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Conserved domains on  [gi|26335069|dbj|BAC31235|]
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unnamed protein product [Mus musculus]

Protein Classification

Protein ALWAYS EARLY( domain architecture ID 5482)

Protein ALWAYS EARLY similar to Arabidposis thaliana ALY1 which functions in sequence-specific DNA binding transcription factor activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DIRP super family cl05876
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
 74-123 5.62e-29

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


The actual alignment was detected with superfamily member pfam06584:

Pssm-ID: 461955  Cd Length: 108  Bit Score: 102.30  E-value: 5.62e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 26335069    74 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRR 123
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRR 50
 
Name Accession Description Interval E-value
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
 74-123 5.62e-29

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


Pssm-ID: 461955  Cd Length: 108  Bit Score: 102.30  E-value: 5.62e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 26335069    74 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRR 123
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRR 50
 
Name Accession Description Interval E-value
DIRP pfam06584
DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related ...
 74-123 5.62e-29

DIRP; DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9 and aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.


Pssm-ID: 461955  Cd Length: 108  Bit Score: 102.30  E-value: 5.62e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 26335069    74 WFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRR 123
Cdd:pfam06584   1 WFYSNIDKPLFESKNDFEEYLNESFPGLKTRRLTRAEWQKIRRSMGKPRR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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