NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27370232|ref|NP_766411|]
View 

leishmanolysin-like peptidase precursor [Mus musculus]

Protein Classification

M8 family metallopeptidase( domain architecture ID 140073)

M8 family metallopeptidase such as the metallo-endopeptidase leishmanolysin, a zinc metallopeptidase with the zinb-binding HEXXH motif and a more C-terminal His residue that is the third ligand of zinc

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Peptidase_M8 super family cl19482
Leishmanolysin;
96-628 4.82e-61

Leishmanolysin;


The actual alignment was detected with superfamily member pfam01457:

Pssm-ID: 388572 [Multi-domain]  Cd Length: 529  Bit Score: 213.17  E-value: 4.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232    96 LLPEKRYLVKNKLFPQAISYLEKTFQVRRpagrillsRQcatnqylrkendphryctgecavhtkcGPVIVPEEHLQqcr 175
Cdd:pfam01457 105 LTEEKRYILVNYILPQALQLHTERLKVRQ--------VQ---------------------------GTWKVTGMDGD--- 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   176 VCREGKWPCGAVGVldpeGVRDADFVLYVGALATErcshENIISYAAYCQQEAKmDRPIAGYANLCPNMISTQPQEFigM 255
Cdd:pfam01457 147 VCGSFKVPPAHVTV----GVSNADFVLYVASVPSE----GGVLAWAFDCQLFPD-GRPAVGVINIPAAYIVSAYDQF--M 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   256 LSTVKHEIIHALGFSAGLFAFYHdqdgnpltsrsadglppfnyslglyqwsdkvvrKVERLWNVRDNKivrHTVYLLVTP 335
Cdd:pfam01457 216 VRVVTHELAHALGFSLTFFEMLG---------------------------------IIGEVKNLRGRD---YLVPVLNSP 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   336 RVVEEARKHFNCPVLEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSMAEKLDWG 415
Cdd:pfam01457 260 TVVAKAREQYGCPTLEGLELEDQGGPGTAGSHLKKRNAKDELMAPAVGAG-YYSALTMAVFQDLGFYQADFTKAEVMPWG 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   416 RGLGCEFVRKSCkfwidQHRQRRQVPSPYCDtlrSNPLQLTCRQDQRAVAVCNLQRFPNPLPPEYQYFDEltgipaedlP 495
Cdd:pfam01457 339 NNAGCDFLTKKC-----MEDNITQWPEMFCN---STERALRCPTDRLSLGTCSITRHPDPLPTYFQYFTD---------P 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   496 YYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILEnqpelfknygAEQYGPHSVCLlqKSAFIMEQcERKLSYPDWGSg 575
Cdd:pfam01457 402 SLGGGSMFMDYCPYIVGYSNGACNQDPSTASPSLME----------FNVFSDASRCL--DGVFRPKH-STGITYPYNGL- 467

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27370232   576 CYQVSCSPQGLKVWVQ---DTSYLCSRAGQVLPVRIQMNGWIHNGNLLCPSCWDFC 628
Cdd:pfam01457 468 CANVRCDRAHHTYSVQvygSSGYVACTPGESVELPTTSAAFVEGGYITCPPYVEVC 523
 
Name Accession Description Interval E-value
Peptidase_M8 pfam01457
Leishmanolysin;
96-628 4.82e-61

Leishmanolysin;


