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Conserved domains on  [gi|27923823|sp|Q9PUN1|]
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RecName: Full=Occludin

Protein Classification

MARVEL and Occludin_ELL domain-containing protein( domain architecture ID 10472796)

MARVEL and Occludin_ELL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 392-493 8.46e-32

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


:

Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 117.63  E-value: 8.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   392 YPPITQTKQRQEYKQEFASDLHEYKRLQAELDELSKIpVPSLNRELGQSSRKDSEEYRTVADKYNRLKEIKSSADYRNKK 471
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRK-FQKLDRELKSLPEGSKEYQDIAEEILQEYKKKKKDPEYQEKK 79

                          90       100
                  ....*....|....*....|..
gi 27923823   472 KRCKGLKTKLNHIKQMVSNYDK 493
Cdd:pfam07303  80 KRCEYLHNKLSHIKRLILEYDQ 101
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 38-244 2.30e-16

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


:

Pssm-ID: 366555  Cd Length: 136  Bit Score: 75.83  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823    38 RWSSPPGIIKIMSIlivVMCVGIFACVAStlpwdlditgqsmgygmgsgsysggytgygfggsqmglgfaYGGNYTDPRA 117
Cdd:pfam01284   1 FLLTPLGILRILQL---VFAIIVLGLIAS-----------------------------------------LIAYAGSYPS 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   118 AKGFILAMAAFCFIIGLVIFVMLVTRTPLSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPVAQasgsafytqivsic 197
Cdd:pfam01284  37 AVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSE-------------- 102

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 27923823   198 nqfyspvqtgvfvNQYLYHYCVVEPQEAIAIVLGFLIVVAFAIIIFF 244
Cdd:pfam01284 103 -------------NQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
 
Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 392-493 8.46e-32

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 117.63  E-value: 8.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   392 YPPITQTKQRQEYKQEFASDLHEYKRLQAELDELSKIpVPSLNRELGQSSRKDSEEYRTVADKYNRLKEIKSSADYRNKK 471
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRK-FQKLDRELKSLPEGSKEYQDIAEEILQEYKKKKKDPEYQEKK 79

                          90       100
                  ....*....|....*....|..
gi 27923823   472 KRCKGLKTKLNHIKQMVSNYDK 493
Cdd:pfam07303  80 KRCEYLHNKLSHIKRLILEYDQ 101
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 38-244 2.30e-16

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 75.83  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823    38 RWSSPPGIIKIMSIlivVMCVGIFACVAStlpwdlditgqsmgygmgsgsysggytgygfggsqmglgfaYGGNYTDPRA 117
Cdd:pfam01284   1 FLLTPLGILRILQL---VFAIIVLGLIAS-----------------------------------------LIAYAGSYPS 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   118 AKGFILAMAAFCFIIGLVIFVMLVTRTPLSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPVAQasgsafytqivsic 197
Cdd:pfam01284  37 AVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSE-------------- 102

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 27923823   198 nqfyspvqtgvfvNQYLYHYCVVEPQEAIAIVLGFLIVVAFAIIIFF 244
Cdd:pfam01284 103 -------------NQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
YczE COG2364
Uncharacterized membrane protein YczE [Function unknown];
123-189 1.67e-03

Uncharacterized membrane protein YczE [Function unknown];


Pssm-ID: 441931  Cd Length: 207  Bit Score: 39.76  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 123 LAMAAFCFIIGLVIF-------------------VMLV----TRTPLSTSRK-FYLIVIIVSAIIGGLVFIATIVYTVGV 178
Cdd:COG2364 105 LLLRILLLLIGIVLLalgvalyigaglgagprdgLMLAlskrTGWSFGVVRTgIEVTVLLIGWLLGGPVGIGTVIAALLI 184

                        90
                ....*....|.
gi 27923823 179 NPVAQASGSAF 189
Cdd:COG2364 185 GPLIQFFLPLL 195
7tm_classC_mGluR-like cd13953
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ...
 103-250 4.69e-03

metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.


Pssm-ID: 320091 [Multi-domain]  Cd Length: 251  Bit Score: 38.76  E-value: 4.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 103 GLGFAYGGNYTDPR-AAKGFILAMA-AFCFIIGLV-------IF--VMLVTRTPLSTSRKF-YLIVIIVSAIIGGLVFIA 170
Cdd:cd13953  53 LLAFLFLLPPSDVLcGLRRFLFGLSfTLVFSTLLVktnriyrIFksGLRSSLRPKLLSNKSqLLLVLFLLLVQVAILIVW 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 171 TIVYTVGVNPVaqasgsafytqivsicnqfyspvqtgVFVNQYLYHYCVVEPQEAIAIVLGFLIVVAFaIIIFFAVKTRK 250
Cdd:cd13953 133 LILDPPKVEKV--------------------------IDSDNKVVELCCSTGNIGLILSLVYNILLLL-ICTYLAFKTRK 185
 
Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 392-493 8.46e-32

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 117.63  E-value: 8.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   392 YPPITQTKQRQEYKQEFASDLHEYKRLQAELDELSKIpVPSLNRELGQSSRKDSEEYRTVADKYNRLKEIKSSADYRNKK 471
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRK-FQKLDRELKSLPEGSKEYQDIAEEILQEYKKKKKDPEYQEKK 79

                          90       100
                  ....*....|....*....|..
gi 27923823   472 KRCKGLKTKLNHIKQMVSNYDK 493
Cdd:pfam07303  80 KRCEYLHNKLSHIKRLILEYDQ 101
MARVEL pfam01284
Membrane-associating domain; MARVEL domain-containing proteins are often found in ...
 38-244 2.30e-16

Membrane-associating domain; MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.


Pssm-ID: 366555  Cd Length: 136  Bit Score: 75.83  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823    38 RWSSPPGIIKIMSIlivVMCVGIFACVAStlpwdlditgqsmgygmgsgsysggytgygfggsqmglgfaYGGNYTDPRA 117
Cdd:pfam01284   1 FLLTPLGILRILQL---VFAIIVLGLIAS-----------------------------------------LIAYAGSYPS 36

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   118 AKGFILAMAAFCFIIGLVIFVMLVTRTPLSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPVAQasgsafytqivsic 197
Cdd:pfam01284  37 AVNFAVFVAVFSFLIALFFLLLYLFGYSYFPSIAWPLIDLIFDALAALFWLAAFIALAAALRGHSE-------------- 102

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 27923823   198 nqfyspvqtgvfvNQYLYHYCVVEPQEAIAIVLGFLIVVAFAIIIFF 244
Cdd:pfam01284 103 -------------NQGSGDLTRRCRAAQAAIAFGFFAWLLFLASAVL 136
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 123-254 7.46e-04

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 41.67  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   123 LAMAAFCFIIGLVI------FV---MLVTRTP-LSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPVAQA----SGSA 188
Cdd:pfam10326  84 ILLALYCGFYGVSIsllavqFIyryLALCRPGkLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEylreELLE 163

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823   189 FY----TQIVSICNQFYSPVQTGvfvNQYLYHycvvePQEAIAIVLGFLIVVAFAIIIFFAVKTRKKINQ 254
Cdd:pfam10326 164 NYnldiDEVAYVGPVYYPTDENG---SKVIRW-----RSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKK 225
YczE COG2364
Uncharacterized membrane protein YczE [Function unknown];
123-189 1.67e-03

Uncharacterized membrane protein YczE [Function unknown];


Pssm-ID: 441931  Cd Length: 207  Bit Score: 39.76  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 123 LAMAAFCFIIGLVIF-------------------VMLV----TRTPLSTSRK-FYLIVIIVSAIIGGLVFIATIVYTVGV 178
Cdd:COG2364 105 LLLRILLLLIGIVLLalgvalyigaglgagprdgLMLAlskrTGWSFGVVRTgIEVTVLLIGWLLGGPVGIGTVIAALLI 184

                        90
                ....*....|.
gi 27923823 179 NPVAQASGSAF 189
Cdd:COG2364 185 GPLIQFFLPLL 195
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
120-261 3.49e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 3.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 120 GFILAMAAFCFIIGLVIFVMLVTRTPlSTSRKFYLIVIIVSAIIGGLVFIATIVYTVGVNPVAQASGS--AFYTQI---- 193
Cdd:COG2211 150 SWRFAFAGLGGLLASVLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSlkESLKALlknr 228

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27923823 194 -------VSICNQFYSPVQTGVFVnqYLYHYCVVEPQEAIAIVLGFLIVVAFAIIIFFAVKTRKkinqYGKTNIL 261
Cdd:COG2211 229 pflllllAYLLFFLALALVAALLL--YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR----FGKKKAF 297
7tm_classC_mGluR-like cd13953
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ...
 103-250 4.69e-03

metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.


Pssm-ID: 320091 [Multi-domain]  Cd Length: 251  Bit Score: 38.76  E-value: 4.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 103 GLGFAYGGNYTDPR-AAKGFILAMA-AFCFIIGLV-------IF--VMLVTRTPLSTSRKF-YLIVIIVSAIIGGLVFIA 170
Cdd:cd13953  53 LLAFLFLLPPSDVLcGLRRFLFGLSfTLVFSTLLVktnriyrIFksGLRSSLRPKLLSNKSqLLLVLFLLLVQVAILIVW 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27923823 171 TIVYTVGVNPVaqasgsafytqivsicnqfyspvqtgVFVNQYLYHYCVVEPQEAIAIVLGFLIVVAFaIIIFFAVKTRK 250
Cdd:cd13953 133 LILDPPKVEKV--------------------------IDSDNKVVELCCSTGNIGLILSLVYNILLLL-ICTYLAFKTRK 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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