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Conserved domains on  [gi|26345382|dbj|BAC36342|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P4Hc smart00702
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ...
 173-371 6.94e-34

Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.


:

Pssm-ID: 214780  Cd Length: 165  Bit Score: 124.04  E-value: 6.94e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382    173 SQEQCRELHSVANGIMLVGDGYRGKTSP-HTANEKFEGATVLKALKFgyegrvplksarlfYDISEKARKIVESYFMLns 251
Cdd:smart00702   1 SPAECQKLLEEAEPLGWRGEVTRGIGNPnETSQYRQSNGTWLELLER--------------DLVIERIRQRLADFLGL-- 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382    252 tlYFSYTHMVCRTALSGQQDrrnDLSHPIHADNCLldpeanecwkeppaYTFRDYSALLYMNDDFDGGEFIFTEMDAkTV 331
Cdd:smart00702  65 --LAGLPLSAEDAQVARYGP---GGHYGPHVDNFL--------------YGDRIATFILYLNDVEEGGELVFPGLRL-MV 124

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 26345382    332 TASIKPKCGRMISFSSG-GENPHGVKAVTRGQRCAVALWFT 371
Cdd:smart00702 125 VATVKPKKGDLLFFPSGhGRSLHGVCPVTRGSRWAITGWIR 165
OM_YfiO super family cl37244
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 15-76 3.14e-03

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


The actual alignment was detected with superfamily member TIGR03302:

Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 38.69  E-value: 3.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26345382    15 FAYYRVGEYVKALECAKAYLMFHPDNEDV-----LDNVDFYESLLDDSTDPASI-EAREDLTAFVKRH 76
Cdd:TIGR03302  78 YAYYKSGDYAEAIAAADRFIRLHPNHPDAdyayyLRGLSNYNQIDRVDRDQTAArEAFEAFQELIRRY 145
 
Name Accession Description Interval E-value
P4Hc smart00702
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ...
 173-371 6.94e-34

Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.


Pssm-ID: 214780  Cd Length: 165  Bit Score: 124.04  E-value: 6.94e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382    173 SQEQCRELHSVANGIMLVGDGYRGKTSP-HTANEKFEGATVLKALKFgyegrvplksarlfYDISEKARKIVESYFMLns 251
Cdd:smart00702   1 SPAECQKLLEEAEPLGWRGEVTRGIGNPnETSQYRQSNGTWLELLER--------------DLVIERIRQRLADFLGL-- 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382    252 tlYFSYTHMVCRTALSGQQDrrnDLSHPIHADNCLldpeanecwkeppaYTFRDYSALLYMNDDFDGGEFIFTEMDAkTV 331
Cdd:smart00702  65 --LAGLPLSAEDAQVARYGP---GGHYGPHVDNFL--------------YGDRIATFILYLNDVEEGGELVFPGLRL-MV 124

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 26345382    332 TASIKPKCGRMISFSSG-GENPHGVKAVTRGQRCAVALWFT 371
Cdd:smart00702 125 VATVKPKKGDLLFFPSGhGRSLHGVCPVTRGSRWAITGWIR 165
2OG-FeII_Oxy_3 pfam13640
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
 280-370 1.85e-13

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.


Pssm-ID: 463943  Cd Length: 94  Bit Score: 65.86  E-value: 1.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382   280 IHADNCLLDPEANEcwkeppaytfRDYSALLYMND--DFDGGEFIFTEMDAktvTASIKPKCGRMISFSSGGENPHGVKA 357
Cdd:pfam13640  14 PHLDFFEGAEGGGQ----------RRLTVVLYLNDweEEEGGELVLYDGDG---VEDIKPKKGRLVLFPSSELSLHEVLP 80

                          90
                  ....*....|...
gi 26345382   358 VTRGQRCAVALWF 370
Cdd:pfam13640  81 VTGGERWSITGWF 93
EGL9 COG3751
Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain ...
 304-370 9.16e-10

Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442965 [Multi-domain]  Cd Length: 195  Bit Score: 58.03  E-value: 9.16e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382 304 RDYSALLYMNDD---FDGGEFIFTEMDAKTVTASIKPKCGRMISFSSgGENPHGVKAVTRgQRCAVALWF 370
Cdd:COG3751 125 RRLSLVLYLNPDwqpEWGGELELYDDDGSEEEVTVAPRFNRLVLFLS-EEFPHEVLPVGR-ERLSIAGWF 192
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 15-76 3.14e-03

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 38.69  E-value: 3.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26345382    15 FAYYRVGEYVKALECAKAYLMFHPDNEDV-----LDNVDFYESLLDDSTDPASI-EAREDLTAFVKRH 76
Cdd:TIGR03302  78 YAYYKSGDYAEAIAAADRFIRLHPNHPDAdyayyLRGLSNYNQIDRVDRDQTAArEAFEAFQELIRRY 145
Fis1_TPR_C pfam14853
Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of ...
 12-40 3.68e-03

Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat


Pssm-ID: 434269 [Multi-domain]  Cd Length: 53  Bit Score: 35.19  E-value: 3.68e-03
                          10        20
                  ....*....|....*....|....*....
gi 26345382    12 YLQFAYYRVGEYVKALECAKAYLMFHPDN 40
Cdd:pfam14853   6 YLAVGHYKLGEYSEARRYVDALLEIEPDN 34
Fis1 cd12212
Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an ...
 12-45 8.01e-03

Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. The Fis1 N-terminus is cytosolic and tethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane, via interactions with Mdv1 or Caf4. Fis1 has tandem Tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions.