Pssm-ID: 366652 [Multi-domain]  Cd Length: 529  Bit Score: 213.17  E-value: 4.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232    96 LLPEKRYLVKNKLFPQAISYLEKTFQVRRpagrillsRQcatnqylrkendphryctgecavhtkcGPVIVPEEHLQqcr 175
Cdd:pfam01457 105 LTEEKRYILVNYILPQALQLHTERLKVRQ--------VQ---------------------------GTWKVTGMDGD--- 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   176 VCREGKWPCGAVGVldpeGVRDADFVLYVGALATErcshENIISYAAYCQQEAKmDRPIAGYANLCPNMISTQPQEFigM 255
Cdd:pfam01457 147 VCGSFKVPPAHVTV----GVSNADFVLYVASVPSE----GGVLAWAFDCQLFPD-GRPAVGVINIPAAYIVSAYDQF--M 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   256 LSTVKHEIIHALGFSAGLFAFYHdqdgnpltsrsadglppfnyslglyqwsdkvvrKVERLWNVRDNKivrHTVYLLVTP 335
Cdd:pfam01457 216 VRVVTHELAHALGFSLTFFEMLG---------------------------------IIGEVKNLRGRD---YLVPVLNSP 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   336 RVVEEARKHFNCPVLEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSMAEKLDWG 415
Cdd:pfam01457 260 TVVAKAREQYGCPTLEGLELEDQGGPGTAGSHLKKRNAKDELMAPAVGAG-YYSALTMAVFQDLGFYQADFTKAEVMPWG 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   416 RGLGCEFVRKSCkfwidQHRQRRQVPSPYCDtlrSNPLQLTCRQDQRAVAVCNLQRFPNPLPPEYQYFDEltgipaedlP 495
Cdd:pfam01457 339 NNAGCDFLTKKC-----MEDNITQWPEMFCN---STERALRCPTDRLSLGTCSITRHPDPLPTYFQYFTD---------P 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   496 YYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILEnqpelfknygAEQYGPHSVCLlqKSAFIMEQcERKLSYPDWGSg 575
Cdd:pfam01457 402 SLGGGSMFMDYCPYIVGYSNGACNQDPSTASPSLME----------FNVFSDASRCL--DGVFRPKH-STGITYPYNGL- 467

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27370232   576 CYQVSCSPQGLKVWVQ---DTSYLCSRAGQVLPVRIQMNGWIHNGNLLCPSCWDFC 628
Cdd:pfam01457 468 CANVRCDRAHHTYSVQvygSSGYVACTPGESVELPTTSAAFVEGGYITCPPYVEVC 523
PTZ00257 PTZ00257
Glycoprotein GP63 (leishmanolysin); Provisional
 96-514 4.16e-37

Glycoprotein GP63 (leishmanolysin); Provisional


Pssm-ID: 240333  Cd Length: 622  Bit Score: 147.16  E-value: 4.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   96 LLPEKRYLVKNKLFPQAISYLEKTFQVRRPAGRILLSRQcatnqylrkendphrycTGECavhtkCGPVIVPEEHLQQcr 175
Cdd:PTZ00257 146 LTEEKRDILVSYLIPQALQLHVERLRVRQVQGSWRVTGM-----------------TGPI-----CGDFKVPKAHVTV-- 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  176 vcregkwpcgavgvldpeGVRDADFVLYVGALATErcshENIISYAAYCQQEAKmDRPIAGYANL-CPNMISTQPQefiG 254
Cdd:PTZ00257 202 ------------------GVSNADFVLYVASVPSE----PGVLAWATTCQVFSD-DHPAVGVMNIpAANIVSRYDQ---G 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  255 MLSTVKHEIIHALGFS------AGLFAFYHDQDGNPLTSrsadglPPFNYSlglyqwsdkvvrkverlwnvrdnkivrht 328
Cdd:PTZ00257 256 TTRTVTHEVAHALGFSsvffenAGIVKSVTNLRGKPFAA------PVINSS----------------------------- 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  329 vyllvtpRVVEEARKHFNCPVLEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSM 408
Cdd:PTZ00257 301 -------TAVAKAREQYGCPTLEYLEVEDQGGSGSAGSHLKGRNAKDELMAPASAAG-YYTALTMAVFEDLGFYKADFSM 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  409 AEKLDWGRGLGCEFVRKSCkfwidQHRQRRQVPSPYCDTLRSnplQLTCRQDQRAVAVCNLQRFPNPLPPEYQYFDEltg 488
Cdd:PTZ00257 373 AEVMPWGRNASCDFLTNKC-----MEDNITQWPEMFCNTTER---RYRCPTDRLKLGTCGIRTYSTPMPTYFQYFTN--- 441

                        410       420
                 ....*....|....*....|....*.
gi 27370232  489 ipaedlPYYGGSVEIADYCPFSQEFS 514
Cdd:PTZ00257 442 ------AFLGGFSAFLDYCPFIVGYS 461
 
Name Accession Description Interval E-value
Peptidase_M8 pfam01457
Leishmanolysin;
96-628 4.82e-61

Leishmanolysin;


Pssm-ID: 366652 [Multi-domain]  Cd Length: 529  Bit Score: 213.17  E-value: 4.82e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232    96 LLPEKRYLVKNKLFPQAISYLEKTFQVRRpagrillsRQcatnqylrkendphryctgecavhtkcGPVIVPEEHLQqcr 175
Cdd:pfam01457 105 LTEEKRYILVNYILPQALQLHTERLKVRQ--------VQ---------------------------GTWKVTGMDGD--- 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   176 VCREGKWPCGAVGVldpeGVRDADFVLYVGALATErcshENIISYAAYCQQEAKmDRPIAGYANLCPNMISTQPQEFigM 255
Cdd:pfam01457 147 VCGSFKVPPAHVTV----GVSNADFVLYVASVPSE----GGVLAWAFDCQLFPD-GRPAVGVINIPAAYIVSAYDQF--M 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   256 LSTVKHEIIHALGFSAGLFAFYHdqdgnpltsrsadglppfnyslglyqwsdkvvrKVERLWNVRDNKivrHTVYLLVTP 335
Cdd:pfam01457 216 VRVVTHELAHALGFSLTFFEMLG---------------------------------IIGEVKNLRGRD---YLVPVLNSP 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   336 RVVEEARKHFNCPVLEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSMAEKLDWG 415
Cdd:pfam01457 260 TVVAKAREQYGCPTLEGLELEDQGGPGTAGSHLKKRNAKDELMAPAVGAG-YYSALTMAVFQDLGFYQADFTKAEVMPWG 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   416 RGLGCEFVRKSCkfwidQHRQRRQVPSPYCDtlrSNPLQLTCRQDQRAVAVCNLQRFPNPLPPEYQYFDEltgipaedlP 495
Cdd:pfam01457 339 NNAGCDFLTKKC-----MEDNITQWPEMFCN---STERALRCPTDRLSLGTCSITRHPDPLPTYFQYFTD---------P 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   496 YYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILEnqpelfknygAEQYGPHSVCLlqKSAFIMEQcERKLSYPDWGSg 575
Cdd:pfam01457 402 SLGGGSMFMDYCPYIVGYSNGACNQDPSTASPSLME----------FNVFSDASRCL--DGVFRPKH-STGITYPYNGL- 467

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27370232   576 CYQVSCSPQGLKVWVQ---DTSYLCSRAGQVLPVRIQMNGWIHNGNLLCPSCWDFC 628
Cdd:pfam01457 468 CANVRCDRAHHTYSVQvygSSGYVACTPGESVELPTTSAAFVEGGYITCPPYVEVC 523
PTZ00257 PTZ00257
Glycoprotein GP63 (leishmanolysin); Provisional
 96-514 4.16e-37

Glycoprotein GP63 (leishmanolysin); Provisional


Pssm-ID: 240333  Cd Length: 622  Bit Score: 147.16  E-value: 4.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232   96 LLPEKRYLVKNKLFPQAISYLEKTFQVRRPAGRILLSRQcatnqylrkendphrycTGECavhtkCGPVIVPEEHLQQcr 175
Cdd:PTZ00257 146 LTEEKRDILVSYLIPQALQLHVERLRVRQVQGSWRVTGM-----------------TGPI-----CGDFKVPKAHVTV-- 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  176 vcregkwpcgavgvldpeGVRDADFVLYVGALATErcshENIISYAAYCQQEAKmDRPIAGYANL-CPNMISTQPQefiG 254
Cdd:PTZ00257 202 ------------------GVSNADFVLYVASVPSE----PGVLAWATTCQVFSD-DHPAVGVMNIpAANIVSRYDQ---G 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  255 MLSTVKHEIIHALGFS------AGLFAFYHDQDGNPLTSrsadglPPFNYSlglyqwsdkvvrkverlwnvrdnkivrht 328
Cdd:PTZ00257 256 TTRTVTHEVAHALGFSsvffenAGIVKSVTNLRGKPFAA------PVINSS----------------------------- 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  329 vyllvtpRVVEEARKHFNCPVLEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNrVLSRITLALMEDTGWYKANYSM 408
Cdd:PTZ00257 301 -------TAVAKAREQYGCPTLEYLEVEDQGGSGSAGSHLKGRNAKDELMAPASAAG-YYTALTMAVFEDLGFYKADFSM 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  409 AEKLDWGRGLGCEFVRKSCkfwidQHRQRRQVPSPYCDTLRSnplQLTCRQDQRAVAVCNLQRFPNPLPPEYQYFDEltg 488
Cdd:PTZ00257 373 AEVMPWGRNASCDFLTNKC-----MEDNITQWPEMFCNTTER---RYRCPTDRLKLGTCGIRTYSTPMPTYFQYFTN--- 441

                        410       420
                 ....*....|....*....|....*.
gi 27370232  489 ipaedlPYYGGSVEIADYCPFSQEFS 514
Cdd:PTZ00257 442 ------AFLGGFSAFLDYCPFIVGYS 461
PTZ00337 PTZ00337
surface protease GP63; Provisional
 194-641 1.57e-34

surface protease GP63; Provisional


Pssm-ID: 185563  Cd Length: 567  Bit Score: 138.88  E-value: 1.57e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  194 GVRDADFVLYVGALATERCSheniiSYAAYCqqeAKMD--RPIAGYANLCPNMISTQpqefIGMLSTVKHEIIHALGFSA 271
Cdd:PTZ00337 178 GVAGADMILYANIFPTSGPA-----AWAIPC---FLLDdgRPFAAAVNFDPRQIAVT----NGDVRVAAHELGHALGFVR 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  272 GLFAFYHdqdgnpltsrsadglppfnyslglyqwsdkvvrKVERLWNVRDnkivRHTVYLLVTPRVVEEARKHFNCPVLE 351
Cdd:PTZ00337 246 DQFLMLH---------------------------------MISEVPNVRG----MSKVSVISTPKTKAMARQYHNCPTLE 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  352 GMELENQGGMGTELNHWEKRLLENEAMTgSHTQNRVLSRITLALMEDTGWYKANYSMAEKLDWGRGLGCEFVRKSC-KFW 430
Cdd:PTZ00337 289 GIELEDEGGPGTALSHWKKRNMRDEMMT-SDVGVGLYSALTLAAFEDMGVYLANYSAAEMLWWGNNSGCGLLEKKClTDG 367

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  431 IDQHrqrrqvPSPYCDTLRSNPlQLTCRQDQRAVAVCNLQRFPNPLPPEYQYFDEltgipaedlPYYGGSVEIADYCPFS 510
Cdd:PTZ00337 368 ISEY------PDLFCNQFDDDE-KFFCTYDRLSLGRCDLKRHEEALPEEYRYFAD---------PRVGGDDLYMSRCPYV 431

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370232  511 QEFSwhlsgeyqrSSDCRilENQPELFKnygAEQYGPHSVCLLQKsafimeqcerKLSYPD--WGSGCYQVSCSPQGLKV 588
Cdd:PTZ00337 432 KAYS---------NGGCT--NGDPSVMP---GSVVGPNSRCVKGQ----------DLQFDDeyIGDVCVDTRCGDGTLSV 487

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27370232  589 -WVQDTSYLCSRAGQVlpVRIQMNGWihNGNLLCPSCWDFCEQCP-------PETDPPAAN 641
Cdd:PTZ00337 488 rFLDDDAWHECQEGET--VTPPSGPW--RGSIVCPQYADVCTAFPnisshpiPVVDPPLAD 544
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH