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Conserved domains on  [gi|26336887|dbj|BAC32127|]
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unnamed protein product [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A060601 super family cl36767
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-96 2.13e-28

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00917:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 106.92  E-value: 2.13e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26336887     25 CVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCpGLFFDNVS--LCCDIQQLQTLKSNLQLPLQFLSR 96
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVR 73
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-96 2.13e-28

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 106.92  E-value: 2.13e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26336887     25 CVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCpGLFFDNVS--LCCDIQQLQTLKSNLQLPLQFLSR 96
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVR 73
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 23-96 1.14e-24

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 92.67  E-value: 1.14e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26336887    23 QSCVWYGECGIAT-GDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSR 96
Cdd:pfam16414   1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSR 75
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-96 2.13e-28

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 106.92  E-value: 2.13e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26336887     25 CVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCpGLFFDNVS--LCCDIQQLQTLKSNLQLPLQFLSR 96
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVR 73
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 23-96 1.14e-24

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 92.67  E-value: 1.14e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26336887    23 QSCVWYGECGIAT-GDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSR 96
Cdd:pfam16414   1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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