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Conserved domains on  [gi|270483795|ref|NP_001161946|]
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transcription initiation factor TFIID subunit 7-like isoform 2 [Homo sapiens]

Protein Classification

transcription initiation factor TFIID subunit 7 family protein( domain architecture ID 10519876)

transcription initiation factor TFIID subunit 7 (TAF7) family protein is a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors

Gene Ontology:  GO:0005669
PubMed:  35700575|16407123

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAFII55_N pfam04658
TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the ...
 12-190 7.43e-68

TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown. The conserved region is situated towards the N-terminus of the protein.


:

Pssm-ID: 461382  Cd Length: 160  Bit Score: 211.22  E-value: 7.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   12 VENQFILRLPLE-HACTVRNLARSQsvKMKDKLKIDLLPDGRHAVVEVEDVPLAAKLVDLPCVIESLRTLDKKTFYKTAD 90
Cdd:pfam04658   1 IEEQFILRLPPDeDADYLRKAIESG--DIKDDLSIKFLKDGRRAVVRIGGQLYAAKLVDLPTIIESMKTIDKKNFYKTAD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   91 ISQMLVCTADGDihlSPEEPAASTDPNIVRKKERGREEKCVWKHGITPPLKNVRKKRFRKTQKKvpdvKEMEkssfteyi 170
Cdd:pfam04658  79 ICQMLLVLGPIK---NEEEAKTEPLPEEPPPKKEVKDKKYQYPHGLTPPLKNVRKRRFRKRLKK----KEIE-------- 143

                         170       180
                  ....*....|....*....|
gi 270483795  171 espDVENEVKRLLRSDAEAV 190
Cdd:pfam04658 144 ---AVEKEVKRLLRADAEAE 160
 
Name Accession Description Interval E-value
TAFII55_N pfam04658
TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the ...
 12-190 7.43e-68

TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown. The conserved region is situated towards the N-terminus of the protein.


Pssm-ID: 461382  Cd Length: 160  Bit Score: 211.22  E-value: 7.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   12 VENQFILRLPLE-HACTVRNLARSQsvKMKDKLKIDLLPDGRHAVVEVEDVPLAAKLVDLPCVIESLRTLDKKTFYKTAD 90
Cdd:pfam04658   1 IEEQFILRLPPDeDADYLRKAIESG--DIKDDLSIKFLKDGRRAVVRIGGQLYAAKLVDLPTIIESMKTIDKKNFYKTAD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   91 ISQMLVCTADGDihlSPEEPAASTDPNIVRKKERGREEKCVWKHGITPPLKNVRKKRFRKTQKKvpdvKEMEkssfteyi 170
Cdd:pfam04658  79 ICQMLLVLGPIK---NEEEAKTEPLPEEPPPKKEVKDKKYQYPHGLTPPLKNVRKRRFRKRLKK----KEIE-------- 143

                         170       180
                  ....*....|....*....|
gi 270483795  171 espDVENEVKRLLRSDAEAV 190
Cdd:pfam04658 144 ---AVEKEVKRLLRADAEAE 160
TAF7 cd08047
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and ...
 13-197 1.07e-55

TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; The TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and are involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs are named after their electrophoretic mobility in polyacrylamide gels in different species. A new, unified nomenclature has been suggested for the pol II TAFs to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs functions such as serving as activator-binding sites, core-promoter recognition or a role in essential catalytic activity. Each TAF, with the help of a specific activator, is required only for expression of subset of genes and is not universally involved for transcription as are GTFs. TAF7 is involved in the regulation of the transition from PIC assembly to initiation and elongation. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers.


Pssm-ID: 173966  Cd Length: 162  Bit Score: 180.16  E-value: 1.07e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795  13 ENQFILRLPLEHACTVRNLARSQSVKMKDkLKIDLLPDGRHAVVEVEDVPLAAKLVDLPCVIESLRTLDKKTFYKTADIS 92
Cdd:cd08047    1 EEQFILRLPPDVADRLRKAIEEGDSNEKL-LSITLFEDSRRAVVRINGQKYPAKLVDLPTIIESHKTLDKKNLYKTADIS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795  93 QMLVCTADGDIhlSPEEPAASTDPNIVRKKErgreekcVWKHGITPPLKNVRKKRFRKTQKKvpdvkemekssftEYIES 172
Cdd:cd08047   80 QMLIVYEPDDS--EKEAKEAKLDKKDKPKKF-------EYPHGLTPPMKNVRKRRFRKTPSK-------------KIAEI 137

                        170       180
                 ....*....|....*....|....*
gi 270483795 173 PDVENEVKRLLRSDAEAVSTRWEVI 197
Cdd:cd08047  138 EEVEKEVKRLLKEDTEAVSVEYEVI 162
Taf7 COG5414
TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation ...
 2-214 9.09e-24

TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation complex [Transcription];


Pssm-ID: 227701  Cd Length: 392  Bit Score: 101.32  E-value: 9.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   2 SESQDEVPDE-VENQFILRLPLEHACT-VRNLARSQ-----SVKMKDKlkidllpdgRHAVVEVEDVPLAAKLVDLPCVI 74
Cdd:COG5414   61 SEASDIEDDPlIEQQFILRLHPSIQIEhVVDLGESGdysgiTIKIKDD---------RSAVVTHNNKKYPAILVDLPCII 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795  75 ESLRTLDKKTFYKTADISQMLVCTadgdihlSPEEPAASTDpNIVRKKERGREEkcvwKHGITPPLKNVRKKRFRKTQKK 154
Cdd:COG5414  132 ESNKSMDSKQHYKVADISQMLVAL-------EAVYHENSFL-NKHLKKEREYYY----LHGLSPPLKYVRARRFRKKSSK 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795 155 vpdvkemekssfteyIESPDVENEVKRLLRSDAEAVSTRWEVIAEDGTKEIESQGSIPGF 214
Cdd:COG5414  200 ---------------IEIEEVEKKVDDLLEKDMKAESVSVVLKDEKELARQERVSSWENF 244
 
Name Accession Description Interval E-value
TAFII55_N pfam04658
TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the ...
 12-190 7.43e-68

TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown. The conserved region is situated towards the N-terminus of the protein.


Pssm-ID: 461382  Cd Length: 160  Bit Score: 211.22  E-value: 7.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   12 VENQFILRLPLE-HACTVRNLARSQsvKMKDKLKIDLLPDGRHAVVEVEDVPLAAKLVDLPCVIESLRTLDKKTFYKTAD 90
Cdd:pfam04658   1 IEEQFILRLPPDeDADYLRKAIESG--DIKDDLSIKFLKDGRRAVVRIGGQLYAAKLVDLPTIIESMKTIDKKNFYKTAD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   91 ISQMLVCTADGDihlSPEEPAASTDPNIVRKKERGREEKCVWKHGITPPLKNVRKKRFRKTQKKvpdvKEMEkssfteyi 170
Cdd:pfam04658  79 ICQMLLVLGPIK---NEEEAKTEPLPEEPPPKKEVKDKKYQYPHGLTPPLKNVRKRRFRKRLKK----KEIE-------- 143

                         170       180
                  ....*....|....*....|
gi 270483795  171 espDVENEVKRLLRSDAEAV 190
Cdd:pfam04658 144 ---AVEKEVKRLLRADAEAE 160
TAF7 cd08047
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and ...
 13-197 1.07e-55

TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; The TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and are involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs are named after their electrophoretic mobility in polyacrylamide gels in different species. A new, unified nomenclature has been suggested for the pol II TAFs to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs functions such as serving as activator-binding sites, core-promoter recognition or a role in essential catalytic activity. Each TAF, with the help of a specific activator, is required only for expression of subset of genes and is not universally involved for transcription as are GTFs. TAF7 is involved in the regulation of the transition from PIC assembly to initiation and elongation. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers.


Pssm-ID: 173966  Cd Length: 162  Bit Score: 180.16  E-value: 1.07e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795  13 ENQFILRLPLEHACTVRNLARSQSVKMKDkLKIDLLPDGRHAVVEVEDVPLAAKLVDLPCVIESLRTLDKKTFYKTADIS 92
Cdd:cd08047    1 EEQFILRLPPDVADRLRKAIEEGDSNEKL-LSITLFEDSRRAVVRINGQKYPAKLVDLPTIIESHKTLDKKNLYKTADIS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795  93 QMLVCTADGDIhlSPEEPAASTDPNIVRKKErgreekcVWKHGITPPLKNVRKKRFRKTQKKvpdvkemekssftEYIES 172
Cdd:cd08047   80 QMLIVYEPDDS--EKEAKEAKLDKKDKPKKF-------EYPHGLTPPMKNVRKRRFRKTPSK-------------KIAEI 137

                        170       180
                 ....*....|....*....|....*
gi 270483795 173 PDVENEVKRLLRSDAEAVSTRWEVI 197
Cdd:cd08047  138 EEVEKEVKRLLKEDTEAVSVEYEVI 162
Taf7 COG5414
TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation ...
 2-214 9.09e-24

TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation complex [Transcription];


Pssm-ID: 227701  Cd Length: 392  Bit Score: 101.32  E-value: 9.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795   2 SESQDEVPDE-VENQFILRLPLEHACT-VRNLARSQ-----SVKMKDKlkidllpdgRHAVVEVEDVPLAAKLVDLPCVI 74
Cdd:COG5414   61 SEASDIEDDPlIEQQFILRLHPSIQIEhVVDLGESGdysgiTIKIKDD---------RSAVVTHNNKKYPAILVDLPCII 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795  75 ESLRTLDKKTFYKTADISQMLVCTadgdihlSPEEPAASTDpNIVRKKERGREEkcvwKHGITPPLKNVRKKRFRKTQKK 154
Cdd:COG5414  132 ESNKSMDSKQHYKVADISQMLVAL-------EAVYHENSFL-NKHLKKEREYYY----LHGLSPPLKYVRARRFRKKSSK 199

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 270483795 155 vpdvkemekssfteyIESPDVENEVKRLLRSDAEAVSTRWEVIAEDGTKEIESQGSIPGF 214
Cdd:COG5414  200 ---------------IEIEEVEKKVDDLLEKDMKAESVSVVLKDEKELARQERVSSWENF 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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