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Conserved domains on  [gi|27769331|gb|AAH42510|]
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CEL protein [Homo sapiens]

Protein Classification

Esterase_lipase and Mucin-like domain-containing protein( domain architecture ID 11987879)

Esterase_lipase and Mucin-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
29-544 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 621.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331    29 VYTEGGFVEGVNKKLGLlGDSVDIFKGIPFAAPTKAL---ENPQPHPGWQGTLKAKNFKKRCLQATITQDSTY----GDE 101
Cdd:pfam00135   5 VTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGElrfQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSsgleGSE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   102 DCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL 181
Cdd:pfam00135  84 DCLYLNVYTPKELKENKNKLPVMVWIHGGGFMFGSGS--------LYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDEA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   182 PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAK 261
Cdd:pfam00135 156 PGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQRAK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   262 KVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYIAGT 339
Cdd:pfam00135 236 ELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL---LVYGSVPFVPFGPVVDGDFLPEHPEELLKsgNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   340 NNMDGHIFASIDMPAINKGNKKVTED-FYKLVSEFTITKGL---RGAKTTFDVYTEsWAQDPSQENKKKTVVDFETDVLF 415
Cdd:pfam00135 313 TKDEGLLFAAYILDNVDILKALEEKLlRSLLIDLLYLLLVDlpeEISAALREEYLD-WGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   416 LVPTEIALAQHRanAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAK 495
Cdd:pfam00135 392 NCPVIRFADLHA--SRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 27769331   496 TGDPNMGdsAVPTHWEPYTTENSGYLEITKKMgssSMKRSLRTNFLRYW 544
Cdd:pfam00135 470 TGNPNGP--EGLPKWPPYTDENGQYLSIDLEP---RVKQGLKAERCAFW 513
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 586-678 4.99e-23

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


:

Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 93.64  E-value: 4.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   586 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTG 665
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 27769331   666 DSGAPPVTPTGDS 678
Cdd:pfam16058  81 SITEPPRDPSGSY 93
kgd super family cl39092
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 644-718 3.38e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


The actual alignment was detected with superfamily member PRK12270:

Pssm-ID: 476867 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 3.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331   644 DAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PRK12270   35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPA 109
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
29-544 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 621.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331    29 VYTEGGFVEGVNKKLGLlGDSVDIFKGIPFAAPTKAL---ENPQPHPGWQGTLKAKNFKKRCLQATITQDSTY----GDE 101
Cdd:pfam00135   5 VTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGElrfQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSsgleGSE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   102 DCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL 181
Cdd:pfam00135  84 DCLYLNVYTPKELKENKNKLPVMVWIHGGGFMFGSGS--------LYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDEA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   182 PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAK 261
Cdd:pfam00135 156 PGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQRAK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   262 KVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYIAGT 339
Cdd:pfam00135 236 ELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL---LVYGSVPFVPFGPVVDGDFLPEHPEELLKsgNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   340 NNMDGHIFASIDMPAINKGNKKVTED-FYKLVSEFTITKGL---RGAKTTFDVYTEsWAQDPSQENKKKTVVDFETDVLF 415
Cdd:pfam00135 313 TKDEGLLFAAYILDNVDILKALEEKLlRSLLIDLLYLLLVDlpeEISAALREEYLD-WGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   416 LVPTEIALAQHRanAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAK 495
Cdd:pfam00135 392 NCPVIRFADLHA--SRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 27769331   496 TGDPNMGdsAVPTHWEPYTTENSGYLEITKKMgssSMKRSLRTNFLRYW 544
Cdd:pfam00135 470 TGNPNGP--EGLPKWPPYTDENGQYLSIDLEP---RVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 28-534 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 577.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  28 AVYTEGGFVEGVNKklgllgDSVDIFKGIPFAAPT---KALENPQPHPGWQGTLKAKNFKKRCLQATITQDS-----TYG 99
Cdd:cd00312   1 LVVTPNGKVRGVDE------GGVYSFLGIPYAEPPvgdLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGlwnakLPG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 100 DEDCLYLNIWVPQGRKqVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRG-NVIVVTFNYRVGPLGFLSTGD 178
Cdd:cd00312  75 SEDCLYLNVYTPKNTK-PGNSLPVMVWIHGGGFMFGSGS--------LYPGDGLAREGdNVIVVSINYRLGVLGFLSTGD 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 179 ANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLF 258
Cdd:cd00312 146 IELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 259 WAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYI 336
Cdd:cd00312 226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKL---LLFSYSPFLPFGPVVDGDFIPDDPEELIKegKFAKVPLI 302

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 337 AGTNNMDGHIFASIDMPAINKGNKKVTEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQdpsQENKKKTVVDFETDVLFL 416
Cdd:cd00312 303 IGVTKDEGGYFAAMLLNFDAKLIIETNDRWLELLPYLLFYADDALADKVLEKYPGDVDD---SVESRKNLSDMLTDLLFK 379

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 417 VPTEIALAQHRANAKSaKTYAYLFSHPSRMPV--YPKWVGADHADDIQYVFGKPFATPTGYrPQDRTVSKAMIAYWTNFA 494
Cdd:cd00312 380 CPARYFLAQHRKAGGS-PVYAYVFDHRSSLSVgrWPPWLGTVHGDEIFFVFGNPLLKEGLR-EEEEKLSRTMMKYWANFA 457

                       490       500       510       520
                ....*....|....*....|....*....|....*....|
gi 27769331 495 KTGDPNMGDsaVPTHWEPYTTENSGYLEITkkMGSSSMKR 534
Cdd:cd00312 458 KTGNPNTEG--NLVVWPAYTSESEKYLDIN--IEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
29-523 1.83e-128

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 390.40  E-value: 1.83e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  29 VYTEGGFVEGVnkklglLGDSVDIFKGIPFAAPT------KAlenPQPHPGWQGTLKAKNFKKRCLQATITQD---STYG 99
Cdd:COG2272  15 VRTEAGRVRGV------VEGGVRVFLGIPYAAPPvgelrwRA---PQPVEPWTGVRDATEFGPACPQPPRPGDpggPAPG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 100 DEDCLYLNIWVPqgRKQVSRDLPVMIWIYGGAFLMGSGHGAnflnnyLYDGEEIATRGnVIVVTFNYRVGPLGF-----L 174
Cdd:COG2272  86 SEDCLYLNVWTP--ALAAGAKLPVMVWIHGGGFVSGSGSEP------LYDGAALARRG-VVVVTINYRLGALGFlalpaL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 175 STGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVAL---SPWV 251
Cdd:COG2272 157 SGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLsvlTLAE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 252 IQKnplfWAKKVAEKVGCPVGDAArmaqCLKVTDPRALTLAYKVPLAGLEYPMlhyvGFVPVIDGDFIPADPINLYAN-- 329
Cdd:COG2272 237 AEA----VGAAFAAALGVAPATLA----ALRALPAEELLAAQAALAAEGPGGL----PFGPVVDGDVLPEDPLEAFAAgr 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 330 AADIDYIAGTNNMDGHIFASIDMPAinkgnKKVTEDFYKlvseftitkglRGAKTTFDVYTESWAQDPSQENKKKTVVDF 409
Cdd:COG2272 305 AADVPLLIGTNRDEGRLFAALLGDL-----GPLTAADYR-----------AALRRRFGDDADEVLAAYPAASPAEALAAL 368

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 410 ETDVLFLVPTeIALAQHRAnAKSAKTYAYLFSHPSRMPVYPKWvGADHADDIQYVFGKPFA-TPTGYRPQDRTVSKAMIA 488
Cdd:COG2272 369 ATDRVFRCPA-RRLAEAHA-AAGAPVYLYRFDWRSPPLRGFGL-GAFHGAELPFVFGNLDApALTGLTPADRALSDQMQA 445

                       490       500       510
                ....*....|....*....|....*....|....*
gi 27769331 489 YWTNFAKTGDPNMGDsavPTHWEPYTTENSGYLEI 523
Cdd:COG2272 446 YWVNFARTGDPNGPG---LPEWPAYDPEDRAVMVF 477
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 586-678 4.99e-23

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 93.64  E-value: 4.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   586 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTG 665
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 27769331   666 DSGAPPVTPTGDS 678
Cdd:pfam16058  81 SITEPPRDPSGSY 93
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 552-718 7.34e-17

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 85.04  E-value: 7.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:PRK07764 615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPA 694

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  632 GDSGAPPVPpTGDAGPPPVPPTGDSGAPPVPPTGDSGAP-------PVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAP 704
Cdd:PRK07764 695 GAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSpaaddpvPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773

                        170
                 ....*....|....
gi 27769331  705 VPPTDDSKEAQMPA 718
Cdd:PRK07764 774 PPPSPPSEEEEMAE 787
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-717 2.30e-11

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 67.10  E-value: 2.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:NF033839 303 PQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPK---PEVKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQ 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:NF033839 380 PETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPET 459


                 ....*....
gi 27769331  709 DDSKEAQMP 717
Cdd:NF033839 460 PKPEVKPQP 468
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 560-717 4.45e-11

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 65.95  E-value: 4.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  560 TPVPPTGDSEATPVP---PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 636
Cdd:NF033839 283 TPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPK 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  637 PPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKE 713
Cdd:NF033839 363 PEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV 442


                 ....
gi 27769331  714 AQMP 717
Cdd:NF033839 443 KPQP 446
PHA03247 PHA03247
large tegument protein UL36; Provisional
 467-717 6.51e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.12  E-value: 6.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   467 KPFATPTGYRPQdrtVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTnflrywTL 546
Cdd:PHA03247 2675 QASSPPQRPRRR---AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA------VP 2745

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   547 TYLALPTVTDQEATPVPPTGDSEATP--VPPTGDSETAPVPPtGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 624
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAGPPAPAPpaAPAAGPPRRLTRPA-VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   625 APPVPPTGDS-------GAPPVPPTGDAG------------PPPVPPTGDSGAPPVPPTGDSGAPPVTPTgdSETAPVPP 685
Cdd:PHA03247 2825 AGPLPPPTSAqptapppPPGPPPPSLPLGgsvapggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRS--TESFALPP 2902

                         250       260       270
                  ....*....|....*....|....*....|..
gi 27769331   686 tgDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 717
Cdd:PHA03247 2903 --DQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-708 4.57e-10

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 62.86  E-value: 4.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVP---PTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 628
Cdd:NF033839 286 EPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPEV 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  629 PPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPV 705
Cdd:NF033839 366 KPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQ 445


                 ...
gi 27769331  706 PPT 708
Cdd:NF033839 446 PEK 448
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 566-712 1.61e-09

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 60.94  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  566 GDSEATPVPPTGDSETAPVP---PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 642
Cdd:NF033839 278 GLTQDTPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQ 357

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331  643 GDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVP--PTDDSK 712
Cdd:NF033839 358 PEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPekPKPEVK 432
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-708 3.64e-09

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 59.78  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPptgdsEATPVPPTGDSEtapVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:NF033839 319 PEVKPQLEKPKP-----EVKPQPEKPKPE---VKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQ 390

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:NF033839 391 PEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEK 470
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-715 2.01e-08

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 57.47  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVP---PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 628
Cdd:NF033839 341 PEVKPQLETPKPEVKPQPEKPKPevkPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  629 PPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:NF033839 421 KPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPSTPN 500


                 ....*..
gi 27769331  709 DDSKEAQ 715
Cdd:NF033839 501 NLSKDKQ 507
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 560-695 7.76e-08

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 54.77  E-value: 7.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  560 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 639
Cdd:NF040712 200 ATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGE 279

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331  640 PPTGD--AGPPPVPPTGDSGAPPVPPTGDSGAPPVTPtgdSETAPVPPTGDSGAPPVP 695
Cdd:NF040712 280 PPAPGaaETPEAAEPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
568-712 1.37e-07

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 54.76  E-value: 1.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 568 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 647
Cdd:COG3469  70 AATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTT 149

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331 648 PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 712
Cdd:COG3469 150 TTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 568-718 2.46e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 53.23  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  568 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDAG 646
Cdd:NF040712 188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPA 267

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331  647 PPPVPPTGDSGAPPVPPTGDSGAPPVTPtgdsETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:NF040712 268 AEPDEATRDAGEPPAPGAAETPEAAEPP----APAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVPS 335
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 558-710 3.66e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 52.85  E-value: 3.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  558 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGA 636
Cdd:NF040712 189 DPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPAA 268

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331  637 PPVPPTGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSETAPVPPtgdSGAPPVPPTGDSEAAPVPPTDD 710
Cdd:NF040712 269 EPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVPSWDD 338
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 554-677 2.01e-06

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 50.54  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  554 VTDQEATPVPPTGDSEATPVPPTGDSETAPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPT 631
Cdd:NF040712 217 VEPAPAAEGAPATDSDPAEAGTPDDLASARRrrAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPP 295

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPtgdsGAPPVPPTGDSGAPPVTPTGD 677
Cdd:NF040712 296 APAPAAPAAPAAPEAEEPARP----EPPPAPKPKRRRRRASVPSWD 337
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 550-662 5.31e-06

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 49.00  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVP 629
Cdd:NF040712 226 APATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAA 304

                         90       100       110
                 ....*....|....*....|....*....|...
gi 27769331  630 PTGDSGAPPVPPtgdAGPPPVPPTGDSGAPPVP 662
Cdd:NF040712 305 PAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 602-685 1.36e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 48.07  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  602 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvtPTGDSETA 681
Cdd:NF041121  16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP--GAALPVRV 93


                 ....
gi 27769331  682 PVPP 685
Cdd:NF041121  94 PAPP 97
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 565-664 3.02e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 47.30  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  565 TGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPptGDSGAPPVPPTGDSGAPPvpptGD 644
Cdd:NF041121  15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYP--GSLAPPPPPPPGPAGAAP----GA 87

                         90       100
                 ....*....|....*....|
gi 27769331  645 AGPPPVPptgdsgAPPVPPT 664
Cdd:NF041121  88 ALPVRVP------APPALPN 101
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 609-707 1.70e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.61  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  609 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPvPPTGDSGAPPVPPtgdsgappvtptgdsETAPVPPTGD 688
Cdd:NF041121  15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPG---------------SLAPPPPPPP 78

                         90
                 ....*....|....*....
gi 27769331  689 SGAPPVPPTGDSEAAPVPP 707
Cdd:NF041121  79 GPAGAAPGAALPVRVPAPP 97
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 613-696 1.79e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.61  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  613 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 692
Cdd:NF041121  16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94


                 ....
gi 27769331  693 PVPP 696
Cdd:NF041121  95 APPA 98
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 592-719 2.32e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 43.99  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  592 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPP 671
Cdd:NF040712 193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS-----DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPA 267

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 27769331  672 VTPTGDSETAPVPPtgdsgAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:NF040712 268 AEPDEATRDAGEPP-----APGAAETPEAAEPPAPAPAAPAAPAAPEA 310
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 559-651 1.03e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 42.30  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  559 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPvPPTGDSGAPPVPptGDSGAPPVPPTGDSGAPPvpptGDSGAPP 638
Cdd:NF041121  20 APPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYP--GSLAPPPPPPPGPAGAAP----GAALPVR 92

                         90
                 ....*....|...
gi 27769331  639 VPptgdaGPPPVP 651
Cdd:NF041121  93 VP-----APPALP 100
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 588-703 1.26e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.98  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   588 GDSGAPPVPPTG----DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGdSGAPPVPP 663
Cdd:TIGR01645 325 GPRAQSPATPSSslptDIGNKAVVSSAKKEAEEVPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSLVAPPG-LVAPTEIN 403

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 27769331   664 TGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAA 703
Cdd:TIGR01645 404 PSFLASPRKKMKREKLPVTFGALDDTLAWKEPSKEDQTSE 443
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 603-721 2.37e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.91  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  603 APPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgAPPVPPTGDAGPPPVPPTGD--SGAPPVPPTGDSGAPPVTPTGDSET 680
Cdd:NF040712 193 GRPLRPLATVPRLAREPADARPEEVEPAP----AAEGAPATDSDPAEAGTPDDlaSARRRRAGVEQPEDEPVGPGAAPAA 268

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 27769331  681 APVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 721
Cdd:NF040712 269 EPDEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAPAAPE 309
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 644-718 3.38e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 3.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331   644 DAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PRK12270   35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPA 109
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 544-642 5.10e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.99  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  544 WTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDS--ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDsgaPPVPPTG 621
Cdd:NF041121  10 WLAAQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPspPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPG---PAGAAPG 86

                         90       100
                 ....*....|....*....|.
gi 27769331  622 DSGAPPVPptgdsgAPPVPPT 642
Cdd:NF041121  87 AALPVRVP------APPALPN 101
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 592-708 7.38e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 39.47  E-value: 7.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 592 APPVPPTGDSGAPPVPPTGDsgappVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSgAPPVPPTGDSGAPP 671
Cdd:cd23959 133 AQVAPPKAEPQTAPVTPFGQ-----LPMFGQHPPPAKPLPAAAAAQQSSASPGEVASPFASGTVS-ASPFATATDTAPSS 206

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 27769331 672 VTPTGDSE--TAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:cd23959 207 GAPDGFPAeaSAPSPFAAPASAASFPAAPVANGEAATPT 245
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 674-717 8.45e-03

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 36.24  E-value: 8.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 27769331   674 PTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 717
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPAD 44
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
29-544 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 621.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331    29 VYTEGGFVEGVNKKLGLlGDSVDIFKGIPFAAPTKAL---ENPQPHPGWQGTLKAKNFKKRCLQATITQDSTY----GDE 101
Cdd:pfam00135   5 VTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGElrfQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSsgleGSE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   102 DCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL 181
Cdd:pfam00135  84 DCLYLNVYTPKELKENKNKLPVMVWIHGGGFMFGSGS--------LYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDEA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   182 PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAK 261
Cdd:pfam00135 156 PGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQRAK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   262 KVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYIAGT 339
Cdd:pfam00135 236 ELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL---LVYGSVPFVPFGPVVDGDFLPEHPEELLKsgNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   340 NNMDGHIFASIDMPAINKGNKKVTED-FYKLVSEFTITKGL---RGAKTTFDVYTEsWAQDPSQENKKKTVVDFETDVLF 415
Cdd:pfam00135 313 TKDEGLLFAAYILDNVDILKALEEKLlRSLLIDLLYLLLVDlpeEISAALREEYLD-WGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   416 LVPTEIALAQHRanAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAK 495
Cdd:pfam00135 392 NCPVIRFADLHA--SRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 27769331   496 TGDPNMGdsAVPTHWEPYTTENSGYLEITKKMgssSMKRSLRTNFLRYW 544
Cdd:pfam00135 470 TGNPNGP--EGLPKWPPYTDENGQYLSIDLEP---RVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 28-534 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 577.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  28 AVYTEGGFVEGVNKklgllgDSVDIFKGIPFAAPT---KALENPQPHPGWQGTLKAKNFKKRCLQATITQDS-----TYG 99
Cdd:cd00312   1 LVVTPNGKVRGVDE------GGVYSFLGIPYAEPPvgdLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGlwnakLPG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 100 DEDCLYLNIWVPQGRKqVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRG-NVIVVTFNYRVGPLGFLSTGD 178
Cdd:cd00312  75 SEDCLYLNVYTPKNTK-PGNSLPVMVWIHGGGFMFGSGS--------LYPGDGLAREGdNVIVVSINYRLGVLGFLSTGD 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 179 ANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLF 258
Cdd:cd00312 146 IELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 259 WAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYI 336
Cdd:cd00312 226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKL---LLFSYSPFLPFGPVVDGDFIPDDPEELIKegKFAKVPLI 302

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 337 AGTNNMDGHIFASIDMPAINKGNKKVTEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQdpsQENKKKTVVDFETDVLFL 416
Cdd:cd00312 303 IGVTKDEGGYFAAMLLNFDAKLIIETNDRWLELLPYLLFYADDALADKVLEKYPGDVDD---SVESRKNLSDMLTDLLFK 379

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 417 VPTEIALAQHRANAKSaKTYAYLFSHPSRMPV--YPKWVGADHADDIQYVFGKPFATPTGYrPQDRTVSKAMIAYWTNFA 494
Cdd:cd00312 380 CPARYFLAQHRKAGGS-PVYAYVFDHRSSLSVgrWPPWLGTVHGDEIFFVFGNPLLKEGLR-EEEEKLSRTMMKYWANFA 457

                       490       500       510       520
                ....*....|....*....|....*....|....*....|
gi 27769331 495 KTGDPNMGDsaVPTHWEPYTTENSGYLEITkkMGSSSMKR 534
Cdd:cd00312 458 KTGNPNTEG--NLVVWPAYTSESEKYLDIN--IEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
29-523 1.83e-128

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 390.40  E-value: 1.83e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  29 VYTEGGFVEGVnkklglLGDSVDIFKGIPFAAPT------KAlenPQPHPGWQGTLKAKNFKKRCLQATITQD---STYG 99
Cdd:COG2272  15 VRTEAGRVRGV------VEGGVRVFLGIPYAAPPvgelrwRA---PQPVEPWTGVRDATEFGPACPQPPRPGDpggPAPG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 100 DEDCLYLNIWVPqgRKQVSRDLPVMIWIYGGAFLMGSGHGAnflnnyLYDGEEIATRGnVIVVTFNYRVGPLGF-----L 174
Cdd:COG2272  86 SEDCLYLNVWTP--ALAAGAKLPVMVWIHGGGFVSGSGSEP------LYDGAALARRG-VVVVTINYRLGALGFlalpaL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 175 STGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVAL---SPWV 251
Cdd:COG2272 157 SGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLsvlTLAE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 252 IQKnplfWAKKVAEKVGCPVGDAArmaqCLKVTDPRALTLAYKVPLAGLEYPMlhyvGFVPVIDGDFIPADPINLYAN-- 329
Cdd:COG2272 237 AEA----VGAAFAAALGVAPATLA----ALRALPAEELLAAQAALAAEGPGGL----PFGPVVDGDVLPEDPLEAFAAgr 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 330 AADIDYIAGTNNMDGHIFASIDMPAinkgnKKVTEDFYKlvseftitkglRGAKTTFDVYTESWAQDPSQENKKKTVVDF 409
Cdd:COG2272 305 AADVPLLIGTNRDEGRLFAALLGDL-----GPLTAADYR-----------AALRRRFGDDADEVLAAYPAASPAEALAAL 368

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 410 ETDVLFLVPTeIALAQHRAnAKSAKTYAYLFSHPSRMPVYPKWvGADHADDIQYVFGKPFA-TPTGYRPQDRTVSKAMIA 488
Cdd:COG2272 369 ATDRVFRCPA-RRLAEAHA-AAGAPVYLYRFDWRSPPLRGFGL-GAFHGAELPFVFGNLDApALTGLTPADRALSDQMQA 445

                       490       500       510
                ....*....|....*....|....*....|....*
gi 27769331 489 YWTNFAKTGDPNMGDsavPTHWEPYTTENSGYLEI 523
Cdd:COG2272 446 YWVNFARTGDPNGPG---LPEWPAYDPEDRAVMVF 477
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 586-678 4.99e-23

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 93.64  E-value: 4.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   586 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTG 665
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 27769331   666 DSGAPPVTPTGDS 678
Cdd:pfam16058  81 SITEPPRDPSGSY 93
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 575-668 1.60e-22

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 92.48  E-value: 1.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   575 PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTG 654
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 27769331   655 DSGAPPVPPTGDSG 668
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 608-700 4.20e-22

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 91.33  E-value: 4.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   608 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTG 687
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 27769331   688 DSGAPPVPPTGDS 700
Cdd:pfam16058  81 SITEPPRDPSGSY 93
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 597-690 1.04e-21

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 90.17  E-value: 1.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   597 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTG 676
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 27769331   677 DSETAPVPPTGDSG 690
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 564-657 9.08e-21

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 87.48  E-value: 9.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   564 PTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 643
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 27769331   644 DAGPPPVPPTGDSG 657
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 619-711 1.10e-19

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 84.39  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   619 PTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTG 698
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 27769331   699 DSEAAPVPPTDDS 711
Cdd:pfam16058  81 SITEPPRDPSGSY 93
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 555-646 8.31e-18

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 79.00  E-value: 8.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   555 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDS 634
Cdd:pfam16058   3 SSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSSSI 82

                          90
                  ....*....|..
gi 27769331   635 GAPPVPPTGDAG 646
Cdd:pfam16058  83 TEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 630-715 6.05e-17

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 76.31  E-value: 6.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   630 PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTD 709
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80


                  ....*.
gi 27769331   710 DSKEAQ 715
Cdd:pfam16058  81 SITEPP 86
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 552-718 7.34e-17

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 85.04  E-value: 7.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:PRK07764 615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPA 694

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  632 GDSGAPPVPpTGDAGPPPVPPTGDSGAPPVPPTGDSGAP-------PVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAP 704
Cdd:PRK07764 695 GAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSpaaddpvPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773

                        170
                 ....*....|....
gi 27769331  705 VPPTDDSKEAQMPA 718
Cdd:PRK07764 774 PPPSPPSEEEEMAE 787
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
108-249 6.13e-15

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 74.14  E-value: 6.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 108 IWVPQGRKqvsRDLPVMIWIYGGAFLMGSGHGANFLnnylydGEEIATRGNVIVVTFNYRVGPlgflstgDANLPGnyGL 187
Cdd:COG0657   3 VYRPAGAK---GPLPVVVYFHGGGWVSGSKDTHDPL------ARRLAARAGAAVVSVDYRLAP-------EHPFPA--AL 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331 188 RDQHMAIAWVKRNIAAFGGDPNNITLFGESAGG--ASVSLQTLSPYNKGLIRRAISQSGV---ALSP 249
Cdd:COG0657  65 EDAYAALRWLRANAAELGIDPDRIAVAGDSAGGhlAAALALRARDRGGPRPAAQVLIYPVldlTASP 131
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 552-635 8.03e-15

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 70.53  E-value: 8.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:pfam16058  11 DPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSSSITEPPRDPS 90


                  ....
gi 27769331   632 GDSG 635
Cdd:pfam16058  91 GSYT 94
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 558-718 5.10e-14

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 75.79  E-value: 5.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  558 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP 637
Cdd:PRK07764 599 GPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  638 PVPPTGDAGPPPVPPTGDSGAPPVP------PTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 711
Cdd:PRK07764 679 AAPPPAPAPAAPAAPAGAAPAQPAPapaatpPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP 758


                 ....*..
gi 27769331  712 KEAQMPA 718
Cdd:PRK07764 759 PPPPAPA 765
PHA03247 PHA03247
large tegument protein UL36; Provisional
 545-708 2.17e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.20  E-value: 2.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   545 TLTYLALPTvtDQEATPVP-PTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGdsgapPVPPTGDS--GAPPVPPTG 621
Cdd:PHA03247 2694 SLTSLADPP--PPPPTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-----PATPGGPArpARPPTTAGP 2766

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   622 DSGAPP-VPPTGDSGAPPVPPTGDAGP--PPVPPTGDSGAPPVPPTGDSGAPPVTPTgDSETAPVPPTGDSGAPPVPPtg 698
Cdd:PHA03247 2767 PAPAPPaAPAAGPPRRLTRPAVASLSEsrESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPTSAQPTAPPPPP-- 2843

                         170
                  ....*....|
gi 27769331   699 dseaAPVPPT 708
Cdd:PHA03247 2844 ----GPPPPS 2849
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 559-721 4.41e-13

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 72.71  E-value: 4.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  559 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPpTGDSGAPPVPPTGDSGAPP 638
Cdd:PRK07764 644 APGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAP-APAATPPAGQADDPAAQPP 722

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  639 VPPTGDAGPPP-----VPPTGDSGAPPVP-PTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 712
Cdd:PRK07764 723 QAAQGASAPSPaaddpVPLPPEPDDPPDPaGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAE 802


                 ....*....
gi 27769331  713 EAQMPAVIR 721
Cdd:PRK07764 803 EVAMELLEE 811
PHA03247 PHA03247
large tegument protein UL36; Provisional
 552-709 7.38e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 72.66  E-value: 7.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEATP-VPPTGDSEATPVPPTGDS--ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA--- 625
Cdd:PHA03247 2580 PAVTSRARRPdAPPQSARPRAPVDDRGDPrgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPapg 2659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   626 ------------------------------PPVPPTGDSGAPPVPPTGDAGPP-------PVPPTGDSGAPPVPPTGDSG 668
Cdd:PHA03247 2660 rvsrprrarrlgraaqassppqrprrraarPTVGSLTSLADPPPPPPTPEPAPhalvsatPLPPGPAAARQASPALPAAP 2739

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 27769331   669 APPVTPTGdsetaPVPPTGDSgAPPVPPTGDSEAAPVPPTD 709
Cdd:PHA03247 2740 APPAVPAG-----PATPGGPA-RPARPPTTAGPPAPAPPAA 2774
PHA03247 PHA03247
large tegument protein UL36; Provisional
 550-718 1.28e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.89  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   550 ALPTVTDQEATPVPPTGdsEATPV-------PPTGDSETAPVPPTGDSGAPP---VPPTGDSGAPPVPPTGDSGAPPVPP 619
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAG--PATPGgparparPPTTAGPPAPAPPAAPAAGPPrrlTRPAVASLSESRESLPSPWDPADPP 2808

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   620 TGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGD------------SGAPPVTPTgdseTAPVPPTG 687
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapggdvrrrppSRSPAAKPA----APARPPVR 2884

                         170       180       190
                  ....*....|....*....|....*....|.
gi 27769331   688 DSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PHA03247 2885 RLARPAVSRSTESFALPPDQPERPPQPQAPP 2915
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 553-709 1.53e-12

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 71.17  E-value: 1.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  553 TVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 632
Cdd:PRK07764 583 QVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331  633 DSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVtPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTD 709
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA-PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDP 738
PHA03247 PHA03247
large tegument protein UL36; Provisional
 561-717 3.75e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 70.35  E-value: 3.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   561 PVPPTGDSeATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGdsgAPPVPPTGdsgapPVPPTGDSgAPPVP 640
Cdd:PHA03247 2691 TVGSLTSL-ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP---APPAVPAG-----PATPGGPA-RPARP 2760

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   641 PTgDAGPP-PVPPTGDSGAPP--VPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP-PVPPTGDSEAAPVPPTDDSKEAQM 716
Cdd:PHA03247 2761 PT-TAGPPaPAPPAAPAAGPPrrLTRPAVASLSESRESLPSPWDPADPPAAVLAPaAALPPAASPAGPLPPPTSAQPTAP 2839


                  .
gi 27769331   717 P 717
Cdd:PHA03247 2840 P 2840
PHA03247 PHA03247
large tegument protein UL36; Provisional
 550-715 4.22e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 4.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   550 ALPTVTDQEATPVPPTGdseATPVPPTGDSETAPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPP 627
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLA---PAAALPPAASPAGPLPPP-TSAQPTAPPPPPGPPPPSLPLGGSVAPggDVRRRPPSRSPA 2872

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   628 VPPTgdsgAPPVPPTGDAGPPPVPPTGDSGA-----PPVPPTGDSGAPPVTPtgdsETAPVPPTgDSGAPPVPPTGDSEA 702
Cdd:PHA03247 2873 AKPA----APARPPVRRLARPAVSRSTESFAlppdqPERPPQPQAPPPPQPQ----PQPPPPPQ-PQPPPPPPPRPQPPL 2943

                         170
                  ....*....|...
gi 27769331   703 APVPPTDDSKEAQ 715
Cdd:PHA03247 2944 APTTDPAGAGEPS 2956
PHA03247 PHA03247
large tegument protein UL36; Provisional
 549-718 4.26e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.97  E-value: 4.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   549 LALPTVTDQEatpVPPTGDSEATPVPPTGDSETAP-VPPTGDSGAPPVPPTGDS--GAPPVPPTGDSGAPPVPPTGDSGA 625
Cdd:PHA03247 2558 AAPPAAPDRS---VPPPRPAPRPSEPAVTSRARRPdAPPQSARPRAPVDDRGDPrgPAPPSPLPPDTHAPDPPPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   626 PPVPPTGDSGAPPVPPTGDAGPPP------------VPPTGDSgAPPVPPTGDSGAPPVTPTGDSETAPVPPTgdsgAPP 693
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPgrvsrprrarrlGRAAQAS-SPPQRPRRRAARPTVGSLTSLADPPPPPP----TPE 2709

                         170       180
                  ....*....|....*....|....*
gi 27769331   694 VPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPA 2734
PHA03247 PHA03247
large tegument protein UL36; Provisional
 550-719 8.69e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.20  E-value: 8.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSET-----APVPPTGD--SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD 622
Cdd:PHA03247 2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPslplgGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE 2896

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   623 SGA-----PPVPPTGDSGAPPVP------PTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGA 691
Cdd:PHA03247 2897 SFAlppdqPERPPQPQAPPPPQPqpqpppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR 2976

                         170       180
                  ....*....|....*....|....*...
gi 27769331   692 PPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:PHA03247 2977 FRVPQPAPSREAPASSTPPLTGHSLSRV 3004
PHA03247 PHA03247
large tegument protein UL36; Provisional
 559-717 1.69e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 1.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   559 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptGDSGAPPVPptgdsgAPPVPPTGDSgAPPVPPTGDSGAPP 638
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP--AAPAPPAVP------AGPATPGGPA-RPARPPTTAGPPAP 2769

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   639 VPPTGDAGPPP---VPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQ 715
Cdd:PHA03247 2770 APPAAPAAGPPrrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS 2849


                  ..
gi 27769331   716 MP 717
Cdd:PHA03247 2850 LP 2851
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-717 2.30e-11

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 67.10  E-value: 2.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:NF033839 303 PQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPK---PEVKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQ 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:NF033839 380 PETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPET 459


                 ....*....
gi 27769331  709 DDSKEAQMP 717
Cdd:NF033839 460 PKPEVKPQP 468
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 106-235 3.97e-11

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 63.35  E-value: 3.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   106 LNIWVPQGRKqvsRDLPVMIWIYGGAFLMGSGHGANFLNNYLydGEEIATRGNViVVTFNYRvgplgflSTGDANLPGNy 185
Cdd:pfam20434   1 LDIYLPKNAK---GPYPVVIWIHGGGWNSGDKEADMGFMTNT--VKALLKAGYA-VASINYR-------LSTDAKFPAQ- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 27769331   186 gLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGL 235
Cdd:pfam20434  67 -IQDVKAAIRFLRANAAKYGIDTNKIALMGFSAGGHLALLAGLSNNNKEF 115
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 560-717 4.45e-11

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 65.95  E-value: 4.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  560 TPVPPTGDSEATPVP---PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 636
Cdd:NF033839 283 TPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPK 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  637 PPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKE 713
Cdd:NF033839 363 PEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV 442


                 ....
gi 27769331  714 AQMP 717
Cdd:NF033839 443 KPQP 446
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
546-718 4.69e-11

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 66.05  E-value: 4.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  546 LTYLAL-PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTGDSG 624
Cdd:PRK12323 358 LRMLAFrPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA--AAAAARAVAAAPARRSPAPEALAA 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  625 APPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAP--VPPTGD-SGAPPVPPTGDSE 701
Cdd:PRK12323 436 ARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADddPPPWEElPPEFASPAPAQPD 515

                        170       180
                 ....*....|....*....|....*....
gi 27769331  702 AAPVP------------PTDDSKEAQMPA 718
Cdd:PRK12323 516 AAPAGwvaesipdpataDPDDAFETLAPA 544
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 557-712 5.49e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 66.35  E-value: 5.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   557 QEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 635
Cdd:PHA03307  171 QAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRsSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG 250

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331   636 APPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSG-APPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 712
Cdd:PHA03307  251 PENECPLPRPAPITLPTRIWEASGWNGPSSRPGpASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS 328
PHA03247 PHA03247
large tegument protein UL36; Provisional
 467-717 6.51e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.12  E-value: 6.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   467 KPFATPTGYRPQdrtVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTnflrywTL 546
Cdd:PHA03247 2675 QASSPPQRPRRR---AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA------VP 2745

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   547 TYLALPTVTDQEATPVPPTGDSEATP--VPPTGDSETAPVPPtGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 624
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAGPPAPAPpaAPAAGPPRRLTRPA-VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   625 APPVPPTGDS-------GAPPVPPTGDAG------------PPPVPPTGDSGAPPVPPTGDSGAPPVTPTgdSETAPVPP 685
Cdd:PHA03247 2825 AGPLPPPTSAqptapppPPGPPPPSLPLGgsvapggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRS--TESFALPP 2902

                         250       260       270
                  ....*....|....*....|....*....|..
gi 27769331   686 tgDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 717
Cdd:PHA03247 2903 --DQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 549-710 1.46e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 64.62  E-value: 1.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  549 LALPTVTDQEATpVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptgdsGAPPVPPTGDSGAPPVPPtgdsGAPPV 628
Cdd:PRK07764 362 MLLPSASDDERG-LLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAA-----APAPAAAAPAAAAAPAPA----AAPQP 431

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  629 PPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPtgdSEAAPVPPT 708
Cdd:PRK07764 432 APAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP-APAAAPEPTAAPAPAPPAAPAPAAAPAAPA---APAAPAGAD 507


                 ..
gi 27769331  709 DD 710
Cdd:PRK07764 508 DA 509
PHA03169 PHA03169
hypothetical protein; Provisional
 563-708 4.48e-10

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 62.30  E-value: 4.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  563 PPTGDSEATPV-----PPTGDSETAPVPPTGDSGaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGappvPPTGDSGAP 637
Cdd:PHA03169 103 PTPSPSGSAEElasglSPENTSGSSPESPASHSP-PPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQ----PSHEDSPEE 177

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331  638 PVPPTG----DAGPPPVPPTGDSGAPPVPPtGDSGAPPVTPTGDSetAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:PHA03169 178 PEPPTSepepDSPGPPQSETPTSSPPPQSP-PDEPGEPQSPTPQQ--APSPNTQQAVEHEDEPTEPEREGPPFPG 249
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-708 4.57e-10

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 62.86  E-value: 4.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVP---PTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 628
Cdd:NF033839 286 EPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPEV 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  629 PPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPV 705
Cdd:NF033839 366 KPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQ 445


                 ...
gi 27769331  706 PPT 708
Cdd:NF033839 446 PEK 448
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 552-707 5.00e-10

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 63.25  E-value: 5.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEATPVPPTGdseATPVPPTGDSETAPVPPTGDSGAPPV----------PPTGDSGAPPVPPTgdsgAPPVPPTG 621
Cdd:pfam03154 188 PPGTTQAATAGPTPS---APSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhPQRLPSPHPPLQPM----TQPPPPSQ 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   622 DSGAPPVPPTGDSGAPPVPPTGDAGPP----PVPPTGdsgAPPVPPTGDSGAPP----VTPTGDSETAPVPPTGDSGAPP 693
Cdd:pfam03154 261 VSPQPLPQPSLHGQMPPMPHSLQTGPShmqhPVPPQP---FPLTPQSSQSQVPPgpspAAPGQSQQRIHTPPSQSQLQSQ 337

                         170
                  ....*....|....
gi 27769331   694 VPPtgdsEAAPVPP 707
Cdd:pfam03154 338 QPP----REQPLPP 347
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 564-706 8.89e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 62.04  E-value: 8.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  564 PTGDSEATPVPPtgdSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtg 643
Cdd:PRK14951 366 PAAAAEAAAPAE---KKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAA-- 440

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331  644 daGPPPVPPtgdSGAPPVPPTGDSGAPP--VTPTGDSETAPVPPTGDSGAPPVPPT--GDSEAAPVP 706
Cdd:PRK14951 441 --APAAVAL---APAPPAQAAPETVAIPvrVAPEPAVASAAPAPAAAPAAARLTPTeeGDVWHATVQ 502
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 577-710 9.77e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 61.65  E-value: 9.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  577 GDSETAPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDS 656
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAA--PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAA 444

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27769331  657 GAPPVPPTGDSGAPPVTPTGDSETAPVPPTgdsgaPPVPPTGDSEAAPVPPTDD 710
Cdd:PRK14951 445 VALAPAPPAQAAPETVAIPVRVAPEPAVAS-----AAPAPAAAPAAARLTPTEE 493
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 555-718 1.03e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 62.11  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   555 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGapPVPPTGDSGAPPvPPTGDSGAPPVPPtgds 634
Cdd:PHA03307   58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGS--PTPPGPSSPDPP-PPTPPPASPPPSP---- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   635 gAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPP----TGDSGAPPVPPTGDSEAAPVPPTDD 710
Cdd:PHA03307  131 -APDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEetarAPSSPPAEPPPSTPPAAASPRPPRR 209


                  ....*...
gi 27769331   711 SKEAQMPA 718
Cdd:PHA03307  210 SSPISASA 217
PHA03247 PHA03247
large tegument protein UL36; Provisional
 557-721 1.20e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.26  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   557 QEATPVPPTGdseaTPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPpVPP-------------TGDSG--APPVPPTG 621
Cdd:PHA03247 2485 EARFPFAAGA----APDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEP-VHPrmltwirgleelaSDDAGdpPPPLPPAA 2559

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   622 DSGAP--PVPPTGDSGAPPVPP-TGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTG 698
Cdd:PHA03247 2560 PPAAPdrSVPPPRPAPRPSEPAvTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD 2639

                         170       180
                  ....*....|....*....|...
gi 27769331   699 DSEAAPVPPTDDSKEAQMPAVIR 721
Cdd:PHA03247 2640 PHPPPTVPPPERPRDDPAPGRVS 2662
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 562-707 1.44e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 61.73  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   562 VPPTGDSEATPVPPTGDSETAPVPPTG-DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGappvPPTGDSGAPPVP 640
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFEPPTGpPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPT----PPGPSSPDPPPP 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   641 PTGDAGPPPVPPTGDSGAPPVPPT---GDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:PHA03307  120 TPPPASPPPSPAPDLSEMLRPVGSpgpPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSP 189
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 563-711 1.49e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 61.73  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   563 PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG-APPVPP 641
Cdd:PHA03307  211 SPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGpASSSSS 290

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   642 TGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 711
Cdd:PHA03307  291 PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPA 360
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 566-712 1.61e-09

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 60.94  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  566 GDSEATPVPPTGDSETAPVP---PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 642
Cdd:NF033839 278 GLTQDTPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQ 357

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331  643 GDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVP--PTDDSK 712
Cdd:NF033839 358 PEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPekPKPEVK 432
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 569-678 2.30e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 60.59  E-value: 2.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  569 EATPVPPTGdseTAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPTGDSGAPPVPPtgdagPP 648
Cdd:PRK14950 357 EALLVPVPA---PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPPRPVAPPVPH-----TP 425

                         90       100       110
                 ....*....|....*....|....*....|
gi 27769331  649 PVPPTGDSGAPPVPPTGDSGAPPVTPTGDS 678
Cdd:PRK14950 426 ESAPKLTRAAIPVDEKPKYTPPAPPKEEEK 455
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 545-669 2.30e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 60.59  E-value: 2.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  545 TLTYLALP---TVTDQEATPVPPtgdseATPVPPTGDSETAPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPTG 621
Cdd:PRK14950 343 TTSYGQLPlelAVIEALLVPVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPP 414

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 27769331  622 DSGAPPVPPTgdsgaPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGA 669
Cdd:PRK14950 415 RPVAPPVPHT-----PESAPKLTRAAIPVDEKPKYTPPAPPKEEEKAL 457
PHA03247 PHA03247
large tegument protein UL36; Provisional
 556-719 2.83e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.72  E-value: 2.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   556 DQEATPVPPTGDSEATPVPPTGDsetaPVPP-------------TGDSG--APPVPPTGDSGAP--PVPPTGDSGAPPVP 618
Cdd:PHA03247 2505 DPDAPPAPSRLAPAILPDEPVGE----PVHPrmltwirgleelaSDDAGdpPPPLPPAAPPAAPdrSVPPPRPAPRPSEP 2580

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   619 PTGDSGA-PPVPPTGDSGAPPVPPTGD--AGPPPVPPTGDSGAPPVPPTgdSGAPPVTPTGDSETAPVPPTGDSGAPPVP 695
Cdd:PHA03247 2581 AVTSRARrPDAPPQSARPRAPVDDRGDprGPAPPSPLPPDTHAPDPPPP--SPSPAANEPDPHPPPTVPPPERPRDDPAP 2658

                         170       180       190
                  ....*....|....*....|....*....|....
gi 27769331   696 P----------TGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:PHA03247 2659 GrvsrprrarrLGRAAQASSPPQRPRRRAARPTV 2692
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-708 3.64e-09

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 59.78  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPptgdsEATPVPPTGDSEtapVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:NF033839 319 PEVKPQLEKPKP-----EVKPQPEKPKPE---VKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQ 390

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:NF033839 391 PEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEK 470
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 546-684 4.77e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 59.73  E-value: 4.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  546 LTYLALPTVTDQEATPVPPTgdseATPVPPT-GDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 624
Cdd:PRK14951 359 LRLLAFKPAAAAEAAAPAEK----KTPARPEaAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAP 434

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331  625 APPVPPTGDSGAPPVPPTGDAGPPPV--------PPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVP 684
Cdd:PRK14951 435 AAAPAAAPAAVALAPAPPAQAAPETVaipvrvapEPAVASAAPAPAAAPAAARLTPTEEGDVWHATVQ 502
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 586-708 4.90e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 59.73  E-value: 4.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  586 PTGDSGAPPVPPTgdsgAPPVPPTGDSGAP-PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPT 664
Cdd:PRK14951 366 PAAAAEAAAPAEK----KTPARPEAAAPAAaPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAA 441

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27769331  665 GDSGAPPVTPTGD--SETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:PRK14951 442 PAAVALAPAPPAQaaPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 549-711 5.25e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 59.80  E-value: 5.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   549 LALPTVTDQEATPVPPTGDSEA---TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG- 624
Cdd:PHA03307  172 AALPLSSPEETARAPSSPPAEPppsTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGp 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   625 --APPVPPTGDSGAPPVPPTG------DAGPPPVPP---TGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPP 693
Cdd:PHA03307  252 enECPLPRPAPITLPTRIWEAsgwngpSSRPGPASSsssPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS 331

                         170
                  ....*....|....*...
gi 27769331   694 VPPTGDSEAAPVPPTDDS 711
Cdd:PHA03307  332 SSESSRGAAVSPGPSPSR 349
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 124-288 6.34e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 56.45  E-value: 6.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   124 MIWIYGGAFLMGSghgANFLNNYLydgEEIATRGNVIVVTFNYRVGPlgflstgDANLPGnyGLRDQHMAIAWVKRNIAA 203
Cdd:pfam07859   1 LVYFHGGGFVLGS---ADTHDRLC---RRLAAEAGAVVVSVDYRLAP-------EHPFPA--AYDDAYAALRWLAEQAAE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   204 FGGDPNNITLFGESAGG---ASVSLQTLspyNKGLIR-RAIsqsgVALSPWV--IQKNPLFWAKKVAEKvgcPVGDAARM 277
Cdd:pfam07859  66 LGADPSRIAVAGDSAGGnlaAAVALRAR---DEGLPKpAGQ----VLIYPGTdlRTESPSYLAREFADG---PLLTRAAM 135

                         170
                  ....*....|....*...
gi 27769331   278 AQCLK-------VTDPRA 288
Cdd:pfam07859 136 DWFWRlylpgadRDDPLA 153
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
550-719 7.34e-09

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 59.12  E-value: 7.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPvPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVP 629
Cdd:PRK12323 395 AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP-APEALAAARQASARGPGGAPAPAPA--PAAAPAAAARPAAAGPRP 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  630 PTGDSGAPPVPPTGDAGPPP----VPPTGD-SGAPPVPPTGDSGAPPvtPTGDSETAPVPPTGDSGAPPVPPTGDSEAAP 704
Cdd:PRK12323 472 VAAAAAAAPARAAPAAAPAPadddPPPWEElPPEFASPAPAQPDAAP--AGWVAESIPDPATADPDDAFETLAPAPAAAP 549

                        170
                 ....*....|....*
gi 27769331  705 VPPTDDSKEAQMPAV 719
Cdd:PRK12323 550 APRAAAATEPVVAPR 564
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 550-683 7.39e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 59.23  E-value: 7.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  550 ALPTVTDQEATPVPPTGDSEATPVPpTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGAPPVP 629
Cdd:PRK07764 679 AAPPPAPAPAAPAAPAGAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSPAA----DDPVPLPPEPDDPPDPAG 753

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27769331  630 PTGDSGAPPVPPTGDAGPPPvPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPV 683
Cdd:PRK07764 754 APAQPPPPPAPAPAAAPAAA-PPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAM 806
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 594-703 7.42e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 59.05  E-value: 7.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  594 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDAGPPPVPPTgDSGAPPVPPTgdsgaPPVT 673
Cdd:PRK14950 362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRETATPPPVPP-RPVAPPVPHT-----PESA 428

                         90       100       110
                 ....*....|....*....|....*....|
gi 27769331  674 PTGDSETAPVPPTGDSGAPPVPPTGDSEAA 703
Cdd:PRK14950 429 PKLTRAAIPVDEKPKYTPPAPPKEEEKALI 458
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 570-721 9.88e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 58.84  E-value: 9.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  570 ATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 649
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331  650 VPPtgdsGAPPVPPTGDSGAPPvtptgdsETAPVPPTGDSGAPPVPPtgdSEAAPVPPTDDSKEAQMPAVIR 721
Cdd:PRK07764 669 WPA----KAGGAAPAAPPPAPA-------PAAPAAPAGAAPAQPAPA---PAATPPAGQADDPAAQPPQAAQ 726
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 552-681 1.22e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 58.46  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTG-DSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 630
Cdd:PRK07764 387 VAGGAGAPAAAAPSAaAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQP 466

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 27769331  631 tgdsgAPPVPPTGDAGPPPVPPTGDSGAPPVPPtgDSGAPPVTPTGDSETA 681
Cdd:PRK07764 467 -----APAPAAAPEPTAAPAPAPPAAPAPAAAP--AAPAAPAAPAGADDAA 510
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 601-719 1.49e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 58.07  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  601 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSET 680
Cdd:PRK07764 383 RRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAP--APAPAPPSPAGNAPAGGAPSPPPAA 460

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 27769331  681 APVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:PRK07764 461 APSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
559-714 1.53e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 58.32  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  559 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDS------GAPPVPP 630
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAaaATRAEAPPAAPAPPATADRgddaadGDAPVPA 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  631 TGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDD 710
Cdd:PRK07003 452 KANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPE 531


                 ....
gi 27769331  711 SKEA 714
Cdd:PRK07003 532 ARPP 535
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 561-708 1.93e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   561 PVPPTGDSEATPVPPTGDSETAPVPPTGDSG---APPVPPTGDSGAPPVPptgDSGAPPVPPTGDSG-APPVPPTGDSGA 636
Cdd:PHA03307  220 PAPAPGRSAADDAGASSSDSSSSESSGCGWGpenECPLPRPAPITLPTRI---WEASGWNGPSSRPGpASSSSSPRERSP 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331   637 PPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAppvTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:PHA03307  297 SPSPSSPGSGPAPSSPRASSSSSSSRESSSSST---SSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSP 365
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 550-711 1.98e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV- 628
Cdd:PHA03307   86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP-ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAs 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   629 -PPTGDSGAPPVPPTGDAGPPPVPPTGDSGaPPVPPTGDSGAPPVT--PTGDSETAPVPPTGDSGAPPVPPTGDSEAAPV 705
Cdd:PHA03307  165 dAASSRQAALPLSSPEETARAPSSPPAEPP-PSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSE 243


                  ....*.
gi 27769331   706 PPTDDS 711
Cdd:PHA03307  244 SSGCGW 249
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 552-715 2.01e-08

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 57.47  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVP---PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 628
Cdd:NF033839 341 PEVKPQLETPKPEVKPQPEKPKPevkPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  629 PPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:NF033839 421 KPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPSTPN 500


                 ....*..
gi 27769331  709 DDSKEAQ 715
Cdd:NF033839 501 NLSKDKQ 507
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 556-711 2.11e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 2.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   556 DQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 635
Cdd:PHA03307   81 ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP-ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASP 159

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27769331   636 APPVPPTGDAGPPPVP-PTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVP--PTGDSGAPPVPPTGDSEAAPVPPTDDS 711
Cdd:PHA03307  160 AAVASDAASSRQAALPlSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSD 238
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 586-709 2.33e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 57.38  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  586 PTGDSGAPPvpptGDSGAPPvPPTGDSGAPPVPPT-GDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDsgAPPVPPT 664
Cdd:PRK14959 373 PSGGGASAP----SGSAAEG-PASGGAATIPTPGTqGPQGTAPAAGMTPSSAAPATPAPSAAPSPRVPWDD--APPAPPR 445

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 27769331  665 gdSGAPPVTPTGDSETAPVP--PTGDSGAPPVPPTGDSEAAPVPPTD 709
Cdd:PRK14959 446 --SGIPPRPAPRMPEASPVPgaPDSVASASDAPPTLGDPSDTAEHTP 490
PHA03169 PHA03169
hypothetical protein; Provisional
 558-692 3.33e-08

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 56.52  E-value: 3.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  558 EATPVPPTGDSEAtPVPPTGDSETAPVPPTGDSGAPPVPPTG-------DSGAPPVPPTG----DSGAPPVPPTGDSGAP 626
Cdd:PHA03169 125 GSSPESPASHSPP-PSPPSHPGPHEPAPPESHNPSPNQQPSSflqpsheDSPEEPEPPTSepepDSPGPPQSETPTSSPP 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  627 PVPPtGDSGAPPVPPTGDAGPPpvPPTGDSGAPPVPPTGDS--GAPPVTPTGDSET--APVPPTGDSGAP 692
Cdd:PHA03169 204 PQSP-PDEPGEPQSPTPQQAPS--PNTQQAVEHEDEPTEPEreGPPFPGHRSHSYTvvGWKPSTRPGGVP 270
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 582-685 3.59e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 56.74  E-value: 3.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  582 APVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtgdsgaPPV 661
Cdd:PRK14950 361 VPVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRETATPPPVPPRPVAPPVPHT------PES 427

                         90       100
                 ....*....|....*....|....
gi 27769331  662 PPTGDSGAPPVtPTGDSETAPVPP 685
Cdd:PRK14950 428 APKLTRAAIPV-DEKPKYTPPAPP 450
PHA03169 PHA03169
hypothetical protein; Provisional
 575-713 3.70e-08

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 56.13  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  575 PTGD-SETAPVPPTGDSGAPPV-----PPTGDSGAPPVPPTGDSGaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP- 647
Cdd:PHA03169  92 PSGSgSESVGSPTPSPSGSAEElasglSPENTSGSSPESPASHSP-PPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPs 170

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27769331  648 ------PPVPPTG----DSGAPPVPPTGDSGAPPVTPtGDSETAPVPPTGDSGapPVPPTGDSEAAPVPPTDDSKE 713
Cdd:PHA03169 171 hedspeEPEPPTSepepDSPGPPQSETPTSSPPPQSP-PDEPGEPQSPTPQQA--PSPNTQQAVEHEDEPTEPERE 243
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 552-717 4.75e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.70  E-value: 4.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEATPVPPtgdseatPVPPTGDSETAPVPPTgdSGAPPVPPtgdSGAPPVPPTGDSGAPPVPP-----TGDSGAP 626
Cdd:pfam03154 172 PVLQAQSGAASPP-------SPPPPGTTQAATAGPT--PSAPSVPP---QGSPATSQPPNQTQSTAAPhtliqQTPTLHP 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   627 PVPPTGDS---GAPPVPPTGDAGPPPVPPTGDSG-APPVPPTGDSGAPPVTPTGDSETAPVPP-TGDSGAPPVP----PT 697
Cdd:pfam03154 240 QRLPSPHPplqPMTQPPPPSQVSPQPLPQPSLHGqMPPMPHSLQTGPSHMQHPVPPQPFPLTPqSSQSQVPPGPspaaPG 319

                         170       180
                  ....*....|....*....|
gi 27769331   698 GDSEAAPVPPTDDSKEAQMP 717
Cdd:pfam03154 320 QSQQRIHTPPSQSQLQSQQP 339
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 597-718 7.31e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 55.88  E-value: 7.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  597 PTGDSGAPPVPPTgdsgAPPVPPTGDSGAP-PVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTgdSGAPPVTPT 675
Cdd:PRK14951 366 PAAAAEAAAPAEK----KTPARPEAAAPAAaPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPA--AAAPAAAPA 439

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 27769331  676 GDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PRK14951 440 AAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAA 482
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 560-695 7.76e-08

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 54.77  E-value: 7.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  560 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 639
Cdd:NF040712 200 ATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGE 279

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331  640 PPTGD--AGPPPVPPTGDSGAPPVPPTGDSGAPPVTPtgdSETAPVPPTGDSGAPPVP 695
Cdd:NF040712 280 PPAPGaaETPEAAEPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 550-708 8.36e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.95  E-value: 8.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   550 ALPTVTDQEATPVPPTGDSEATPvPPTGDSETAPVPPTGDSGAPPVPPT----------GDSGAPPVPPTGDSGAPPVPP 619
Cdd:PHA03307  264 TLPTRIWEASGWNGPSSRPGPAS-SSSSPRERSPSPSPSSPGSGPAPSSprasssssssRESSSSSTSSSSESSRGAAVS 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   620 TGDSGAPPVPPTGDSGAPPVPPTGdAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPvPPTGDSGAPPVPPTGD 699
Cdd:PHA03307  343 PGPSPSRSPSPSRPPPPADPSSPR-KRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDAT-GRFPAGRPRPSPLDAG 420


                  ....*....
gi 27769331   700 SEAAPVPPT 708
Cdd:PHA03307  421 AASGAFYAR 429
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 549-707 9.64e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.54  E-value: 9.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   549 LALPTVTDQEATPVPPTGDSEATPVPPTGdseTAPVPPtgdSGAPPVPPTGDSGAPPVPP-----TGDSGAPPVPPTGDS 623
Cdd:pfam03154 174 LQAQSGAASPPSPPPPGTTQAATAGPTPS---APSVPP---QGSPATSQPPNQTQSTAAPhtliqQTPTLHPQRLPSPHP 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   624 ---GAPPVPPTGDSGAPPVPPTGDAGP-PPVPPTGDSGAPPVP-PTGDSGAPPVTPTGDSETAPVPPTGDSG----APPV 694
Cdd:pfam03154 248 plqPMTQPPPPSQVSPQPLPQPSLHGQmPPMPHSLQTGPSHMQhPVPPQPFPLTPQSSQSQVPPGPSPAAPGqsqqRIHT 327

                         170
                  ....*....|...
gi 27769331   695 PPTGDSEAAPVPP 707
Cdd:pfam03154 328 PPSQSQLQSQQPP 340
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 549-714 1.03e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.54  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   549 LALPTVTDQEATPVPPTGDSEATPVPPtgdSETAPVPPTGDSGAPPVPPTGDSGAPPV--PPtgdSGAPP----VPPTGD 622
Cdd:pfam03154 350 LSMPHIKPPPTTPIPQLPNPQSHKHPP---HLSGPSPFQMNSNLPPPPALKPLSSLSThhPP---SAHPPplqlMPQSQQ 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   623 SGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVP--PTGDSGAPPVTPTGDSETApVPPTGDSGAPPVP----- 695
Cdd:pfam03154 424 LPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPqhPFVPGGPPPITPPSGPPTS-TSSAMPGIQPPSSasvss 502

                         170       180
                  ....*....|....*....|.
gi 27769331   696 --PTGDSEAAPVPPTDDSKEA 714
Cdd:pfam03154 503 sgPVPAAVSCPLPPVQIKEEA 523
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
568-712 1.37e-07

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 54.76  E-value: 1.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 568 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 647
Cdd:COG3469  70 AATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTT 149

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331 648 PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 712
Cdd:COG3469 150 TTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 605-720 1.60e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 54.82  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  605 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdAGPPPVPPTGDSgAPPVPPTGDSGAPPVTPTgdsetAPVP 684
Cdd:PRK14950 362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPPRPVAPPVPHT-----PESA 428

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 27769331  685 PTGDSGAPPVPPTGDSEaAPVPPTDDSKEAQMPAVI 720
Cdd:PRK14950 429 PKLTRAAIPVDEKPKYT-PPAPPKEEEKALIADGDV 463
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 572-707 1.74e-07

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 51.41  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   572 PVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPtgdsgaPPVPPTGDAGPPPVP 651
Cdd:pfam06346   3 PPPLPGDSSTIPLPPGACIPTPPPLPGGGGPPPPPPLPGSAAIPPPPPL--PGGTSIPP------PPPLPGAASIPPPPP 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27769331   652 PTGDSGAPPVPP----TGDSGAPPVTPTGDSETAPVPP-TGDSGAPPVPPTGDSEAAPVPP 707
Cdd:pfam06346  75 LPGSTGIPPPPPlpggAGIPPPPPPLPGGAGVPPPPPPlPGGPGIPPPPPFPGGPGIPPPP 135
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
554-705 1.86e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.47  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  554 VTDQEATPVPPTGDS---EATPVPPTGDSETAPVPptgdsGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 630
Cdd:PRK07003 410 LAPKAAAAAAATRAEappAAPAPPATADRGDDAAD-----GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDA 484

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331  631 TGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTgdSETAPVPPTGDSgaPPVPPTGDSEAAPV 705
Cdd:PRK07003 485 PPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPA--PEARPPTPAAAA--PAARAGGAAAALDV 555
PHA03247 PHA03247
large tegument protein UL36; Provisional
 582-699 1.92e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   582 APVPPTGDSGAPpvpptgdSGAPPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPptgdAGPPPVPPTGDSGAP 659
Cdd:PHA03247  378 ASLPTRKRRSAR-------HAATPFarGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPP----ATPLPSAEPGSDDGP 446

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 27769331   660 PVPPTGDSGAP---PVTPTGDSETAPVPPTGDSGAPPVPPTGD 699
Cdd:PHA03247  447 APPPERQPPAPatePAPDDPDDATRKALDALRERRPPEPPGAD 489
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
550-715 2.25e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.47  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTgdsGAPPVPPTGDS------GAPPVPPTGDS 623
Cdd:PRK07003 379 AVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP---AAPAPPATADRgddaadGDAPVPAKANA 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  624 GAPPVPPTGDSGA-PPVPPTGDAGPPPV--PPTGDSGAPPVPPTGDSGAPPVTptgDSETAPVPPTGDSGAPPVPPTgdS 700
Cdd:PRK07003 456 RASADSRCDERDAqPPADSGSASAPASDapPDAAFEPAPRAAAPSAATPAAVP---DARAPAAASREDAPAAAAPPA--P 530

                        170
                 ....*....|....*
gi 27769331  701 EAAPVPPTDDSKEAQ 715
Cdd:PRK07003 531 EARPPTPAAAAPAAR 545
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 568-718 2.46e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 53.23  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  568 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDAG 646
Cdd:NF040712 188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPA 267

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331  647 PPPVPPTGDSGAPPVPPTGDSGAPPVTPtgdsETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:NF040712 268 AEPDEATRDAGEPPAPGAAETPEAAEPP----APAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVPS 335
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 563-676 2.98e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 53.92  E-value: 2.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  563 PPTGdsEATPVPPTGDSETAPVPPT-GDSGAPPVPP-TGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVP 640
Cdd:PRK14959 380 APSG--SAAEGPASGGAATIPTPGTqGPQGTAPAAGmTPSSAAPATPAPSAAPSPRVPW---DDAPPAPPRSGIPPRPAP 454

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 27769331  641 PTGDAGPPPVPPTGDSGAPPVPPT-GDSGAP-PVTPTG 676
Cdd:PRK14959 455 RMPEASPVPGAPDSVASASDAPPTlGDPSDTaEHTPSG 492
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 586-719 3.25e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 53.72  E-value: 3.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  586 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPtgdAGPPPVPPTGDSGAPP--VPP 663
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPAS-----APQQAP---AVPLPETTSQLLAARQqlQRA 432

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 27769331  664 TGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:PRK07994 433 QGATKAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVE 488
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 558-710 3.66e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 52.85  E-value: 3.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  558 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGA 636
Cdd:NF040712 189 DPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPAA 268

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331  637 PPVPPTGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSETAPVPPtgdSGAPPVPPTGDSEAAPVPPTDD 710
Cdd:NF040712 269 EPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVPSWDD 338
PHA03247 PHA03247
large tegument protein UL36; Provisional
 559-655 4.01e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 4.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   559 ATPV--PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 636
Cdd:PHA03247  392 ATPFarGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPP----ATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPD 467

                          90       100
                  ....*....|....*....|..
gi 27769331   637 PPVPPTGDA---GPPPVPPTGD 655
Cdd:PHA03247  468 DATRKALDAlreRRPPEPPGAD 489
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 623-696 4.09e-07

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 52.24  E-value: 4.09e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331   623 SGAPPVPptgdsgAPPVPPTGDAGPPPVPPTGDSGAP-PVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPP 696
Cdd:pfam07174  37 AHADPEP------APPPPSTATAPPAPPPPPPAPAAPaPPPPPAAPNAPNAPPPPADPNAPPPPPADPNAPPPPA 105
PHA03247 PHA03247
large tegument protein UL36; Provisional
 570-666 4.26e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 4.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   570 ATPV--PPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 647
Cdd:PHA03247  392 ATPFarGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPP----ATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPD 467

                          90       100
                  ....*....|....*....|..
gi 27769331   648 PPVPPTGDS---GAPPVPPTGD 666
Cdd:PHA03247  468 DATRKALDAlreRRPPEPPGAD 489
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
580-719 4.31e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 53.31  E-value: 4.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  580 ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPP---PVPPTGDS 656
Cdd:PRK07003 359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPaapAPPATADR 438

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27769331  657 ------GAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:PRK07003 439 gddaadGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAV 507
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 567-709 4.91e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.64  E-value: 4.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   567 DSEATPVPPTGDSETAPVPPTGDSG------APPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGAPPV 639
Cdd:PHA03307   17 GGEFFPRPPATPGDAADDLLSGSQGqlvsdsAELAAVTVVAGAAACDRFEPPTGPPPgPGTEAPANESRSTPTWSLSTLA 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   640 PPTGDAGPPPVPPTGDSGAPPvPPTGDSGAPPvtPTGDSETAPVPPTGDSGAPpvPPTGDSEAAPVPPTD 709
Cdd:PHA03307   97 PASPAREGSPTPPGPSSPDPP-PPTPPPASPP--PSPAPDLSEMLRPVGSPGP--PPAASPPAAGASPAA 161
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
121-246 4.98e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 51.56  E-value: 4.98e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 121 LPVMIWIYGGaflmgsghGANFLNNYLYDGEEIATRGnVIVVTFNYRvgplGFlsTGDANLPGNYGLRDQHMAIAWVkrn 200
Cdd:COG1506  23 YPVVVYVHGG--------PGSRDDSFLPLAQALASRG-YAVLAPDYR----GY--GESAGDWGGDEVDDVLAAIDYL--- 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 27769331 201 IAAFGGDPNNITLFGESAGGASVSLqtLSPYNKGLIRRAISQSGVA 246
Cdd:COG1506  85 AARPYVDPDRIGIYGHSYGGYMALL--AAARHPDRFKAAVALAGVS 128
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 483-682 5.96e-07

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 52.78  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  483 SKAMIAY-WTNFAKTGDPN--MGDSAVPTHWEPYTTE----NSGYLEITKK-MGSSSMKRslrtnflrywtLTYLALPTV 554
Cdd:PLN02217 462 SKAYLGRpWKEYSRTIIMNtfIPDFVPPEGWQPWLGDfglnTLFYSEVQNTgPGAAITKR-----------VTWPGIKKL 530

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  555 TDQEATPVPPT----GDseaTPVPPTGdsetAPVPP---TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDsgapp 627
Cdd:PLN02217 531 SDEEILKFTPAqyiqGD---AWIPGKG----VPYIPglfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTS----- 598

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 27769331  628 vPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTgdSGAPPVTPTGDSETAP 682
Cdd:PLN02217 599 -PPAGHLGSPPATPSKIVSPSTSPPASHLGSPSTTPS--SPESSIKVASTETASP 650
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 592-707 9.17e-07

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 49.65  E-value: 9.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   592 APPVPPTGdsGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpPTGDAGPP------PVPPTGDSGAPPVPPTG 665
Cdd:pfam15240  45 GPQGPPPG--GFPPQPPASDDPPGPPPPGGPQQPPPQGGKQKPQGPP--PQGGPRPPpgkpqgPPPQGGNQQQGPPPPGK 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 27769331   666 DSGAPPvtptgdSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:pfam15240 121 PQGPPP------QGGGPPPQGGNQQGPPPPPPGNPQGPPQRP 156
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 552-698 1.05e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.48  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEATPVPPTGDSEA--TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP 629
Cdd:PHA03307  119 PTPPPASPPPSPAPDLSEMlrPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTP 198

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331   630 PTGDSGAPPVP--PTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPTGDSGAPPVPPTG 698
Cdd:PHA03307  199 PAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgWGPENECPLPRPAPITLPTRIWEA 272
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 560-717 1.10e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.39  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   560 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGA----------PPVPPTGDSGAPPVP 629
Cdd:PRK10263  341 TQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP----EGYPQQSQYAQPAVqyneplqqpvQPQQPYYAPAAEQPA 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   630 PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvTPTGDSETA---PVPPTGDSGAPPVPPTGDSeAAPVP 706
Cdd:PRK10263  417 QQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAP-QSTYQTEQTyqqPAAQEPLYQQPQPVEQQPV-VEPEP 494

                         170
                  ....*....|.
gi 27769331   707 PTDDSKEAQMP 717
Cdd:PRK10263  495 VVEETKPARPP 505
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
563-718 1.46e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 51.77  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  563 PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVppt 642
Cdd:PRK07003 367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAA--- 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  643 gdAGPPPVPPTGDSGAPPVPPTGDSGAPPVT-------PTGDSETA----PVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 711
Cdd:PRK07003 444 --DGDAPVPAKANARASADSRCDERDAQPPAdsgsasaPASDAPPDaafePAPRAAAPSAATPAAVPDARAPAAASREDA 521


                 ....*..
gi 27769331  712 KEAQMPA 718
Cdd:PRK07003 522 PAAAAPP 528
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 566-707 1.60e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   566 GDSEATPVPPTGdseTAPVPPTGDSGAPPVPPtgDSGAPPVPP---TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 642
Cdd:PHA03307  250 GPENECPLPRPA---PITLPTRIWEASGWNGP--SSRPGPASSsssPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRES 324

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331   643 GDAGPPPVPPTgdSGAPPVPPtGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:PHA03307  325 SSSSTSSSSES--SRGAAVSP-GPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPT 386
PHA03378 PHA03378
EBNA-3B; Provisional
 552-707 1.69e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 51.61  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP--VPPTgdSGAPPVPPTGDSGAPPVPPTG---DSGAP 626
Cdd:PHA03378 664 PTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPpaAPPG--RAQRPAAATGRARPPAAAPGRarpPAAAP 741

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  627 -PVPPTGDSGAPPVPPTGDAGPPPvPPTGDSGAP-PVPPTGDSGAPPVTPTGDSetAPVPPtgdsgaPPVPPTGDSEAAP 704
Cdd:PHA03378 742 gRARPPAAAPGRARPPAAAPGRAR-PPAAAPGAPtPQPPPQAPPAPQQRPRGAP--TPQPP------PQAGPTSMQLMPR 812


                 ...
gi 27769331  705 VPP 707
Cdd:PHA03378 813 AAP 815
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 550-707 1.73e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTgdSGAPPVPPtGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP 629
Cdd:PHA03307  298 PSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSES--SRGAAVSP-GPSPSRSPSPSRPPPPADPSSPRKRPRPSRA 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   630 PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPtgdSGAPPVTPTGDSETAPVPPTGDsgaPPVPPTGDS--EAAPVPP 707
Cdd:PHA03307  375 PSSPAASAGRPTRRRARAAVAGRARRRDATGRFP---AGRPRPSPLDAGAASGAFYARY---PLLTPSGEPwpGSPPPPP 448
dnaA PRK14086
chromosomal replication initiator protein DnaA;
557-712 1.76e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 51.36  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  557 QEATPVPPT---GDSEATPVPPTGD----SETAPVPPTGDSGAPPVPPTG-DSGAPPVPPTGDSgappvPPTGDSGAPPV 628
Cdd:PRK14086 124 PRADDRPPGlprQDQLPTARPAYPAyqqrPEPGAWPRAADDYGWQQQRLGfPPRAPYASPASYA-----PEQERDREPYD 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  629 PPTGDSGAPPVPPTGDaGPPPVPPTGDSGAPPVPPTGdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:PRK14086 199 AGRPEYDQRRRDYDHP-RPDWDRPRRDRTDRPEPPPG-AGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGE 276


                 ....
gi 27769331  709 DDSK 712
Cdd:PRK14086 277 PTAR 280
PHA03247 PHA03247
large tegument protein UL36; Provisional
 547-707 1.94e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   547 TYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDS--------GAPPVP 618
Cdd:PHA03247  230 TYLQDEPFVERRVVISHPLRGDIAAPAPPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDgvwgaalaGAPLAL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   619 PTGDSGAPPVPPTGDSG----------APPVP---------------PT------------GDAGPPPVPP------TGD 655
Cdd:PHA03247  310 PAPPDPPPPAPAGDAEEeddedgamevVSPLPrprqhyplgfpkrrrPTwtppssledlsaGRHHPKRASLptrkrrSAR 389

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   656 SGAPPV--PPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVP------PTGDSEAAPVPP 707
Cdd:PHA03247  390 HAATPFarGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPatplpsAEPGSDDGPAPP 449
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 554-677 2.01e-06

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 50.54  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  554 VTDQEATPVPPTGDSEATPVPPTGDSETAPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPT 631
Cdd:NF040712 217 VEPAPAAEGAPATDSDPAEAGTPDDLASARRrrAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPP 295

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPtgdsGAPPVPPTGDSGAPPVTPTGD 677
Cdd:NF040712 296 APAPAAPAAPAAPEAEEPARP----EPPPAPKPKRRRRRASVPSWD 337
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
559-707 2.09e-06

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 50.70  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   559 ATPVppTGDSEATPVPpTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP-----VPPTGDSGAPPVPPTGD 633
Cdd:pfam16014  31 APPV--TVAVEALPGQ-NSEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVVLSTLPaamavTPPIPASMANVVAPPTQ 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   634 SGAPPVP--PTGDAGP-----------------PPVPPTGDSGAPPV------PPTGD--SGAPP---------VTPTGD 677
Cdd:pfam16014 108 PAASSTAacAVSSVLPeikikqeaepmdtsqsvPPLTPTSISPALTSlannlsVPAGDllPGASPrkkprkqqhVISTEE 187

                         170       180       190
                  ....*....|....*....|....*....|
gi 27769331   678 SETAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:pfam16014 188 GEMMETNSTDEEKSAPKPLTSRAEKRKSPP 217
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 595-697 2.13e-06

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 50.77  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  595 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAP--PVPPTGDSGAPPV 672
Cdd:PHA03264 254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                         90       100
                 ....*....|....*....|....*
gi 27769331  673 TPTGDSETAPVPPTGDSGAPPVPPT 697
Cdd:PHA03264 334 RPEGWPSLEAITFPPPTPATPAVPR 358
PHA03247 PHA03247
large tegument protein UL36; Provisional
 560-714 2.44e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   560 TPVPPTGDSEATPVPPTGDSETAPVPPTGD-----SGAPPVPPTGDSGAPPVPPTGDSG----------APPVP------ 618
Cdd:PHA03247  268 APETARGATGPPPPPEAAAPNGAAAPPDGVwgaalAGAPLALPAPPDPPPPAPAGDAEEeddedgamevVSPLPrprqhy 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   619 ---------PT------------GDSGAPPVPP------TGDSGAPPV--PPTGDAGPPPVPPTGDSGAPPVPPTGDSGA 669
Cdd:PHA03247  348 plgfpkrrrPTwtppssledlsaGRHHPKRASLptrkrrSARHAATPFarGPGGDDQTRPAAPVPASVPTPAPTPVPASA 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 27769331   670 PPvtPTGDSETAPVPPTGDSGAPP---VPPTGDSEAAPVPPTDDSKEA 714
Cdd:PHA03247  428 PP--PPATPLPSAEPGSDDGPAPPperQPPAPATEPAPDDPDDATRKA 473
PHA03247 PHA03247
large tegument protein UL36; Provisional
 549-684 3.15e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 3.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   549 LALPTVTDQ-EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPptgdSGAPP 627
Cdd:PHA03247 2886 LARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL-APTTDPAGAGEP----SGAVP 2960

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331   628 VPPTGDSGAPPVPPTGDAGPPPVPPTgDSGAPPVPPTGDSGAPPVTPTGDS-----ETAPVP 684
Cdd:PHA03247 2961 QPWLGALVPGRVAVPRFRVPQPAPSR-EAPASSTPPLTGHSLSRVSSWASSlalheETDPPP 3021
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 477-720 3.31e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.69  E-value: 3.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   477 PQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTD 556
Cdd:pfam05109 600 PQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGE 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   557 QEATPVPPTGD----SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvpptgDSGAPPVPPTGDSGAppVPPTG 632
Cdd:pfam05109 680 NITQVTPASTSthhvSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPP-----KNATSPQAPSGQKTA--VPTVT 752

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   633 DSGAPPVPPTGDAGpppvpPTGDSGAPPVPPTGDSGAPPVTP-TGDSETAPVPPTGDSGAPP-----VPPTGDSEAA-PV 705
Cdd:pfam05109 753 STGGKANSTTGGKH-----TTGHGARTSTEPTTDYGGDSTTPrTRYNATTYLPPSTSSKLRPrwtftSPPVTTAQATvPV 827

                         250
                  ....*....|....*
gi 27769331   706 PPTDDSKEAQMPAVI 720
Cdd:pfam05109 828 PPTSQPRFSNLSMLV 842
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 546-670 5.18e-06

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 49.15  E-value: 5.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   546 LTYLALPTVTDQEATPVPPTGDSEATPVPptgdsetAPVPPTgDSGAPPVPPtgdsgaPPVPPTGDSGAPPVPPtgDSGA 625
Cdd:pfam07174  15 WATLAIAAVAGASAVAVALPAVAHADPEP-------APPPPS-TATAPPAPP------PPPPAPAAPAPPPPPA--APNA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 27769331   626 PPVPPtgdsgaPPVPPTGdagppPVPPTGDSGAPPvPPTGDSGAP 670
Cdd:pfam07174  79 PNAPP------PPADPNA-----PPPPPADPNAPP-PPAVDPNAP 111
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 550-662 5.31e-06

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 49.00  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVP 629
Cdd:NF040712 226 APATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAA 304

                         90       100       110
                 ....*....|....*....|....*....|...
gi 27769331  630 PTGDSGAPPVPPtgdAGPPPVPPTGDSGAPPVP 662
Cdd:NF040712 305 PAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 573-686 5.74e-06

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 49.23  E-value: 5.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  573 VPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDAGPPPV 650
Cdd:PHA03264 254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 27769331  651 PPTGDSGAPPVPptgdsgAPPVTPtgdseTAPVPPT 686
Cdd:PHA03264 334 RPEGWPSLEAIT------FPPPTP-----ATPAVPR 358
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
564-716 7.79e-06

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 49.22  E-value: 7.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  564 PTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 643
Cdd:PRK12727 117 PVSVPRQAPAAAPVRAASIPSPAAQALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIA 196

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27769331  644 DAGPPPVPPTGDSGAPPVPP--TGDSGAPPVTPtgdseTAPVPPTgdSGAPPVPPTGDSEAAPVP-PTDDSKEAQM 716
Cdd:PRK12727 197 AALAAHAAYAQDDDEQLDDDgfDLDDALPQILP-----PAALPPI--VVAPAAPAALAAVAAAAPaPQNDEELKQL 265
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 579-721 7.85e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 49.09  E-value: 7.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  579 SETAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTGDSgAPPVPPTGDAGPPPVPPTGDSGA 658
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVA--PPQAPAVPPPPASAPQQAPAVPL-PETTSQLLAARQQLQRAQGATKA 438

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331  659 PPVPPTGDSGAPPVTPTGDsETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQM-PAVIR 721
Cdd:PRK07994 439 KKSEPAAASRARPVNSALE-RLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVAtPKALK 501
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 564-694 8.66e-06

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 48.32  E-value: 8.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  564 PTGDSEATPVPPTgdseTAPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTG 643
Cdd:PHA02682  76 PSGQSPLAPSPAC----AAPAPAC-PACAPAAPAPAVTCPAPAPACPPATAPTCPP------PAVCPAPARPAPACPPST 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27769331  644 DAGPPPVPPTGDSGAPPVPPT--GDSGAPPVTPTGDSETAPVPPtgdsGAPPV 694
Cdd:PHA02682 145 RQCPPAPPLPTPKPAPAAKPIflHNQLPPPDYPAASCPTIETAP----AASPV 193
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 561-718 9.24e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.40  E-value: 9.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   561 PVPPTGDSEATPVPPTGDSETAPvPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDSGAPP 638
Cdd:PHA03307  264 TLPTRIWEASGWNGPSSRPGPAS-SSSSPRERSPSPSPSSPGSGPAPSSPRASSSssSSRESSSSSTSSSSESSRGAAVS 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   639 VPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPV------PPTGDSEAAPVPPTDDSK 712
Cdd:PHA03307  343 PGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRArrrdatGRFPAGRPRPSPLDAGAA 422


                  ....*.
gi 27769331   713 EAQMPA 718
Cdd:PHA03307  423 SGAFYA 428
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 560-706 9.40e-06

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 48.77  E-value: 9.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  560 TPVPPTG------DSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAP--PV-------PPTGDSGAPPVP-PTGDS 623
Cdd:PLN03209 387 IPTPPSSspasskSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPlsPYaryedlkPPTSPSPTAPTGvSPSVS 466

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  624 GAPPVPPTGDSgAPPVPPTGDAGPPPVPPTGDSGAPPV----PPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGD 699
Cdd:PLN03209 467 STSSVPAVPDT-APATAATDAAAPPPANMRPLSPYAVYddlkPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQ 545


                 ....*..
gi 27769331  700 SEAAPVP 706
Cdd:PLN03209 546 HHAQPKP 552
PHA03247 PHA03247
large tegument protein UL36; Provisional
 567-718 9.73e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 9.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   567 DSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGD-----SGAPPVPPTGDSGAPPVPPTGDSG------ 635
Cdd:PHA03247  253 AAPAPPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVwgaalAGAPLALPAPPDPPPPAPAGDAEEeddedg 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   636 ----APPVP---------------PT------------GDAGPPPVPP------TGDSGAPPV--PPTGDSGAPPVTPTG 676
Cdd:PHA03247  333 amevVSPLPrprqhyplgfpkrrrPTwtppssledlsaGRHHPKRASLptrkrrSARHAATPFarGPGGDDQTRPAAPVP 412

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 27769331   677 DSETAPVPPTGDSGAPPVPPT-------GDSEAAPVPPTDDSKEAQMPA 718
Cdd:PHA03247  413 ASVPTPAPTPVPASAPPPPATplpsaepGSDDGPAPPPERQPPAPATEP 461
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
561-710 1.06e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.08  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  561 PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP 640
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAP 527

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  641 PTGDAGPP------PVPPTG------------------DSGAPPVPPTGDSGAPPVTPTGDSETAPVP-PT--------- 686
Cdd:PRK07003 528 PAPEARPPtpaaaaPAARAGgaaaaldvlrnagmrvssDRGARAAAAAKPAAAPAAAPKPAAPRVAVQvPTpraraatgd 607

                        170       180
                 ....*....|....*....|....*
gi 27769331  687 -GDSGAPPVPPTGDSEAAPvPPTDD 710
Cdd:PRK07003 608 aPPNGAARAEQAAESRGAP-PPWED 631
PTZ00429 PTZ00429
beta-adaptin; Provisional
 565-711 1.09e-05

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 48.78  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  565 TGDSEATPVPPTgdsetapvPPTGDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGD--SGAPpvPP 641
Cdd:PTZ00429 613 TEDDDAVELPST--------PSMGTQDGSPAPSAAPAGYDIFEFAGDgTGAPHPVASGSNGAQHADPLGDlfSGLP--ST 682

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  642 TGDAGPPPVPPTGdSGAPPVPPTgdsgappVTPTGDSETAPVPPTGDSGAPpvpptGDSEAAPVPPTDDS 711
Cdd:PTZ00429 683 VGASSPAFQAASG-SQAPASPPT-------AASAIEDLFANGMGSGSQTVP-----LPISAAPQSADRDT 739
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 552-722 1.10e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 48.52  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 552 PTVTDQEATPVPPTGdseATPVPPTGDSETAPVPPTgdsgappVPPTGDSGAPPVPPTGDSGAP-PVPPTGDSGAPP--- 627
Cdd:COG5180 338 PAGVPEAASDAGQPP---SAYPPAEEAVPGKPLEQG-------APRPGSSGGDGAPFQPPNGAPqPGLGRRGAPGPPmga 407

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 628 -----------VPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTptgdSETAPVPPTGDSGAPPVPP 696
Cdd:COG5180 408 gdlvqaaldggGRETASLGGAAGGAGQGPKADFVPGDAESVSGPAGLADQAGAAAST----AMADFVAPVTDATPVDVAD 483

                       170       180
                ....*....|....*....|....*.
gi 27769331 697 TGDSEAAPVPPTDDSKEAQMPAVIRF 722
Cdd:COG5180 484 VLGVRPDAILGGNVAPASGLDAETRI 509
motB PRK12799
flagellar motor protein MotB; Reviewed
 565-701 1.11e-05

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 48.56  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  565 TGDSEATPVPPTGDSETAPVPPTGDSGAPpvpptgdsgAPPVPPTGDSGaPPVPPTGDSgAPPVPPTGDSGAPPVPPTGD 644
Cdd:PRK12799 296 HGTVPVAAVTPSSAVTQSSAITPSSAAIP---------SPAVIPSSVTT-QSATTTQAS-AVALSSAGVLPSDVTLPGTV 364

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331  645 AGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSE 701
Cdd:PRK12799 365 ALPAAEPVNMQPQPMSTTETQQSSTGNITSTANGPTTSLPAAPASNIPVSPTSRDAQ 421
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 541-717 1.11e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 48.52  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 541 LRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVP---------------PTGDSGAPPVPPTGDSGAPP 605
Cdd:COG5180 154 LLQRSDPILAKDPDGDSASTLPPPAEKLDKVLTEPRDALKDSPEKldrpkvevkdeaqeePPDLTGGADHPRPEAASSPK 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 606 VPPTGDSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPP 685
Cdd:COG5180 234 VDPPSTSEARSRPATVDAQPEMRPP-ADAKERRRAAIGDTPAAEPPGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPP 312

                       170       180       190
                ....*....|....*....|....*....|..
gi 27769331 686 TGDSGAPpvPPTGDSEAAPVPPTDDSKEAQMP 717
Cdd:COG5180 313 ATRPVRP--PGGARDPGTPRPGQPTERPAGVP 342
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 619-719 1.21e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.56  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  619 PTGDSGAPPVPPTgDSGAPPVPPTGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTG 698
Cdd:PRK14951 366 PAAAAEAAAPAEK-KTPARPEAAAPAAAPVAQAAAAPAPAAA-PAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA 443

                         90       100
                 ....*....|....*....|.
gi 27769331  699 DSEAAPVPPTDDSKEAQMPAV 719
Cdd:PRK14951 444 AVALAPAPPAQAAPETVAIPV 464
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 561-717 1.32e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   561 PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG----APPVPPtgdSGAPPVPPtgdSGAPPVPPTGDSGA 636
Cdd:pfam03154 149 PSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGttqaATAGPT---PSAPSVPP---QGSPATSQPPNQTQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   637 PPVPP------TGDAGPPPVP---PTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP----PVPPTgdseaa 703
Cdd:pfam03154 223 STAAPhtliqqTPTLHPQRLPsphPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPShmqhPVPPQ------ 296

                         170
                  ....*....|....
gi 27769331   704 PVPPTDDSKEAQMP 717
Cdd:pfam03154 297 PFPLTPQSSQSQVP 310
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 602-685 1.36e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 48.07  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  602 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvtPTGDSETA 681
Cdd:NF041121  16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP--GAALPVRV 93


                 ....
gi 27769331  682 PVPP 685
Cdd:NF041121  94 PAPP 97
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 561-695 1.45e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   561 PVPPTGDSEATPVPPTGDSETAPVPPTGDSG-APPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDSGAPPVPPTGDSG--- 635
Cdd:pfam03154 243 PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGqMPPMPHSLQTGPSHMQhPVPPQPFPLTPQSSQSQVPPGPSPAAPGqsq 322

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27769331   636 -APPVPPTGDAGPPPVPPTgDSGAPPVP-PTGDSGAPPVTPTGDSET-----------APVPPTGDSGAPPVP 695
Cdd:pfam03154 323 qRIHTPPSQSQLQSQQPPR-EQPLPPAPlSMPHIKPPPTTPIPQLPNpqshkhpphlsGPSPFQMNSNLPPPP 394
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 470-697 1.47e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 48.42  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   470 ATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYT-TENSGYLEITKKMGSS-----SMKRSLRTNFLRY 543
Cdd:pfam17823 166 SAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARgISTAATATGHPAAGTAlaavgNSSPAAGTVTAAV 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   544 WTLTYLALPTVTDQEAT-----------------PVP----PTGDSEATPVPPTGDSETAPV-------PPTGDSGAPPV 595
Cdd:pfam17823 246 GTVTPAALATLAAAAGTvasaagtinmgdpharrLSPakhmPSDTMARNPAAPMGAQAQGPIiqvstdqPVHNTAGEPTP 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   596 PPTGDSGAPPVPPTGDSGAPPVPPT-----GDSGAPPVPPTGDSGAPPVPPTG-DAGPPPVPPTGDSGAPPVPPTGDSGA 669
Cdd:pfam17823 326 SPSNTTLEPNTPKSVASTNLAVVTTtkaqaKEPSASPVPVLHTSMIPEVEATSpTTQPSPLLPTQGAAGPGILLAPEQVA 405

                         250       260
                  ....*....|....*....|....*...
gi 27769331   670 PPVTPTGDSeTAPVPPTgdSGAPPVPPT 697
Cdd:pfam17823 406 TEATAGTAS-AGPTPRS--SGDPKTLAM 430
PRK11633 PRK11633
cell division protein DedD; Provisional
 584-705 1.50e-05

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 46.92  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  584 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAppvPPTGDSGAPPVPPTgDSGAPPVPPtgDAGPPPVPPTgdsGAPPVPP 663
Cdd:PRK11633  44 VPKPGDRDEPDMMPAATQALPTQPPEGAAEA---VRAGDAAAPSLDPA-TVAPPNTPV--EPEPAPVEPP---KPKPVEK 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 27769331  664 TgdsgAPPVTPTGDSETAPVPPtgdsgaPPVPPTGDSEAAPV 705
Cdd:PRK11633 115 P----KPKPKPQQKVEAPPAPK------PEPKPVVEEKAAPT 146
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 624-711 2.04e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 47.78  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  624 GAPPVPP--TGDSGAPPVPPTGDAGPPPVPPTGDSGAPPV-----PPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPP 696
Cdd:PLN02217 554 GVPYIPGlfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVapstsPPAGHLGSPPATPSKIVSPSTSPPASHLGSPSTTP 633

                         90
                 ....*....|....*
gi 27769331  697 TGDSEAAPVPPTDDS 711
Cdd:PLN02217 634 SSPESSIKVASTETA 648
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 584-674 2.30e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 47.96  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   584 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgappvpPTGDAGPPPVPPTGDSGAPPVPP 663
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK---------PAAAAAAAAAPAAPPAAAAAAAP 108

                          90
                  ....*....|.
gi 27769331   664 TGDSGAPPVTP 674
Cdd:PRK12270  109 AAAAVEDEVTP 119
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 550-719 2.58e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   550 ALPTVTDQEATPVPPTgdseaTPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPptgdSGAPPVPptgdSGAPPVP 629
Cdd:PRK10263  325 AATTATQSWAAPVEPV-----TQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP----EGYPQQS----QYAQPAV 391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   630 PTGDSGAPPVPPTGDAGPPPvpptgdsgAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTD 709
Cdd:PRK10263  392 QYNEPLQQPVQPQQPYYAPA--------AEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQ 463

                         170
                  ....*....|
gi 27769331   710 DSKEAQMPAV 719
Cdd:PRK10263  464 TEQTYQQPAA 473
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 621-712 2.60e-05

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 47.15  E-value: 2.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 621 GDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPT--GDSGAPPVPPTGDSGAPPVTPT--GDSETAPVPPTGDSGAPPVPP 696
Cdd:COG3266 262 SSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAqpSAVALPAAPAAAAAAAAPAEAAapQPTAAKPVVTETAAPAAPAPE 341

                        90
                ....*....|....*.
gi 27769331 697 TGDSEAAPVPPTDDSK 712
Cdd:COG3266 342 AAAAAAAPAAPAVAKK 357
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 575-668 2.74e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 47.63  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  575 PTGDSETAPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptgdSGAPPVPPtgdagPPPVPP 652
Cdd:PRK14954 376 NDGGVAPSPAgsPDVKKKAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTP------EQQPPVAR-----SAPLPP 444

                         90
                 ....*....|....*.
gi 27769331  653 TGDSGAPPVPPTGDSG 668
Cdd:PRK14954 445 SPQASAPRNVASGKPG 460
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 565-664 3.02e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 47.30  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  565 TGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPptGDSGAPPVPPTGDSGAPPvpptGD 644
Cdd:NF041121  15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYP--GSLAPPPPPPPGPAGAAP----GA 87

                         90       100
                 ....*....|....*....|
gi 27769331  645 AGPPPVPptgdsgAPPVPPT 664
Cdd:NF041121  88 ALPVRVP------APPALPN 101
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 560-672 3.05e-05

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 44.86  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   560 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGA----PPVPPTGDSGAPPVPPTGDSGAPPVPP-TGDSGAPPVPPT--G 632
Cdd:pfam06346  23 TPPPLPGGGGPPPPPPLPGSAAIPPPPPLPGGTsippPPPLPGAASIPPPPPLPGSTGIPPPPPlPGGAGIPPPPPPlpG 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 27769331   633 DSGAPPVPPTGDAGP----PPVPPTGDSGAPPVPPTGDSGAPPV 672
Cdd:pfam06346 103 GAGVPPPPPPLPGGPgippPPPFPGGPGIPPPPPGMGMPPPPPF 146
PRK11633 PRK11633
cell division protein DedD; Provisional
 573-683 3.37e-05

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 45.76  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  573 VPPTGDS-ETAPVPPTGDSgAPPVPPTGDSGAppvPPTGDSGAPPVPPTgDSGAPPVPPtgdsgAPPVPPTGDAGPPPVP 651
Cdd:PRK11633  44 VPKPGDRdEPDMMPAATQA-LPTQPPEGAAEA---VRAGDAAAPSLDPA-TVAPPNTPV-----EPEPAPVEPPKPKPVE 113

                         90       100       110
                 ....*....|....*....|....*....|...
gi 27769331  652 -PTGDSGAPPVPPTGDSGAPPVTPTGDSETAPV 683
Cdd:PRK11633 114 kPKPKPKPQQKVEAPPAPKPEPKPVVEEKAAPT 146
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 559-711 3.54e-05

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 45.75  E-value: 3.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   559 ATPVPPTGdseatpVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPTGDSGA 636
Cdd:pfam15822  41 APPAVPSG------LPPSTAPSTVPFGPAPTGMYPSIPLTGPSPGPPAPfpPSGPSCPPPGGPYPAPTVPGPGPIGPYPT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   637 PPVP----------PTGDAGPPPVPPTGDSGAPPVPPT--GDSGAPPVT-PTGDSETAPVPPTGDSGAPP-----VPPTG 698
Cdd:pfam15822 115 PNMPfpelprpygaPTDPAAAAPSGPWGSMSSGPWAPGmgGQYPAPNMPyPSPGPYPAVPPPQSPGAAPPvpwgtVPPGP 194

                         170
                  ....*....|...
gi 27769331   699 DSEAAPVPPTDDS 711
Cdd:pfam15822 195 WGPPAPYPDPTGS 207
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 608-711 3.98e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 46.98  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  608 PTGDSGAPPvpptGDSGAPPvppTGDSGAPPVPPTGDAGPPPVPP----TGDSGAPPVPPTGDSGAPPVTPtgdSETAPV 683
Cdd:PRK14959 373 PSGGGASAP----SGSAAEG---PASGGAATIPTPGTQGPQGTAPaagmTPSSAAPATPAPSAAPSPRVPW---DDAPPA 442

                         90       100
                 ....*....|....*....|....*...
gi 27769331  684 PPTgdSGAPPVPPTGDSEAAPVPPTDDS 711
Cdd:PRK14959 443 PPR--SGIPPRPAPRMPEASPVPGAPDS 468
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 568-715 4.18e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 46.78  E-value: 4.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  568 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPP--VPPTGDA 645
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVA--PPQAPAVPPPPASAPQQAP---AVPLPETTSQLLAARQqlQRAQGAT 436

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  646 GPPPVPPTGDSGAPPVPptgdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQ 715
Cdd:PRK07994 437 KAKKSEPAAASRARPVN----SALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKK 502
PRK11901 PRK11901
hypothetical protein; Reviewed
 553-704 4.85e-05

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 46.21  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  553 TVTDQEATPVPPtgdsEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGD--------------------S 612
Cdd:PRK11901  86 SLSSGNQSSPSA----ANNTSDGHDASGVKNTAPPQDISAPPISPTPTQAAPPQTPNGQqrielpgnisdalsqqqgqvN 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  613 GAPPVPPTGDSGAPPVPPTgdsgappVPPTGDAGPPPVPPTgdsgaPPVPPTGDSGAPPVTPTGDSETAPVPPTG-DSGA 691
Cdd:PRK11901 162 AASQNAQGNTSTLPTAPAT-------VAPSKGAKVPATAET-----HPTPPQKPATKKPAVNHHKTATVAVPPATsGKPK 229

                        170
                 ....*....|...
gi 27769331  692 PPVPPTGDSEAAP 704
Cdd:PRK11901 230 SGAASARALSSAP 242
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 586-674 5.02e-05

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 46.04  E-value: 5.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  586 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGdaGPPPVppTGDSGAPPVPPTG 665
Cdd:PHA03201   4 ARSRSPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRG--CPAGV--TFSSSAPPRPPLG 79


                 ....*....
gi 27769331  666 DSGAPPVTP 674
Cdd:PHA03201  80 LDDAPAATP 88
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 552-715 5.07e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 46.46  E-value: 5.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTG-DSGAPPVPPTGDSGAPPVPPTgdSGAPPVPP 630
Cdd:PLN03209 396 ASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYARyEDLKPPTSPSPTAPTGVSPSV--SSTSSVPA 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  631 TGDSgAPPVPPTGDAGPPPVPPTGDSGAPpvppTGDSGAPPVTPTgdsETAPVPPTGDSGAPPVPPTGDSeAAPVPPTDD 710
Cdd:PLN03209 474 VPDT-APATAATDAAAPPPANMRPLSPYA----VYDDLKPPTSPS---PAAPVGKVAPSSTNEVVKVGNS-APPTALADE 544


                 ....*
gi 27769331  711 SKEAQ 715
Cdd:PLN03209 545 QHHAQ 549
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 563-696 6.15e-05

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 44.26  E-value: 6.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   563 PPTGDSEATPVPPTGDSETAPvPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPP-----VPPTGDSGAPPvPPTGDSGAP 637
Cdd:pfam15240  38 QSQQGGQGPQGPPPGGFPPQP-PASDDPPGPP-PPGGPQQPPPQGGKQKPQGPPpqggpRPPPGKPQGPP-PQGGNQQQG 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 27769331   638 PVPPTGDAGPPPvpptgdSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTgDSGAPPVPP 696
Cdd:pfam15240 115 PPPPGKPQGPPP------QGGGPPPQGGNQQGPPPPPPGNPQGPPQRPP-QPGNPQGPP 166
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 602-711 6.32e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 46.24  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  602 GAPPVPP--TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDagpppvPPTGDSGAPPVPPT---GDSGAPPVTPTG 676
Cdd:PLN02217 554 GVPYIPGlfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTS------PPAGHLGSPPATPSkivSPSTSPPASHLG 627

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 27769331  677 DSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 711
Cdd:PLN02217 628 SPSTTPSSPESSIKVASTETASPESSIKVASTESS 662
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 582-709 6.43e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   582 APVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG----APPVPPTGDAGPPPVPPTGDSG 657
Cdd:PHA03307  776 EPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGsessGPARPPGAAARPPPARSSESSK 855

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 27769331   658 APPVPPTGDSGAPPvtptGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTD 709
Cdd:PHA03307  856 SKPAAAGGRARGKN----GRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAP 903
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 600-682 6.71e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.42  E-value: 6.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   600 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSE 679
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116


                  ...
gi 27769331   680 TAP 682
Cdd:PRK12270  117 VTP 119
dnaA PRK14086
chromosomal replication initiator protein DnaA;
553-718 7.30e-05

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 45.97  E-value: 7.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  553 TVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTG---DSGAPPVPPTGDSGA---PPVPPTGDSGAP-PVPPTGDSGA 625
Cdd:PRK14086  87 TVDPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGgprADDRPPGLPRQDQLPtarPAYPAYQQRPEPgAWPRAADDYG 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  626 PPVPPTG-DSGAPPVPPTGDAGPP----PVPPTGDSGAPPVPPTGDSGAPPVT-PTGDSETAPVPPTG----------DS 689
Cdd:PRK14086 167 WQQQRLGfPPRAPYASPASYAPEQerdrEPYDAGRPEYDQRRRDYDHPRPDWDrPRRDRTDRPEPPPGaghvhrggpgPP 246

                        170       180
                 ....*....|....*....|....*....
gi 27769331  690 GAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PRK14086 247 ERDDAPVVPIRPSAPGPLAAQPAPAPGPG 275
Gag_spuma pfam03276
Spumavirus gag protein;
582-707 7.43e-05

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 45.89  E-value: 7.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   582 APVPPTGDSGAPPVppTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDAGPPPVPPTGDSG---- 657
Cdd:pfam03276 176 AEISPGAQGGIPPG--ASFSGLPSLPAIGGIHLPAIPGIHARAPPGNIARSLGDDIM-PSLGDAGMPQPRFAFHPGnpfa 252

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 27769331   658 -APPVPPTGDSG----APPVTPTGDSETAPVPPTGDSGAPPVPPtgdSEAAPVPP 707
Cdd:pfam03276 253 eAEGHPFAEAEGerprDIPRAPRIDAPSAPAIPAIQPIAPPMIP---PIGAPIPI 304
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
544-697 8.20e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 45.90  E-value: 8.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 544 WTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDS 623
Cdd:COG3469  68 STAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGST 147

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331 624 GAPPVPPTGDSGAPPVPPTGDAGPPPvpptgdsGAPPVPPTGdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPT 697
Cdd:COG3469 148 TTTTTVSGTETATGGTTTTSTTTTTT-------SASTTPSAT-TTATATTASGATTPSATTTATTTGPPTPGLP 213
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 567-649 8.23e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.04  E-value: 8.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   567 DSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsGAPPVPPTGDSGAPPVPPTGDAG 646
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAA----AAAAAAPAAPPAAAAAAAPAAAA 112


                  ...
gi 27769331   647 PPP 649
Cdd:PRK12270  113 VED 115
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 552-719 8.23e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 45.82  E-value: 8.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP--------VPPTGDSGAPPVPPTGDSGAPPvPPTGDS 623
Cdd:COG5180 278 PGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPPATRPVRPPggardpgtPRPGQPTERPAGVPEAASDAGQ-PPSAYP 356

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 624 GAPPVPPT--GDSGAPPVPPTGDAGPPPVPPTGD----SGAPPVPPTGDSGAPPVTPTGDsetAPVPPTGD--------- 688
Cdd:COG5180 357 PAEEAVPGkpLEQGAPRPGSSGGDGAPFQPPNGApqpgLGRRGAPGPPMGAGDLVQAALD---GGGRETASlggaaggag 433

                       170       180       190
                ....*....|....*....|....*....|...
gi 27769331 689 --SGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:COG5180 434 qgPKADFVPGDAESVSGPAGLADQAGAAASTAM 466
PHA03247 PHA03247
large tegument protein UL36; Provisional
 549-714 8.23e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 8.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   549 LALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPpvpptGDSGAPPVPPTGDSGAPPV 628
Cdd:PHA03247 2898 FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG-----EPSGAVPQPWLGALVPGRV 2972

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   629 PPTGDSGAPPVPPTGDAGPPPVPPTG-----------------DSGAPPV-------PPTGDSGAPP----VTPTGDSET 680
Cdd:PHA03247 2973 AVPRFRVPQPAPSREAPASSTPPLTGhslsrvsswasslalheETDPPPVslkqtlwPPDDTEDSDAdslfDSDSERSDL 3052

                         170       180       190
                  ....*....|....*....|....*....|....
gi 27769331   681 APVPPtgDSGAPPVPPTgdSEAAPVPPTDDSKEA 714
Cdd:PHA03247 3053 EALDP--LPPEPHDPFA--HEPDPATPEAGARES 3082
PHA03378 PHA03378
EBNA-3B; Provisional
 538-674 8.41e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 8.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  538 TNFLRYWTLTYLALPTVTDQEATP--VPPTG----DSEATPVPPTGDSETAPVPPTGDSGAPPvPPTGDSGAPPVPPTGD 611
Cdd:PHA03378 683 TMLPIQWAPGTMQPPPRAPTPMRPpaAPPGRaqrpAAATGRARPPAAAPGRARPPAAAPGRAR-PPAAAPGRARPPAAAP 761

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331  612 SGAPPvpPTGDSGAP-PVPPtgdsgaPPVPPTG----DAGPPPVPPtgdsgaPPVPPTGDSGAPPVTP 674
Cdd:PHA03378 762 GRARP--PAAAPGAPtPQPP------PQAPPAPqqrpRGAPTPQPP------PQAGPTSMQLMPRAAP 815
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
596-719 9.14e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 9.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  596 PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPT 675
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAP---AAAAAARAVAAAPARRSPAPEALAAARQASA 441

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 27769331  676 GDSETAPVPPtgdSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:PRK12323 442 RGPGGAPAPA---PAPAAAPAAAARPAAAGPRPVAAAAAAAPAR 482
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 561-710 9.69e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 45.82  E-value: 9.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 561 PVPPTGDSEATPVPPTGDSETAPVP----------PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 630
Cdd:COG5180 233 KVDPPSTSEARSRPATVDAQPEMRPpadakerrraAIGDTPAAEPPGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPP 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 631 TGDSGAPP--------------------VPPTG-DAGPPPVPPTGDSGAPPVPPtGDSGAPPVTPTGDSETAPVPPTGD- 688
Cdd:COG5180 313 ATRPVRPPggardpgtprpgqpterpagVPEAAsDAGQPPSAYPPAEEAVPGKP-LEQGAPRPGSSGGDGAPFQPPNGAp 391

                       170       180
                ....*....|....*....|....*
gi 27769331 689 ---SGAPPVPPTGDSEAAPVPPTDD 710
Cdd:COG5180 392 qpgLGRRGAPGPPMGAGDLVQAALD 416
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 563-717 9.98e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 9.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   563 PPTGDSEAT---PVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAppvppTGDSGA--------PPV--PPTGDSGAPPVP 629
Cdd:pfam03154 113 PSEGEGESSdgrSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNES-----DSDSSAqqqilqtqPPVlqAQSGAASPPSPP 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   630 PTGDSGAPPVPPTgdAGPPPVPPTGDSGAPPVPPTGDSGAPPVT-----PTGDSETAPVPPTGDSGAPPVPPTGDSEAAP 704
Cdd:pfam03154 188 PPGTTQAATAGPT--PSAPSVPPQGSPATSQPPNQTQSTAAPHTliqqtPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQP 265

