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Conserved domains on  [gi|268038289|gb|ACY91917|]
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MADS-domain transcription factor, partial [Symplocos chinensis]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 10210286)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS super family cl00109
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 1-64 3.59e-29

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


The actual alignment was detected with superfamily member cd00265:

Pssm-ID: 469617 [Multi-domain]  Cd Length: 77  Bit Score: 103.02  E-value: 3.59e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268038289   1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSPSTSliEILDKYQKQSGQRLW 64
Cdd:cd00265   16 RQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSME--KIIERYQKTSGSSLW 77
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 67-148 1.39e-21

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


:

Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 84.05  E-value: 1.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268038289   67 KHENLSNEIDRIKKENDNMQIELRHLKGEDITSLHHKELMVIEEALENGIASIRDKQMEI----VEMMRKKENMMEEENK 142
Cdd:pfam01486   5 EQENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLlleqIEELKKKERILQEENK 84


                  ....*.
gi 268038289  143 HLNYKL 148
Cdd:pfam01486  85 ELRKKL 90
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-64 3.59e-29

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 103.02  E-value: 3.59e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268038289   1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSPSTSliEILDKYQKQSGQRLW 64
Cdd:cd00265   16 RQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSME--KIIERYQKTSGSSLW 77
MADS smart00432
MADS domain;
1-44 7.31e-22

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 83.76  E-value: 7.31e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 268038289     1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSP 44
Cdd:smart00432  16 RQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 67-148 1.39e-21

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 84.05  E-value: 1.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268038289   67 KHENLSNEIDRIKKENDNMQIELRHLKGEDITSLHHKELMVIEEALENGIASIRDKQMEI----VEMMRKKENMMEEENK 142
Cdd:pfam01486   5 EQENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLlleqIEELKKKERILQEENK 84


                  ....*.
gi 268038289  143 HLNYKL 148
Cdd:pfam01486  85 ELRKKL 90
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
1-41 2.25e-19

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 77.08  E-value: 2.25e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 268038289    1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEY 41
Cdd:pfam00319   8 RQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-45 5.48e-06

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 45.78  E-value: 5.48e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 268038289   1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSPS 45
Cdd:COG5068   97 RSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPK 141
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 1-64 3.59e-29

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 103.02  E-value: 3.59e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 268038289   1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSPSTSliEILDKYQKQSGQRLW 64
Cdd:cd00265   16 RQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSME--KIIERYQKTSGSSLW 77
MADS smart00432
MADS domain;
1-44 7.31e-22

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 83.76  E-value: 7.31e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 268038289     1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSP 44
Cdd:smart00432  16 RQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 67-148 1.39e-21

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 84.05  E-value: 1.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268038289   67 KHENLSNEIDRIKKENDNMQIELRHLKGEDITSLHHKELMVIEEALENGIASIRDKQMEI----VEMMRKKENMMEEENK 142
Cdd:pfam01486   5 EQENWQQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLlleqIEELKKKERILQEENK 84


                  ....*.
gi 268038289  143 HLNYKL 148
Cdd:pfam01486  85 ELRKKL 90
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 1-44 1.55e-20

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 80.25  E-value: 1.55e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 268038289   1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSP 44
Cdd:cd00120   16 RQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFWSS 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
1-41 2.25e-19

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 77.08  E-value: 2.25e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 268038289    1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEY 41
Cdd:pfam00319   8 RQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 1-47 1.26e-15

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 68.44  E-value: 1.26e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 268038289   1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSPSTS 47
Cdd:cd00266   16 RAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSEV 62
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-45 5.48e-06

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 45.78  E-value: 5.48e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 268038289   1 RQVTYSKRRNGIIKKAKEITILCDAKVSLVIFASSGKMHEYCSPS 45
Cdd:COG5068   97 RSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPK 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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