NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27882549|gb|AAH44530|]
View 

Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b [Danio rerio]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10553538)

WD40 domain-containing protein similar to Homo sapiens F-box-like/WD repeat-containing protein TBL1X/TBL1Y/TBL1XR1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 104-408 6.08e-119

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 347.40  E-value: 6.08e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFE 183
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVV 263
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 264 ATKECKAELREHEHVVECISWAPESAHptiseatgsenkksgkpgpfLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRG 343
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEK--------------------LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27882549 344 VLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWE 408
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 10-34 8.05e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


:

Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.00  E-value: 8.05e-07
                          10        20
                  ....*....|....*....|....*
gi 27882549    10 ELNRAIADYLRSNGYEEAYSTFKKE 34
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 104-408 6.08e-119

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 347.40  E-value: 6.08e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFE 183
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVV 263
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 264 ATKECKAELREHEHVVECISWAPESAHptiseatgsenkksgkpgpfLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRG 343
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEK--------------------LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27882549 344 VLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWE 408
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
104-407 5.79e-100

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 303.37  E-value: 5.79e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFE 183
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVV 263
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 264 ATKECKAELREHEHVVECISWAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRG 343
Cdd:COG2319 276 ATGELLRTLTGHSGGVNSVAFSPD--------------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27882549 344 VLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVW 407
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 136-408 3.67e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 3.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  136 DYEAGDfertLKGHTDSVQDISFDQTGKLLASCSADMTIKLwdfqgFECirtmhghdhnvssvaimpngDHIVSASRDKT 215
Cdd:PLN00181 473 DLKQGD----LLNSSNLVCAIGFDRDGEFFATAGVNKKIKI-----FEC--------------------ESIIKDGRDIH 523

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  216 MKMWEVA-----TGYCvktftghreWVRMVRpnqdgTLLASCSNDQTVRVWVVATKECKAELREHEHVVECISWApeSAH 290
Cdd:PLN00181 524 YPVVELAsrsklSGIC---------WNSYIK-----SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS--SAD 587

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  291 PTIseatgsenkksgkpgpfLLSGSRDKTIKMWDISTGMCLMTLVGHDNwVRGVLF-HPGGRFVVSCADDKTLRIWDYKN 369
Cdd:PLN00181 588 PTL-----------------LASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpSESGRSLAFGSADHKVYYYDLRN 649

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 27882549  370 KRC-MKTLSAHEHFVTSLDFHKASPyVVTGSVDQTVKVWE 408
Cdd:PLN00181 650 PKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 327-366 5.40e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 5.40e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 27882549    327 TGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWD 366
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
328-366 8.95e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 8.95e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27882549   328 GMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWD 366
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 10-34 8.05e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.00  E-value: 8.05e-07
                          10        20
                  ....*....|....*....|....*
gi 27882549    10 ELNRAIADYLRSNGYEEAYSTFKKE 34
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 7-39 9.02e-07

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 45.12  E-value: 9.02e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27882549      7 QRDELNRAIADYLRSNGYEEAYSTFKKEAELDV 39
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 104-408 6.08e-119

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 347.40  E-value: 6.08e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFE 183
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVV 263
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 264 ATKECKAELREHEHVVECISWAPESAHptiseatgsenkksgkpgpfLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRG 343
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEK--------------------LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27882549 344 VLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWE 408
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
104-407 5.79e-100

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 303.37  E-value: 5.79e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFE 183
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVV 263
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 264 ATKECKAELREHEHVVECISWAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRG 343
Cdd:COG2319 276 ATGELLRTLTGHSGGVNSVAFSPD--------------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27882549 344 VLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVW 407
Cdd:COG2319 336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
94-408 3.90e-97

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 296.05  E-value: 3.90e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  94 WIPRPPEKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMT 173
Cdd:COG2319  64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCS 253
Cdd:COG2319 144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWDISTGMCLMT 333
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--------------------GRLLASGSADGTVRLWDLATGELLRT 283

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27882549 334 LVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWE 408
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
124-407 3.59e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 226.72  E-value: 3.59e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 124 VSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
Cdd:COG2319  10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 204 GDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVVATKECKAELREHEHVVECIS 283
Cdd:COG2319  90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 284 WAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLR 363
Cdd:COG2319 170 FSPD--------------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 27882549 364 IWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVW 407
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 184-410 4.09e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.20  E-value: 4.09e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVV 263
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 264 ATKECKAELREHEHVVECISWAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRG 343
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPD--------------------GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS 140

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27882549 344 VLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWECR 410
Cdd:cd00200 141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
104-327 1.06e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.78  E-value: 1.06e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFE 183
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVWVV 263
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27882549 264 ATKECKAELREHEHVVECISWAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWDIST 327
Cdd:COG2319 360 ATGELLRTLTGHTGAVTSVAFSPD--------------------GRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 92-261 1.19e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.83  E-value: 1.19e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  92 KEW-IPRPPEKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSA 170
Cdd:cd00200 118 KVWdVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 171 DMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLLA 250
Cdd:cd00200 198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                       170
                ....*....|.
gi 27882549 251 SCSNDQTVRVW 261
Cdd:cd00200 278 SGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 136-408 3.67e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 3.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  136 DYEAGDfertLKGHTDSVQDISFDQTGKLLASCSADMTIKLwdfqgFECirtmhghdhnvssvaimpngDHIVSASRDKT 215
Cdd:PLN00181 473 DLKQGD----LLNSSNLVCAIGFDRDGEFFATAGVNKKIKI-----FEC--------------------ESIIKDGRDIH 523

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  216 MKMWEVA-----TGYCvktftghreWVRMVRpnqdgTLLASCSNDQTVRVWVVATKECKAELREHEHVVECISWApeSAH 290
Cdd:PLN00181 524 YPVVELAsrsklSGIC---------WNSYIK-----SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS--SAD 587

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  291 PTIseatgsenkksgkpgpfLLSGSRDKTIKMWDISTGMCLMTLVGHDNwVRGVLF-HPGGRFVVSCADDKTLRIWDYKN 369
Cdd:PLN00181 588 PTL-----------------LASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFpSESGRSLAFGSADHKVYYYDLRN 649

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 27882549  370 KRC-MKTLSAHEHFVTSLDFHKASPyVVTGSVDQTVKVWE 408
Cdd:PLN00181 650 PKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 327-366 5.40e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 5.40e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 27882549    327 TGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWD 366
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 96-261 8.09e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 8.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549   96 PRPPekyALSGHRSPVTRVIFHPVFSL-MVSASEDATIKVWDYEAGDFERT-------LKGHTDSVQDISFDQTGK-LLA 166
Cdd:PTZ00421  66 SNPP---ILLGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMnVLA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWEVATGYCVKTFTGHRE-------WVRm 239
Cdd:PTZ00421 143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclWAK- 221

                        170       180
                 ....*....|....*....|..
gi 27882549  240 vRPNQDGTLLASCSNDQTVRVW 261
Cdd:PTZ00421 222 -RKDLIITLGCSKSQQRQIMLW 242
WD40 pfam00400
WD domain, G-beta repeat;
328-366 8.95e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.50  E-value: 8.95e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27882549   328 GMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWD 366
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-178 1.97e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 1.97e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 27882549    140 GDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWD 178
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
140-178 4.00e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 4.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27882549   140 GDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWD 178
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-220 1.69e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 27882549    182 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWE 220
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 223-261 3.43e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 3.43e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 27882549    223 TGYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVW 261
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
370-408 5.05e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 5.05e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27882549   370 KRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWE 408
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
182-220 5.52e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 5.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27882549   182 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTMKMWE 220
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
224-261 5.57e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 5.57e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 27882549   224 GYCVKTFTGHREWVRMVRPNQDGTLLASCSNDQTVRVW 261
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 369-408 9.22e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 9.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 27882549    369 NKRCMKTLSAHEHFVTSLDFHKASPYVVTGSVDQTVKVWE 408
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 78-180 2.92e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 52.64  E-value: 2.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549   78 EITLGGPVGQKRDPKEWipRPPEKYALSGHRSPVTRVIFHPVFS-LMVSASEDATIKVWDY--------EAGDFERTLKG 148
Cdd:PTZ00420  46 EVEGGGLIGAIRLENQM--RKPPVIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIphndesvkEIKDPQCILKG 123

                         90       100       110
                 ....*....|....*....|....*....|...
gi 27882549  149 HTDSVQDISFDQTGK-LLASCSADMTIKLWDFQ 180
Cdd:PTZ00420 124 HKKKISIIDWNPMNYyIMCSSGFDSFVNIWDIE 156
WD40 COG2319
WD40 repeat [General function prediction only];
308-409 2.93e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 2.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549 308 GPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHEHFVTSLD 387
Cdd:COG2319   6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                        90       100
                ....*....|....*....|..
gi 27882549 388 FHKASPYVVTGSVDQTVKVWEC 409
Cdd:COG2319  86 FSPDGRLLASASADGTVRLWDL 107
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-136 7.29e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.29e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27882549    104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWD 136
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 10-34 8.05e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.00  E-value: 8.05e-07
                          10        20
                  ....*....|....*....|....*
gi 27882549    10 ELNRAIADYLRSNGYEEAYSTFKKE 34
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 7-39 9.02e-07

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 45.12  E-value: 9.02e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27882549      7 QRDELNRAIADYLRSNGYEEAYSTFKKEAELDV 39
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 pfam00400
WD domain, G-beta repeat;
104-136 3.29e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.29e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 27882549   104 LSGHRSPVTRVIFHPVFSLMVSASEDATIKVWD 136
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 146-221 4.00e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 4.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  146 LKGHTDSVQDISFDQT-GKLLASCSADMTIKLWDF----------QGFECIrtMHGHDHNVSSVAIMPNGDHIVSASR-D 213
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIphndesvkeiKDPQCI--LKGHKKKISIIDWNPMNYYIMCSSGfD 147


                 ....*...
gi 27882549  214 KTMKMWEV 221
Cdd:PTZ00420 148 SFVNIWDI 155
PTZ00421 PTZ00421
coronin; Provisional
 309-410 3.12e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  309 PF----LLSGSRDKTIKMWDI-------STGMCLMTLVGHDNWVRGVLFHPGGRFVVSCAD-DKTLRIWDYKNKRCMKTL 376
Cdd:PTZ00421  85 PFdpqkLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVI 164

                         90       100       110
                 ....*....|....*....|....*....|....
gi 27882549  377 SAHEHFVTSLDFHKASPYVVTGSVDQTVKVWECR 410
Cdd:PTZ00421 165 KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 265-324 7.65e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.65e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549    265 TKECKAELREHEHVVECISWAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWD 324
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--------------------GKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
100-136 9.91e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 9.91e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 27882549 100 EKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWD 136
Cdd:COG2319 364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-136 3.31e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 3.31e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 27882549 100 EKYALSGHRSPVTRVIFHPVFSLMVSASEDATIKVWD 136
Cdd:cd00200 253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
266-324 3.46e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 27882549   266 KECKAELREHEHVVECISWAPEsahptiseatgsenkksgkpGPFLLSGSRDKTIKMWD 324
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD--------------------GKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 121-261 4.11e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.77  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  121 SLMVSASEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTG-KLLASCSADMTIKLWDFQGFECIRTMHGhDHNVSSVA 199
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27882549  200 I-MPNGDHIVSASRDKTMKMWEVAT---GYCvkTFTGHREWVRMVRpNQDGTLLASCSNDQTVRVW 261
Cdd:PLN00181 625 FpSESGRSLAFGSADHKVYYYDLRNpklPLC--TMIGHSKTVSYVR-FVDSSTLVSSSTDNTLKLW 687
PTZ00421 PTZ00421
coronin; Provisional
 311-380 1.60e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.65  E-value: 1.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27882549  311 LLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLFHPGGRFVVSCADDKTLRIWDYKNKRCMKTLSAHE 380
Cdd:PTZ00421 141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH