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Conserved domains on  [gi|27311170|ref|NP_758888|]
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vif protein [Simian immunodeficiency virus SIV-mnd 2]

Protein Classification

virion infectivity factor( domain architecture ID 138)

virion infectivity factor forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions

Gene Ontology:  GO:0019058|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vif super family cl02899
Retroviral Vif (Viral infectivity) protein; Human immunodeficiency virus type 1 (HIV-1) Vif is ...
 1-151 2.05e-41

Retroviral Vif (Viral infectivity) protein; Human immunodeficiency virus type 1 (HIV-1) Vif is required for productive infection of T lymphocytes and macrophages. Virions produced in the absence of Vif have abnormal core morphology and those produced in primary T cells carry immature core proteins and low levels of mature capsid.


The actual alignment was detected with superfamily member pfam00559:

Pssm-ID: 278957  Cd Length: 200  Bit Score: 139.09  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27311170     1 MEKQWIVIPTWKLDRHAVERWNSLVKYHKYKGEKhLDKWDLKAHFQC------SGWWTHSQKYIPLEEDEQIIITILWNL 74
Cdd:pfam00559   1 DENRWIVMITWQVDGMRIEKWHALVKHHKYRSGD-AEEVFYRHHYESphhkigWAWWTCSEVHFPLQGDAHLEIQAYWGL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27311170    75 -TPEKGWLSTYAMTIEYKFTNYYTHIDPQTADRMIHWKYLPCFTEQAIRQALLG-KRLTVCYFHWGHKGKVGSLQYLAL 151
Cdd:pfam00559  80 hTGEKDWHLGHAVRIEWRKEKFSTDVDPDCADILIHLTYFDCFSAGAIRKAILGeILLPCCEYPQAGHAKVGSLQYLAL 158
 
Name Accession Description Interval E-value
Vif pfam00559
Retroviral Vif (Viral infectivity) protein; Human immunodeficiency virus type 1 (HIV-1) Vif is ...
 1-151 2.05e-41

Retroviral Vif (Viral infectivity) protein; Human immunodeficiency virus type 1 (HIV-1) Vif is required for productive infection of T lymphocytes and macrophages. Virions produced in the absence of Vif have abnormal core morphology and those produced in primary T cells carry immature core proteins and low levels of mature capsid.


Pssm-ID: 278957  Cd Length: 200  Bit Score: 139.09  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27311170     1 MEKQWIVIPTWKLDRHAVERWNSLVKYHKYKGEKhLDKWDLKAHFQC------SGWWTHSQKYIPLEEDEQIIITILWNL 74
Cdd:pfam00559   1 DENRWIVMITWQVDGMRIEKWHALVKHHKYRSGD-AEEVFYRHHYESphhkigWAWWTCSEVHFPLQGDAHLEIQAYWGL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27311170    75 -TPEKGWLSTYAMTIEYKFTNYYTHIDPQTADRMIHWKYLPCFTEQAIRQALLG-KRLTVCYFHWGHKGKVGSLQYLAL 151
Cdd:pfam00559  80 hTGEKDWHLGHAVRIEWRKEKFSTDVDPDCADILIHLTYFDCFSAGAIRKAILGeILLPCCEYPQAGHAKVGSLQYLAL 158
 
Name Accession Description Interval E-value
Vif pfam00559
Retroviral Vif (Viral infectivity) protein; Human immunodeficiency virus type 1 (HIV-1) Vif is ...
 1-151 2.05e-41

Retroviral Vif (Viral infectivity) protein; Human immunodeficiency virus type 1 (HIV-1) Vif is required for productive infection of T lymphocytes and macrophages. Virions produced in the absence of Vif have abnormal core morphology and those produced in primary T cells carry immature core proteins and low levels of mature capsid.


Pssm-ID: 278957  Cd Length: 200  Bit Score: 139.09  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27311170     1 MEKQWIVIPTWKLDRHAVERWNSLVKYHKYKGEKhLDKWDLKAHFQC------SGWWTHSQKYIPLEEDEQIIITILWNL 74
Cdd:pfam00559   1 DENRWIVMITWQVDGMRIEKWHALVKHHKYRSGD-AEEVFYRHHYESphhkigWAWWTCSEVHFPLQGDAHLEIQAYWGL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27311170    75 -TPEKGWLSTYAMTIEYKFTNYYTHIDPQTADRMIHWKYLPCFTEQAIRQALLG-KRLTVCYFHWGHKGKVGSLQYLAL 151
Cdd:pfam00559  80 hTGEKDWHLGHAVRIEWRKEKFSTDVDPDCADILIHLTYFDCFSAGAIRKAILGeILLPCCEYPQAGHAKVGSLQYLAL 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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