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Conserved domains on  [gi|27369736|ref|NP_766114|]
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tetratricopeptide repeat protein 24 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-181 1.62e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.18  E-value: 1.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  38 YNDLGMGYFQLQLFPLAVEAFLQALPLCRqpsEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSG 117
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDP---DDAEALYNLGLAYLRLGRYEEALADYEQALELDP------DDAEALNN 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369736 118 LAFSLSQLGDHRAAWDSYLHALQAAQDTGDvkgqwqACEGLGAAAARLGQHDQALKYYKEALAL 181
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDEAIEAYERALEL 139
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-181 1.62e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.18  E-value: 1.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  38 YNDLGMGYFQLQLFPLAVEAFLQALPLCRqpsEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSG 117
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDP---DDAEALYNLGLAYLRLGRYEEALADYEQALELDP------DDAEALNN 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369736 118 LAFSLSQLGDHRAAWDSYLHALQAAQDTGDvkgqwqACEGLGAAAARLGQHDQALKYYKEALAL 181
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDEAIEAYERALEL 139
TPR_12 pfam13424
Tetratricopeptide repeat;
70-144 3.00e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 3.00e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369736    70 EQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSV--GQRWEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQD 144
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 152-184 5.96e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 5.96e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27369736    152 WQACEGLGAAAARLGQHDQALKYYKEALALCQH 184
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
Mgr3-like cd24145
Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; ...
 12-182 1.32e-03

Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; Mgr3 (also called mitochondrial genome-required protein 3) is a component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. The supercomplex is composed of Mgr1, Mgr3, and Yme1. Mgr3, together with Mgr1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation.


Pssm-ID: 467945 [Multi-domain]  Cd Length: 307  Bit Score: 40.02  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  12 VLRALEESRKLADADRSTDQglLGPFYNDLGMGYFQLQLFPLAVEAFLQAL------PLCRQPSEQATVLQNLGMTHnvl 85
Cdd:cd24145 126 LKKAVEILLKLGELWMSPSE--VGAFLEELATAYDLYGRFCLALPLYMQALslkgqiLLSQANCHSLVLMNNEAAEL--- 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  86 gnyweAQEFHQKAASLHGSVGQRWEQGrsfsglafSLSQLGDHRAAWdsYLHALQAAQDT-GDVKGQW--QACE----GL 158
Cdd:cd24145 201 -----ALHALRKPLSSTLIEASRLPQK--------SRDQLLEAALKW--AQKALDVAKSIkPKDRDPEcdQACAlalyNL 265

                       170       180
                ....*....|....*....|....
gi 27369736 159 GAAAARLGQHDQALKYYKEALALC 182
Cdd:cd24145 266 GVIAEMLGNLDEARKLYKEAISLA 289
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-181 1.62e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.18  E-value: 1.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  38 YNDLGMGYFQLQLFPLAVEAFLQALPLCRqpsEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSG 117
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDP---DDAEALYNLGLAYLRLGRYEEALADYEQALELDP------DDAEALNN 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369736 118 LAFSLSQLGDHRAAWDSYLHALQAAQDTGDvkgqwqACEGLGAAAARLGQHDQALKYYKEALAL 181
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDEAIEAYERALEL 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
14-251 8.53e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 8.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  14 RALEESRKLADAdrstdqgllgpfYNDLGMGYFQLQLFPLAVEAFLQALPLcrQPsEQATVLQNLGMTHNVLGNYWEAQE 93
Cdd:COG0457  33 KALELDPDDAEA------------LYNLGLAYLRLGRYEEALADYEQALEL--DP-DDAEALNNLGLALQALGRYEEALE 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  94 FHQKAASLHGsvgqrwEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDvkgqwqACEGLGAAAARLGQhdqalk 173
Cdd:COG0457  98 DYDKALELDP------DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDAD------ALYNLGIALEKLGR------ 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27369736 174 yYKEALALCQHEPSSVRERLVAKLADAMRTFVAQEKIAQARFLPSAPGKLQTSRKAKTSARVQSSAEDAQESQWEGEA 251
Cdd:COG0457 160 -YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLA 236
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
70-181 8.05e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.40  E-value: 8.05e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  70 EQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGdvk 149
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDP------DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA--- 76

                        90       100       110
                ....*....|....*....|....*....|..
gi 27369736 150 gqwQACEGLGAAAARLGQHDQALKYYKEALAL 181
Cdd:COG0457  77 ---EALNNLGLALQALGRYEEALEDYDKALEL 105
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 39-181 1.58e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 52.69  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  39 NDLGMGYFQLQLFPLAVEAFLQALPLCRQPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSVGQRWEQGRSFSGL 118
Cdd:COG3914   5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELA 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27369736 119 AFSLSQLGDHRAAWDSYLHALQAAQDtgdvkgQWQACEGLGAAAARLGQHDQALKYYKEALAL 181
Cdd:COG3914  85 ALLLQALGRYEEALALYRRALALNPD------NAEALFNLGNLLLALGRLEEALAALRRALAL 141
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 21-181 3.35e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.92  E-value: 3.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  21 KLADADRSTDQGLLGPFYNDLGMGYFQLQLFPLAVEAFLQALPLcrQPSEqATVLQNLGMTHNVLGNYWEAQEFHQKAAS 100
Cdd:COG3914  64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL--NPDN-AEALFNLGNLLLALGRLEEALAALRRALA 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736 101 LHGsvgqrwEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAqdtgdvKGQWQACEGLGAAAARLGQHDQALKYYKEALA 180
Cdd:COG3914 141 LNP------DFAEAYLNLGEALRRLGRLEEAIAALRRALELD------PDNAEALNNLGNALQDLGRLEEAIAAYRRALE 208


                .
gi 27369736 181 L 181
Cdd:COG3914 209 L 209
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 9-228 6.07e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 6.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736   9 LSDVLRALEESRKLADADRSTDQGL-----LGPFYNDLGMGYFQLQLFPLAVEAFLQALplcRQPSEQATVLQNLGMTHN 83
Cdd:COG3914  81 LELAALLLQALGRYEEALALYRRALalnpdNAEALFNLGNLLLALGRLEEALAALRRAL---ALNPDFAEAYLNLGEALR 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  84 VLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDVKGQWQaceglgAAAA 163
Cdd:COG3914 158 RLGRLEEAIAALRRALELDP------DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLL------FALR 225

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27369736 164 RLGQHDQALKYYKEALALCQHEPSSV-------RERLVAKLADAMRTFVAQEKIAQARFLPSAPGKLQTSRK 228
Cdd:COG3914 226 QACDWEVYDRFEELLAALARGPSELSpfallylPDDDPAELLALARAWAQLVAAAAAPELPPPPNPRDPDRK 297
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 5-181 6.93e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 50.76  E-value: 6.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736   5 RQYGLSDVLRALEESRKLADADRSTDQGLLGPFYNDLGMGYFQLQLFPLAVEAFLQALPLCRQPSEQATVLQNLGMthnv 84
Cdd:COG3914  15 AALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQA---- 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  85 LGNYWEAQEFHQKAASLHGSVGQRWEQgrsfsgLAFSLSQLGDHRAAWDSYLHALQAAQDtgdvkgQWQACEGLGAAAAR 164
Cdd:COG3914  91 LGRYEEALALYRRALALNPDNAEALFN------LGNLLLALGRLEEALAALRRALALNPD------FAEAYLNLGEALRR 158

                       170
                ....*....|....*..
gi 27369736 165 LGQHDQALKYYKEALAL 181
Cdd:COG3914 159 LGRLEEAIAALRRALEL 175
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 14-213 9.50e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 9.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  14 RALEESRKLADADRSTDQGLLGpfyndLGMGYFQLQLFPLAVEAFLQALplcRQPSEQATVLQNLGMTHNVLGNYWEAQE 93
Cdd:COG2956  60 RAIRIHQKLLERDPDRAEALLE-----LAQDYLKAGLLDRAEELLEKLL---ELDPDDAEALRLLAEIYEQEGDWEKAIE 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  94 FHQKAASLHGSVGQRW--------EQG--------------------RSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDT 145
Cdd:COG2956 132 VLERLLKLGPENAHAYcelaelylEQGdydeaiealekalkldpdcaRALLLLAELYLEQGDYEEAIAALERALEQDPDY 211

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27369736 146 GDVKgqwqacEGLGAAAARLGQHDQALKYYKEALAlcQHEPSSVRERLVAKLADAMRTFVAQEKIAQA 213
Cdd:COG2956 212 LPAL------PRLAELYEKLGDPEEALELLRKALE--LDPSDDLLLALADLLERKEGLEAALALLERQ 271
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 54-200 1.76e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 1.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  54 AVEAFLQALplcRQPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSVGQRWeqgrsfSGLAFSLSQLGDHRAAWD 133
Cdd:COG4235   2 AIARLRQAL---AANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADAL------LDLAEALLAAGDTEEAEE 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369736 134 SYLHALqaAQDTGDVKGQWQacegLGAAAARLGQHDQALKYYKEALALcqHEPSSVRERLVAKLADA 200
Cdd:COG4235  73 LLERAL--ALDPDNPEALYL----LGLAAFQQGDYAEAIAAWQKLLAL--LPADAPARLLEASIAEA 131
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 14-193 1.43e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 1.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  14 RALEESRKLADADRSTDQGLLGpfyndLGMGYFQLQLFPLAVEAFLQALplcRQPSEQATVLQNLGMTHNVLGNYWEAQE 93
Cdd:COG2956  26 KAIDLLEEALELDPETVEAHLA-----LGNLYRRRGEYDRAIRIHQKLL---ERDPDRAEALLELAQDYLKAGLLDRAEE 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  94 FHQKAASLHGsvgqrwEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDVKgqwqaCEgLGAAAARLGQHDQALK 173
Cdd:COG2956  98 LLEKLLELDP------DDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY-----CE-LAELYLEQGDYDEAIE 165

                       170       180
                ....*....|....*....|
gi 27369736 174 YYKEALALcqhEPSSVRERL 193
Cdd:COG2956 166 ALEKALKL---DPDCARALL 182
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
22-180 1.96e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 1.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  22 LADADRSTDQGLLGPFYNDLGMGYFQLQLFPLAVEAFLQALPLCrqpSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASL 101
Cdd:COG4785  60 AERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELD---PDLAEAYNNRGLAYLLLGDYDAALEDFDRALEL 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736 102 hgsvgqRWEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDV----------KGQWQACEGL----GAAAARLGQ 167
Cdd:COG4785 137 ------DPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERalwlylaerkLDPEKALALLledwATAYLLQGD 210

                       170
                ....*....|...
gi 27369736 168 HDQALKYYKEALA 180
Cdd:COG4785 211 TEEARELFKLALA 223
TPR_12 pfam13424
Tetratricopeptide repeat;
70-144 3.00e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 3.00e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369736    70 EQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSV--GQRWEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQD 144
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_12 pfam13424
Tetratricopeptide repeat;
116-183 3.18e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 3.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736   116 SGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDVKGQWQAC--EGLGAAAARLGQHDQALKYYKEALALCQ 183
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATtlLNLGRLYLELGRYEEALELLERALALAE 76
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 69-216 4.23e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 4.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  69 SEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDtgdv 148
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDP------DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD---- 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27369736 149 kgQWQACEGLGAAAARLGQHDQALKYYKEALALCQHEPsSVRERLVAKLADAMRTFVAQEKIAQARFL 216
Cdd:COG4783  71 --EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHP-EAYLRLARAYRALGRPDEAIAALEKALEL 135
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 45-181 1.97e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 1.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  45 YFQLQLFPLAVEAFLQALPLCRQPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSGLAFSLSQ 124
Cdd:COG5010  27 YEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDP------NNPELYYNLALLYSR 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369736 125 LGDHRAAWDSYLHALQAAQDtgdvkgQWQACEGLGAAAARLGQHDQALKYYKEALAL 181
Cdd:COG5010 101 SGDKDEAKEYYEKALALSPD------NPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
85-181 4.28e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.00  E-value: 4.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  85 LGNYWEAQEFHQKAASLHgsvgqrWEQGRSFSGLAFSLSQLGDHRAAWDsYLHALQAAQDtgdvkgQWQACEGLGAAAAR 164
Cdd:COG3063   5 LGDLEEAEEYYEKALELD------PDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPN------NAEALLNLAELLLE 71

                        90
                ....*....|....*..
gi 27369736 165 LGQHDQALKYYKEALAL 181
Cdd:COG3063  72 LGDYDEALAYLERALEL 88
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
45-144 4.91e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 4.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  45 YFQLQLFPLAVEAFLQALPLcrQPsEQATVLQNLGMTHNVLGNYWEAQEFhQKAASLHGsvgqrwEQGRSFSGLAFSLSQ 124
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALEL--DP-DNADALNNLGLLLLEQGRYDEAIAL-EKALKLDP------NNAEALLNLAELLLE 71

                        90       100
                ....*....|....*....|
gi 27369736 125 LGDHRAAWDSYLHALQAAQD 144
Cdd:COG3063  72 LGDYDEALAYLERALELDPS 91
TPR_1 pfam00515
Tetratricopeptide repeat;
153-184 5.13e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.02  E-value: 5.13e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 27369736   153 QACEGLGAAAARLGQHDQALKYYKEALALCQH 184
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 152-184 5.96e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 5.96e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 27369736    152 WQACEGLGAAAARLGQHDQALKYYKEALALCQH 184
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
Mgr3-like cd24145
Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; ...
 12-182 1.32e-03

Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; Mgr3 (also called mitochondrial genome-required protein 3) is a component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. The supercomplex is composed of Mgr1, Mgr3, and Yme1. Mgr3, together with Mgr1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation.


Pssm-ID: 467945 [Multi-domain]  Cd Length: 307  Bit Score: 40.02  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  12 VLRALEESRKLADADRSTDQglLGPFYNDLGMGYFQLQLFPLAVEAFLQAL------PLCRQPSEQATVLQNLGMTHnvl 85
Cdd:cd24145 126 LKKAVEILLKLGELWMSPSE--VGAFLEELATAYDLYGRFCLALPLYMQALslkgqiLLSQANCHSLVLMNNEAAEL--- 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  86 gnyweAQEFHQKAASLHGSVGQRWEQGrsfsglafSLSQLGDHRAAWdsYLHALQAAQDT-GDVKGQW--QACE----GL 158
Cdd:cd24145 201 -----ALHALRKPLSSTLIEASRLPQK--------SRDQLLEAALKW--AQKALDVAKSIkPKDRDPEcdQACAlalyNL 265

                       170       180
                ....*....|....*....|....
gi 27369736 159 GAAAARLGQHDQALKYYKEALALC 182
Cdd:cd24145 266 GVIAEMLGNLDEARKLYKEAISLA 289
TPR_12 pfam13424
Tetratricopeptide repeat;
38-98 1.39e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.98  E-value: 1.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27369736    38 YNDLGMGYFQLQLFPLAVEAFLQALPLCRQPSE-----QATVLQNLGMTHNVLGNYWEAQEFHQKA 98
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGpdhplTATTLLNLGRLYLELGRYEEALELLERA 71
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 152-182 1.65e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.58  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 27369736   152 WQACEGLGAAAARLGQHDQALKYYKEALALC 182
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELD 31
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 5-142 2.84e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.02  E-value: 2.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736   5 RQYGLSDVLRALEESRKLADADRSTDQGLLGPFYNDLGMGYFQLQLFPLAVEAFLQALPLCrqpSEQATVLQNLGMTHNV 84
Cdd:COG5010  24 VEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLD---PNNPELYYNLALLYSR 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27369736  85 LGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAA 142
Cdd:COG5010 101 SGDKDEAKEYYEKALALSP------DNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 41-142 4.27e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 4.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  41 LGMGYFQLQLFPLAVEAFLQALPLcrQPsEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqrwEQGRSFSGLAF 120
Cdd:COG4235  23 LGRAYLRLGRYDEALAAYEKALRL--DP-DNADALLDLAEALLAAGDTEEAEELLERALALDP------DNPEALYLLGL 93

                        90       100
                ....*....|....*....|..
gi 27369736 121 SLSQLGDHRAAWDSYLHALQAA 142
Cdd:COG4235  94 AAFQQGDYAEAIAAWQKLLALL 115
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-177 4.80e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 4.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  38 YNDLGMGYFQLQLFPLAVEAFLQALPLcrQPsEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGsvgqRWEQGRSFSG 117
Cdd:COG0457 113 LYNLGLALLELGRYDEAIEAYERALEL--DP-DDADALYNLGIALEKLGRYEEALELLEKLEAAAL----AALLAAALGE 185

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736 118 LAFSLSQLGDHRAAWDSYLHALQAAQDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKE 177
Cdd:COG0457 186 AALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
COG3899 COG3899
Predicted ATPase [General function prediction only];
54-214 8.32e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 38.30  E-value: 8.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736   54 AVEAFLQALPLCR---QPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSVGQRWEQGRSFSGLAFSLS-----QL 125
Cdd:COG3899  724 ALRYLERALELLPpdpEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYAnlgllLL 803

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369736  126 GDHRAAWDSYLHALQAAQDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKEALALCQHEPSSVRERLVAKLADAMRTFV 205
Cdd:COG3899  804 GDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAA 883


                 ....*....
gi 27369736  206 AQEKIAQAR 214
Cdd:COG3899  884 AALAAAAAA 892
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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