Pssm-ID: 276936 [Multi-domain]  Cd Length: 115  Bit Score: 35.99  E-value: 8.01e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 26345382  12 YLQFAYYRVGEYVKALECAKAYLMFHPDNEDVLD 45
Cdd:cd12212  68 YLALGHYKLGEYSEARRYVDALLEIEPDNRQALA 101
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 15-76 8.48e-03

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 37.55  E-value: 8.48e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26345382  15 FAYYRVGEYVKALECAKAYLMFHPDNEDVlDNVDF------YESLLDDSTDPAS-IEAREDLTAFVKRH 76
Cdd:COG4105  77 YAYYKQGDYEEAIAAADRFIKLYPNSPNA-DYAYYlrglsyYEQSPDSDRDQTStRKAIEAFQELINRY 144
 
Name Accession Description Interval E-value
P4Hc smart00702
Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of ...
 173-371 6.94e-34

Prolyl 4-hydroxylase alpha subunit homologues; Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.


Pssm-ID: 214780  Cd Length: 165  Bit Score: 124.04  E-value: 6.94e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382    173 SQEQCRELHSVANGIMLVGDGYRGKTSP-HTANEKFEGATVLKALKFgyegrvplksarlfYDISEKARKIVESYFMLns 251
Cdd:smart00702   1 SPAECQKLLEEAEPLGWRGEVTRGIGNPnETSQYRQSNGTWLELLER--------------DLVIERIRQRLADFLGL-- 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382    252 tlYFSYTHMVCRTALSGQQDrrnDLSHPIHADNCLldpeanecwkeppaYTFRDYSALLYMNDDFDGGEFIFTEMDAkTV 331
Cdd:smart00702  65 --LAGLPLSAEDAQVARYGP---GGHYGPHVDNFL--------------YGDRIATFILYLNDVEEGGELVFPGLRL-MV 124

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 26345382    332 TASIKPKCGRMISFSSG-GENPHGVKAVTRGQRCAVALWFT 371
Cdd:smart00702 125 VATVKPKKGDLLFFPSGhGRSLHGVCPVTRGSRWAITGWIR 165
2OG-FeII_Oxy_3 pfam13640
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ...
 280-370 1.85e-13

2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily.


Pssm-ID: 463943  Cd Length: 94  Bit Score: 65.86  E-value: 1.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382   280 IHADNCLLDPEANEcwkeppaytfRDYSALLYMND--DFDGGEFIFTEMDAktvTASIKPKCGRMISFSSGGENPHGVKA 357
Cdd:pfam13640  14 PHLDFFEGAEGGGQ----------RRLTVVLYLNDweEEEGGELVLYDGDG---VEDIKPKKGRLVLFPSSELSLHEVLP 80

                          90
                  ....*....|...
gi 26345382   358 VTRGQRCAVALWF 370
Cdd:pfam13640  81 VTGGERWSITGWF 93
EGL9 COG3751
Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain ...
 304-370 9.16e-10

Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442965 [Multi-domain]  Cd Length: 195  Bit Score: 58.03  E-value: 9.16e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26345382 304 RDYSALLYMNDD---FDGGEFIFTEMDAKTVTASIKPKCGRMISFSSgGENPHGVKAVTRgQRCAVALWF 370
Cdd:COG3751 125 RRLSLVLYLNPDwqpEWGGELELYDDDGSEEEVTVAPRFNRLVLFLS-EEFPHEVLPVGR-ERLSIAGWF 192
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 15-76 3.14e-03

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 38.69  E-value: 3.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26345382    15 FAYYRVGEYVKALECAKAYLMFHPDNEDV-----LDNVDFYESLLDDSTDPASI-EAREDLTAFVKRH 76
Cdd:TIGR03302  78 YAYYKSGDYAEAIAAADRFIRLHPNHPDAdyayyLRGLSNYNQIDRVDRDQTAArEAFEAFQELIRRY 145
Fis1_TPR_C pfam14853
Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of ...
 12-40 3.68e-03

Fis1 C-terminal tetratricopeptide repeat; The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat


Pssm-ID: 434269 [Multi-domain]  Cd Length: 53  Bit Score: 35.19  E-value: 3.68e-03
                          10        20
                  ....*....|....*....|....*....
gi 26345382    12 YLQFAYYRVGEYVKALECAKAYLMFHPDN 40
Cdd:pfam14853   6 YLAVGHYKLGEYSEARRYVDALLEIEPDN 34
Fis1 cd12212
Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an ...
 12-45 8.01e-03

Mitochondrial Fission Protein Fis1, cytosolic domain; Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. The Fis1 N-terminus is cytosolic and tethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane, via interactions with Mdv1 or Caf4. Fis1 has tandem Tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions.


Pssm-ID: 276936 [Multi-domain]  Cd Length: 115  Bit Score: 35.99  E-value: 8.01e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 26345382  12 YLQFAYYRVGEYVKALECAKAYLMFHPDNEDVLD 45
Cdd:cd12212  68 YLALGHYKLGEYSEARRYVDALLEIEPDNRQALA 101
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 15-76 8.48e-03

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 37.55  E-value: 8.48e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26345382  15 FAYYRVGEYVKALECAKAYLMFHPDNEDVlDNVDF------YESLLDDSTDPAS-IEAREDLTAFVKRH 76
Cdd:COG4105  77 YAYYKQGDYEEAIAAADRFIKLYPNSPNA-DYAYYlrglsyYEQSPDSDRDQTStRKAIEAFQELINRY 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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