|
Name |
Accession |
Description |
Interval |
E-value |
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
19-379 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 590.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIHVGQDPEQwTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTI 97
Cdd:pfam01053 1 DTLAVHAGQRPDP-QTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAiTAAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 98 THLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVH 177
Cdd:pfam01053 80 LALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 178 KHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNR 257
Cdd:pfam01053 160 KHG-ILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 258 GLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTL 337
Cdd:pfam01053 239 GLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 262476 338 AESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:pfam01053 319 AVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVG 360
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
16-379 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 558.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 16 QHFATQAIHVGQDPEQWTsRAVVPPISLSTTFKQGAPGQ--------HSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:COG0626 1 MGPATRAVHAGRDPDPQT-GAVSPPIYLTSTFVFPSAEAlaarfageEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 88 ASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKV 166
Cdd:COG0626 80 ASGMAAiSAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 167 IDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAV 246
Cdd:COG0626 160 VDIAAIAAIAHAAG-ALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 247 PSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAE 326
Cdd:COG0626 239 LSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAAR 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 262476 327 IFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVG 371
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
36-379 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 548.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 36 AVVPPISLSTTFKQGAP--------GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQ 106
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPaeaadlfaLREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAiSTVLLALLKAGDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 107 IICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdIILVV 186
Cdd:cd00614 82 VVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHG-ALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 187 DNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRM 266
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 267 EKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFES 346
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350
....*....|....*....|....*....|...
gi 262476 347 LAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVG 353
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
13-379 |
1.94e-163 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 464.12 E-value: 1.94e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 13 PHFQHFATQAIHVGQDPEQWTSrAVVPPISLSTTFKQGAPGQ-HSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGL 91
Cdd:PRK07811 8 HANQGFATRAIHAGYEPDPATG-AVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 92 AAT-VTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIE 170
Cdd:PRK07811 87 AATdCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 171 GCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPI 250
Cdd:PRK07811 167 ALAELAHDAG-AKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 251 DCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLK 330
Cdd:PRK07811 246 DAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 262476 331 NLKLFTLAESLGGFESLAELPAIMTHASVLKNDrdvLGISDTLIRLSVG 379
Cdd:PRK07811 326 RTKVFTLAESLGGVESLIEHPSAMTHASTAGSQ---LEVPDDLVRLSVG 371
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
20-379 |
3.84e-147 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 422.21 E-value: 3.84e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 20 TQAIHVGQDPEQWTSrAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITH 99
Cdd:PRK07671 5 TKLIHGGIIGDPSTG-AVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 100 LLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKH 179
Cdd:PRK07671 84 LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 180 GdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGL 259
Cdd:PRK07671 164 G-LLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 260 KTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIkGTLQHAEIFLKNLKLFTLAE 339
Cdd:PRK07671 243 KTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAE 321
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 262476 340 SLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK07671 322 SLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVG 361
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
17-379 |
3.54e-139 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 402.35 E-value: 3.54e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHvGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVT 96
Cdd:PRK06176 2 RMQTKLIH-GGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 97 ITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIV 176
Cdd:PRK06176 81 VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 177 HKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCN 256
Cdd:PRK06176 161 KDHG-LLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQhAEIFLKNLKLFT 336
Cdd:PRK06176 240 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 262476 337 LAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK06176 319 LGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVG 361
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
19-397 |
1.54e-123 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 362.22 E-value: 1.54e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIHVGQDPEQWTsrAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTIT 98
Cdd:TIGR01329 2 STLLVNTDNKNDPYD--ASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 99 HLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHK 178
Cdd:TIGR01329 80 RLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 179 HGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRG 258
Cdd:TIGR01329 160 QN-ALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 259 LKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGcTGMVTFYIKGTLQHAEIFLKNLKLFTLA 338
Cdd:TIGR01329 239 IKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKG-AGSVLSFETGSVALSKRLVEATKLFSIT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 262476 339 ESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 397
Cdd:TIGR01329 318 VSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
36-379 |
1.98e-119 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 352.18 E-value: 1.98e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 36 AVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICMDDVY 114
Cdd:TIGR02080 21 CVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAiHLVTTALLGPDDLLVAPHDCY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 115 GGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdIILVVDNTFMSPY 194
Cdd:TIGR02080 101 GGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVG-AVVVVDNTFLSPA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 195 FQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGM 274
Cdd:TIGR02080 180 LQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 275 AVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIM 354
Cdd:TIGR02080 260 AIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPATM 339
|
330 340
....*....|....*....|....*
gi 262476 355 THASVLKNDRDVLGISDTLIRLSVG 379
Cdd:TIGR02080 340 THAAMGPEARAEAGISDTLLRLSVG 364
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
18-379 |
6.11e-118 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 348.74 E-value: 6.11e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 18 FATQAIHVGQDPE-QWTSRAVvpPISLSTTF-----KQGA---PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK06234 9 FATKAIHGGHIGDkQFGSLAT--PIYQTSTFifdsaEQGGrrfAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 89 SGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVI 167
Cdd:PRK06234 87 SGMGAiSSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 168 DIEGCAHIVHKHG-DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNCESLHNRLRF--LQNSLG 244
Cdd:PRK06234 167 DIKAISNIAHENNkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFV-VGKEEFINQVKLfgIKDMTG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 245 AVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQH 324
Cdd:PRK06234 246 SVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 262476 325 AEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK06234 326 GKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVG 380
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
16-396 |
1.13e-117 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 348.03 E-value: 1.13e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 16 QHFATQAIHVGQDPEQWTSrAVVPPISLSTTF-----KQGA---PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:TIGR01328 2 MTFATRAIHAGYPPKDQFG-ALTPPIYQTSTFvfdscEQGGnrfAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 88 ASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKV 166
Cdd:TIGR01328 81 SSGMGAiAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 167 IDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHN-RLRFLQNSLGA 245
Cdd:TIGR01328 161 IDMERVCRDAHSQG-VKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 246 VPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHA 325
Cdd:TIGR01328 240 VISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262476 326 EIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKA 396
Cdd:TIGR01328 320 KKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
18-401 |
1.52e-117 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 347.53 E-value: 1.52e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 18 FATQAIH--VGQDPEqwtSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATV 95
Cdd:PRK08064 7 IDTLLLHnqYKHDKQ---TGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAIS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 96 TITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHI 175
Cdd:PRK08064 84 TAFLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 176 VHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLC 255
Cdd:PRK08064 164 AKAIG-CLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 256 NRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFyikgTLQHAEI---FLKNL 332
Cdd:PRK08064 243 LRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSF----TLQSEEAvrqFVSHV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262476 333 KLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPS 401
Cdd:PRK08064 319 KLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEEPV 387
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
16-379 |
1.03e-115 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 342.07 E-value: 1.03e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 16 QHFATQAIHVGQDPEQWTSrAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATV 95
Cdd:PRK08247 3 STIETKLAQIGNRSDERTG-TVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 96 TITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHI 175
Cdd:PRK08247 82 LVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 176 VHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLC 255
Cdd:PRK08247 162 AKKHG-LLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 256 NRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLpshpqhelvkrqctgcTGMVTFyikgTLQHAE---IFLKNL 332
Cdd:PRK08247 241 IRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGR----------------GGMLSF----RLQDEEwvnPFLKSL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 262476 333 KLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK08247 301 KLITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVG 347
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
13-379 |
1.66e-115 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 343.55 E-value: 1.66e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 13 PHFQHFATQAIHVGQDPEQwTSRAVVPPISLSTTFK-----QGA---PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYC 84
Cdd:COG2873 3 EKKYGFETLALHAGQEPDP-TTGARAVPIYQTTSYVfddaeHAAdlfALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 85 LAFASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPT 163
Cdd:COG2873 82 LATASGQAAiTLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 164 QKVIDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNC-------------- 229
Cdd:COG2873 162 LDVLDIEAIAEIAHEHG-VPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVI-VDGgnfdwaangkfpel 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 230 ----ESLHN----------------RLRFLQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKV 289
Cdd:COG2873 240 tepdPSYHGlvyteafgnaafitkaRVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 290 IYPGLPSHPQHELVKRQCT-GCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLG 368
Cdd:COG2873 319 NYPGLPSHPYHELAQKYLPkGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAG 398
|
410
....*....|.
gi 262476 369 ISDTLIRLSVG 379
Cdd:COG2873 399 VTPDLIRLSVG 409
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
36-379 |
9.37e-114 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 340.47 E-value: 9.37e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 36 AVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYG 115
Cdd:PLN02509 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 116 GTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILvVDNTFMSPYF 195
Cdd:PLN02509 183 GSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVL-VDNSIMSPVL 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 196 QRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMA 275
Cdd:PLN02509 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 276 VAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGcTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMT 355
Cdd:PLN02509 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKG-AGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 420
|
330 340
....*....|....*....|....
gi 262476 356 HASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PLN02509 421 HASIPAEVREARGLTEDLVRISAG 444
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
18-400 |
3.35e-112 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 334.46 E-value: 3.35e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 18 FATQAIHVGQDPEQwTSRAVVPPISLSTTF-----KQGA---PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK07503 10 FSTRAIHHGYDPLD-HGGALVPPVYLTATFafptaEYGAecfAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALAS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 90 GLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVID 168
Cdd:PRK07503 89 GMGAiTATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 169 IEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNCESLHNRLRF--LQNSLGAV 246
Cdd:PRK07503 169 IAAVAEIAHGAG-AKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLV-VGGKALADRIRLegLKDMTGAV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 247 PSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAE 326
Cdd:PRK07503 247 MSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGR 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262476 327 IFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPP 400
Cdd:PRK07503 327 RFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACAVA 400
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
16-395 |
8.97e-109 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 324.87 E-value: 8.97e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 16 QHFATQAIHVGQDPEQWTSrAVVPPISLSTTF-----KQGA---PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:PRK06767 4 KHMETALIHHGYTSEEHKG-SLTPPLFQTSTFtfetaQQGEasfAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 88 ASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKV 166
Cdd:PRK06767 83 GSGMAAiSATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 167 IDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAV 246
Cdd:PRK06767 163 IDLKQVIRVAKRNG-LLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 247 PSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYpglpshPQHELVKRQCTGCTGMVTFYIKGTLQHAE 326
Cdd:PRK06767 242 MAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEETQ 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262476 327 IFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALK 395
Cdd:PRK06767 316 AFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
17-379 |
1.09e-101 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 306.93 E-value: 1.09e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHVGQD--PEQWTSRAVVPpiSLSTTFKQGA------PGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK08133 6 GFDTLAVRAGQLrsPFGEHSEALFL--TSSFVFESAAeaaarfAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 89 SGLAATVTIT-HLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVI 167
Cdd:PRK08133 84 SGMAAILAVVmALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 168 DIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQnSLGAVP 247
Cdd:PRK08133 164 DIAALAEIAHAAG-ALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFGFLR-TAGPTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 248 SPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEI 327
Cdd:PRK08133 242 SPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWR 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 262476 328 FLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK08133 322 VIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVG 373
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
17-379 |
1.78e-100 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 304.60 E-value: 1.78e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHVGQDPEQwTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVT 96
Cdd:PRK08776 12 SAATAAVRAGIDRDT-AYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 97 ITH-LLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHI 175
Cdd:PRK08776 91 VLNaLLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 176 VHKHGDIIlVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLC 255
Cdd:PRK08776 171 AHKVGALT-VVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 256 NRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLF 335
Cdd:PRK08776 250 LRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 262476 336 TLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK08776 330 TLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVG 373
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
19-379 |
1.65e-98 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 298.73 E-value: 1.65e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIHVGQDPEQwTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTI 97
Cdd:PRK08861 7 ATIAVRTGIESDS-QYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSAlNLWV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 98 THLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVH 177
Cdd:PRK08861 86 SALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 178 KHGDIIlVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNR 257
Cdd:PRK08861 166 AVGALV-AVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 258 GLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTL 337
Cdd:PRK08861 245 GIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALFSL 324
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 262476 338 AESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK08861 325 AESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVG 366
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
17-379 |
1.05e-97 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 297.04 E-value: 1.05e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHVGQDpEQWTSRAVVPPISLSTTFK--------QGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK08249 8 GVGTKAVWAGEK-EYLPYGATQVPVVLSVAYGyddidewyDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 89 SGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVI 167
Cdd:PRK08249 87 TGMAAiSNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 168 DIEGCAHIVHKHGDIIlVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVvMGLVSVNCESLHNRLRFLQNSLGAVP 247
Cdd:PRK08249 167 DIERLAAAAKKVGALV-VVDNTFATPINQNPLALGADLVIHSATKFLSGHADA-LGGVVCGSKELMEQVYHYREINGATM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 248 SPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEI 327
Cdd:PRK08249 245 DPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKR 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 262476 328 FLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK08249 325 LLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVG 376
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
17-379 |
3.59e-97 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 294.42 E-value: 3.59e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHVGQDPEQWTSrAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVT 96
Cdd:PRK07269 6 HINTILAQAGIKSDEATG-ALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 97 ITHLLKAGDQIICMDDVYGGTNRYFRQVASEFglKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIV 176
Cdd:PRK07269 85 AFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEG--RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 177 HKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCN 256
Cdd:PRK07269 163 HAKG-AKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLpshpqhelvkrqctgcTGMVTFYI--KGTLQHaeiFLKNLKL 334
Cdd:PRK07269 242 RGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVadETRIPH---ILNSLKV 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 262476 335 FTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK07269 303 FTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIG 347
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
17-379 |
6.46e-96 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 293.11 E-value: 6.46e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHVGQDPEQWT-SRAVvpPISLSTTF-----KQGAPG---QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTgSRAV--PIYQTTSYvfdstEHAAALfglQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 88 ASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKV 166
Cdd:TIGR01326 79 ASGQAAiTYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 167 IDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLV----------------SVNCE 230
Cdd:TIGR01326 159 LDIEAIAEVAHRHG-IPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIvdggkfdwnngrfplfTTPDP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 231 SLHN----------------RLRFLQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGL 294
Cdd:TIGR01326 238 SYHGlvftetlgnpafilkaRVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 295 PSHPQHELVKRQCTGCTGMV-TFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTL 373
Cdd:TIGR01326 317 ASHPHHALAKKYLPKGFGAVlSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGL 396
|
....*.
