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Conserved domains on  [gi|26334681|dbj|BAC31041|]
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unnamed protein product [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 1.30e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.30e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681     87 TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-224 4.22e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 4.22e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 26334681 171 PYHATVPEMSILGTSVTNVTATDADEpvyGNSAKLVYSILEGQP--YFSIEPETGT 224
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGE 53
 
Name Accession Description Interval E-value
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 1.30e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.30e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681     87 TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 81-163 5.51e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 5.51e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681  81 LVGRLH-TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQ 158
Cdd:cd11304  15 VVLTVSaTDPDSGENgEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD-GGGPPLSSTATVTITVL 93


                ....*
gi 26334681 159 DINDN 163
Cdd:cd11304  94 DVNDN 98
Cadherin pfam00028
Cadherin domain;
75-158 2.92e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 2.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681    75 SGPEPILVGRLHTDLDPGSKkIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFI 154
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 26334681   155 IKVQ 158
Cdd:pfam00028  89 ITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-224 4.22e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 4.22e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 26334681 171 PYHATVPEMSILGTSVTNVTATDADEpvyGNSAKLVYSILEGQP--YFSIEPETGT 224
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGE 53
Cadherin pfam00028
Cadherin domain;
172-224 1.98e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 1.98e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 26334681   172 YHATVPEMSILGTSVTNVTATDADEpvyGNSAKLVYSILEGQPY--FSIEPETGT 224
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGD 52
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-224 6.17e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.71  E-value: 6.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 26334681    190 TATDADEpvyGNSAKLVYSILEG--QPYFSIEPETGT 224
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGE 34
 
Name Accession Description Interval E-value
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 1.30e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.30e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681     87 TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 81-163 5.51e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 5.51e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681  81 LVGRLH-TDLDPGSK-KIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFIIKVQ 158
Cdd:cd11304  15 VVLTVSaTDPDSGENgEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD-GGGPPLSSTATVTITVL 93


                ....*
gi 26334681 159 DINDN 163
Cdd:cd11304  94 DVNDN 98
Cadherin pfam00028
Cadherin domain;
75-158 2.92e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 2.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681    75 SGPEPILVGRLHTDLDPGSKkIKYILSGDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDfETNKPLEPPSEFI 154
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 26334681   155 IKVQ 158
Cdd:pfam00028  89 ITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-224 4.22e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.49  E-value: 4.22e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 26334681 171 PYHATVPEMSILGTSVTNVTATDADEpvyGNSAKLVYSILEGQP--YFSIEPETGT 224
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGE 53
Cadherin pfam00028
Cadherin domain;
172-224 1.98e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 1.98e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 26334681   172 YHATVPEMSILGTSVTNVTATDADEpvyGNSAKLVYSILEGQPY--FSIEPETGT 224
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGD 52
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 70-163 6.54e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.96  E-value: 6.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26334681  70 VLEEFSGPEpiLVGRLHTDLDPGSKKIKYILS--GDGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPl 147
Cdd:cd00031   6 AVEGRSRGS--FRVSIPTDLIASSGEIIKISAagKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP- 82

                        90
                ....*....|....*.
gi 26334681 148 EPPSEFIIKVQDINDN 163
Cdd:cd00031  83 QTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-224 6.17e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 37.71  E-value: 6.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 26334681    190 TATDADEpvyGNSAKLVYSILEG--QPYFSIEPETGT 224
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGE 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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