                         170
                  ....*....|...
gi 27769331   705 VPPTddSKEAQMP 717
Cdd:pfam03154 266 LPQP--SLHGQMP 276
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 545-693 1.03e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.49  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  545 TLTYLALPTVTDQEATPVPPTGDSEATPVP-----PTGDSETAPVPPTGDSGAPPVPPtgDSGAPPVPPTGDSGAPPVPP 619
Cdd:PHA03269  11 TIACINLIIANLNTNIPIPELHTSAATQKPdpapaPHQAASRAPDPAVAPTSAASRKP--DLAQAPTPAASEKFDPAPAP 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331  620 TGDSGAPPvpptgdsgAPPVPPTGDAGPPPVPPTGDSGAPPVPPtgdsgAPPVTPTGDSETAPVPPTGDSGAPP 693
Cdd:PHA03269  89 HQAASRAP--------DPAVAPQLAAAPKPDAAEAFTSAAQAHE-----APADAGTSAASKKPDPAAHTQHSPP 149
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 559-706 1.08e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   559 ATPVPPTGDSEATPVPP--TGDSETAPVPPTGDSGAPpVPPTGDSGAPPVPPT---GDSGAppvpptgDSGAPPVPPTGD 633
Cdd:pfam05109 440 AAPNTTTGLPSSTHVPTnlTAPASTGPTVSTADVTSP-TPAGTTSGASPVTPSpspRDNGT-------ESKAPDMTSPTS 511

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331   634 SGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGApPVTPTGDSeTAPVP----PTGDSGAPPVPPTGDSEAAPVP 706
Cdd:pfam05109 512 AVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSA-VTTPTPNA-TSPTPavttPTPNATIPTLGKTSPTSAVTTP 586
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 550-697 1.11e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.63  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  550 ALPTVTDQEATPVPPTGDSEATPVPPTgdSETAPVPPTGDSGAPPVPPTGDSGAPP--VPPTGDSGAPPVPPTGDSGAPP 627
Cdd:PRK07994 374 SAAPAASAQATAAPTAAVAPPQAPAVP--PPPASAPQQAPAVPLPETTSQLLAARQqlQRAQGATKAKKSEPAAASRARP 451

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  628 VPPTGDSGApPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPT 697
Cdd:PRK07994 452 VNSALERLA-SVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPELAAKLAAEA 520
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 600-718 1.20e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   600 DSGAPPVPPTGDSGAPPVPPTGDSGApPVPPTGDSGAPPVPPTGDAGPPPVPPTG-DSGAPPVPPTGDSGAPPVTP---- 674
Cdd:PHA03307   17 GGEFFPRPPATPGDAADDLLSGSQGQ-LVSDSAELAAVTVVAGAAACDRFEPPTGpPPGPGTEAPANESRSTPTWSlstl 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 27769331   675 ---TGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PHA03307   96 apaSPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG 142
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 583-660 1.20e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.65  E-value: 1.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331   583 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPP 660
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 556-707 1.29e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.24  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  556 DQEATPVPPTGDSEATPVPptgdseTAPVPPTgdsgAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPP--VPPTGD 633
Cdd:PRK07994 369 EVPPQSAAPAASAQATAAP------TAAVAPP----QAPAVPPPPASAPQQAP---AVPLPETTSQLLAARQqlQRAQGA 435

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27769331  634 SGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDS--ETAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:PRK07994 436 TKAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRwkATNPVEVKKEPVATPKALKKALEHEKTPE 511
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
550-670 1.35e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  550 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP---VPPTGDSGAP----PVPPTGDSGAPPVPPTGD 622
Cdd:PRK12323 454 PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweeLPPEFASPAPaqpdAAPAGWVAESIPDPATAD 533

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 27769331  623 SGAPPVPPTGDSGAPPVPPTGDAGPPPVPPT-GDSGAPPVPPTGDSGAP 670
Cdd:PRK12323 534 PDDAFETLAPAPAAAPAPRAAAATEPVVAPRpPRASASGLPDMFDGDWP 582
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 582-666 1.40e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 44.50  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  582 APVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDAGPPPVPPTGDSGAP-P 660
Cdd:PHA03201   8 SPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaA 86


                 ....*.
gi 27769331  661 VPPTGD 666
Cdd:PHA03201  87 TPPPLD 92
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 608-704 1.42e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.47  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  608 PTGDSGAPPVPPTgdsgAPPVPPTgDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPpvtptgdSETAPVPPTG 687
Cdd:PHA02682  76 PSGQSPLAPSPAC----AAPAPAC-PACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAP-------ARPAPACPPS 143

                         90
                 ....*....|....*..
gi 27769331  688 DSGAPPVPPTGDSEAAP 704
Cdd:PHA02682 144 TRQCPPAPPLPTPKPAP 160
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 633-715 1.43e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   633 DSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTgdsETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 712
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAA---PAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113


                  ...
gi 27769331   713 EAQ 715
Cdd:PRK12270  114 EDE 116
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 571-655 1.50e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 44.50  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  571 TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDAGPP-P 649
Cdd:PHA03201   8 SPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaA 86


                 ....*.
gi 27769331  650 VPPTGD 655
Cdd:PHA03201  87 TPPPLD 92
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 562-638 1.57e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331   562 VPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPT-GDSGAPPVPPTGDSGAPPVPPTGDSGAPP 638
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKpAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 573-660 1.64e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   573 VPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgaPPVPPTGDAGPPPVPP 652
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAA------PAAPPAAAAAAAPAAA 111


                  ....*...
gi 27769331   653 TGDSGAPP 660
Cdd:PRK12270  112 AVEDEVTP 119
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 609-707 1.70e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.61  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  609 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPvPPTGDSGAPPVPPtgdsgappvtptgdsETAPVPPTGD 688
Cdd:NF041121  15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPG---------------SLAPPPPPPP 78

                         90
                 ....*....|....*....
gi 27769331  689 SGAPPVPPTGDSEAAPVPP 707
Cdd:NF041121  79 GPAGAAPGAALPVRVPAPP 97
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 581-720 1.72e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 44.92  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  581 TAPVPPTGDSGA-------PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSgapPVPPTGDSGAPPVPPTG--DAGPPPVP 651
Cdd:PLN03209 310 TAPLTPMEELLAkipsqrvPPKESDAADGPKPVPTKPVTPEAPSPPIEEE---PPQPKAVVPRPLSPYTAyeDLKPPTSP 386

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331  652 -PTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPV-------PPTDDSKEAQMPAVI 720
Cdd:PLN03209 387 iPTPPSSSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYaryedlkPPTSPSPTAPTGVSP 463
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
559-684 1.72e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 44.98  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  559 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 638
Cdd:PRK12727 134 SIPSPAAQALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAYAQDDDEQL 213

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 27769331  639 VPP--TGDAGPPP-VPPtgdsgaPPVPPTGDSGAPPVTPTGDSETAPVP 684
Cdd:PRK12727 214 DDDgfDLDDALPQiLPP------AALPPIVVAPAAPAALAAVAAAAPAP 256
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 616-699 1.74e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 44.11  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  616 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTpTGDSETAPVPPTGDSGAP-PV 694
Cdd:PHA03201   9 PSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPAGV-TFSSSAPPRPPLGLDDAPaAT 87


                 ....*
gi 27769331  695 PPTGD 699
Cdd:PHA03201  88 PPPLD 92
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 545-643 1.77e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 44.15  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   545 TLTYLALPTVT--DQEATPVPPTgDSEATPVPPTGDSE-TAPVPPtgdsgAPPVPPTGdsgAPPVPPTGDSGAPPVPPTg 621
Cdd:pfam07174  27 SAVAVALPAVAhaDPEPAPPPPS-TATAPPAPPPPPPApAAPAPP-----PPPAAPNA---PNAPPPPADPNAPPPPPA- 96

                          90       100
                  ....*....|....*....|..
gi 27769331   622 DSGAPPVPPTgdsgAPPVPPTG 643
Cdd:pfam07174  97 DPNAPPPPAV----DPNAPEPG 114
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 563-647 1.77e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 45.06  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  563 PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVP 640
Cdd:PRK14959 410 PAAGMTPSSAAPATPAPSAAPSPRVPWDDAPPAPPR--SGIPPRPAPRMPEASPVPgaPDSVASASDAPPTLGDPSDTAE 487


                 ....*..
gi 27769331  641 PTgDAGP 647
Cdd:PRK14959 488 HT-PSGP 493
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 613-696 1.79e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.61  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  613 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 692
Cdd:NF041121  16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94


                 ....
gi 27769331  693 PVPP 696
Cdd:NF041121  95 APPA 98
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 611-693 1.80e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   611 DSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVT-PTGDSETAPVPPTGDS 689
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAAS-----APAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAaPAAPPAAAAAAAPAAA 111


                  ....
gi 27769331   690 GAPP 693
Cdd:PRK12270  112 AVED 115
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 557-720 1.81e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 44.92  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  557 QEATPVPPTgdsEATPVPPTGDSETAPVPPTGDSGAPPVPPTG--DSGAPPVP-PTGDSGAPPVPPTGDSGAPPVPPTGD 633
Cdd:PLN03209 337 DGPKPVPTK---PVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAyeDLKPPTSPiPTPPSSSPASSKSVDAVAKPAEPDVV 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  634 SGAPPVPPTGDAGPPPV------------------PPTGDSGAPPVPpTGDSGAPPVTPTGDSETAPVPPTGDSGAPPvp 695
Cdd:PLN03209 414 PSPGSASNVPEVEPAQVeakktrplspyaryedlkPPTSPSPTAPTG-VSPSVSSTSSVPAVPDTAPATAATDAAAPP-- 490

                        170       180
                 ....*....|....*....|....*
gi 27769331  696 PTGDSEAAPVPPTDDSKEAQMPAVI 720
Cdd:PLN03209 491 PANMRPLSPYAVYDDLKPPTSPSPA 515
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 561-653 1.85e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 44.67  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  561 PVPPTGDSEATPvPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVP--PTGDSGAPP 638
Cdd:PRK14959 398 PTPGTQGPQGTA-PAAGMTPSSAAPATPAPSAAPSPRVPWDDAPPAPPR--SGIPPRPAPRMPEASPVPgaPDSVASASD 474

                         90
                 ....*....|....*
gi 27769331  639 VPPTGDAGPPPVPPT 653
Cdd:PRK14959 475 APPTLGDPSDTAEHT 489
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 564-696 1.95e-04

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 43.57  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  564 PTGDSEATPVPPtgdsetaPVPPTgdSGAPPVPPTGDSgAPPVPPT----GDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 639
Cdd:PHA03418  44 PQEDPDKNPSPP-------PDPPL--TPRPPAQPNGHN-KPPVTKQpggeGTEEDHQAPLAADADDDPRPGKRSKADEHG 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331  640 PPTGDAGPPPV-------PPTGDSGAPPvPPTGDSGAPPvtPTGDSETAPVPPTGD---SGAPPVPP 696
Cdd:PHA03418 114 PAPGRAALAPFkldldqdPLHGDPDPPP-GATGGQGEEP--PEGGEESQPPLGEGEgavEGHPPPLP 177
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
559-674 2.04e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  559 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP----VPPTGD-SGAPPVPPTGDSGAPPVPPTGDSGAPP--VPPT 631
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPadddPPPWEElPPEFASPAPAQPDAAPAGWVAESIPDPatADPD 535

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP 674
Cdd:PRK12323 536 DAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 622-704 2.17e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   622 DSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSE 701
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116


                  ...
gi 27769331   702 AAP 704
Cdd:PRK12270  117 VTP 119
PRK10856 PRK10856
cytoskeleton protein RodZ;
608-702 2.20e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.86  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  608 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdAGPPPVPPTGDSGAPPVPPTGDSGAPPV-TPTGDSETAPVPPT 686
Cdd:PRK10856 163 PLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVAT---APAPAVDPQQNAVVAPSQANVDTAATPApAAPATPDGAAPLPT 239

                         90
                 ....*....|....*.
gi 27769331  687 GDsgAPPVPPTGDSEA 702
Cdd:PRK10856 240 DQ--AGVSTPAADPNA 253
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 595-680 2.21e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   595 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtgdsgAPPVPPTGDSGAPPVTP 674
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAA-----PAAPPAAAAAAAPAAAA 112


                  ....*.
gi 27769331   675 TGDSET 680
Cdd:PRK12270  113 VEDEVT 118
PHA03369 PHA03369
capsid maturational protease; Provisional
 559-664 2.26e-04

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 44.60  E-value: 2.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  559 ATPVPPTGDSEATPVPPTGdSETAPvPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPptgdsgAPP 638
Cdd:PHA03369 351 ASLTAPSRVLAAAAKVAVI-AAPQT-HTGPADRQRPQRPDGIPYSVP-ARSPMTAYPPVPQFCGDPGLVSP------YNP 421

                         90       100
                 ....*....|....*....|....*.
gi 27769331  639 VPPTGDAGPPPVPPTgdsgaPPVPPT 664
Cdd:PHA03369 422 QSPGTSYGPEPVGPV-----PPQPTN 442
Gag_spuma pfam03276
Spumavirus gag protein;
562-676 2.28e-04

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 44.35  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   562 VPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--------------- 626
Cdd:pfam03276 186 IPPGASFSGLPSLPAIGGIHLPAIPGIHARAPPGNIARSLGDDIMPSLGDAGMPQPRFAFHPGNPfaeaeghpfaeaege 265

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331   627 -----PVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDS--GAPPVTPTG 676
Cdd:pfam03276 266 rprdiPRAPRIDAPSAPAIPAIQPIAPPMIPP--IGAPIPIPHGASipGEHIRNPRE 320
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 592-719 2.32e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 43.99  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  592 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPP 671
Cdd:NF040712 193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS-----DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPA 267

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 27769331  672 VTPTGDSETAPVPPtgdsgAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 719
Cdd:NF040712 268 AEPDEATRDAGEPP-----APGAAETPEAAEPPAPAPAAPAAPAAPEA 310
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 562-664 2.34e-04

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 44.23  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  562 VPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPV 639
Cdd:PHA03264 254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                         90       100
                 ....*....|....*....|....*
gi 27769331  640 PPTGDAGPPPVPPTGDSGAPPVPPT 664
Cdd:PHA03264 334 RPEGWPSLEAITFPPPTPATPAVPR 358
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 584-718 2.37e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 44.72  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  584 VPPtgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP--VPPTGDSGA- 658
Cdd:PRK14949 647 TPP---SRAPPASLSKPASSPDASQTSASFDLDPDfeLATHQSVPEAALASGSAPAPPPVPDPYDRPPweEAPEVASANd 723

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27769331  659 PPVPPTGDSGAPPVTPTGDSETAPVPPTgdSGAPP-VPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PRK14949 724 GPNNAAEGNLSESVEDASNSELQAVEQQ--ATHQPqVQAEAQSPASTTALTQTSSEVQDTE 782
PRK10856 PRK10856
cytoskeleton protein RodZ;
553-677 2.40e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.86  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  553 TVTDQEATPVPPTGDseaTPVPpTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVPPTG 632
Cdd:PRK10856 145 TMADQSSAELSQNSG---QSVP-LDTSTTTDPATTPAPAAPVDTTPTNSQTPAVAT---APAPAVDPQQNAVVAPSQANV 217

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27769331  633 DSGAPPVP-PTGDAGPPPVPPTGDsgAPPVPPTGDSGAPPVTPTGD 677
Cdd:PRK10856 218 DTAATPAPaAPATPDGAAPLPTDQ--AGVSTPAADPNALVMNFTAD 261
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 551-681 2.82e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   551 LPTVTDQEATPVPPTGDSEATPVPPTGDSetAPVPPTGDSGA--PPVP--PTGDSGAPPVPPTgdSGAPPVPPTGDSGAP 626
Cdd:pfam03154 418 MPQSQQLPPPPAQPPVLTQSQSLPPPAAS--HPPTSGLHQVPsqSPFPqhPFVPGGPPPITPP--SGPPTSTSSAMPGIQ 493

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331   627 PVPPTGDSGAPPVPPTGDAGPPPV-----PP--TGDSGAPPVPPTGDSGAPPV--TPTGDSETA 681
Cdd:pfam03154 494 PPSSASVSSSGPVPAAVSCPLPPVqikeeALdeAEEPESPPPPPRSPSPEPTVvnTPSHASQSA 557
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
574-686 2.93e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.00  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  574 PPTGDSETAPvPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP--TGDSGAPPVPPTGDSGAPPVPPTGdAGPPPVP 651
Cdd:PRK14971 371 GGRGPKQHIK-PVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQsaTQPAGTPPTVSVDPPAAVPVNPPS-TAPQAVR 448

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 27769331  652 PTGDSGAPPVPPTG-DSGAPPVT---------PTGDSETAPVPPT 686
Cdd:PRK14971 449 PAQFKEEKKIPVSKvSSLGPSTLrpiqekaeqATGNIKEAPTGTQ 493
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 549-671 3.58e-04

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 43.69  E-value: 3.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 549 LALPTVTDQEATPVPPTGDSEATPVP-PTGDSETAPVPPTGDsGAPPVPPTGDSGAP--PVPPTGDSGAP-PVPPTgdsg 624
Cdd:COG3266 244 LVLLLLIIGSALKAPSQASSASAPATtSLGEQQEVSLPPAVA-AQPAAAAAAQPSAValPAAPAAAAAAAaPAEAA---- 318

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 27769331 625 aPPVPPTgdsgAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPP 671
Cdd:COG3266 319 -APQPTA----AKPVVTETAAPAAPAPEAAAAAAAPAAPAVAKKLAA 360
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 617-707 4.25e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.73  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   617 VPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPtgdsETAPVPPtgdsgAPPVPP 696
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAA----PAAPPAA-----AAAAAP 108

                          90
                  ....*....|.
gi 27769331   697 TGDSEAAPVPP 707
Cdd:PRK12270  109 AAAAVEDEVTP 119
PRK10856 PRK10856
cytoskeleton protein RodZ;
597-691 4.26e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.09  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  597 PTGDSGAPPVPPTGDSgAPPVPPTGDSGapPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVP-PTGDSGAPPVTPT 675
Cdd:PRK10856 163 PLDTSTTTDPATTPAP-AAPVDTTPTNS--QTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaAPATPDGAAPLPT 239

                         90
                 ....*....|....*.
gi 27769331  676 GDseTAPVPPTGDSGA 691
Cdd:PRK10856 240 DQ--AGVSTPAADPNA 253
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 552-667 4.27e-04

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 42.42  E-value: 4.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATpvppTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPV-------PPTGDsgaPPVPPTGDSG 624
Cdd:PHA03418  74 PPVTKQPGG----EGTEEDHQAPLAADADDDPRPGKRSKADEHGPAPGRAALAPFkldldqdPLHGD---PDPPPGATGG 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 27769331  625 APPVPPTGDSGAPPVPPTGDAG----PPPVPPTGDsgapPVPPTGDS 667
Cdd:PHA03418 147 QGEEPPEGGEESQPPLGEGEGAveghPPPLPPAPE----PKPHNGDA 189
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
558-701 4.45e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  558 EATPVPPTGDSEATPvPPTGDSETAPVPptgdsgAPPVPPTGDSGAPPVPptGDSGAPPVPPTGDSGAPPVPPTGDSGAP 637
Cdd:PRK12323 449 APAPAPAAAPAAAAR-PAAAGPRPVAAA------AAAAPARAAPAAAPAP--ADDDPPPWEELPPEFASPAPAQPDAAPA 519

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331  638 PVPPTGDAGPPPVPPTGDSGAPPVPPTGdSGAPPVTPTGDSETAPVPPtgDSGAPPVPPTGDSE 701
Cdd:PRK12323 520 GWVAESIPDPATADPDDAFETLAPAPAA-APAPRAAAATEPVVAPRPP--RASASGLPDMFDGD 580
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 638-719 4.47e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 42.99  E-value: 4.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   638 PVPPTGDAGPPPvpptgdsgAPPVPPTGDSG-APPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQM 716
Cdd:pfam07174  32 ALPAVAHADPEP--------APPPPSTATAPpAPPPPPPAPAAPAPPPPPAAPNAPNAPPPPADPNAPPPPPADPNAPPP 103


                  ...
gi 27769331   717 PAV 719
Cdd:pfam07174 104 PAV 106
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 617-707 4.49e-04

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 43.46  E-value: 4.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  617 VPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPP--VTPTGDSETAPVPPTGDSGAPPV 694
Cdd:PHA03264 254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPepAGRDGAAGGEPKPGPPRPAPDAD 333

                         90
                 ....*....|....*
gi 27769331  695 PPTG--DSEAAPVPP 707
Cdd:PHA03264 334 RPEGwpSLEAITFPP 348
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 606-686 4.63e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.73  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   606 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPVPP 685
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK--PAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115


                  .
gi 27769331   686 T 686
Cdd:PRK12270  116 E 116
PRK12495 PRK12495
hypothetical protein; Provisional
 553-646 5.08e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 42.16  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  553 TVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGD-SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 631
Cdd:PRK12495  85 TAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDPTAQPATPDERRSPRQRPPVS 164

                         90
                 ....*....|....*
gi 27769331  632 GDSGAPPVPPTGDAG 646
Cdd:PRK12495 165 GEPPTPSTPDAHVAG 179
PRK11633 PRK11633
cell division protein DedD; Provisional
 604-709 5.18e-04

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 42.30  E-value: 5.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  604 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvppTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPV 683
Cdd:PRK11633  42 PLVPKPGDRDEPDMMPAATQALPTQPPEGAAEAVR---AGDAAAPSLDPA--TVAPPNTPVEPEPAPVEPPKPKPVEKPK 116

                         90       100
                 ....*....|....*....|....*.
gi 27769331  684 PPTGDSGAPPVPPTGDSEAAPVPPTD 709
Cdd:PRK11633 117 PKPKPQQKVEAPPAPKPEPKPVVEEK 142
PRK12495 PRK12495
hypothetical protein; Provisional
 554-657 5.57e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 42.16  E-value: 5.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  554 VTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 632
Cdd:PRK12495  75 GDDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDPTAQPATPDER 154

                         90       100
                 ....*....|....*....|....*
gi 27769331  633 DSGAPPVPPTGDAGPPPVPPTGDSG 657
Cdd:PRK12495 155 RSPRQRPPVSGEPPTPSTPDAHVAG 179
PRK12495 PRK12495
hypothetical protein; Provisional
 566-668 6.27e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 41.78  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  566 GDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD 644
Cdd:PRK12495  76 DDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDPTAQPATPDERR 155

                         90       100
                 ....*....|....*....|....
gi 27769331  645 AGPPPVPPTGDSGAPPVPPTGDSG 668
Cdd:PRK12495 156 SPRQRPPVSGEPPTPSTPDAHVAG 179
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 568-681 6.57e-04

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 42.44  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   568 SEATPVPPTGDSETAPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDSGAPPV---PPT 642
Cdd:pfam16072 156 SGTTVINAGGQQPAAPAAPA----YPVAPAAYPAQAPAAAPAPAPGAPqtPLAPLNPVAAAPAAAAGAAAAPVVaaaAPA 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 27769331   643 GDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETA 681
Cdd:pfam16072 232 AAAPPPPAPAAPPADAAPPAPGGIICVPVRVPEPDPKDA 270
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 552-674 7.37e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 7.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGA----PPVPPTGDSGAPPVPPTGDSGAPP 627
Cdd:PHA03307  790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAaarpPPARSSESSKSKPAAAGGRARGKN 869

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 27769331   628 vPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP 674
Cdd:PHA03307  870 -GRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGP 915
PHA03419 PHA03419
E4 protein; Provisional
 587-693 7.77e-04

E4 protein; Provisional


Pssm-ID: 223079 [Multi-domain]  Cd Length: 200  Bit Score: 41.47  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  587 TGDSGAPPVPPTGDSGAPPVPPTGDSGaPPVPPTGDSGAPPVPPTG------DSGAPPVPPTGDAGPPPVP---PTGDSG 657
Cdd:PHA03419  47 TGYPFCPPTTPHPSSQPPPCPPSPGHP-PQTNDTHEKDLALQPPPGgkkkekKKKETEKPAQGGEKPDQGPeakGEGEGH 125

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 27769331  658 APPVPPTGDsgaPPVTPTGDSETAPVPPTGDSGAPP 693
Cdd:PHA03419 126 EPEDPPPED---TPPPPGGEGEVEGGPSPGPGPGPL 158
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 581-656 7.91e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 42.81  E-value: 7.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27769331  581 TAPVPPTGDSGAPPVPptgdsgAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDAGPPPVPPTGDS 656
Cdd:PRK14965 382 PAPPSAAWGAPTPAAP------AAP-PPAAAPPVPPAAPARPAAARPAPAPAPPAAAA-PPARSADPAAAASAGDR 449
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 572-712 8.75e-04

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 41.65  E-value: 8.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  572 PVPPTGDSETAPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPT----GDSGAPPVPPTGDSGAPPVPPTGDAGP 647
Cdd:PHA03418  34 PLLPAPHHPNPQEDPDKNPSPPPDPPL--TPRPPAQPNGHN-KPPVTKQpggeGTEEDHQAPLAADADDDPRPGKRSKAD 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27769331  648 PPVPPTGDSGAPPV-------PPTGDSGAPPVTPTGDSETapvPPTGDSGAPPVPPTGDSEA----APVPPTDDSK 712
Cdd:PHA03418 111 EHGPAPGRAALAPFkldldqdPLHGDPDPPPGATGGQGEE---PPEGGEESQPPLGEGEGAVeghpPPLPPAPEPK 183
PRK10856 PRK10856
cytoskeleton protein RodZ;
613-705 9.13e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.94  E-value: 9.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  613 GAPPVPPTGDSGAPPvpptGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVP--PTGDSG 690
Cdd:PRK10856 158 SGQSVPLDTSTTTDP----ATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaaPATPDG 233

                         90
                 ....*....|....*
gi 27769331  691 APPVPPTGDSEAAPV 705
Cdd:PRK10856 234 AAPLPTDQAGVSTPA 248
Gag_spuma pfam03276
Spumavirus gag protein;
560-717 9.32e-04

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 42.43  E-value: 9.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   560 TPVPPTGDSEATPvPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPV------PPTGDSG----APPVPPTGDSGAPPVP 629
Cdd:pfam03276 206 LPAIPGIHARAPP-GNIARSLGDDIMPSLGDAGMPQPRFAFHPGNPFaeaeghPFAEAEGerprDIPRAPRIDAPSAPAI 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   630 PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTG------------DSGAPPVTPTGDSETAPVPPTGDSGAPPVPPT 697
Cdd:pfam03276 285 PAIQPIAPPMIPPIGAPIPIPHGASIPGEHIRNPREepirlgreapaiDGRFAPAIDDLFCRIINALLCGIIGALLGGGD 364

                         170       180
                  ....*....|....*....|
gi 27769331   698 GDSEAAPVPPTDDSKEAQMP 717
Cdd:pfam03276 365 CISLDPADAILFDRAVAQLF 384
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 611-704 9.46e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.62  E-value: 9.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  611 DSGAPPVPPTGdsgappvPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvtptgdSETAPVPPTgdsg 690
Cdd:PRK14954 377 DGGVAPSPAGS-------PDVKKKAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTP------EQQPPVARS---- 439

                         90
                 ....*....|....
gi 27769331  691 aPPVPPTGDSEAAP 704
Cdd:PRK14954 440 -APLPPSPQASAPR 452
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 557-685 9.92e-04

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 42.11  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   557 QEATPVPPTGDSEATPVPPTgdsETAPVPPTGDSGAPPVPPTGdSGAPPVPPtGDSGAPPV----PPTGDSGAPPVPPtg 632
Cdd:pfam15279 181 PPPSPLPAFMEPSSMPPPFL---RPPPSIPQPNSPLSNPMLPG-IGPPPKPP-RNLGPPSNpmhrPPFSPHHPPPPPT-- 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 27769331   633 dsgaPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPP 685
Cdd:pfam15279 254 ----PPGPPPGLPPPPPRGFTPPFGPPFPPVNMMPNPPEMNFGLPSLAPLVPP 302
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 628-708 1.02e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.57  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   628 VPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTgdSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:PRK12270   38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK--PAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115


                  .
gi 27769331   708 T 708
Cdd:PRK12270  116 E 116
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 559-651 1.03e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 42.30  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  559 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPvPPTGDSGAPPVPptGDSGAPPVPPTGDSGAPPvpptGDSGAPP 638
Cdd:NF041121  20 APPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYP--GSLAPPPPPPPGPAGAAP----GAALPVR 92

                         90
                 ....*....|...
gi 27769331  639 VPptgdaGPPPVP 651
Cdd:NF041121  93 VP-----APPALP 100
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 555-721 1.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   555 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG----APPVPPTGDSGAPPVPPTGDSGAPPVPP 630
Cdd:PHA03307  782 RGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGsessGPARPPGAAARPPPARSSESSKSKPAAA 861

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   631 TGDSGAPPvpptGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSEtAPVPPTGDSGAPPVPPTGDSEAAPVPPTDD 710
Cdd:PHA03307  862 GGRARGKN----GRRRPRPPEPRARPGAAA-PPKAAAAAPPAGAPAPRP-RPAPRVKLGPMPPGGPDPRGGFRRVPPGDL 935

                         170
                  ....*....|.
gi 27769331   711 SKEAQMPAVIR 721
Cdd:PHA03307  936 HTPAPSAAALA 946
PHA03369 PHA03369
capsid maturational protease; Provisional
 568-687 1.20e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 42.29  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  568 SEATPVPPTGDSETAPVPPTGdsGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTgdagp 647
Cdd:PHA03369 349 KTASLTAPSRVLAAAAKVAVI--AAPQTHTGPADRQRPQRPDGIPYSVP-ARSPMTAYPPVPQFCGDPGLVSPYN----- 420

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 27769331  648 pPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTG 687
Cdd:PHA03369 421 -PQSPG--TSYGPEPVGPVPPQPTNPYVMPISMANMVYPG 457
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 560-644 1.21e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 41.80  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  560 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAP-P 638
Cdd:PHA03201   8 SPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaA 86


                 ....*.
gi 27769331  639 VPPTGD 644
Cdd:PHA03201  87 TPPPLD 92
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 588-703 1.26e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.98  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   588 GDSGAPPVPPTG----DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGdSGAPPVPP 663
Cdd:TIGR01645 325 GPRAQSPATPSSslptDIGNKAVVSSAKKEAEEVPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSLVAPPG-LVAPTEIN 403

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 27769331   664 TGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAA 703
Cdd:TIGR01645 404 PSFLASPRKKMKREKLPVTFGALDDTLAWKEPSKEDQTSE 443
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 568-707 1.31e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   568 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 647
Cdd:PHA03307  773 ALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSE 852

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   648 PPVPptgDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:PHA03307  853 SSKS---KPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAP 909
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
599-714 1.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.07  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  599 GDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPpVPPTGDAGPPPVPPtgdsgaPPVPPTgdSGAPPVTPTGDS 678
Cdd:PRK14971 366 GDDASGGRGPK----QHIKPVFTQPAAAPQPSAAAAASP-SPSQSSAAAQPSAP------QSATQP--AGTPPTVSVDPP 432

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 27769331  679 ETAPVPPTGdSGAPPVPPTGDSEAAPVPPTDDSKEA 714
Cdd:PRK14971 433 AAVPVNPPS-TAPQAVRPAQFKEEKKIPVSKVSSLG 467
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 575-706 1.40e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.47  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  575 PTGDSETAPVPPTGDSGAPP--VPPTGDSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDSGAPPVPPTGDAGPP---P 649
Cdd:PTZ00436 211 PSGKKSAKAAAPAKAAAAPAkaAAPPAKAAAAPAKAAAAPAKAAAPP-AKAAAPPAKAAAPPAKAAAPPAKAAAPPakaA 289

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  650 VPPTGDSGAP---PVPPTGDSGAPPVTPTGDSETApVPPTGDSGAPPVPPTGDSEAAPVP 706
Cdd:PTZ00436 290 APPAKAAAAPakaAAAPAKAAAAPAKAAAPPAKAA-APPAKAATPPAKAAAPPAKAAAAP 348
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 555-641 1.41e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.18  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   555 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDS 634
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPP-KPAAAAAAAAAPAAPPAAAAAAAPAAAA 112


                  ....*..
gi 27769331   635 GAPPVPP 641
Cdd:PRK12270  113 VEDEVTP 119
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 552-645 1.42e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 41.48  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTgdseATPVPPtgdsETAPVPPTGDSGAPPVPPtGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPT 631
Cdd:PHA03291 199 PADVFVPATPRPTP----RTTASP----ETTPTPSTTTSPPSTTIP-APSTTIAAPQAGTTPEAEGTP-----APPTPGG 264

                         90
                 ....*....|....
gi 27769331  632 GDSGAPPVPPTGDA 645
Cdd:PHA03291 265 GEAPPANATPAPEA 278
PRK12438 PRK12438
hypothetical protein; Provisional
 590-648 1.47e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 42.16  E-value: 1.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27769331  590 SGAPPVPPTGDSGAPpvPPTGdsGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTGDAGPP 648
Cdd:PRK12438 899 TGRVATAPGGDAASA--PPPG--AGPPAPP------QAVPPPRTTQPPAAPPRGPDVPP 947
Med25_SD1 pfam11235
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ...
 562-693 1.50e-03

Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear.


Pssm-ID: 463244 [Multi-domain]  Cd Length: 157  Bit Score: 39.77  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   562 VPPTGDSEATPVPPtgdSETAPVPPTGDSGA----------PPVPPT----GDSGAPPVPPTGDSGAP------------ 615
Cdd:pfam11235   1 LPVGGGSAPGPLQS---KQPVPLPPAAPSGAtlsaapqqplPPVPPQyqvpGNLSAAQVAAQNAVEAAknqkaglgprfs 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331   616 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPP 693
Cdd:pfam11235  78 PITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPVPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSP 155
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 569-666 1.52e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.98  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  569 EATPVPPTgdseTAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgaPPVPPTGDSGAPPV--PPTGDAG 646
Cdd:PLN02983 139 EALPQPPP----PAPVVMMQPPPPHAMPPASPPAAQPAPSAPASSPPPTPAS-----PPPAKAPKSSHPPLksPMAGTFY 209

                         90       100
                 ....*....|....*....|
gi 27769331  647 PPPVPptgdsGAPPVPPTGD 666
Cdd:PLN02983 210 RSPAP-----GEPPFVKVGD 224
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
552-714 1.52e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 41.96  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 552 PTVTDQEATPVPPTGDSeatpvPPTGDSETAPVPPTGDSGAPPVPPTgdSGAPPVpptgdsgAPPVPPTGDSGAPPVPPT 631
Cdd:COG5665 256 SSQQPKSQPTSPSGGTT-----PPSTNQLTTSNTPTSTAKAQPQPPT--KKQPAK-------EPPSDTASGNPSAPSVLI 321

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 632 gDSGAPPVPPTGDAGPPPVPPTGDSGAP---PVPP-----TGDSGAPPVTPT-----------GDSETAPVPPTGDSGAP 692
Cdd:COG5665 322 -NSDSPTSEDPATASVPTTEETTAFTTPssvPSTPaekdtPATDLATPVSPTppetsvdkkvsPDSATSSTKSEKEGGTA 400

                       170       180
                ....*....|....*....|....*
gi 27769331 693 --PVPP-TGDSEAAPVPPTDDSKEA 714
Cdd:COG5665 401 ssPMPPnIAIGAKDDVDATDPSQEA 425
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 620-700 1.63e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 41.42  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   620 TGDSGAPPVPPTGdsgappvPPTGDAGPPPVPPTGDSGAPPvpptgdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGD 699
Cdd:TIGR00601  81 TGKVAPPAATPTS-------APTPTPSPPASPASGMSAAPA------SAVEEKSPSEESATATAPESPSTSVPSSGSDAA 147


                  .
gi 27769331   700 S 700
Cdd:TIGR00601 148 S 148
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 634-719 1.64e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 41.65  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  634 SGAPPVPPTGDAGPPPVPPtgdsgAPPvPPTGDSGAPPVTPTGDSETAPVPPtgdsgapPVPPtgdseAAPVPPTDDSKE 713
Cdd:PRK14965 379 RGAPAPPSAAWGAPTPAAP-----AAP-PPAAAPPVPPAAPARPAAARPAPA-------PAPP-----AAAAPPARSADP 440


                 ....*.
gi 27769331  714 AQMPAV 719
Cdd:PRK14965 441 AAAASA 446
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 566-652 1.73e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.80  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   566 GDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPptgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDA 645
Cdd:PRK12270   39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAP------AAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAA 112


                  ....*..
gi 27769331   646 GPPPVPP 652
Cdd:PRK12270  113 VEDEVTP 119
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 600-682 1.77e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.80  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   600 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPptGDSGAPPVPPTGDSGAPPVTPTGDSE 679
Cdd:PRK12270   35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKP--AAAAAAAAAPAAPPAAAAAAAPAAAA 112


                  ...
gi 27769331   680 TAP 682
Cdd:PRK12270  113 VED 115
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 586-718 1.92e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.09  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  586 PTGDSGAPPVPPTGDSGAPP--VPPTGDSGAPPvpptGDSGAPPVPPTGDSGAPPVPPTGDAGPP--PVPPTGDSGAPP- 660
Cdd:PTZ00436 211 PSGKKSAKAAAPAKAAAAPAkaAAPPAKAAAAP----AKAAAAPAKAAAPPAKAAAPPAKAAAPPakAAAPPAKAAAPPa 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27769331  661 ---VPPTGDSGAPPVTPTGDSETAPVPptGDSGAPPVPPTGDSEAAPVPPtddSKEAQMPA 718
Cdd:PTZ00436 287 kaaAPPAKAAAAPAKAAAAPAKAAAAP--AKAAAPPAKAAAPPAKAATPP---AKAAAPPA 342
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 619-709 1.94e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 41.03  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  619 PTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGdsetAPVPPTGDSGAPPVPPTG 698
Cdd:PHA03201   4 ARSRSPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRG----CPAGVTFSSSAPPRPPLG 79

                         90
                 ....*....|...
gi 27769331  699 --DSEAAPVPPTD 709
Cdd:PHA03201  80 ldDAPAATPPPLD 92
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 599-704 2.10e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 41.37  E-value: 2.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 599 GDSGAPPVPPTGDSGAPPVPPTGDsGAPPVPPTGDSGAP--PVPPTGDAG-PPPVPPTgdsgaPPVPPTgdsgAPPVTPT 675
Cdd:COG3266 262 SSASAPATTSLGEQQEVSLPPAVA-AQPAAAAAAQPSAValPAAPAAAAAaAAPAEAA-----APQPTA----AKPVVTE 331

                        90       100
                ....*....|....*....|....*....
gi 27769331 676 GDSETAPVPPTGDSGAPPVPPTGDSEAAP 704
Cdd:COG3266 332 TAAPAAPAPEAAAAAAAPAAPAVAKKLAA 360
PHA03379 PHA03379
EBNA-3A; Provisional
 564-707 2.13e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 41.58  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  564 PTGDSEATPVPPT--------GDSETAPvpPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtGDSg 635
Cdd:PHA03379 408 ASEPTYGTPRPPVekprpevpQSLETAT--SHGSAQVPEPPPVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEP-GDQ- 483

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331  636 APPVPPTGDAGPPPVP-PTGdsgaPPVPP--TGDSGAPPVTPtgdsetAPVPPTGDSGAP-PVPPTG-DSEAAPVPP 707
Cdd:PHA03379 484 LPGVVQDGRPACAPVPaPAG----PIVRPweASLSQVPGVAF------APVMPQPMPVEPvPVPTVAlERPVCPAPP 550
PRK12438 PRK12438
hypothetical protein; Provisional
 601-654 2.17e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 41.39  E-value: 2.17e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27769331  601 SGAPPVPPTGDSGAPPvpPTGdsGAPPVPPtgdsgaPPVPPTGDAGPPPVPPTG 654
Cdd:PRK12438 899 TGRVATAPGGDAASAP--PPG--AGPPAPP------QAVPPPRTTQPPAAPPRG 942
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 585-696 2.19e-03

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 40.95  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   585 PPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPtGDAGPPPVPPTGDSGAP-PVPP 663
Cdd:pfam15279 176 KPQQHPPPSPLPAFMEPSSMPPPFL--RPPPSIPQPNSPLSNPMLPG--IGPPPKPP-RNLGPPSNPMHRPPFSPhHPPP 250

                          90       100       110
                  ....*....|....*....|....*....|...
gi 27769331   664 TGDSGAPPVTPTGDSETAPVPPTGdsgaPPVPP 696
Cdd:pfam15279 251 PPTPPGPPPGLPPPPPRGFTPPFG----PPFPP 279
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
552-698 2.28e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 41.19  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPpTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTGDSgaPPVPPT 631
Cdd:pfam05539 187 PTYPSQVTPQSQPATQGHQTATANQRLSSTEPVG-TQGTTTSSNPEP--QTEPPPSQRGPSGSPQHPPSTTS--QDQSTT 261

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331   632 GDSGA-PPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTG 698
Cdd:pfam05539 262 GDGQEhTQRRKTPPATSNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGSSPPHSSPPGVQANPTT 329
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 602-721 2.28e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 41.09  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  602 GAPPVPPTGDSGAPPVPPTGDSGA--PPVPPTgdsgAPPVPPTGDAGPPPVPPTGDSGAPPvpptgDSGAPPVTPTGDSE 679
Cdd:PHA03291 162 GLAAFPAEGTLAAPPLGEGSADGScdPALPLS----APRLGPADVFVPATPRPTPRTTASP-----ETTPTPSTTTSPPS 232

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 27769331  680 TAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 721
Cdd:PHA03291 233 TTIPAPSTTIAAPQAGTTPEAEGTPAPPTPGGGEAPPANATP 274
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 603-721 2.37e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.91  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  603 APPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgAPPVPPTGDAGPPPVPPTGD--SGAPPVPPTGDSGAPPVTPTGDSET 680
Cdd:NF040712 193 GRPLRPLATVPRLAREPADARPEEVEPAP----AAEGAPATDSDPAEAGTPDDlaSARRRRAGVEQPEDEPVGPGAAPAA 268

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 27769331  681 APVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 721
Cdd:NF040712 269 EPDEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAPAAPE 309
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 626-707 2.38e-03

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 39.08  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   626 PPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGA---PPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEA 702
Cdd:pfam06346   1 PPPPPLPGDSSTIPLPPGACIPTPPPLPGGGGPPPPPPLPGSAAippPPPLPGGTSIPPPPPLPGAASIPPPPPLPGSTG 80


                  ....*
gi 27769331   703 APVPP 707
Cdd:pfam06346  81 IPPPP 85
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
576-708 2.39e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  576 TGDSETAPvPPTGDSgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP--TGDSGAPPVPPTGDAGPPPVPPT 653
Cdd:PRK14971 363 TQKGDDAS-GGRGPK-QHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQsaTQPAGTPPTVSVDPPAAVPVNPP 440

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 27769331  654 GdSGAPPVPPTGDSGAPPVTPTGDSETAPvPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:PRK14971 441 S-TAPQAVRPAQFKEEKKIPVSKVSSLGP-STLRPIQEKAEQATGNIKEAPTGTQ 493
PHA03378 PHA03378
EBNA-3B; Provisional
 571-707 2.39e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  571 TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP--VPPTgdSGAPPVPPTGDAGPP 648
Cdd:PHA03378 650 TPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPpaAPPG--RAQRPAAATGRARPP 727

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27769331  649 PVPPTgdSGAPPVPPTGDSGAPPVTPtgdseTAPVPPTGDSGAPPVPPTGDSEAAPVPP 707
Cdd:PHA03378 728 AAAPG--RARPPAAAPGRARPPAAAP-----GRARPPAAAPGRARPPAAAPGAPTPQPP 779
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 582-708 2.43e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 41.09  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  582 APVPPTGDSGAPPVPPTGDSGA--PPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPP---VPPTGDAGPPPVPPTGDS 656
Cdd:PHA03291 164 AAFPAEGTLAAPPLGEGSADGScdPALPLS----APRLGPADVFVPATPRPTPRTTASPettPTPSTTTSPPSTTIPAPS 239