gi 262476 374 IRLSVG 379
Cdd:TIGR01326 397 IRLSVG 402
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
19-379 |
7.02e-96 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 291.97 E-value: 7.02e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAI--HVGQDPeqwtSRAVVPPISLSTTFKQGAPGQHS--GFE--YSRSGNPTRNCLEKAVAALDGAKYCLAFASGLA 92
Cdd:PRK08574 4 GTDAVrgYRGSDP----YGSLQPPIYLTALFRQEGEAYPSdrGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 93 ATVTI-THLLKAGDQIICMDDVYGGTNRYFRQVaSEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEG 171
Cdd:PRK08574 80 AISTLfFSLLKAGDRVVLPMEAYGTTLRLLKSL-EKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 172 CAHiVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPID 251
Cdd:PRK08574 159 VAK-AAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 252 CYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKR--QCTGCTGMVTFYIKGTLQHAEIFL 329
Cdd:PRK08574 238 AYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRlfGKDLYGGVVSFRVKGGRDAVLKFL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 262476 330 KNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK08574 318 RSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVG 367
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
19-379 |
1.38e-95 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 291.41 E-value: 1.38e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIHVG-QDPEQWTsrAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAAT-VT 96
Cdd:PRK08045 6 ATIAVRSGlNDDEQYG--CVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIhLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 97 ITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIV 176
Cdd:PRK08045 84 TTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 177 HKHGDIIlVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCN 256
Cdd:PRK08045 164 REAGAVS-VVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFT 336
Cdd:PRK08045 243 RGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFT 322
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 262476 337 LAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK08045 323 LAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTG 365
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
15-379 |
3.96e-95 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 289.88 E-value: 3.96e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 15 FQHFATQAIHVGQ--DPEQWTsraVVPPISLSTTF------KQGAPGQHSG--FEYSRSGNPTRNCLEKAVAALDGAKYC 84
Cdd:PRK06434 6 LNGFNTRAVQSGElrDPRFGN---VTTPIFETSTFvypnseKEAYMDSTRGmpYIYTRWGNPTVQAFEEKYAVLENAEHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 85 LAFASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITpETKLVWIETPTNPT 163
Cdd:PRK06434 83 LSFSSGMGAiTSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLDFDPS-NYDLIYAESITNPT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 164 QKVIDIEGCAHIVHKHgdiILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSL 243
Cdd:PRK06434 162 LKVPDIKNVSSFCHEN---DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 244 GAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLpshpqhELVKRQCTGCTGMVTFYIKgTLQ 323
Cdd:PRK06434 239 GSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELR-SME 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 262476 324 HAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK06434 312 DVHKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIG 367
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
53-379 |
1.84e-91 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 280.58 E-value: 1.84e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 53 GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVT-ITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLK 131
Cdd:TIGR01325 41 GELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAAIFAaLMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 132 ISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSAT 211
Cdd:TIGR01325 121 TVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAVAELAHAAG-AKVVVDNVFATPLLQQPLKLGADVVVYSAT 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 212 KYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIY 291
Cdd:TIGR01325 200 KHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYY 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 292 PGLPSHPQHELVKRQCTGCTGMVTFYIKGTlQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISD 371
Cdd:TIGR01325 280 PGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGD 358
|
....*...
gi 262476 372 TLIRLSVG 379
Cdd:TIGR01325 359 GLVRLSVG 366
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
14-379 |
3.40e-86 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 268.46 E-value: 3.40e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 14 HFQHFATQAIHVGQDPEqWTSRAVVPPISLSTTF------------------KQGAPGQHSGFEYSRSGNPTRNCLEKAV 75
Cdd:PRK07049 14 RELHPETQMLNYGYDPE-LSEGAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 76 AALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLK-ISFVDCSKIKLLEAAITP---- 149
Cdd:PRK07049 93 AVYEGAESAALFSSGMSAiATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSEAAIGAAAEAaaak 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 150 -ETKLVWIETPTNPTQKVIDIEG----CAHIVHKHGDI-ILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMG 223
Cdd:PRK07049 173 gRVSLILIETPANPTNSLVDVAAvrrvADAIEARQGHRpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 224 LVSVNcESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGL--PSHPQHE 301
Cdd:PRK07049 253 AVLGR-KALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGA 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262476 302 LVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK07049 332 VYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIG 409
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
19-379 |
9.04e-85 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 263.23 E-value: 9.04e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIHVGQDPEqwtSRAVVPPISLSTTFKqgAPGQHSgFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTI 97
Cdd:PRK06460 4 ATRTVREDIDEA---TGAITTPIYQTTAYH--YPEGEK-YRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAiSTTA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 98 THLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVH 177
Cdd:PRK06460 78 LALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 178 KHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCEsLHNRLRFLQNSLGAVPSPIDCYLCNR 257
Cdd:PRK06460 158 ENG-SILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGK-LLNVIDQMRRTLGTSLDPHAAYLTLR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 258 GLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTL 337
Cdd:PRK06460 236 GIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIP 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 262476 338 AESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK06460 316 AQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVG 357
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
20-397 |
8.61e-84 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 262.47 E-value: 8.61e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 20 TQAIHVGQDPEQWT-SRAVvpPISLSTT--FKQGAPG------QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASG 90
Cdd:PRK08248 11 TLAIHAGQEIDPTTgSRAV--PIYQTTSygFRDSEHAanlfslKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 91 LAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDI 169
Cdd:PRK08248 89 QAAiTYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 170 EGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVS----------------------- 226
Cdd:PRK08248 169 EAVAAIAHEHG-IPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpgltepdpsy 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 227 ---VNCESL-------HNRLRFLQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPS 296
Cdd:PRK08248 248 hglVYTDAVgeaayitKARVQLLRD-LGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 297 HPQHELVKRQC-TGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIR 375
Cdd:PRK08248 327 HPSYELAKKYLpKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVR 406
|
410 420
....*....|....*....|..
gi 262476 376 LSVGLEDEEDLLEDLDQALKAA 397
Cdd:PRK08248 407 LSVGTEAIDDILDDLRQAIRQS 428
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
53-397 |
3.74e-81 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 254.68 E-value: 3.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 53 GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLK 131
Cdd:PRK07504 52 GEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAvTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 132 ISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSAT 211
Cdd:PRK07504 132 STLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAG-AKLVVDNVFATPLFQKPLELGAHIVVYSAT 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 212 KYMNGHSDVVMGLV-SVNC---ESLHNRLRFLQNSLgavpSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVE 287
Cdd:PRK07504 211 KHIDGQGRCLGGVVlSDKAwieEHLQDYFRHTGPSL----SPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVA 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 288 KVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVL 367
Cdd:PRK07504 287 RVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAEL 366
|
330 340 350
....*....|....*....|....*....|
gi 262476 368 GISDTLIRLSVGLEDEEDLLEDLDQALKAA 397
Cdd:PRK07504 367 GISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
18-397 |
1.16e-78 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 249.27 E-value: 1.16e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 18 FATQAIHVGQDPEQWT-SRAVvpPISLSTTF-----KQGAP---GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFA 88
Cdd:PRK08134 9 FDTLALHAGAAPDPATgARAV--PIHLTTSFvfrdsDHAAAlfnLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 89 SGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVI 167
Cdd:PRK08134 87 SGQAAlHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 168 DIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLV----------SVNCESL----- 232
Cdd:PRK08134 167 DIPTVAAIAHEAG-VPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweaSGKFPELtepya 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 233 --HNR------------LRFLQNSL---GAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLP 295
Cdd:PRK08134 246 gfHGMvfaeestvaaflLRARREGLrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELE 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 296 SHPQHELVKRQC-TGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLI 374
Cdd:PRK08134 326 SHPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTI 405
|
410 420
....*....|....*....|...
gi 262476 375 RLSVGLEDEEDLLEDLDQALKAA 397
Cdd:PRK08134 406 RLSIGLEDADDLIDDLKRALKAA 428
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
17-379 |
1.29e-76 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 243.89 E-value: 1.29e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHVGQDPEQWT-SRAVvpPI--SLSTTFKQGAPGQ------HSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:PRK07812 13 SFETKQIHAGQTPDPATnARAL--PIyqTTSYTFDDTDHAAalfglaEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 88 ASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFV-DCSKIKLLEAAITPETKLVWIETPTNPTQK 165
Cdd:PRK07812 91 ASGQAAeTFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 166 VIDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLV----------------SVNC 229
Cdd:PRK07812 171 VLDIPGVAEVAHEAG-VPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpgfTTPD 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 230 ESLHN---------------RLRFLQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGL 294
Cdd:PRK07812 250 PSYHGvvfaelgppayalkaRVQLLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 295 PSHPQHELVKRQCTGCTG-MVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTL 373
Cdd:PRK07812 329 PSSPWYERAKRLAPKGTGaVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGL 408
|
....*.
gi 262476 374 IRLSVG 379
Cdd:PRK07812 409 VRLAVG 414
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
19-379 |
8.22e-76 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 239.90 E-value: 8.22e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIH-VGQDPEQWTSraVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKyCLAFASGLAA-TVT 96
Cdd:PRK07582 5 GTRSVHaGGPEAVPGEP--VLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGAE-ALVFPSGMAAiTAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 97 ITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIklLEAAITPeTKLVWIETPTNPTQKVIDIEGCAHIV 176
Cdd:PRK07582 82 LRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGM--AEAALAG-ADLVLAETPSNPGLDVCDLAALAAAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 177 HKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCN 256
Cdd:PRK07582 159 HAAG-ALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAH 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 257 RGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIkGTLQHAEIFLKNLKLFT 336
Cdd:PRK07582 238 RSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAERFVAASRLVV 316
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 262476 337 LAESLGGFESLAELPAIMTHAsvlkndrdvlgISDTLIRLSVG 379
Cdd:PRK07582 317 AATSFGGVHTSADRRARWGDA-----------VPEGFVRLSCG 348
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
20-397 |
5.62e-75 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 239.42 E-value: 5.62e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 20 TQAIHVGQDPEQwTSRAVVPPISLSTTF-----KQGAPG---QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGL 91
Cdd:PRK06084 5 TLAIHAGYSPDP-TTKAVAVPIYQTTSYafddtQHGADLfdlKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 92 AA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIE 170
Cdd:PRK06084 84 AAiTYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 171 GCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLV------------------SVNCESL 232
Cdd:PRK06084 164 ALADAAHRHG-VPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVvdsgkfpwaehkerfallNTPDPSY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 233 HN--------------RLRFLQ-NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSH 297
Cdd:PRK06084 243 HGvtyteafgpaafigRCRVVPlRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 298 PQHELVKRQCTGC-TGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVlkNDRDVL--GISDTLI 374
Cdd:PRK06084 323 PEHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQL--NDEELEkaGVSRDMV 400
|
410 420
....*....|....*....|...
