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Conserved domains on  [gi|282158057|ref|NP_001164074|]
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astrotactin-1 isoform 1 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASTN_1_2_N super family cl44858
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641 0e+00

Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.


The actual alignment was detected with superfamily member pfam19441:

Pssm-ID: 437273  Cd Length: 555  Bit Score: 1141.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    95 EISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMIL 174
Cdd:pfam19441    1 EISGNTDDIPLVRWRQQWLENGTLLFHIHHQDGAPNLPGFDPTDEPQTESAEEELRILHISVMGGMAAALLSILCLSLIL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   175 YTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQ 254
Cdd:pfam19441   81 TPRRKGCKRQRAAEPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   255 RECMNGGEDFASQVTRTLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINN 334
Cdd:pfam19441  161 RECMNGGEDFASQVTRTLDSLQGCNEKASMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKQIGG 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   335 KARAGSAFLNPEGDSSTEAENDPQLTFYTDPSRSRRRSRVGSPRSPVNKTTLTLISVTSCVIGLVCSSHVSCPLVVKITL 414
Cdd:pfam19441  241 KARAGRAFDNPEGDEGQERARDPLLGFSCDPSRGRGRPGLGSAPSGGNAASLTLISVCFCVISLVCARHAICPLEIKFSL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   415 HVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWAMDLCARRLLDPCEHQCDPETG--------ECLCYE 486
Cdd:pfam19441  321 HLGEHKIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWALDLCARRLLDPCEHQCDPETGkrefelgtEALCGA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   487 GYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCK 566
Cdd:pfam19441  401 GRMKDAVDKHLCIRNEWGMNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCK 480
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 282158057   567 TDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVCPSGLSPMKDSS 641
Cdd:pfam19441  481 TDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSRDNGGCSKNFRCISDRKLDSTGCVCPAGLSPMKDGT 555
ASTN1_2_EGF_Fn super family cl45145
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134 1.91e-66

ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.


The actual alignment was detected with superfamily member pfam19743:

Pssm-ID: 437575  Cd Length: 216  Bit Score: 223.65  E-value: 1.91e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   917 LSDSgtkRMAAGVRMECQSKGRCPSSCPLCHVTSSPETPAEPVLLEVTRASPIYELVTNNQTQRLLQEATMSSLWCSGTG 996
Cdd:pfam19743    1 LSDD---QLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNVTKEAFKSALMSSYWCSGKG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   997 DVIEDWCRCDSTAFGADGLPTCAPLPQPVLRLSTVHEPSSTLVVLEWEHSEPPIGVQIVDYLIRQEKVTDRMDhSKVETE 1076
Cdd:pfam19743   78 DVIDDWCRCDLSAFDKDGLPNCSPLPQPVLRLSPYVEPSSTVVSLEWMDVQPAIGTKVSDYILQHKKVDEYTD-TDLYTG 156
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057  1077 TVLSFVDDIISGAKAPCAMPSQVPDKQ--FTMISLIIRCLEPDTIYMFTLWGVDNTGRRS 1134
Cdd:pfam19743  157 EFLSFADDLLSGLGTSCVAAGRSHGDVpeSSIYSVIFKCLEPDGLYKFTLYAVDTRGRHS 216
Annexin_like pfam18411
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237 8.91e-55

Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.


:

Pssm-ID: 465756  Cd Length: 93  Bit Score: 185.07  E-value: 8.91e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057  1145 CPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVLYHYNQHYESFGEFTWRCEDELGPRKAGLILSQ 1224
Cdd:pfam18411    1 CPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMELGAPMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRR 80
                           90
                   ....*....|...
gi 282158057  1225 LGDLSSWCNGLLQ 1237
Cdd:pfam18411   81 LEKVSSHCSSLLR 93
MACPF smart00457
membrane-attack complex / perforin;
804-991 6.32e-46

membrane-attack complex / perforin;


:

Pssm-ID: 214671  Cd Length: 195  Bit Score: 163.76  E-value: 6.32e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    804 PVLQHWKVRSVMYHIKLNQAAISQAFSNALHSLDGATSRADFVALLDQFGNHYIQEAVYGFEESCSIWYPNKQVQRRLwL 883
Cdd:smart00457    1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKG-L 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    884 EYEDISKGNSPSDESEERERDP-KVLTFPEYIASLSDSGTKR-----MAAGVRMECqSKGRCPSSCPLCHVTSSPETPAE 957
Cdd:smart00457   80 TSEDISKCLAGSSNSFAGSVSAeHCLQSSSYIKYLSTSLRREshtqvLGGHVTVLC-DLLRGPSSNSLDFSDWAESVPNE 158
                           170       180       190
                    ....*....|....*....|....*....|....*...
gi 282158057    958 PVLLEVtRASPIYELVTNN----QTQRLLQEATMSSLW 991
Cdd:smart00457  159 PVLIDV-SLAPIYELLPPNpelsQKREALRQALRSYLK 195
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699 4.40e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 4.40e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 282158057   652 CSDGfNGGCEQLCLqqmapfpDDPTLYnilmFCGCIEDYKLGVDGRSC 699
Cdd:pfam14670    1 CSVN-NGGCSHLCL-------NTPGGY----TCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
ASTN_1_2_N pfam19441
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641 0e+00

Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.


