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Conserved domains on  [gi|27765091|ref|NP_775323|]
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beta-galactoside alpha-2,6-sialyltransferase 1 isoform a [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467713  Cd Length: 266  Bit Score: 580.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985   1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 217 ANFQQDVGTKTTIRLMNSQLVTTEKR-FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23985  81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23985 161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                       250       260
                ....*....|....*....|....*.
gi 27765091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23985 241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 580.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985   1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 217 ANFQQDVGTKTTIRLMNSQLVTTEKR-FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23985  81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23985 161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                       250       260
                ....*....|....*....|....*.
gi 27765091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23985 241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-384 2.17e-29

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 114.63  E-value: 2.17e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091   169 LPKESiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN--SQLVTTEKRFLKD 246
Cdd:pfam00777  32 LPKVS-PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091   247 SLYNEGILIV----------WDPS-VYHSDIPkwyqnpdyNFFNNYKTYRKLHPNQP---FYILKPqmpwelwDILQEI- 311
Cdd:pfam00777 111 HPRDPFVEFVlvpfkgrdllWLPAfLTKGNVS--------RSLRVLYTLKEVKIPVDpdkVLFLHP-------DFLRYVa 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091   312 -----SPeEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYqkfFDSAC--TMGAY--HPLLYEKNLVKHL 382
Cdd:pfam00777 176 nfwlrSH-GLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHY---YDNVLmkKGGFYgvHDMPFEFKLLQKL 251


                  ..
gi 27765091   383 NQ 384
Cdd:pfam00777 252 HK 253
 
Name Accession Description Interval E-value
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-401 0e+00

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 580.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23985   1 AEELLCELKDKVNVSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 217 ANFQQDVGTKTTIRLMNSQLVTTEKR-FLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23985  81 AGFQQDVGTKTTIRLINSQLVTTEKHkFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23985 161 LHPQMQWELWDIIQENSPEEIQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYE 240

                       250       260
                ....*....|....*....|....*.
gi 27765091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23985 241 KNLVKHLNQGTDEDIYLLGKVTLPGF 266
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 137-401 6.75e-150

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 425.15  E-value: 6.75e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 137 AEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT 216
Cdd:cd23968   1 SEDLLCRLKKAAPFSTLRKTTSPFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 217 ANFQQDVGTKTTIRLMNSQLVT-TEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYI 295
Cdd:cd23968  81 KGFEKDVGSKTTLRLINSQILSkPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 296 LKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYE 375
Cdd:cd23968 161 IDPRFLWRLWDILQEYTPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAE 240

                       250       260
                ....*....|....*....|....*.
gi 27765091 376 KNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23968 241 KLLVRHLNVGSDDDIFRKGRATLPGF 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 134-401 6.52e-124

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 359.15  E-value: 6.52e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 134 KFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESI-RTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFN 212
Cdd:cd23986   1 KLSRQELLCELKKRVQVRTLDGKEAPFSALGWEKYVPKIPLsKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 213 GAPTANFQQDVGTKTTIRLMNSQLVTTEK-RFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQ 291
Cdd:cd23986  81 SAPTRGYEKDVGNKTTIRIINSQILTNPNhHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 292 PFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHP 371
Cdd:cd23986 161 PFYILHPKFIWQLWDIIQENTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHP 240

                       250       260       270
                ....*....|....*....|....*....|
gi 27765091 372 LLYEKNLVKHLNQGTDEDIYLLGKATLPGF 401
Cdd:cd23986 241 LLYEKLLIQRMNKGTEDDLYRKGKVILPGF 270
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 184-382 2.63e-54

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 178.33  E-value: 2.63e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV-----TTEKRFLKDSLYNEGILIVWD 258
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAgfylrGPRCGCHPLPLEEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 259 PSVYhsdipkwyqnpdynFFNNYKTYRKLHPNQPFYILK--PQMPWELWDILQEISPEEIQ-PNPPSSGMLGIIIMMTLC 335
Cdd:cd19952  81 AAAA--------------DFKRLKRRKKRHDNAVLLLTDpaPDLLSYVRKRLEKLGLKSFFgGNAPSSGLLAVLLALQLC 146

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 27765091 336 DQVDIYEF--LPSKRKTDVCYYYQKFFDSActMGAYHPLLYEKNLVKHL 382
Cdd:cd19952 147 DSVDLYGFgvDSGHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 169-384 2.17e-29

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 114.63  E-value: 2.17e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091   169 LPKESiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN--SQLVTTEKRFLKD 246
Cdd:pfam00777  32 LPKVS-PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLGFS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091   247 SLYNEGILIV----------WDPS-VYHSDIPkwyqnpdyNFFNNYKTYRKLHPNQP---FYILKPqmpwelwDILQEI- 311
Cdd:pfam00777 111 HPRDPFVEFVlvpfkgrdllWLPAfLTKGNVS--------RSLRVLYTLKEVKIPVDpdkVLFLHP-------DFLRYVa 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091   312 -----SPeEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYqkfFDSAC--TMGAY--HPLLYEKNLVKHL 382
Cdd:pfam00777 176 nfwlrSH-GLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHY---YDNVLmkKGGFYgvHDMPFEFKLLQKL 251


                  ..
gi 27765091   383 NQ 384
Cdd:pfam00777 252 HK 253
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 162-358 2.72e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 103.88  E-value: 2.72e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 162 TSEWEGYLPKESIrTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT--------TIRLMN 233
Cdd:cd23963  45 TKSLYELLPKTSP-FSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRY 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 234 SQLVTTE--KRFLKD-SLYNEGILivwdpsVYHSDIPKWYQNPdynFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQE 310
Cdd:cd23963 124 NSLKKNRdrDKFLNRlKEYNGSIL------WYPKFSFKSSTNL---LLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKR 194

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 27765091 311 ISPEeiqpNPPSSGMLGIIIMMTLCDQVDIYEFLP---SKRKTDVCY-YYQK 358
Cdd:cd23963 195 RGLE----KRPSTGLYLVSLALTFCDEIHLYGFWPfptDPNGRPVPYhYYDD 242
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 182-370 2.20e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 100.01  E-value: 2.20e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 182 GRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM---NSQLVTTEKRFLKDSLYNEGILIVWD 258
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVshsSLPRLLRNAILLLAGTRAPTVVVFWG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 259 PSVYhsdipkwYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQ-------EISPEEIqpnppSSGMLGIIIM 331
Cdd:cd23965  82 PETK-------MNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEketgksrIKSGTWL-----STGWFTMLLA 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 27765091 332 MTLCDQVDIYEFLPSK-----RKTDVCY-YYQKFFDSACTMGAYH 370
Cdd:cd23965 150 LDVCDEIKVYGMVPENycrehPNSKVPYhYYEPGGLKECTYYNYH 194
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 183-382 9.77e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 97.75  E-value: 9.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRlmnsqLVTTEKRFLKDSLYNEGILIVWDPsvY 262
Cdd:cd23967   4 RCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFR-----MFYPESAFRDPEEYDSDWLLVLVP--F 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 263 HSDIPKWYQ------NPDYNFFNNYKTYRKLH--PNQpFYILKPQMPWEL-WDILQEISPEEIQPNPPSSGMLGIIIMMT 333
Cdd:cd23967  77 KSMDLLWLQavikgkKPNGKGGFWKKIATSVPkpPKK-IRILNPYILQEAaFDLIGLPMNGKQGKNVPTTGIIAIVMALH 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 27765091 334 LCDQVDIYEF-LPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHL 382
Cdd:cd23967 156 YCDEVDIAGFgYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 183-382 7.34e-19

