY 147
Cdd:cd23986 137 KWykkpdyNLFTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP--SSGFIGILIMMSMCREVHVY 210
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 1-172 1.75e-13

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 67.69  E-value: 1.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTS-------VPLLLRNYshyfqKARDTLYMVwgqgrhm 73
Cdd:cd23966  89 LRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESavdldpgVHLVLVPF-----KVLDLQWLI------- 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  74 DRVLGGRTYRTLLQLTRmYPGL-----QVY--TFtermMAY-CDQIFQDEtgknrrqsGSFLSTGWFTMILALELCEEIV 145
Cdd:cd23966 157 SALTTGEITRTYTPVKR-FIKAdkdkvLVInpAF----IKYvHDNWTEHH--------GRYPSTGFLALIFALHICDEVS 223

                       170       180
                ....*....|....*....|....*..
gi 28373094 146 VYGMVSDSYCREkshpsvpYHYFEKGR 172
Cdd:cd23966 224 VFGFGADSKGNW-------HHYWEKNR 243
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 3-182 4.80e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 63.43  E-value: 4.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   3 GSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVvsHTSVPLLLRNYSHYFQ-----------KARDTLYMV-WGQG 70
Cdd:cd23964  96 GSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYT--FFPESLHNSLLKHVPQdkdtkylfipfKIRDYDYLDaVLSG 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  71 RHMDRVL--GGRTYRTL---LQLTRM---YPGLQVYTFTERMmaycdqifqdetgknRRQSGSFLSTGWFTMILALELCE 142
Cdd:cd23964 174 KPVPDGCdkGKRPPPLFgpkLNATNVrllHPDFIRYLFNRWL---------------NSSTSYRPTTGALMLLTALHTCD 238

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 28373094 143 EIVVYGMVSDsycrekshPSVPYHYFEKGRLDECQMYLAH 182
Cdd:cd23964 239 QVSVYGFGYD--------PRFSLHYYDKTFVKFTVFYANH 270
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 4-169 8.95e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 62.98  E-value: 8.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   4 SGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSHYFQKARdTLYMVWgqgrHMDRVLGGRTYR 83
Cdd:cd23980  96 SYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFK-TLDLEW----VISATTTGTISH 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  84 TLLQLTRmypglQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYGMVSDSycreKSHpsv 163
Cdd:cd23980 171 TYVPVPR-----KIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADS----KGN--- 238


                ....*.
gi 28373094 164 PYHYFE 169
Cdd:cd23980 239 WHHYWE 244
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 1-205 9.54e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 59.97  E-value: 9.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLL---LRNYS------HYFQKARDTL-----YMV 66
Cdd:cd23988  76 LLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNESdrekfvHRLSMLNDSVlwipaFMV 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  67 WGQGRHMDRVlGGRTYRTLLQLTRMYPGLQV------YTFTERMmaycdQIfqdetgknRRQsgsflSTGWFTMILALEL 140
Cdd:cd23988 156 KGGEKHVEWV-NALILKNKLKVRTAYPSLRLihavrgYWLTNKV-----NI--------KRP-----STGLLMYTLATRF 216

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28373094 141 CEEIVVYGMVsdSYCREKSHPSVPYHYFEKGRLdecqMYLAHEQAPRSAHRFITEKAVFSRWAKK 205
Cdd:cd23988 217 CDEIHLYGFW--PFPKDANGNPVKYHYYDDLKY----RYFSNAGPHRMPLEFKTLNVLHNRGALK 275
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 1-147 1.02e-10

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 59.72  E-value: 1.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTsvplLLRNYSHYFQKarDTLY-----MVWGQGRH--- 72
Cdd:cd23985  57 LKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHKFLK--DSLYnegilIVWDPAPYhsd 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  73 ------------MDRVlggRTYRTLlqltrmYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSflSTGWFTMILALEL 140
Cdd:cd23985 131 ipewyknpdynfFENY---KTYRRL------NPNQPFYILHPQMQWELWDIIQENSPEEIQPNPP--SSGMLGIILMMTL 199


                ....*..
gi 28373094 141 CEEIVVY 147
Cdd:cd23985 200 CDQVDVY 206
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 1-172 3.48e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 55.50  E-value: 3.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVP---LLLRNySHYFQKARDTLYMVWGQGRHMDRVL 77
Cdd:cd23969  76 LLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPhayGDLVN-ATDKEKFVERLRQLGDSILWIPAFV 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  78 --GGRTY---------RTLLQLTRMYPGLQVYTFTERMMAycdqifQDETGKNRRQSGSFLSTgwftmiLALELCEEIVV 146
Cdd:cd23969 155 skGGEEHvqwtneiilKHKLNVKTAYPPLRLNHAIRGYWL------TTKFRIKRPSTGLLMYT------LATRFCDEIHL 222

                       170       180
                ....*....|....*....|....*....
gi 28373094 147 YGMV---SDSYCRekshpSVPYHYFEKGR 172
Cdd:cd23969 223 YGFYpfsEDGNGR-----AVKYHYYDNRK 246
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 1-38 8.40e-09

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 53.51  E-value: 8.40e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLR 38
Cdd:cd23982  14 LKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIR 51
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 3-54 6.61e-08

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 50.89  E-value: 6.61e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 28373094   3 GSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYSH 54
Cdd:cd23983  16 GLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDP 67
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 1-168 1.00e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 51.10  E-value: 1.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPtVGFEADVGQRSTLRvvshTSVPLLLRNYSHYFQKARDTLY---MVWGQG------- 70
Cdd:cd23971  76 LKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNLV----TANPSILREKFHNLKKRRRPFVermKVYGNAllllpaf 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  71 -RHMDRVLGGRTYRTLLQLTRMYpglQVYTFTERMMAYCDQIFQDETGKNRRqsgsfLSTGWFTMILALELCEEIVVYGM 149
Cdd:cd23971 151 sYTSNTEPSLRALYTLEDFGSPQ---KVLFFNPEYLRNLSRYWKSKGLKARR-----LSTGLMLVSAALELCENVHLYGF 222

                       170       180
                ....*....|....*....|..
gi 28373094 150 VSDSycrekSHPS---VPYHYF 168
Cdd:cd23971 223 WPFS-----TDLDgnpISHHYY 239
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 6-38 3.73e-07

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 48.97  E-value: 3.73e-07
                        10        20        30
                ....*....|....*....|....*....|...
gi 28373094   6 LGAEIDSAECVFRMNQAPTVGFEADVGQRSTLR 38
Cdd:cd23984  19 LGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFR 51
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 3-52 9.15e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 48.21  E-value: 9.15e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 28373094   3 GSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNY 52
Cdd:cd23974  98 GSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAY 147
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 6-173 1.35e-06

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 47.22  E-value: 1.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   6 LGAEIDSAECVFRMNQAPTVGFEADVGQRSTLRVVSHTSVPLLLRNYShyfqkaRDTLYMVWG----------QGRHMDR 75
Cdd:cd23981  19 LGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYE------KDSLFVLAGfkwqdfkwlkYIVYKEK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  76 VLGGRTY-RTLLQLTRMYPG----LQVYTFTERMMAYCDQIFQDE-TGKnrrqsGSFLSTGWFTMILALELCEEIVVYGM 149
Cdd:cd23981  93 VSASDGFwKSVATRVPREPHeiriLNPYFIQEAAFSFIGLPFNNGlMGR-----GNIPTLGSVAITMALHNCDEVAVAGF 167

                       170       180
                ....*....|....*....|....
gi 28373094 150 VSDsycreKSHPSVPYHYFEKGRL 173
Cdd:cd23981 168 GYD-----MNTPNAPLHYYETIKM 186
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 4-169 3.60e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 43.59  E-value: 3.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   4 SGLGAEIDSAECVFRMNQAPTVG-FEADVGQRSTLRVVS-----------HTSVPLLLRNYSHYfqkaRDTLYMVWGQGR 71
Cdd:cd23991  79 SSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANpsiisikyaklNERRKPFLETVSVY----GDAFLLLPAFSY 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  72 HMDRVLGGRTYRTLLQLTRMypgLQVYTFTERMMAYCDQIFQDETGKNRRqsgsfLSTGWFTMILALELCEEIVVYGMVS 151
Cdd:cd23991 155 RSNTALSFKVYYTLEDFKAK---QKVIFFHPIYLKHLAQFWRSKGVQVYR-----LSTGLMITSAALELCEEVKLYGFWP 226

                       170
                ....*....|....*...
gi 28373094 152 DSYCREKShpSVPYHYFE 169
Cdd:cd23991 227 FSKNTEGK--PISHHYYD 242
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 4-169 8.07e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 42.51  E-value: 8.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094   4 SGLGAEIDSAECVFRMNQAP-TVGFEADVGQRSTLRvvshTSVPLLLRNYshyFQKardtlyMVWGQGRHMDRV-LGGRT 81
Cdd:cd23989  78 SGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLV----TANPSIIDKR---FQN------LLWSRKSFVESMkVYGRS 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373094  82 YRTLLQL---TRMYPGLQVY-----TFTERMMAYCDQIFQDETG---KNRRQSGSFLSTGWFTMILALELCEEIVVYGMV 150
Cdd:cd23989 145 YIYMPAFsmkTGTDPSLRVYytladVGANQTVLFANPNFLRNVGkfwKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFW 224

                       170
                ....*....|....*....
gi 28373094 151 SDSYCREKSHPSvpYHYFE 169
Cdd:cd23989 225 PFSVDLDERTIS--HHYYD 241
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 1-37 2.03e-03

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 38.38  E-value: 2.03e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 28373094   1 MLGSGLGAEIDSAECVFRMNQAPTVGFEADVGQRSTL 37
Cdd:cd23987  76 LLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL 112
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 3-36 3.73e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 37.50  E-value: 3.73e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 28373094   3 GSGLGAEIDSAECVFRMNQAPTVGFEADVGQRST 36
Cdd:cd23972  96 GSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTS 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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