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27769331  657 GAPPVPPTGDSGAPPVTPtgdsetapvpptgdsgAPPVPPTGDSEAAPVPPT 708
Cdd:PHA03291 240 TTIAAPQAGTTPEAEGTP----------------APPTPGGGEAPPANATPA 275
PRK12438 PRK12438
hypothetical protein; Provisional
 612-673 2.55e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 41.39  E-value: 2.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331  612 SGAPPVPPTGDSGAPpvPPTGdsGAPPVPPTgdAGPPPVPPTgdsgaPPVPPTGDSGAPPVT 673
Cdd:PRK12438 899 TGRVATAPGGDAASA--PPPG--AGPPAPPQ--AVPPPRTTQ-----PPAAPPRGPDVPPAA 949
PHA03378 PHA03378
EBNA-3B; Provisional
 560-647 2.60e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  560 TPVPPTGDSEATPVPPTGDSETAPvPPTGDSGAP-PVPPtgdSGAPPVPPTGDSGAP-PVPPtgdsgaPPVPPTGDSGAP 637
Cdd:PHA03378 742 GRARPPAAAPGRARPPAAAPGRAR-PPAAAPGAPtPQPP---PQAPPAPQQRPRGAPtPQPP------PQAGPTSMQLMP 811

                         90
                 ....*....|
gi 27769331  638 PVPPtGDAGP 647
Cdd:PHA03378 812 RAAP-GQQGP 820
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 557-634 2.70e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.88  E-value: 2.70e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27769331  557 QEATPVPPTGDSEATPVPPTGdsetaPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDS 634
Cdd:PRK14965 378 ERGAPAPPSAAWGAPTPAAPA-----APPPAAAPPVPPAAPARPAAARPAPAPAPPAAAA-PPARSADPAAAASAGDR 449
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 552-709 2.70e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   552 PTVTDQEAT-PVPPTGDSEATPVPPTgdseTAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 630
Cdd:pfam05109 466 PTVSTADVTsPTPAGTTSGASPVTPS----PSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGK 541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   631 TGDSGAPPVPPTGDAGPPP--VPPTGDSGAPPVPPTGDSGApPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPV--- 705
Cdd:pfam05109 542 TSPTSAVTTPTPNATSPTPavTTPTPNATIPTLGKTSPTSA-VTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVvts 620


                  ....
gi 27769331   706 PPTD 709
Cdd:pfam05109 621 PPKN 624
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 552-627 2.88e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 2.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331   552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPT-GDSGAPPVPPTGDSGAPPVPPTGDSGAPP 627
Cdd:PRK12270   39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKpAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 561-663 2.94e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 39.25  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   561 PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP-----VPPTGDSGAPPVPPTGDSGAPPVP------PTGDSGAPPVP 629
Cdd:pfam15240  56 PQPPASDDPPGPPPPGGPQQPPPQGGKQKPQGPPpqggpRPPPGKPQGPPPQGGNQQQGPPPPgkpqgpPPQGGGPPPQG 135

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 27769331   630 ptGDSGAPPVPPTGDA-GPPPVPPTGdsGAPPVPP 663
Cdd:pfam15240 136 --GNQQGPPPPPPGNPqGPPQRPPQP--GNPQGPP 166
motB PRK12799
flagellar motor protein MotB; Reviewed
 588-712 3.27e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.47  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  588 GDSGAPPV---PPTGDSGAPPVPPTGDSGAP-----PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAP 659
Cdd:PRK12799 294 DTHGTVPVaavTPSSAVTQSSAITPSSAAIPspaviPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVN 373

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27769331  660 PVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPvpptgDSEAAPVPPTDDSK 712
Cdd:PRK12799 374 MQPQPMSTTETQQSSTGNITSTANGPTTSLPAAP-----ASNIPVSPTSRDAQ 421
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 644-718 3.38e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 3.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331   644 DAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:PRK12270   35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPA 109
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 535-713 3.50e-03

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 40.71  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  535 SLRTNFLRYW--TLTYLALPTVTDQEATPVPPTGDSEATPVPPT----GDSETAPVPPTGDSGAPPVPPTGDSGAPPVPP 608
Cdd:PHA03321 403 ALATELFRTGvpSEHYEASLRLLSSRQPPGAPAPRRDNDPPPPPrarpGSTPACARRARAQRARDAGPEYVDPLGALRRL 482

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  609 TgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtgDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGD 688
Cdd:PHA03321 483 P--AGAAPPPEPAAAPSPATYYTRMGGGPPRLPPRNRATETLRP--DWGPPAAAPPEQMEDPYLEPDDDRFDRRDGAAAA 558

                        170       180
                 ....*....|....*....|....*
gi 27769331  689 SGAPPVPPTGDSEAAPVPPTDDSKE 713
Cdd:PHA03321 559 ATSHPREAPAPDDDPIYEGVSDSEE 583
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 558-682 3.59e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 3.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 558 EATPVPPTGDSEATPVPPTGDSETAPvPPTGDSGAPPVPPTGDSGAPPVPPTGDsGAPPVPPTGDSGAP--PVPPTGDSG 635
Cdd:COG3266 233 AAGAAEVLTARLVLLLLIIGSALKAP-SQASSASAPATTSLGEQQEVSLPPAVA-AQPAAAAAAQPSAValPAAPAAAAA 310

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 27769331 636 AP-PVPPT--GDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAP 682
Cdd:COG3266 311 AAaPAEAAapQPTAAKPVVTETAAPAAPAPEAAAAAAAPAAPAVAKKLAA 360
PRK10856 PRK10856
cytoskeleton protein RodZ;
552-636 3.81e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 40.01  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  552 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDsgAPPVPP 630
Cdd:PRK10856 170 TDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaAPATPDGAAPLPTDQ--AGVSTP 247


                 ....*.
gi 27769331  631 TGDSGA 636
Cdd:PRK10856 248 AADPNA 253
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 557-680 3.81e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 39.84  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  557 QEATPVPPTGDSEATPVPPTGDSETAPVPP----TGDSGAPPVPPTGDSGAPP--VPPTGDSGAPPVPPTgDSGAPPVPP 630
Cdd:PHA02682  74 QRPSGQSPLAPSPACAAPAPACPACAPAAPapavTCPAPAPACPPATAPTCPPpaVCPAPARPAPACPPS-TRQCPPAPP 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27769331  631 -TGDSGAPPVPPT--GDAGPPPVPPTGD----SGAPPVPPTGDSGAPPVTPTGDSET 680
Cdd:PHA02682 153 lPTPKPAPAAKPIflHNQLPPPDYPAAScptiETAPAASPVLEPRIPDKIIDADNDD 209
PTZ00429 PTZ00429
beta-adaptin; Provisional
 556-659 3.92e-03

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 40.69  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  556 DQEATPVPPT---GDSEATPVPPTGDSETAPVPPTGD-SGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDS------- 623
Cdd:PTZ00429 615 DDDAVELPSTpsmGTQDGSPAPSAAPAGYDIFEFAGDgTGAPHPVASGSNGAQHADPLGDlFSGLPSTVGASSpafqaas 694

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 27769331  624 --GAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAP 659
Cdd:PTZ00429 695 gsQAPASPPTAASAIEDLFANGMGSGSQTVPLPISAAP 732
PRK12438 PRK12438
hypothetical protein; Provisional
 634-693 4.18e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 40.62  E-value: 4.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  634 SGAPPVPPTGDAGPPpvPPTGdsGAPPVPPTgdSGAPPVTPtgdseTAPVPPTGDSGAPP 693
Cdd:PRK12438 899 TGRVATAPGGDAASA--PPPG--AGPPAPPQ--AVPPPRTT-----QPPAAPPRGPDVPP 947
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 590-718 4.39e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 40.44  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   590 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGdsga 669
Cdd:TIGR01645 320 GAAVLGPRAQSPATPSSSLPTDIGNKAVVSSAKKEAEEVPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSLVAPPG---- 395

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 27769331   670 pPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 718
Cdd:TIGR01645 396 -LVAPTEINPSFLASPRKKMKREKLPVTFGALDDTLAWKEPSKEDQTSE 443
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
632-721 4.91e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  632 GDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 711
Cdd:PRK14971 366 GDDASGGRGPKQHIKPVFTQPA--AAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTA 443

                         90
                 ....*....|
gi 27769331  712 KEAQMPAVIR 721
Cdd:PRK14971 444 PQAVRPAQFK 453
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
620-714 5.01e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 40.33  E-value: 5.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  620 TGDSGAPPVPPTGDSGAPPVPPtgdagPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGdSGAPPVPPTGD 699
Cdd:PRK14948 512 SQSGSASNTAKTPPPPQKSPPP-----PAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADS-SPPPPIPEEPT 585

                         90
                 ....*....|....*
gi 27769331  700 SEAAPVPPTDDSKEA 714
Cdd:PRK14948 586 PSPTKDSSPEEIDKA 600
dnaA PRK14086
chromosomal replication initiator protein DnaA;
582-709 5.09e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.19  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  582 APVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD----AGPPPVPPTGDSG 657
Cdd:PRK14086  86 ITVDPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAyqqrPEPGAWPRAADDY 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27769331  658 APPVPPTG-DSGAPPVTPTGDS-ETAPVPPTGDSGAPPVPPTGDSEAAPVPPTD 709
Cdd:PRK14086 166 GWQQQRLGfPPRAPYASPASYApEQERDREPYDAGRPEYDQRRRDYDHPRPDWD 219
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 544-642 5.10e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.99  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  544 WTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDS--ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDsgaPPVPPTG 621
Cdd:NF041121  10 WLAAQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPspPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPG---PAGAAPG 86

                         90       100
                 ....*....|....*....|.
gi 27769331  622 DSGAPPVPptgdsgAPPVPPT 642
Cdd:NF041121  87 AALPVRVP------APPALPN 101
PRK10856 PRK10856
cytoskeleton protein RodZ;
624-722 5.31e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 39.62  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  624 GAPPVPPTGDSGAPPVP---PTGDAGPPPVPPTGdsgappvPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVP-PTGD 699
Cdd:PRK10856 158 SGQSVPLDTSTTTDPATtpaPAAPVDTTPTNSQT-------PAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaAPAT 230

                         90       100
                 ....*....|....*....|....*...
gi 27769331  700 SEAAPVPPTDDSKEAQMPA-----VIRF 722
Cdd:PRK10856 231 PDGAAPLPTDQAGVSTPAAdpnalVMNF 258
PRK11901 PRK11901
hypothetical protein; Reviewed
 587-712 5.58e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 39.67  E-value: 5.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  587 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPpvpptGDSGAPPVPPTGDSGAPPVPPTG-----------DA---------G 646
Cdd:PRK11901  88 SSGNQSSPSAANNTSDGHDASGVKNTAPP-----QDISAPPISPTPTQAAPPQTPNGqqrielpgnisDAlsqqqgqvnA 162

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27769331  647 PPPVPPTGDSGAPPVPPTGDSGAPPVTPTGdSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 712
Cdd:PRK11901 163 ASQNAQGNTSTLPTAPATVAPSKGAKVPAT-AETHPTPPQKPATKKPAVNHHKTATVAVPPATSGK 227
PHA03247 PHA03247
large tegument protein UL36; Provisional
 618-717 5.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   618 PPTGDSGAPPVPPTGDSGA--PPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPpvtptgdseTAPVPPTGDSGAPPVP 695
Cdd:PHA03247  247 PLRGDIAAPAPPPVVGEGAdrAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAA---------LAGAPLALPAPPDPPP 317

                          90       100
                  ....*....|....*....|..
gi 27769331   696 PTGDSEAAPVPPTDDSKEAQMP 717
Cdd:PHA03247  318 PAPAGDAEEEDDEDGAMEVVSP 339
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 541-669 6.14e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 40.05  E-value: 6.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   541 LRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGdsgaPPVPPTgdsgappVPPT 620
Cdd:TIGR01645 326 PRAQSPATPSSSLPTDIGNKAVVSSAKKEAEEVPPLPQAAPAVVKPGPMEIPTPVPPPG----LAIPSL-------VAPP 394

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 27769331   621 GdSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGA 669
Cdd:TIGR01645 395 G-LVAPTEINPSFLASPRKKMKREKLPVTFGALDDTLAWKEPSKEDQTS 442
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 590-676 6.26e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 39.72  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  590 SGAPPVPPTGDSGAPPVPPtgdSGAPPvpptgdSGAPPVPPTgdSGAPPVpptgdAGPPPVPPTGDSGAPPVPPTGDSGA 669
Cdd:PRK14965 379 RGAPAPPSAAWGAPTPAAP---AAPPP------AAAPPVPPA--APARPA-----AARPAPAPAPPAAAAPPARSADPAA 442


                 ....*..
gi 27769331  670 PPVTPTG 676
Cdd:PRK14965 443 AASAGDR 449
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 130-221 6.33e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 39.13  E-value: 6.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 130 GAFLMGSGHGANfLNNYLYDGEEIATRGnVIVVTFNYRvgplGF-LSTGDanlPGNYGLRDQHMAIAWVKRNIAAFGGDP 208
Cdd:COG1073  38 PAVVVAHGNGGV-KEQRALYAQRLAELG-FNVLAFDYR----GYgESEGE---PREEGSPERRDARAAVDYLRTLPGVDP 108

                        90
                ....*....|...
gi 27769331 209 NNITLFGESAGGA 221
Cdd:COG1073 109 ERIGLLGISLGGG 121
DUF3729 pfam12526
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ...
 583-654 7.00e-03

Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.


Pssm-ID: 372164 [Multi-domain]  Cd Length: 115  Bit Score: 36.98  E-value: 7.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27769331   583 PVPPtgDSGAPPVPPTGDSGAPPV----PPTGDSGAPPVPPTGDSGAP-PVPPTGDSGAPPVP--PTGDAGPPPVPPTG 654
Cdd:pfam12526  29 FSPP--ESAHPDPPPPVGDPRPPVvdtpPPVSAVWVLPPPSEPAAPEPdLVPPVTGPAGPPSPlaPPAPAQKPPLPPPR 105
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 566-653 7.04e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 39.67  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331   566 GDSEATPVPPTGDSETapvpptgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDA 645
Cdd:TIGR01645 325 GPRAQSPATPSSSLPT-------DIGNKAVVSSAKKEAEEVPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSLVAPPGLV 397


                  ....*...
gi 27769331   646 GPPPVPPT 653
Cdd:TIGR01645 398 APTEINPS 405
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 592-708 7.38e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 39.47  E-value: 7.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 592 APPVPPTGDSGAPPVPPTGDsgappVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSgAPPVPPTGDSGAPP 671
Cdd:cd23959 133 AQVAPPKAEPQTAPVTPFGQ-----LPMFGQHPPPAKPLPAAAAAQQSSASPGEVASPFASGTVS-ASPFATATDTAPSS 206

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 27769331 672 VTPTGDSE--TAPVPPTGDSGAPPVPPTGDSEAAPVPPT 708
Cdd:cd23959 207 GAPDGFPAeaSAPSPFAAPASAASFPAAPVANGEAATPT 245
KLF17_N cd21574
N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like ...
 591-687 7.39e-03

N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like factor 17, is a protein that, in humans, is encoded by the KLF17 gene and acts as a tumor suppressor. It negatively regulates epithelial-mesenchymal transition and metastasis in breast cancer. KLF17 is thought to be the human ortholog of the mouse gene, zinc finger protein 393 (Zfp393), although it has diverged significantly. KLF17 can regulate gene transcription from CACCC-box elements. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF17.


Pssm-ID: 410567  Cd Length: 286  Bit Score: 38.90  E-value: 7.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 591 GAPPVPPTGDSGAPPVPPTGdSGAPPVPPTGdsgaPPVPPTgdSGAPPVPPTGD-----AGPPPVPPTGDSG------AP 659
Cdd:cd21574 121 KGPQMMPLGEPNIPGVAMTF-SGNLRMPPSG----LPVSAS--SGIPMMSHIRAptmpySGPPTVPSNRDSLtpkmllAP 193

                        90       100       110
                ....*....|....*....|....*....|..
gi 27769331 660 PVPPTGDSGAPP----VTPTGDSETAPVPPTG 687
Cdd:cd21574 194 TMPSTEAQAVLPslaqMLPPRDPHNLGMPPAG 225
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 558-716 7.43e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 39.56  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  558 EATPVP------PTGDSEATPVPPTG----DSETAPVPPTGDSGAppvpptGDSGAPPVPPTGDSGAPPVPPTgdsgaPP 627
Cdd:PTZ00441 294 PVPPTPeddnprPTDDEFAVPNFNEGldvpDNPQDPVPPPNEGKD------GNPNEENLFPPGDDEVPDESNV-----PP 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  628 VPPTGDSGAPPVPPTGDAGPP-PVPPTGDSGAPPVPPTGDSGAP---PVTPTGDSETAPVPPTGDSGappvppTGDSEAA 703
Cdd:PTZ00441 363 NPPNVPGGSNSEFSSDVENPPnPPNPDIPEQEPNIPEDSNKEVPedvPMEPEDDRDNNFNEPKKPEN------KGDGQNE 436

                        170
                 ....*....|...
gi 27769331  704 PVPPTDDSKEAQM 716
Cdd:PTZ00441 437 PVIPKPLDNERDQ 449
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 570-685 7.70e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 39.47  E-value: 7.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331 570 ATPVPPTGDSETAPVPPTGDsgappVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 649
Cdd:cd23959 133 AQVAPPKAEPQTAPVTPFGQ-----LPMFGQHPPPAKPLPAAAAAQQSSASPGEVASPFASGTVSASPFATATDTAPSSG 207

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 27769331 650 VPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPP 685
Cdd:cd23959 208 APDGFPAEASAPSPFAAPASAASFPAAPVANGEAAT 243
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 568-638 7.96e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 39.34  E-value: 7.96e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331  568 SEATPVPPTGDSETAPVPPtgdsgAPPvPPTGDSGAPPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDSGAPP 638
Cdd:PRK14965 379 RGAPAPPSAAWGAPTPAAP-----AAP-PPAAAPPVPPAAPARPAAARPAPaPAPPAAAAPPARSADPAAAA 444
PRK13881 PRK13881
conjugal transfer protein TrbI; Provisional
 603-721 8.42e-03

conjugal transfer protein TrbI; Provisional


Pssm-ID: 237541  Cd Length: 472  Bit Score: 39.37  E-value: 8.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  603 APPVPPTGDSG-----APPVppTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVT---- 673
Cdd:PRK13881  58 APAQGPKEKAGntsmfAKEI--AGDQTGGLIEPASPLKVPEMPTGPASAPLPIARPDNPDAPPTPPANPGNPGQVNddea 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27769331  674 -----------------PTGDSETAPvpptGDSGAPPVPPtgdSEAAPVPPTDDSKEAQMPAVIR 721
Cdd:PRK13881 136 qrirmaklqmfeeavkaKTTVRVDAP----RSNGSAPGGP---STYTGTPQTRDEMLARIAAVRQ 193
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 591-703 8.45e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 39.17  E-value: 8.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  591 GAPPVPPTGDSGAPPVPPTGDSGA--PPVPPTgdsgAPPVPPTGD-SGAPPVPPTGDAGPP---PVPPTGDSGAPPVPPT 664
Cdd:PHA03291 162 GLAAFPAEGTLAAPPLGEGSADGScdPALPLS----APRLGPADVfVPATPRPTPRTTASPettPTPSTTTSPPSTTIPA 237

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 27769331  665 GDSGAPPVTP--TGDSETAPVPPTGDSG-APPVPPTGDSEAA 703
Cdd:PHA03291 238 PSTTIAAPQAgtTPEAEGTPAPPTPGGGeAPPANATPAPEAS 279
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 674-717 8.45e-03

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 36.24  E-value: 8.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 27769331   674 PTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 717
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPAD 44
DUF3729 pfam12526
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ...
 582-651 8.91e-03

Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.


Pssm-ID: 372164 [Multi-domain]  Cd Length: 115  Bit Score: 36.59  E-value: 8.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27769331   582 APVPPTGDSGAPPV---PPTGDSGAPPVPPTGDSGAP-PVPPTGDSGAPPVPPtgdsgAPPVPPTGDAGPPPVP 651
Cdd:pfam12526  38 DPPPPVGDPRPPVVdtpPPVSAVWVLPPPSEPAAPEPdLVPPVTGPAGPPSPL-----APPAPAQKPPLPPPRP 106
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 557-692 9.28e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 39.16  E-value: 9.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  557 QEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP--VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTG 632
Cdd:PTZ00436 207 KAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAkaAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPakAAAPPA 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27769331  633 DSGAPPVPPTGDAGPPPVPPTGDSGAPP--VPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 692
Cdd:PTZ00436 287 KAAAPPAKAAAAPAKAAAAPAKAAAAPAkaAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
flhF PRK06995
flagellar biosynthesis protein FlhF;
578-720 9.73e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 39.18  E-value: 9.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  578 DSETAPVPPTGDSGAPPVPPtgdsgaPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtgdsg 657
Cdd:PRK06995  45 DSDLAALAPPAAAAPAAAQP------PPAAAPAAVSRPAAPA-AEPAPWLVEHAKRLTAQREQLVARAAAPAAPE----- 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27769331  658 aPPVPPTGDSGAPPVTPTGDSETAPVPptgdsgAPPVPPTGDSEAAPVPPTDDSKEAQMPAVI 720
Cdd:PRK06995 113 -AQAPAAPAERAAAENAARRLARAAAA------APRPRVPADAAAAVADAVKARIERIVNDTV 168
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 557-655 9.86e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 38.67  E-value: 9.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27769331  557 QEATPVPPTgdseATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgaPPVPPTGDSGAPPV--PPTGDS 634
Cdd:PLN02983 138 KEALPQPPP----PAPVVMMQPPPPHAMPPASPPAAQPAPSAPASSPPPTPAS-----PPPAKAPKSSHPPLksPMAGTF 208

                         90       100
                 ....*....|....*....|.
gi 27769331  635 GAPPVPptgdaGPPPVPPTGD 655
Cdd:PLN02983 209 YRSPAP-----GEPPFVKVGD 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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