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 84.33  E-value: 7.34e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM--NSQLVTTEKRFLKDSLYnegILIVWDPS 260
Cdd:cd23982   4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypESAQFDPGIENDPDTLL---VLVPFKPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 261 VYHsdipkWYqnpdYNFFNNYKTYRKLHPNQP----------FYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIII 330
Cdd:cd23982  81 DFY-----WL----YEILSNEKRVRKGFWKQPpriwdanpkqIRILNPYYTYVAATKLLQVPGQRKKKQKPTTGLLAITL 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27765091 331 MMTLCDQVDIYEF---LPSKRKTDVCYYYQKFFDSacTMGAYHPLLYEKNLVKHL 382
Cdd:cd23982 152 ALHLCDEVHIAGFgypDNGNSNQPIHYYNQITLKS--MANSGHNLNAEAQAIQRL 204
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 182-370 3.13e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 82.99  E-value: 3.13e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 182 GRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ----LVTTEKRFLK---DSLYnegil 254
Cdd:cd23977   2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTsvplLLRNQGYFFQqsrDTKY----- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 255 IVWDPSVYHSDIPKwyqNPDYNFFnnyKTYRKLHPNQPFYILKPQMPWELWDILQ-EISPEEIQPNP-PSSGMLGIIIMM 332
Cdd:cd23977  77 VIWGPERNMDRDGG---GKTYRAL---LTLAKMYPHLQVYTLTEEKMAYCDGVFQnETGKNRMKSGSfLSTGWFTMILAL 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 27765091 333 TLCDQVDIY-----EFLPSKRKTDVCY-YYQKFFDSACTMGAYH 370
Cdd:cd23977 151 ELCEEILVYgmvsdSYCRNKNHSSVPYhYYEKGRLDECRMYLVH 194
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 183-384 2.21e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 81.92  E-value: 2.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTT--IRLMNSQLVTTEKRFL--KDSLYnegILIVWD 258
Cdd:cd23964  84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSfyTFFPESLHNSLLKHVPqdKDTKY---LFIPFK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 259 PSVYHS--DIPKWYQNPDYNFFNN--YKTYRKLHPNQPFYILKPqmpwelwDILQEI------SPEEiqpNPPSSGMLGI 328
Cdd:cd23964 161 IRDYDYldAVLSGKPVPDGCDKGKrpPPLFGPKLNATNVRLLHP-------DFIRYLfnrwlnSSTS---YRPTTGALML 230

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 27765091 329 IIMMTLCDQVDIYEFLPSKRKTDVcYYYQKFFDSACTMGAyHPLLYEKNLVKHLNQ 384
Cdd:cd23964 231 LTALHTCDQVSVYGFGYDPRFSLH-YYDKTFVKFTVFYAN-HDFTNERKLWRKLHE 284
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 184-382 4.03e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 80.90  E-value: 4.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNS----------QLVTTEKRFLKDsLYNEGI 253
Cdd:cd23970  71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPsilekyynnlLTIQDRNNFFLS-LKKLDG 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 254 LIVWDPSV-YHSDIPKWYQNPDynFFNNYKTYRKLHPNQPFYIlkpqMPW--ELWDiLQEISPEEIqpnppSSGMLGIII 330
Cdd:cd23970 150 AILWIPAFfFHTSATVTRTLVD--FFVEHRGQLKVQLAWPGNI----MQHvnRYWK-TKHLSPKRL-----STGILMYTL 217

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27765091 331 MMTLCDQVDIYEFLP---SKRKTDVCYYYQKFFDSACTMG--AYHPLLYEKNLVKHL 382
Cdd:cd23970 218 ASAICEEIHLYGFWPfgfDPTGTPLPYHYYDKKGTKFTTKwqESHQLPAEFVLLYKM 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 184-376 5.03e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 77.22  E-value: 5.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSqlvTTEKRFLKD-----SLYNEGILIVWD 258
Cdd:cd23976  18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAH---SSIQRILRNrnellNVSQGTVFIFWG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 259 PSVYHSDIPKWYqnpdynFFNNYKTYRKLHPNQPFYILKPQMPWELWDIL-QEISPEEIQPNP-PSSGMLGIIIMMTLCD 336
Cdd:cd23976  95 PSNYMRRDGKGL------VYNNLQLMNQILPKLKVYTITRHKMLQFDELFkRETGKDRKISNTwLSTGWFTMIIALELCD 168

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27765091 337 QVDIY-----EFLPSKRKTDVCY-YYQKFFDSACTM---------GAYHPLLYEK 376
Cdd:cd23976 169 RINVYgmvppDFCRDPNHPSVPYhYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 183-343 7.51e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 76.94  E-value: 7.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMnsqlvttekrflkdslYNEGILIVwDPSVY 262
Cdd:cd23966  79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM----------------YPESAVDL-DPGVH 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 263 HSDIP------KWYQNPdynfFNNYKTYRKLHPNQPFYILKPqmpwelwDILQEISPE----------EIQPNPPSSGML 326
Cdd:cd23966 142 LVLVPfkvldlQWLISA----LTTGEITRTYTPVKRFIKADK-------DKVLVINPAfikyvhdnwtEHHGRYPSTGFL 210

                       170
                ....*....|....*..
gi 27765091 327 GIIIMMTLCDQVDIYEF 343
Cdd:cd23966 211 ALIFALHICDEVSVFGF 227
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 184-376 5.30e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 73.74  E-value: 5.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMN----SQLVTTEKRFLkdSLYNEGILIVWDP 259
Cdd:cd23978   4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQEFL--NRTPETTLIFWGP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 260 SvyhsdiPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPP--SSGMLGIIIMMTLCDQ 337
Cdd:cd23978  82 P------NKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSwlSTGWFTMVIAVELCDN 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27765091 338 VDIYEFLP----SKR----KTDVCYYYQKFFDSACT--------MGAYHPLLYEK 376
Cdd:cd23978 156 VHVYGMVPpnycSKRptpkKMPYHYYEPKGPDECVTyiqnehgrRGNHHRFITEK 210
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 183-382 1.40e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 72.09  E-value: 1.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVttekrfLKDSLYNEG----ILIVWD 258
Cdd:cd23984   4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESI------FSDPSHYDPnttvVLIPFK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 259 PSVYH--SDIPKWYQNPDYNFFNnyKTYRKL--HPNQ-----PFYILKpqMPWELWDiLQEISPEEIQPNPPSSGMLGII 329
Cdd:cd23984  78 PHDLRwlLDLLMGKKVSAKGFWK--KPALNLiyKPNQirilnPFILRI--AAYELLH-FPKRFPKEKKPKHPTTGIIAIT 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27765091 330 IMMTLCDQVDI----YEFLPSkrkTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHL 382
Cdd:cd23984 153 LALHICNEVHIagfkYDFSNL---NSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 184-356 1.54e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 73.22  E-value: 1.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV----------TTEKRFLKD-SLYNEG 252
Cdd:cd23969  67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIphaygdlvnaTDKEKFVERlRQLGDS 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 253 ILivWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYilkpQMPWELWdilqeiSPEEIQPNPPSSGMLGIIIMM 332
Cdd:cd23969 147 IL--WIPAFVSKGGEEHVQWTNEIILKHKLNVKTAYPPLRLN----HAIRGYW------LTTKFRIKRPSTGLLMYTLAT 214

                       170       180
                ....*....|....*....|....*..
gi 27765091 333 TLCDQVDIYEFLPSK---RKTDVCYYY 356
Cdd:cd23969 215 RFCDEIHLYGFYPFSedgNGRAVKYHY 241
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 183-343 9.07e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 71.07  E-value: 9.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTirlmnSQLVTTEKrfLKDSLYNEGILIV------ 256
Cdd:cd23980  83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT-----HHFVYPES--FRELAQNVSMILVpfktld 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 257 --WDPS-VYHSDIPKWYqnpdynffnnYKTYRKLHPNQP-FYILKPQMPWELWD-ILQEispeeiQPNPPSSGMLGIIIM 331
Cdd:cd23980 156 leWVISaTTTGTISHTY----------VPVPRKIKVKKEkILIYHPAFIKYVFDrWLQG------HGRYPSTGILSVIFS 219

                       170
                ....*....|..
gi 27765091 332 MTLCDQVDIYEF 343
Cdd:cd23980 220 LHVCDEVDLYGF 231
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 183-343 1.44e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 69.38  E-value: 1.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMnsqlvttekrflkdslYNEGILIVW---DP 259
Cdd:cd23983   4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMT----------------YPEGAPKSEqeyDP 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 260 S------VYHSDIPKWYQNPDYN----------FFNNYKTYRKLHPNQpFYILKPQMPWEL-WDILQEISPEEI----QP 318
Cdd:cd23983  68 TslfvavLFKSVDFAWLKAMVKKeplsfwsrlfFWKEVADSIPLKPSQ-FRILNPLIIKETaLDILQYPEPQSRlwgwDK 146

                       170       180
                ....*....|....*....|....*
gi 27765091 319 NPPSSGMLGIIIMMTLCDQVDIYEF 343
Cdd:cd23983 147 NVPTLGVTAVVLATHLCDEVSLAGF 171
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 183-383 1.81e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.62  E-value: 1.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT-----TIRLMNSQLVTTEKRFLKDSLYNEGILIVW 257
Cdd:cd23972  84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNSLISYWNLGFTRTPQGQDLQYIF 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 258 DPS------VYHSDI-----PKWYQNPD--YNFFN---NYKTYRKLHPNQPFYILKPQMPWELWDIlqeispEEIQPNPP 321
Cdd:cd23972 164 IPSdirdyvMLRSAIlgvpvPEGLDKGDrpHKYFGpeaSAKKFKLLHPDFISYLTDRFLKSKLLNT------HYGHLYMP 237

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27765091 322 SSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQK------FFdsactmgAYHPLLYEKNLVKHLN 383
Cdd:cd23972 238 STGALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERkkkplvFY-------ANHDMLLEAALWRRLH 298
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 175-377 8.70e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 68.63  E-value: 8.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 175 RTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKT------TIRLMNS-------------Q 235
Cdd:cd23974  78 PNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTsfytfsTNTLMNSlrayagvgfngppQ 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 236 LVTTEKRFLKDslYNEGILIVwDPSVYHSDI---PKWYQNPDYNFFNNYKT--YRKLHPNQPFY---------ILKPQMp 301
Cdd:cd23974 158 SKETRYIFLPD--HDRDYLLV-KAALTHTPIdrgRDKSKRPSKYFGKDVTAekFKIYHPDFIRYlrnrflwspILNTKQ- 233

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27765091 302 welWDILQeispeeiqpnpPSSGMLGIIIMMTLCDQVDIYEFLpskrKTDVCYYYQKFFDSactmgAYHPLLYEKN 377
Cdd:cd23974 234 ---RDIYR-----------PSTGAVMLLAALHTCDQVSAYGFM----TPDYGKYSDHYYDK-----TYHKVVFYAN 286
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 169-345 1.12e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 67.67  E-value: 1.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 169 LPKESIrTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTaNFQQDVGTKTTIRLMN-SQLVT-----TEKR 242
Cdd:cd23971  53 LPKESP-FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSKTNLVTANpSILREkfhnlKKRR 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 243 --FLKD-SLYNEGILIV--------WDPS--VYH--SDIPKWyQNPdynFFnnyktyrkLHPNqpfYILKPQMPWELWDi 307
Cdd:cd23971 131 rpFVERmKVYGNALLLLpafsytsnTEPSlrALYtlEDFGSP-QKV---LF--------FNPE---YLRNLSRYWKSKG- 194

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 27765091 308 LQEISpeeiqpnpPSSGMLGIIIMMTLCDQVDIYEFLP 345
Cdd:cd23971 195 LKARR--------LSTGLMLVSAALELCENVHLYGFWP 224
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 169-362 3.35e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 66.50  E-value: 3.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 169 LPKESiRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV----------T 238
Cdd:cd23987  53 LPRTS-PLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVqrafedlvneT 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 239 TEKRFLK--DSLyNEGILivWDPSVYH---SDIPKWYQN----PDYNFFNNYKTYRKLHPNQPFYIlkpqmpwelwdilq 309
Cdd:cd23987 132 WKEKFLQrlQSL-NGSIL--WIPAFMAkggEERVEWVNDlilkHHINVRTAYPSLRLLHAVRGYWL-------------- 194

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 27765091 310 eisPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTD---VCYYYqkfFDS 362
Cdd:cd23987 195 ---TNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNqnpVKYHY---YDS 244
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 183-358 5.77e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 65.93  E-value: 5.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTI------RLMNSQLVTTEKRF------------- 243
Cdd:cd23973  85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFyvhtahSITSSLMILQKRGFknipqdkdikyil 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 244 --------------LKDSLYNEGILIVWDPSVYHSD--IPKWY--QNPDynfFNNYKTYRKLHPNqpfyilkpQMPWELW 305
Cdd:cd23973 165 fpegprdyqwlealLKNKTIPSGAYYGRRPRSYFSGdfTEDKYlvLHPD---FLRYVKNRFLRSK--------TLKGKYW 233

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 27765091 306 DILQeispeeiqpnpPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQK 358
Cdd:cd23973 234 AIYR-----------PTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDK 275
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 183-249 1.07e-11

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 63.79  E-value: 1.07e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ-LVTTEKRFLKDSLY 249
Cdd:cd23981   4 RCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEgAIQKPEQYEKDSLF 71
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 184-363 2.06e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 64.21  E-value: 2.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLV----------TTEKRFLKD-SLYNEG 252
Cdd:cd23988  67 CAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggfrneSDREKFVHRlSMLNDS 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 253 ILivWDPSVYHSDIPKWYQNPDYNFFNN-------YKTYRKLHPNQPFYIlkpqmpwelwdilqeisPEEIQPNPPSSGM 325
Cdd:cd23988 147 VL--WIPAFMVKGGEKHVEWVNALILKNklkvrtaYPSLRLIHAVRGYWL-----------------TNKVNIKRPSTGL 207

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 27765091 326 LGIIIMMTLCDQVDIYEFLPSKRK---TDVCYYY-----QKFFDSA 363
Cdd:cd23988 208 LMYTLATRFCDEIHLYGFWPFPKDangNPVKYHYyddlkYRYFSNA 253
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 180-351 4.20e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 63.23  E-value: 4.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 180 PWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPT-ANFQQDVGTKTTIRLMNSQLVT------TEKR--FLKD-SLY 249
Cdd:cd23991  63 PYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTgGNISKDVGSKTNLVTANPSIISikyaklNERRkpFLETvSVY 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 250 NEGILIvwdpsvyhsdIPKWYQNPDYNF-FNNYKTYRKLHPNQPFYILKPQMpweLWDILQEISPEEIQPNPPSSGMLGI 328
Cdd:cd23991 143 GDAFLL----------LPAFSYRSNTALsFKVYYTLEDFKAKQKVIFFHPIY---LKHLAQFWRSKGVQVYRLSTGLMIT 209

                       170       180
                ....*....|....*....|...
gi 27765091 329 IIMMTLCDQVDIYEFLPSKRKTD 351
Cdd:cd23991 210 SAALELCEEVKLYGFWPFSKNTE 232
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 183-232 7.70e-11

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 62.20  E-value: 7.70e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLM 232
Cdd:cd23979  82 RCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFM 131
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 184-259 1.03e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.10  E-value: 1.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 184 CAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQ----LVTTEKRFLKDSlyNEGILIVWDP 259
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTsvplLLKNPDYFFKET--NETIYVIWGP 81
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 180-372 9.14e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 59.07  E-value: 9.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 180 PWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAP-TANFQQDVGTKTTIRLMNSQLVttEKRFlkDSLYNEGILIVWD 258
Cdd:cd23989  62 PLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSII--DKRF--QNLLWSRKSFVES 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 259 PSVY-HSDI--PKWYQNPDYN-FFNNYKTYRKLHPNQPFYILKPqmpwelwDILQEISP----EEIQPNPPSSGMLGIII 330
Cdd:cd23989 138 MKVYgRSYIymPAFSMKTGTDpSLRVYYTLADVGANQTVLFANP-------NFLRNVGKfwksKGVHAKRLSTGLFLVSA 210

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 27765091 331 MMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPL 372
Cdd:cd23989 211 ALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHAM 252
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 183-343 1.12e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 58.69  E-value: 1.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 183 RCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTAN-FQQDVGTKTTIRLMNSQLVTteKRFLKDSLYNEGILIVWdpSV 261
Cdd:cd23990  66 KCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPSIIT--ERFHKLEKWRRPFYEVL--QV 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27765091 262 YHSD---IPKWY--QNPDYNF-----FNNYKTYRKLHPNQPFYILKPQMPWelwdilqeiSPEEIQPNPPSSGMLGIIIM 331
Cdd:cd23990 142 YENAsvvLPAFYntRNTDVSIrvkyvLDDFESQQAVYYFHPQYLLNVSRFW---------LRQGVRAKRISSGLMLVTAA 212

                       170
                ....*....|..
gi 27765091 332 MTLCDQVDIYEF 343
Cdd:cd23990 213 LELCEEVHLYGF 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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