gi 262476 375 RLSVGLEDEEDLLEDLDQALKAA 397
Cdd:PRK06084 401 RLSIGIEHIDDIIADLAQALDAS 423
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
18-397 |
5.17e-74 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 236.92 E-value: 5.17e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 18 FATQAIHVGQDPEQwTSRAVVPPISLSTTF-----KQGAP--G-QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK05994 8 FATLAVHAGAQPDP-TTGARATPIYQTTSFvfndaDHAASlfGlQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 90 GLAATVTITH-LLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVID 168
Cdd:PRK05994 87 GHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 169 IEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNC------------------- 229
Cdd:PRK05994 167 IAAIAEVAHRAG-LPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGII-VDGgtfdwsksgkypmlseprp 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 230 --------ESLHN-------RLRFLQNsLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGL 294
Cdd:PRK05994 245 eyhglvlhETFGNfafaiaaRVLGLRD-LGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 295 PSHPQHELVKRQCTGCTGMV-TFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTL 373
Cdd:PRK05994 324 PDDPYHALAQKYSPKGAGAVfTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDV 403
|
410 420
....*....|....*....|....
gi 262476 374 IRLSVGLEDEEDLLEDLDQALKAA 397
Cdd:PRK05994 404 VRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
20-379 |
1.52e-72 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 232.39 E-value: 1.52e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 20 TQAIHVGQDPEQWTSrAVVPPISLSTT--FKQGAP--GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-T 94
Cdd:PRK05967 15 TRLAHDGNDPGDYHG-FVNPPVVHASTvlFPDAETmaTRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAAvT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 95 VTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAH 174
Cdd:PRK05967 94 VPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 175 IVHKHGDIILVvDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNcESLHNRLRFLQNSLGAVPSPIDCYL 254
Cdd:PRK05967 174 AAHRHGAIVMM-DNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSAN-EKCWPQLLEAHGTLGLCAGPDDTYQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 255 CNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTL----QHAEIFLK 330
Cdd:PRK05967 252 ILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPekgkAKAHAFLD 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 262476 331 NLKLFTLAESLGGFESLAeLPAIMTHASVLKNDRDvlgisDTLIRLSVG 379
Cdd:PRK05967 332 ALEIFGLGYSWGGYESLA-LHVKLGDRTVAKAPYA-----GPVIRLQIG 374
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
8-397 |
1.01e-70 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 227.27 E-value: 1.01e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 8 SQGFLPHfqhfaTQAIHVGQDPEQWTSRAVVPPI---SLsTTFKQGAP------GQHSGFEYSRSGNPTRNCLEKAVAAL 78
Cdd:PRK05968 2 NDGLDPF-----DLAALITAHDEGNAFDAVVPPIfqtSL-FTFDSYDEmedvyaGEKVRPIYSRGDNPTVRAFEEMLAKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 79 DGAKYCLAFASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAItPETKLVWIE 157
Cdd:PRK05968 76 EGAEDARGFASGMAAiSSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 158 TPTNPTQKVIDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsVNCESLHNRLR 237
Cdd:PRK05968 155 SPTSWVFELQDVAALAALAKRHG-VVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVV-AGSKEHIARIN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 238 FLQNS-LGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELvkrqcTGCTGMVTF 316
Cdd:PRK05968 233 AEAYPyLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGL-----SGTSGLFSF 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 317 YIKGTLQHAEiFLKNLKLFTLAESLGGFESLAeLPA-IMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALK 395
Cdd:PRK05968 308 IFREGIDVRA-FADALKLFRLGVSWGGHESLV-VPAeVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWADLEQALA 385
|
..
gi 262476 396 AA 397
Cdd:PRK05968 386 AA 387
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
12-379 |
1.78e-69 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 224.61 E-value: 1.78e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 12 LPHFQHFATQAIHVGQDPEQWTSRAvvPPISLSTTF--------KQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKY 83
Cdd:PRK07810 10 LPDGVSQATIGVRGGLLRSGFEETA--EALYLTSGYvyesaaaaEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 84 CLAFASGLAATVT-ITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNP 162
Cdd:PRK07810 88 CFATASGMSAVFTaLGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 163 TQKVIDIEGCAHIVHKHGDIIlVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNS 242
Cdd:PRK07810 168 MQSLVDIAAVSELAHAAGAKV-VLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRH 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 243 LGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTL 322
Cdd:PRK07810 247 TGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262476 323 ----QHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PRK07810 327 daakKRAFEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVG 387
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
20-379 |
3.24e-69 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 223.22 E-value: 3.24e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 20 TQAIHVGQDPEQWtSRAVVPPISLSTT--FKQGAP--GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-T 94
Cdd:TIGR01324 1 TRLIHSGRQPRFS-QGSVNPPLQRASTvlFDSHAAqrRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAvT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 95 VTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAH 174
Cdd:TIGR01324 80 NSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 175 IVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVnCESLHNRLRFLQNSLGAVPSPIDCYL 254
Cdd:TIGR01324 160 AARNPG-IVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVA-NARTWDQLREHSYLMGQMVDADDAYT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 255 CNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHA-EIFLKNLK 333
Cdd:TIGR01324 238 TLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQvHAFLDHLQ 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 262476 334 LFTLAESLGGFESLAeLP--AIMTHASVLKNDrdvlgISDTLIRLSVG 379
Cdd:TIGR01324 318 LFGLGYSWGGYESLA-LCnqPELGHRPNIKRN-----LEGPLIRVHIG 359
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
36-397 |
5.90e-68 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 220.33 E-value: 5.90e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 36 AVVPPISLSTTFK-----------QGAPGqhsGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAA-TVTITHLLKA 103
Cdd:PRK05939 9 AVHKPIHTSVTYGyedardlidvfQGKKP---GFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAiAAVFLTLLRA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 104 GDQIICMDDVYGGTNRYFRQVAsEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdII 183
Cdd:PRK05939 86 GDHLVSSQFLFGNTNSLFGTLR-GLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERG-LL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 184 LVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVS----------VNCESLHNR---------------LRf 238
Cdd:PRK05939 164 YVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsayPNIFPAYRKgdpqqwgltqirkkgLR- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 239 lqnSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYI 318
Cdd:PRK05939 243 ---DMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFEL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 319 KGTLQHAEiFLKNLKLFTLAESLGGFESLAeLPAIMT-HASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAA 397
Cdd:PRK05939 320 ADGIDCFD-FLNRLKLVIKATHLGDTRTLV-IPVAPTiYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
19-379 |
2.43e-67 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 218.83 E-value: 2.43e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIHVGQDpEQWTSRAVVPPISLSTTF--------KQGAPGQHSG-FEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK09028 6 ATKIVSAGRD-KKWTKGVINPPVFRASTVvfdtvaemRHAAKNRANGeMFYGRRGTPTHFAFQAAIVELEGGAGTALYPS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 90 GLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVID 168
Cdd:PRK09028 85 GAAAiSNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 169 IEGCAHIVHKHgDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNcESLHNRLRFLQNSLGAVPS 248
Cdd:PRK09028 165 VPTLSRIAHEH-DIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATAN-EKHWDQLREHSYLMGQCTS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 249 PIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIK-GTLQHAEI 327
Cdd:PRK09028 243 PDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKqGDPKAVTA 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 262476 328 FLKNLKLFTLAESLGGFESLaelpaIMTHASVlKNDRDVL--GISDTLIRLSVG 379
Cdd:PRK09028 323 LVEGMQHFKMGFSWGGFESL-----ILGVFGI-NKLRTATnwDFSKPLIRLHIG 370
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
17-379 |
1.72e-63 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 208.81 E-value: 1.72e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 17 HFATQAIHVGQD-PEQWTSraVVPPISLSTT--FKQGAP------GQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAF 87
Cdd:PRK07050 9 ALQTRIVQPDDQiPPGFRS--FVTPVARASTvvFPDLATmraldwRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 88 ASGLAATVTITH-LLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKV 166
Cdd:PRK07050 87 PSGLAAISLVYFgLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 167 IDIEGCAHIVHKHGdIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAV 246
Cdd:PRK07050 167 PDVPAITAAARARG-VVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 247 PSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGM--VTFYIKGTLQH 324
Cdd:PRK07050 246 VSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLfsVVFDERYSPAQ 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 262476 325 AEIFLKNLKLFTLAESLGGFESLAeLPAIMTHASVLKNDRDvlgisDTLIRLSVG 379
Cdd:PRK07050 326 VDAFVEALELFAIGWSWGGACSLA-MPYDVASMRTAKWPHR-----GTLVRLYIG 374
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
18-379 |
2.66e-59 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 198.94 E-value: 2.66e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 18 FATQAIHVGQDPEQWTSRAVVPpISLSTTF--------KQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFAS 89
Cdd:PRK05613 14 FETRSIHAGQSVDSDTSARNLP-IYQTTSYvfdsaehaKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 90 GLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFV-DCSKIKLLEAAITPETKLVWIETPTNPTQKVI 167
Cdd:PRK05613 93 GQAAeTAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 168 DIEGCAHIVHKHgDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVS--------------------V 227
Cdd:PRK05613 173 DIPAVAEVAHRN-QVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIdggkfdwtverdgkpvfpyfV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 228 NCESLHNRLRF---------------LQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYP 292
Cdd:PRK05613 252 TPDPAYHGLKYadlgapafglkaragLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 293 GLPSHPQHELVKRQCTGCTGMV-TFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISD 371
Cdd:PRK05613 332 GLKDSPWYATKEKLGLKYTGSVlSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQ 411
|
....*...
gi 262476 372 TLIRLSVG 379
Cdd:PRK05613 412 ATVRLSVG 419
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
16-379 |
2.14e-54 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 184.91 E-value: 2.14e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 16 QHFATQAIHVGQDPeQWTSRAVVPPI--SLSTTF------KQGAPGQHSG--FeYSRSGNPTRNCLEKAVAALDGAKYCL 85
Cdd:PRK08114 4 KKLDTQLVNAGRSK-KYTQGSVNSVIqrASSLVFdsveakKHATRNRANGelF-YGRRGTLTHFSLQEAMCELEGGAGCA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 86 AFASGLAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQ 164
Cdd:PRK08114 82 LYPCGAAAvANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSITM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 165 KVIDIEGCAHIVH-KHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNcESLHNRLRflQNS- 242
Cdd:PRK08114 162 EVHDVPAIVAAVRsVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVAN-ARCWEQLR--ENSy 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 243 -LGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGT 321
Cdd:PRK08114 239 lMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKKK 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262476 322 LQHAEI--FLKNLKLFTLAESLGGFESL------AELPAIMTHASVlkndrdvlGISDTLIRLSVG 379
Cdd:PRK08114 319 LTDEQLanYLDNFSLFSMAYSWGGFESLilanqpEEIAAIRPAGEV--------DFTGTLIRLHIG 376
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
36-379 |
1.31e-51 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 178.42 E-value: 1.31e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 36 AVVPPISLSTTFKqGAPGQHSGFE-YSRSGNPTRNCLEKAVAALDG--AKYCLAfaSGLAA-TVTITHLLKAGDQIICMD 111
Cdd:PLN02242 46 TVMEPDTMRRMFS-GELGPDRDFYiYSRHFNPTVLNLGRQMAALEGteAAYCTA--SGMSAiSSVLLQLCSSGGHVVASN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 112 DVYGGTNRYFRQ-VASEFGLKISFVDCSKIKLLEAAITP-ETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdIILVVDNT 189
Cdd:PLN02242 123 TLYGGTHALLAHfLPRKCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKG-VTVVVDNT 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 190 FmSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVsvnC--ESLHNRLRFLQNS----LGAVPSPIDCYLCNRGLKTLH 263
Cdd:PLN02242 202 F-APMVLSPARLGADVVVHSISKFISGGADIIAGAV---CgpAELVNSMMDLHHGalmlLGPTMNPKVAFELSERLPHLS 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 264 VRMEKHFKNGMAVAQFLESNPWveKVIYPGLPSHPQHELVKRQ---CTGCTGMVTFYIkGTLQHAEIFLKNLKLFT---- 336
Cdd:PLN02242 278 LRMKEHCRRAMEYAKRMKELGL--KVIYPGLEDHPQHALLKSMankGYGFGGLLCLDM-DTEERANRLMRYLQNSTqfgf 354
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 262476 337 LAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVG 379
Cdd:PLN02242 355 MAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
19-379 |
7.13e-50 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 174.09 E-value: 7.13e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 19 ATQAIHVGQDPEQWTSRavVPPISLSTTFKQGAPG--------QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASG 90
Cdd:PRK06702 8 GTICVQGGYTPKNGEPR--VLPLYQSTTYKYDTSDdlaalfnlEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 91 LAA-TVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCS-KIKLLEAAITPETKLVWIETPTNPTQKVID 168
Cdd:PRK06702 86 QAAiMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 169 IEGCAHIVhKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVS---------------VNCESLH 233
Cdd:PRK06702 166 FKEFSDAA-KELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 234 NRLRFLQN----------------SLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSH 297
Cdd:PRK06702 245 HGVSYVQNfgaaayivkarvqllrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 298 PQHELVKRQCT-GCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRL 376
Cdd:PRK06702 325 ENYSLAQKYLKkGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRL 404
|
...
gi 262476 377 SVG 379
Cdd:PRK06702 405 SVG 407
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
71-216 |
1.06e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 62.79 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 71 LEKAVAAL--DGAKYCLAFASGLAATVTITH-LLKAGDQIICMDDVYGGTNRYFrqvASEFGLKISFVD--------CSK 139
Cdd:cd01494 5 LEEKLARLlqPGNDKAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSRYWVA---AELAGAKPVPVPvddagyggLDV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 140 IKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdIILVVDNTFMSPY----FQRPLALGADISMYSATKYMN 215
Cdd:cd01494 82 AILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYG-ILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLG 160
|
.
gi 262476 216 G 216
Cdd:cd01494 161 G 161
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
100-315 |
8.15e-10 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 59.66 E-value: 8.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 100 LLKAGDQIICMDDVYGGtnryFRQVASEFGLKISFVDCSK-------IKLLEAAITPETKLVWIETPTNPTQKVID---I 169
Cdd:cd00609 79 LLNPGDEVLVPDPTYPG----YEAAARLAGAEVVPVPLDEeggflldLELLEAAKTPKTKLLYLNNPNNPTGAVLSeeeL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 170 EGCAHIVHKHgDIILVVDNT---FMSPYFQRPLALGAD-----ISMYSATKYMNghsdvVMGL----VSVNCESLHNRLR 237
Cdd:cd00609 155 EELAELAKKH-GILIISDEAyaeLVYDGEPPPALALLDayervIVLRSFSKTFG-----LPGLrigyLIAPPEELLERLK 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 238 FLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHF----KNGMAVAQFLESNPWVEKV-------IYPGLPSHPQHELVKRQ 306
Cdd:cd00609 229 KLLPYTTSGPSTLSQAAAAAALDDGEEHLEELReryrRRRDALLEALKELGPLVVVkpsggffLWLDLPEGDDEEFLERL 308
|
....*....
gi 262476 307 CTGCTGMVT 315
Cdd:cd00609 309 LLEAGVVVR 317
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
71-241 |
3.28e-08 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 54.85 E-value: 3.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 71 LEKAVAALDGAKYCLAFASGLAATVTITHLL--KAGDQIICmddvyggTNRYFrqVAS-----EFGLKISFVDCSK---- 139
Cdd:cd00616 23 FEKAFAEYLGVKYAVAVSSGTAALHLALRALgiGPGDEVIV-------PSFTF--VATanailLLGATPVFVDIDPdtyn 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 140 --IKLLEAAITPETKLVwieTPTNPTQKVIDIEGCAHIVHKHGdIILVVDN--TFMSPYFQRPLALGADISMYS--ATK- 212
Cdd:cd00616 94 idPELIEAAITPRTKAI---IPVHLYGNPADMDAIMAIAKRHG-LPVIEDAaqALGATYKGRKVGTFGDAGAFSfhPTKn 169
|
170 180 190
....*....|....*....|....*....|.
gi 262476 213 --YMNGhsdvvmGLVSVNCESLHNRLRFLQN 241
Cdd:cd00616 170 ltTGEG------GAVVTNDEELAERARLLRN 194
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
71-241 |
9.00e-07 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 50.45 E-value: 9.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 71 LEKAVAALDGAKYCLAFASGLAATVTITHLL--KAGDQIICmddvyggTNRYFrqVAS-----EFGLKISFVDCSK---- 139
Cdd:COG0399 35 FEEEFAAYLGVKHAVAVSSGTAALHLALRALgiGPGDEVIT-------PAFTF--VATanailYVGATPVFVDIDPdtyn 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 140 --IKLLEAAITPETklvwietptnptqKVI----------DIEGCAHIVHKHGdIILVVDN--TFMSPYFQRPLALGADI 205
Cdd:COG0399 106 idPEALEAAITPRT-------------KAIipvhlygqpaDMDAIMAIAKKHG-LKVIEDAaqALGATYKGKKVGTFGDA 171
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 262476 206 SMYS--ATK---YMNGhsdvvmGLVSVNCESLHNRLRFLQN 241
Cdd:COG0399 172 GCFSfyPTKnltTGEG------GAVVTNDEELAERARSLRN 206
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
71-241 |
3.32e-06 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 48.82 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 71 LEKAVAALDGAKYCLAFASGLAATVTITHLLKA--GDQIICMDDVYGGTNryfrQVASEFGLKISFVD------CSKIKL 142
Cdd:pfam01041 29 FERAFAAYLGVKHAIAVSSGTAALHLALRALGVgpGDEVITPSFTFVATA----NAALRLGAKPVFVDidpdtyNIDPEA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 143 LEAAITPETKLVwieTPTNPTQKVIDIEGCAHIVHKHGdIILVVD--NTFMSPYFQRPLALGADISMYS--ATKYM---N 215
Cdd:pfam01041 105 IEAAITPRTKAI---IPVHLYGQPADMDAIRAIAARHG-LPVIEDaaHALGATYQGKKVGTLGDAATFSfhPTKNLttgE 180
|
170 180
....*....|....*....|....*.
gi 262476 216 GhsdvvmGLVSVNCESLHNRLRFLQN 241
Cdd:pfam01041 181 G------GAVVTNDPELAEKARVLRN 200
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
75-188 |
4.31e-06 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 48.59 E-value: 4.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 75 VAALDGAKYCLAFAsgLAAtvtithLLKAGDQIICMD---DVYggtnryfRQVASEFGLKISFVDCSK-------IKLLE 144
Cdd:COG0436 93 ILVTNGAKEALALA--LLA------LLNPGDEVLVPDpgyPSY-------RAAVRLAGGKPVPVPLDEengflpdPEALE 157
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 262476 145 AAITPETKLVWIETPTNPTQKVI---DIEGCAHIVHKHgDIILVVDN 188
Cdd:COG0436 158 AAITPRTKAIVLNSPNNPTGAVYsreELEALAELAREH-DLLVISDE 203
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
66-187 |
5.89e-06 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 47.99 E-value: 5.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 66 PTRNCLEKAVAALDGAKYClafaSGLAATVT----------ITHLLKAGDQIICMDDVY----------GGTNRYFRQVA 125
Cdd:PRK09082 71 ALREAIAAKTARLYGRQYD----ADSEITVTagatealfaaILALVRPGDEVIVFDPSYdsyapaielaGGRAVRVALQP 146
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262476 126 SEFGlkisfVDCSKIKlleAAITPETKLVWIETPTNPTQKVI---DIEGCAHIVHKHgDIILVVD 187
Cdd:PRK09082 147 PDFR-----VDWQRFA---AAISPRTRLIILNTPHNPSGTVWsaaDMRALWQLIAGT-DIYVLSD 202
|
|
| PRK12414 |
PRK12414 |
putative aminotransferase; Provisional |
68-190 |
4.17e-05 |
|
putative aminotransferase; Provisional
Pssm-ID: 183514 Cd Length: 384 Bit Score: 45.16 E-value: 4.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 68 RNCLEKAVAALDGAKY-------CLAFAS-GLAATvtITHLLKAGDQIICMD---DVYGGTNRYfrQVASEFGLKISF-- 134
Cdd:PRK12414 72 REALAEKTERLYGARYdpasevtVIASASeGLYAA--ISALVHPGDEVIYFEpsfDSYAPIVRL--QGATPVAIKLSPed 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262476 135 --VDCSKIKlleAAITPETKLVWIETPTNPTQKVI---DIEGCAHIVhKHGDIILVVDNTF 190
Cdd:PRK12414 148 frVNWDEVA---AAITPRTRMIIVNTPHNPSATVFsaaDLARLAQLT-RNTDIVILSDEVY 204
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
71-187 |
1.54e-04 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 43.45 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 71 LEKAVAALDGAKYCLAFASGLAATVT----------ITHLLKAGDQIICMDDVYGGTNRYFRqvASefGLKISFVDCSK- 139
Cdd:pfam00155 44 LREALAKFLGRSPVLKLDREAAVVFGsgaganiealIFLLANPGDAILVPAPTYASYIRIAR--LA--GGEVVRYPLYDs 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 262476 140 ------IKLLEAAITPETKLVWIETPTNPTQKVIDIEG---CAHIVHKHGdIILVVD 187
Cdd:pfam00155 120 ndfhldFDALEAALKEKPKVVLHTSPHNPTGTVATLEElekLLDLAKEHN-ILLLVD 175
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
127-187 |
5.95e-04 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 41.65 E-value: 5.95e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262476 127 EFGLKISFVDcskiklLEAAITPETKLVWIETPTNPTQKVI---DIEGCAHIVHKHgDIILVVD 187
Cdd:PRK05764 147 ENGFKLTVEQ------LEAAITPKTKALILNSPSNPTGAVYspeELEAIADVAVEH-DIWVLSD 203
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
92-187 |
9.35e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 41.18 E-value: 9.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 92 AATVTITHLLKAGDQIICMDDVY----------GGTNRYFRQVASEFGLKISfvdcskIKLLEAAITPETKLVWIETPTN 161
Cdd:PRK07777 97 AIAAAVLGLVEPGDEVLLIEPYYdsyaaviamaGAHRVPVPLVPDGRGFALD------LDALRAAVTPRTRALIVNSPHN 170
|
90 100
....*....|....*....|....*....
gi 262476 162 PTQKVI---DIEGCAHIVHKHgDIILVVD 187
Cdd:PRK07777 171 PTGTVLtaaELAAIAELAVEH-DLLVITD 198
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
143-187 |
1.20e-03 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.20e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 262476 143 LEAAITPETKLVWIETPTNPTQKVI---DIEGCAHIVHKHgDIILVVD 187
Cdd:PRK07682 147 IEAAITAKTKAILLCSPNNPTGAVLnksELEEIAVIVEKH-DLIVLSD 193
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
143-191 |
2.81e-03 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 39.34 E-value: 2.81e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 262476 143 LEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG-DIILVVDNTFM 191
Cdd:COG0079 129 LLAAITERTDLVFLCNPNNPTGTLLPREELEALLEALPaDGLVVVDEAYA 178
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
143-163 |
3.84e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 39.16 E-value: 3.84e-03
10 20
....*....|....*....|.
gi 262476 143 LEAAITPETKLVWIETPTNPT 163
Cdd:PRK06108 151 LLAAITPRTRALFINSPNNPT 171
|
|
| PRK06348 |
PRK06348 |
pyridoxal phosphate-dependent aminotransferase; |
140-198 |
4.25e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180537 Cd Length: 384 Bit Score: 38.93 E-value: 4.25e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262476 140 IKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHI--VHKHGDIILVVDNTFMSPYFQRP 198
Cdd:PRK06348 152 VKKLEALITSKTKAIILNSPNNPTGAVFSKETLEEIakIAIEYDLFIISDEVYDGFSFYED 212
|
|
| PRK08912 |
PRK08912 |
aminotransferase; |
92-187 |
4.31e-03 |
|
aminotransferase;
Pssm-ID: 181580 Cd Length: 387 Bit Score: 39.19 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 92 AATVTITHLLKAGDQIICMDDVY----------GGTNRYFRQVASEFGLKISfvdcskikLLEAAITPETKLVWIETPTN 161
Cdd:PRK08912 99 ALAAALLALVEPGDEVVLFQPLYdaylplirraGGVPRLVRLEPPHWRLPRA--------ALAAAFSPRTKAVLLNNPLN 170
|
90 100
....*....|....*....|....*....
gi 262476 162 PTQKVI---DIEGCAHIVHKHgDIILVVD 187
Cdd:PRK08912 171 PAGKVFpreELALLAEFCQRH-DAVAICD 198
|
|
| PRK06107 |
PRK06107 |
aspartate transaminase; |
135-190 |
5.31e-03 |
|
aspartate transaminase;
Pssm-ID: 180403 Cd Length: 402 Bit Score: 38.56 E-value: 5.31e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262476 135 VDCSK---IKL----LEAAITPETKLVWIETPTNPTQKVI---DIEGCAHIVHKHGDIILVVDNTF 190
Cdd:PRK06107 144 VACPEeqgFKLtpeaLEAAITPRTRWLILNAPSNPTGAVYsraELRALADVLLRHPHVLVLTDDIY 209
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
140-216 |
6.00e-03 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 38.38 E-value: 6.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262476 140 IKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGdIILVVD--NTFMSpyfqRPL---ALGADISMYSATKyM 214
Cdd:pfam00266 129 LDELEKLITPKTKLVAITHVSNVTGTIQPVPEIGKLAHQYG-ALVLVDaaQAIGH----RPIdvqKLGVDFLAFSGHK-L 202
|
..
gi 262476 215 NG 216
Cdd:pfam00266 203 YG 204
|
|
| |