Pssm-ID: 437273  Cd Length: 555  Bit Score: 1141.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    95 EISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMIL 174
Cdd:pfam19441    1 EISGNTDDIPLVRWRQQWLENGTLLFHIHHQDGAPNLPGFDPTDEPQTESAEEELRILHISVMGGMAAALLSILCLSLIL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   175 YTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQ 254
Cdd:pfam19441   81 TPRRKGCKRQRAAEPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   255 RECMNGGEDFASQVTRTLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINN 334
Cdd:pfam19441  161 RECMNGGEDFASQVTRTLDSLQGCNEKASMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKQIGG 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   335 KARAGSAFLNPEGDSSTEAENDPQLTFYTDPSRSRRRSRVGSPRSPVNKTTLTLISVTSCVIGLVCSSHVSCPLVVKITL 414
Cdd:pfam19441  241 KARAGRAFDNPEGDEGQERARDPLLGFSCDPSRGRGRPGLGSAPSGGNAASLTLISVCFCVISLVCARHAICPLEIKFSL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   415 HVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWAMDLCARRLLDPCEHQCDPETG--------ECLCYE 486
Cdd:pfam19441  321 HLGEHKIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWALDLCARRLLDPCEHQCDPETGkrefelgtEALCGA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   487 GYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCK 566
Cdd:pfam19441  401 GRMKDAVDKHLCIRNEWGMNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCK 480
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 282158057   567 TDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVCPSGLSPMKDSS 641
Cdd:pfam19441  481 TDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSRDNGGCSKNFRCISDRKLDSTGCVCPAGLSPMKDGT 555
ASTN1_2_EGF_Fn pfam19743
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134 1.91e-66

ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.


Pssm-ID: 437575  Cd Length: 216  Bit Score: 223.65  E-value: 1.91e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   917 LSDSgtkRMAAGVRMECQSKGRCPSSCPLCHVTSSPETPAEPVLLEVTRASPIYELVTNNQTQRLLQEATMSSLWCSGTG 996
Cdd:pfam19743    1 LSDD---QLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNVTKEAFKSALMSSYWCSGKG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   997 DVIEDWCRCDSTAFGADGLPTCAPLPQPVLRLSTVHEPSSTLVVLEWEHSEPPIGVQIVDYLIRQEKVTDRMDhSKVETE 1076
Cdd:pfam19743   78 DVIDDWCRCDLSAFDKDGLPNCSPLPQPVLRLSPYVEPSSTVVSLEWMDVQPAIGTKVSDYILQHKKVDEYTD-TDLYTG 156
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057  1077 TVLSFVDDIISGAKAPCAMPSQVPDKQ--FTMISLIIRCLEPDTIYMFTLWGVDNTGRRS 1134
Cdd:pfam19743  157 EFLSFADDLLSGLGTSCVAAGRSHGDVpeSSIYSVIFKCLEPDGLYKFTLYAVDTRGRHS 216
Annexin_like pfam18411
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237 8.91e-55

Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.


Pssm-ID: 465756  Cd Length: 93  Bit Score: 185.07  E-value: 8.91e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057  1145 CPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVLYHYNQHYESFGEFTWRCEDELGPRKAGLILSQ 1224
Cdd:pfam18411    1 CPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMELGAPMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRR 80
                           90
                   ....*....|...
gi 282158057  1225 LGDLSSWCNGLLQ 1237
Cdd:pfam18411   81 LEKVSSHCSSLLR 93
MACPF smart00457
membrane-attack complex / perforin;
804-991 6.32e-46

membrane-attack complex / perforin;


Pssm-ID: 214671  Cd Length: 195  Bit Score: 163.76  E-value: 6.32e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    804 PVLQHWKVRSVMYHIKLNQAAISQAFSNALHSLDGATSRADFVALLDQFGNHYIQEAVYGFEESCSIWYPNKQVQRRLwL 883
Cdd:smart00457    1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKG-L 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    884 EYEDISKGNSPSDESEERERDP-KVLTFPEYIASLSDSGTKR-----MAAGVRMECqSKGRCPSSCPLCHVTSSPETPAE 957
Cdd:smart00457   80 TSEDISKCLAGSSNSFAGSVSAeHCLQSSSYIKYLSTSLRREshtqvLGGHVTVLC-DLLRGPSSNSLDFSDWAESVPNE 158
                           170       180       190
                    ....*....|....*....|....*....|....*...
gi 282158057    958 PVLLEVtRASPIYELVTNN----QTQRLLQEATMSSLW 991
Cdd:smart00457  159 PVLIDV-SLAPIYELLPPNpelsQKREALRQALRSYLK 195
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699 4.40e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 4.40e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 282158057   652 CSDGfNGGCEQLCLqqmapfpDDPTLYnilmFCGCIEDYKLGVDGRSC 699
Cdd:pfam14670    1 CSVN-NGGCSHLCL-------NTPGGY----TCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
ASTN_1_2_N pfam19441
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641 0e+00

Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.


Pssm-ID: 437273  Cd Length: 555  Bit Score: 1141.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    95 EISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMIL 174
Cdd:pfam19441    1 EISGNTDDIPLVRWRQQWLENGTLLFHIHHQDGAPNLPGFDPTDEPQTESAEEELRILHISVMGGMAAALLSILCLSLIL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   175 YTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQ 254
Cdd:pfam19441   81 TPRRKGCKRQRAAEPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   255 RECMNGGEDFASQVTRTLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINN 334
Cdd:pfam19441  161 RECMNGGEDFASQVTRTLDSLQGCNEKASMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKQIGG 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   335 KARAGSAFLNPEGDSSTEAENDPQLTFYTDPSRSRRRSRVGSPRSPVNKTTLTLISVTSCVIGLVCSSHVSCPLVVKITL 414
Cdd:pfam19441  241 KARAGRAFDNPEGDEGQERARDPLLGFSCDPSRGRGRPGLGSAPSGGNAASLTLISVCFCVISLVCARHAICPLEIKFSL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   415 HVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWAMDLCARRLLDPCEHQCDPETG--------ECLCYE 486
Cdd:pfam19441  321 HLGEHKIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWALDLCARRLLDPCEHQCDPETGkrefelgtEALCGA 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   487 GYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCK 566
Cdd:pfam19441  401 GRMKDAVDKHLCIRNEWGMNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCK 480
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 282158057   567 TDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVCPSGLSPMKDSS 641
Cdd:pfam19441  481 TDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSRDNGGCSKNFRCISDRKLDSTGCVCPAGLSPMKDGT 555
ASTN1_2_EGF_Fn pfam19743
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134 1.91e-66

ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.


Pssm-ID: 437575  Cd Length: 216  Bit Score: 223.65  E-value: 1.91e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   917 LSDSgtkRMAAGVRMECQSKGRCPSSCPLCHVTSSPETPAEPVLLEVTRASPIYELVTNNQTQRLLQEATMSSLWCSGTG 996
Cdd:pfam19743    1 LSDD---QLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNVTKEAFKSALMSSYWCSGKG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057   997 DVIEDWCRCDSTAFGADGLPTCAPLPQPVLRLSTVHEPSSTLVVLEWEHSEPPIGVQIVDYLIRQEKVTDRMDhSKVETE 1076
Cdd:pfam19743   78 DVIDDWCRCDLSAFDKDGLPNCSPLPQPVLRLSPYVEPSSTVVSLEWMDVQPAIGTKVSDYILQHKKVDEYTD-TDLYTG 156
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057  1077 TVLSFVDDIISGAKAPCAMPSQVPDKQ--FTMISLIIRCLEPDTIYMFTLWGVDNTGRRS 1134
Cdd:pfam19743  157 EFLSFADDLLSGLGTSCVAAGRSHGDVpeSSIYSVIFKCLEPDGLYKFTLYAVDTRGRHS 216
Annexin_like pfam18411
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237 8.91e-55

Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.


Pssm-ID: 465756  Cd Length: 93  Bit Score: 185.07  E-value: 8.91e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057  1145 CPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVLYHYNQHYESFGEFTWRCEDELGPRKAGLILSQ 1224
Cdd:pfam18411    1 CPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMELGAPMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRR 80
                           90
                   ....*....|...
gi 282158057  1225 LGDLSSWCNGLLQ 1237
Cdd:pfam18411   81 LEKVSSHCSSLLR 93
MACPF smart00457
membrane-attack complex / perforin;
804-991 6.32e-46

membrane-attack complex / perforin;


Pssm-ID: 214671  Cd Length: 195  Bit Score: 163.76  E-value: 6.32e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    804 PVLQHWKVRSVMYHIKLNQAAISQAFSNALHSLDGATSRADFVALLDQFGNHYIQEAVYGFEESCSIWYPNKQVQRRLwL 883
Cdd:smart00457    1 FLVARDTVRNRLYSVKLDELPLALEFLKALRDLPDTYNRGAYARFIDDYGTHYITSATLGGEYSLLLVLDKESLERKG-L 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282158057    884 EYEDISKGNSPSDESEERERDP-KVLTFPEYIASLSDSGTKR-----MAAGVRMECqSKGRCPSSCPLCHVTSSPETPAE 957
Cdd:smart00457   80 TSEDISKCLAGSSNSFAGSVSAeHCLQSSSYIKYLSTSLRREshtqvLGGHVTVLC-DLLRGPSSNSLDFSDWAESVPNE 158
                           170       180       190
                    ....*....|....*....|....*....|....*...
gi 282158057    958 PVLLEVtRASPIYELVTNN----QTQRLLQEATMSSLW 991
Cdd:smart00457  159 PVLIDV-SLAPIYELLPPNpelsQKREALRQALRSYLK 195
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699 4.40e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.84  E-value: 4.40e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 282158057   652 CSDGfNGGCEQLCLqqmapfpDDPTLYnilmFCGCIEDYKLGVDGRSC 699
Cdd:pfam14670    1 CSVN-NGGCSHLCL-------NTPGGY----TCSCPEGYELQDDGRTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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