NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27573793]
View 

Chain A, Thrombospondin 1

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641280)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

CATH:  2.20.100.10
SCOP:  4003415

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 5-57 1.77e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.92  E-value: 1.77e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27573793      5 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 57
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 62-113 9.91e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 9.91e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 27573793     62 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDC 113
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 5-57 1.77e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.92  E-value: 1.77e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27573793      5 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 57
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 62-113 9.91e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 9.91e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 27573793     62 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDC 113
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
6-56 4.62e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 61.28  E-value: 4.62e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27573793     6 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 56
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
63-113 1.84e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 57.04  E-value: 1.84e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27573793    63 GPWSPWDICSVTCGGGVQKRSRLCNNPTPqfGGKDCVGDVTENQICNKQDC 113
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 63-84 1.90e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 1.90e-05
                         10        20
                 ....*....|....*....|..
gi 27573793   63 GPWSPWDICSVTCGGGVQKRSR 84
Cdd:PTZ00441 241 GPWDEWTPCSVTCGKGTHSRSR 262
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 5-59 2.54e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 38.77  E-value: 2.54e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27573793    5 WSHWSPWSSCSVTCG--DGVITRIRLCNSPSpqmnGKPCEGEARETKACKKDACPIN 59
Cdd:PTZ00087 233 YTEWGEWSNCSMECDhpDNVQIRERKCAHPS----GDCFKGDLKETRPCQVPLPPCN 285
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 5-57 1.77e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.92  E-value: 1.77e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27573793      5 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 57
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 62-113 9.91e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 9.91e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 27573793     62 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDC 113
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
6-56 4.62e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 61.28  E-value: 4.62e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27573793     6 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 56
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
63-113 1.84e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 57.04  E-value: 1.84e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27573793    63 GPWSPWDICSVTCGGGVQKRSRLCNNPTPqfGGKDCVGDVTENQICNKQDC 113
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 6-56 1.03e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.96  E-value: 1.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27573793     6 SHWSPWSSCSVTCGDGVITRIRLCNSPsPQMNGKPCeGEARETKACKKDAC 56
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 63-113 1.85e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 44.19  E-value: 1.85e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27573793    63 GPWSPWDICSVTCGGGVQKRSRLCNNPtPQFGGKDCvGDVTENQICNKQDC 113
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 63-84 1.90e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 1.90e-05
                         10        20
                 ....*....|....*....|..
gi 27573793   63 GPWSPWDICSVTCGGGVQKRSR 84
Cdd:PTZ00441 241 GPWDEWTPCSVTCGKGTHSRSR 262
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 5-59 2.54e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 38.77  E-value: 2.54e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27573793    5 WSHWSPWSSCSVTCG--DGVITRIRLCNSPSpqmnGKPCEGEARETKACKKDACPIN 59
Cdd:PTZ00087 233 YTEWGEWSNCSMECDhpDNVQIRERKCAHPS----GDCFKGDLKETRPCQVPLPPCN 285
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 8-58 3.38e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 38.41  E-value: 3.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 27573793    8 WSPWSSCSVTCGDGVITRIRlcnspsPQMNGKpCEGEARETkaCKKDACPI 58
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSR------PILHEG-CTTHMVEE--CEEEECPV 284
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 63-113 3.41e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 33.20  E-value: 3.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 27573793    63 GPWSPwdiCSVTCGGGVQKRSRLCNNPTPQ--FGGKDCVGDV--TENQICNKQDC 113
Cdd:pfam19030   4 GPWGE---CSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKkpPETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH