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Conserved domains on  [gi|26329269|dbj|BAC28373|]
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unnamed protein product [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 377-533 2.80e-45

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


:

Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 158.68  E-value: 2.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   377 CTFDDG-FCFWTQDLDDDNEWERiqVTTFPCYTGPRFDHTYGNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEPVCLHF 455
Cdd:pfam00629   1 CDFEDGnLCGWTQDSSDDFDWER--VSGPSVKTGPSSDHTQGTGSGHFMYVDTSSGAPGQTARLLSPLLPPSRSPQCLRF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   456 WYYMCCENVYNLNIHI-SSAETTDKIVFQRKGNYGRNWNYGQVTLNE-TGEFKVVFNAFRNRG-CSTIALDDISLTNGIC 532
Cdd:pfam00629  79 WYHMSGSGVGTLRVYVrENGGTLDTLLWSISGDQGPSWKEARVTLSSsTQPFQVVFEGIRGGGsRGGIALDDISLSSGPC 158


                  .
gi 26329269   533 S 533
Cdd:pfam00629 159 P 159
CUB pfam00431
CUB domain;
554-661 4.79e-34

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 125.49  E-value: 4.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   554 CGGpfELWEPNSTFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLE----NINDVVEVRDGGEFDSLLLAVYTGP 629
Cdd:pfam00431   1 CGG--VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEdhdeCGYDYVEIRDGPSASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 26329269   630 GPVKDLFSTTNRMTVIFTTNMETRRKGFKANF 661
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 53-154 3.35e-19

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


:

Pssm-ID: 214554  Cd Length: 121  Bit Score: 83.61  E-value: 3.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269     53 GKSHEVRGTFKITSG--VTYNPNLQDKHSVDFKVLAFDLQQMIDEIFESSSLKNEYEKSKVFQFEKGSVIVLFDLFFAQW 130
Cdd:smart00200   2 TQSFGVSLSVLSVEGenLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLKPDFVGTEVIEFRNGSVVVDLGLLFNEG 81

                           90       100
                   ....*....|....*....|....*
gi 26329269    131 V-SDKNVKEELIQGIEANISSQLVT 154
Cdd:smart00200  82 VtNGQDVEEDLLQVIKQAAYSLKIT 106
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 255-361 2.35e-17

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member pfam00431:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 110  Bit Score: 78.11  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   255 CDGRFllTGDSGVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSF-----IPHYTDVLDIYEGIGPSKILRGSFW-E 328
Cdd:pfam00431   1 CGGVL--TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFeledhDECGYDYVEIRDGPSASSPLLGRFCgS 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 26329269   329 TDPGTIRIFSNLVTVTFLIkSDEYDYIGFNATY 361
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVS-DASVQKRGFKATY 110
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 673-703 3.28e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.28e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 26329269    673 CQDDEFQCKDGNCIPLGNLCDSYPHCRDGSD 703
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSD 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 214-247 1.05e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.88  E-value: 1.05e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 26329269 214 CQPGSRPCAHaWNCVATDLFCDGEVNCPDGSDED 247
Cdd:cd00112   1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEE 33
 
Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 377-533 2.80e-45

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 158.68  E-value: 2.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   377 CTFDDG-FCFWTQDLDDDNEWERiqVTTFPCYTGPRFDHTYGNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEPVCLHF 455
Cdd:pfam00629   1 CDFEDGnLCGWTQDSSDDFDWER--VSGPSVKTGPSSDHTQGTGSGHFMYVDTSSGAPGQTARLLSPLLPPSRSPQCLRF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   456 WYYMCCENVYNLNIHI-SSAETTDKIVFQRKGNYGRNWNYGQVTLNE-TGEFKVVFNAFRNRG-CSTIALDDISLTNGIC 532
Cdd:pfam00629  79 WYHMSGSGVGTLRVYVrENGGTLDTLLWSISGDQGPSWKEARVTLSSsTQPFQVVFEGIRGGGsRGGIALDDISLSSGPC 158


                  .
gi 26329269   533 S 533
Cdd:pfam00629 159 P 159
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 372-532 6.87e-39

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 141.33  E-value: 6.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    372 YEKIDCTFDDG-FCFWTQDLDDDNEWERIQVTTFpcYTGPRFDHTygNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEP 450
Cdd:smart00137   1 TSPGNCDFEEGsTCGWHQDSNDDGHWERVSSATG--IPGPNRDHT--TGNGHFMFFETSSGAEGQTARLLSPPLYENRST 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    451 VCLHFWYYMCCENVYNLNIHI-SSAETTDKIVFQRKGNYGRNWNYGQVTLN-ETGEFKVVFNAFRNRG-CSTIALDDISL 527
Cdd:smart00137  77 HCLTFWYYMYGSGSGTLNVYVrENNGSQDTLLWSRSGTQGGQWLQAEVALSsWPQPFQVVFEGTRGKGhSGYIALDDILL 156


                   ....*
gi 26329269    528 TNGIC 532
Cdd:smart00137 157 SNGPC 161
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 377-532 6.58e-36

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 132.50  E-value: 6.58e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269 377 CTFDDGFCFWTQDLDDDNEWERIQVTTFPCYTGPrfDHTYGNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEPVCLHFW 456
Cdd:cd06263   1 CDFEDGLCGWTQDSTDDFDWTRVSGSTPSPGTPP--DHTHGTGSGHYLYVESSSGREGQKARLLSPLLPPPRSSHCLSFW 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26329269 457 YYMCCENVYNLNIHI-SSAETTDKIVFQRKGNYGRNWNYGQVTLNET-GEFKVVFNAFRNRG-CSTIALDDISLTNGIC 532
Cdd:cd06263  79 YHMYGSGVGTLNVYVrEEGGGLGTLLWSASGGQGNQWQEAEVTLSASsKPFQVVFEGVRGSGsRGDIALDDISLSPGPC 157
CUB pfam00431
CUB domain;
554-661 4.79e-34

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 125.49  E-value: 4.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   554 CGGpfELWEPNSTFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLE----NINDVVEVRDGGEFDSLLLAVYTGP 629
Cdd:pfam00431   1 CGG--VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEdhdeCGYDYVEIRDGPSASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 26329269   630 GPVKDLFSTTNRMTVIFTTNMETRRKGFKANF 661
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 554-663 1.06e-28

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 110.58  E-value: 1.06e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269 554 CGGPFeLWEPNSTFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLEN----INDVVEVRDGGEFDSLLLAVYTGP 629
Cdd:cd00041   1 CGGTL-TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESspncSYDYLEIYDGPSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 26329269 630 GPVKDLFSTTNRMTVIFTTNMETRRKGFKANFTS 663
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 566-661 1.70e-24

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 98.23  E-value: 1.70e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    566 TFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLENIN----DVVEVRDGGEFDSLLLAVYTGPGPVKDLFST-TN 640
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsSN 81

                           90       100
                   ....*....|....*....|.
gi 26329269    641 RMTVIFTTNMETRRKGFKANF 661
Cdd:smart00042  82 SLTLTFVSDSSVQKRGFSARY 102
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 53-154 3.35e-19

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 83.61  E-value: 3.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269     53 GKSHEVRGTFKITSG--VTYNPNLQDKHSVDFKVLAFDLQQMIDEIFESSSLKNEYEKSKVFQFEKGSVIVLFDLFFAQW 130
Cdd:smart00200   2 TQSFGVSLSVLSVEGenLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLKPDFVGTEVIEFRNGSVVVDLGLLFNEG 81

                           90       100
                   ....*....|....*....|....*
gi 26329269    131 V-SDKNVKEELIQGIEANISSQLVT 154
Cdd:smart00200  82 VtNGQDVEEDLLQVIKQAAYSLKIT 106
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 56-144 5.18e-18

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 79.59  E-value: 5.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    56 HEVRGTFKITSgVTYNPNLQDKHSVDFKVLAFDLQQMIDEIFESSSLKNEYEKSKVFQFEK--GSVIVLFDLFFAQWVSD 133
Cdd:pfam01390   1 QYYTGSFKITN-LQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRLRPdgGSVVVDVVLVFRFPSTE 79

                          90
                  ....*....|..
gi 26329269   134 -KNVKEELIQGI 144
Cdd:pfam01390  80 pALDREKLIEEI 91
CUB pfam00431
CUB domain;
255-361 2.35e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 78.11  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   255 CDGRFllTGDSGVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSF-----IPHYTDVLDIYEGIGPSKILRGSFW-E 328
Cdd:pfam00431   1 CGGVL--TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFeledhDECGYDYVEIRDGPSASSPLLGRFCgS 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 26329269   329 TDPGTIRIFSNLVTVTFLIkSDEYDYIGFNATY 361
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVS-DASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 255-363 1.87e-14

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 70.13  E-value: 1.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269 255 CDGRFLLTgDSGVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSF-----IPHYTDVLDIYEGIGPSKILRGSFW-E 328
Cdd:cd00041   1 CGGTLTAS-TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFdlessPNCSYDYLEIYDGPSTSSPLLGRFCgS 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 26329269 329 TDPGTIRIFSNLVTVTFliKSDEYD-YIGFNATYST 363
Cdd:cd00041  80 TLPPPIISSGNSLTVRF--RSDSSVtGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 266-361 3.21e-10

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 57.40  E-value: 3.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    266 GVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSF-----IPHYTDVLDIYEGIGPSKILRGSF--WETDPGTIRIFS 338
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFdlessDNCEYDYVEIYDGPSASSPLLGRFcgSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|....
gi 26329269    339 NLVTVTFliKSDEYD-YIGFNATY 361
Cdd:smart00042  81 NSLTLTF--VSDSSVqKRGFSARY 102
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 673-703 3.28e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.28e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 26329269    673 CQDDEFQCKDGNCIPLGNLCDSYPHCRDGSD 703
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSD 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 673-703 3.43e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 3.43e-09
                        10        20        30
                ....*....|....*....|....*....|.
gi 26329269 673 CQDDEFQCKDGNCIPLGNLCDSYPHCRDGSD 703
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSD 31
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
672-703 8.35e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 8.35e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 26329269   672 PCQDDEFQCKDGNCIPLGNLCDSYPHCRDGSD 703
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSD 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 214-247 1.05e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.88  E-value: 1.05e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 26329269 214 CQPGSRPCAHaWNCVATDLFCDGEVNCPDGSDED 247
Cdd:cd00112   1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 213-246 1.07e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.92  E-value: 1.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 26329269    213 ECQPGSRPCAHAwNCVATDLFCDGEVNCPDGSDE 246
Cdd:smart00192   1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
213-273 6.67e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 37.81  E-value: 6.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26329269  213 ECQPGSRPCAHAwnCVATD---LFCDG-EVNCPDGSDEDTGLCATACDGRFLLTGDSGV-FQADRY 273
Cdd:NF041328  61 GCGPGTVACGGA--CVDTAsdpAHCGAcGAACAPGQVCEGGACREACSEGLTRCGGACVdLATDPL 124
 
Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 377-533 2.80e-45

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 158.68  E-value: 2.80e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   377 CTFDDG-FCFWTQDLDDDNEWERiqVTTFPCYTGPRFDHTYGNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEPVCLHF 455
Cdd:pfam00629   1 CDFEDGnLCGWTQDSSDDFDWER--VSGPSVKTGPSSDHTQGTGSGHFMYVDTSSGAPGQTARLLSPLLPPSRSPQCLRF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   456 WYYMCCENVYNLNIHI-SSAETTDKIVFQRKGNYGRNWNYGQVTLNE-TGEFKVVFNAFRNRG-CSTIALDDISLTNGIC 532
Cdd:pfam00629  79 WYHMSGSGVGTLRVYVrENGGTLDTLLWSISGDQGPSWKEARVTLSSsTQPFQVVFEGIRGGGsRGGIALDDISLSSGPC 158


                  .
gi 26329269   533 S 533
Cdd:pfam00629 159 P 159
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 372-532 6.87e-39

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 141.33  E-value: 6.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    372 YEKIDCTFDDG-FCFWTQDLDDDNEWERIQVTTFpcYTGPRFDHTygNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEP 450
Cdd:smart00137   1 TSPGNCDFEEGsTCGWHQDSNDDGHWERVSSATG--IPGPNRDHT--TGNGHFMFFETSSGAEGQTARLLSPPLYENRST 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    451 VCLHFWYYMCCENVYNLNIHI-SSAETTDKIVFQRKGNYGRNWNYGQVTLN-ETGEFKVVFNAFRNRG-CSTIALDDISL 527
Cdd:smart00137  77 HCLTFWYYMYGSGSGTLNVYVrENNGSQDTLLWSRSGTQGGQWLQAEVALSsWPQPFQVVFEGTRGKGhSGYIALDDILL 156


                   ....*
gi 26329269    528 TNGIC 532
Cdd:smart00137 157 SNGPC 161
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 377-532 6.58e-36

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 132.50  E-value: 6.58e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269 377 CTFDDGFCFWTQDLDDDNEWERIQVTTFPCYTGPrfDHTYGNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEPVCLHFW 456
Cdd:cd06263   1 CDFEDGLCGWTQDSTDDFDWTRVSGSTPSPGTPP--DHTHGTGSGHYLYVESSSGREGQKARLLSPLLPPPRSSHCLSFW 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26329269 457 YYMCCENVYNLNIHI-SSAETTDKIVFQRKGNYGRNWNYGQVTLNET-GEFKVVFNAFRNRG-CSTIALDDISLTNGIC 532
Cdd:cd06263  79 YHMYGSGVGTLNVYVrEEGGGLGTLLWSASGGQGNQWQEAEVTLSASsKPFQVVFEGVRGSGsRGDIALDDISLSPGPC 157
CUB pfam00431
CUB domain;
554-661 4.79e-34

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 125.49  E-value: 4.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   554 CGGpfELWEPNSTFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLE----NINDVVEVRDGGEFDSLLLAVYTGP 629
Cdd:pfam00431   1 CGG--VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEdhdeCGYDYVEIRDGPSASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 26329269   630 GPVKDLFSTTNRMTVIFTTNMETRRKGFKANF 661
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 554-663 1.06e-28

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 110.58  E-value: 1.06e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269 554 CGGPFeLWEPNSTFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLEN----INDVVEVRDGGEFDSLLLAVYTGP 629
Cdd:cd00041   1 CGGTL-TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESspncSYDYLEIYDGPSTSSPLLGRFCGS 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 26329269 630 GPVKDLFSTTNRMTVIFTTNMETRRKGFKANFTS 663
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 566-661 1.70e-24

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 98.23  E-value: 1.70e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    566 TFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLENIN----DVVEVRDGGEFDSLLLAVYTGPGPVKDLFST-TN 640
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsSN 81

                           90       100
                   ....*....|....*....|.
gi 26329269    641 RMTVIFTTNMETRRKGFKANF 661
Cdd:smart00042  82 SLTLTFVSDSSVQKRGFSARY 102
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 53-154 3.35e-19

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 83.61  E-value: 3.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269     53 GKSHEVRGTFKITSG--VTYNPNLQDKHSVDFKVLAFDLQQMIDEIFESSSLKNEYEKSKVFQFEKGSVIVLFDLFFAQW 130
Cdd:smart00200   2 TQSFGVSLSVLSVEGenLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLKPDFVGTEVIEFRNGSVVVDLGLLFNEG 81

                           90       100
                   ....*....|....*....|....*
gi 26329269    131 V-SDKNVKEELIQGIEANISSQLVT 154
Cdd:smart00200  82 VtNGQDVEEDLLQVIKQAAYSLKIT 106
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 56-144 5.18e-18

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 79.59  E-value: 5.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    56 HEVRGTFKITSgVTYNPNLQDKHSVDFKVLAFDLQQMIDEIFESSSLKNEYEKSKVFQFEK--GSVIVLFDLFFAQWVSD 133
Cdd:pfam01390   1 QYYTGSFKITN-LQYTPDLGNPSSQEFKSLSRRIESLLNELFRNSSLRKQYIKSHVLRLRPdgGSVVVDVVLVFRFPSTE 79

                          90
                  ....*....|..
gi 26329269   134 -KNVKEELIQGI 144
Cdd:pfam01390  80 pALDREKLIEEI 91
CUB pfam00431
CUB domain;
255-361 2.35e-17

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 78.11  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269   255 CDGRFllTGDSGVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSF-----IPHYTDVLDIYEGIGPSKILRGSFW-E 328
Cdd:pfam00431   1 CGGVL--TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFeledhDECGYDYVEIRDGPSASSPLLGRFCgS 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 26329269   329 TDPGTIRIFSNLVTVTFLIkSDEYDYIGFNATY 361
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVS-DASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 255-363 1.87e-14

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 70.13  E-value: 1.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269 255 CDGRFLLTgDSGVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSF-----IPHYTDVLDIYEGIGPSKILRGSFW-E 328
Cdd:cd00041   1 CGGTLTAS-TSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFdlessPNCSYDYLEIYDGPSTSSPLLGRFCgS 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 26329269 329 TDPGTIRIFSNLVTVTFliKSDEYD-YIGFNATYST 363
Cdd:cd00041  80 TLPPPIISSGNSLTVRF--RSDSSVtGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 266-361 3.21e-10

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 57.40  E-value: 3.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329269    266 GVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSF-----IPHYTDVLDIYEGIGPSKILRGSF--WETDPGTIRIFS 338
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFdlessDNCEYDYVEIYDGPSASSPLLGRFcgSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|....
gi 26329269    339 NLVTVTFliKSDEYD-YIGFNATY 361
Cdd:smart00042  81 NSLTLTF--VSDSSVqKRGFSARY 102
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 673-703 3.28e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.28e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 26329269    673 CQDDEFQCKDGNCIPLGNLCDSYPHCRDGSD 703
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSD 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 673-703 3.43e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 3.43e-09
                        10        20        30
                ....*....|....*....|....*....|.
gi 26329269 673 CQDDEFQCKDGNCIPLGNLCDSYPHCRDGSD 703
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSD 31
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
672-703 8.35e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 8.35e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 26329269   672 PCQDDEFQCKDGNCIPLGNLCDSYPHCRDGSD 703
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSD 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 214-247 1.05e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.88  E-value: 1.05e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 26329269 214 CQPGSRPCAHaWNCVATDLFCDGEVNCPDGSDED 247
Cdd:cd00112   1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 213-246 1.07e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.92  E-value: 1.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 26329269    213 ECQPGSRPCAHAwNCVATDLFCDGEVNCPDGSDE 246
Cdd:smart00192   1 TCPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
213-273 6.67e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 37.81  E-value: 6.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26329269  213 ECQPGSRPCAHAwnCVATD---LFCDG-EVNCPDGSDEDTGLCATACDGRFLLTGDSGV-FQADRY 273
Cdd:NF041328  61 GCGPGTVACGGA--CVDTAsdpAHCGAcGAACAPGQVCEGGACREACSEGLTRCGGACVdLATDPL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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