|
Name |
Accession |
Description |
Interval |
E-value |
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-781 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 1020.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 1 MQQKIGEKIWNSNIENEVSKKWDEGRIYDFKVSDKNN-FVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFF 79
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPvYSIDTPPPTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 80 PIGIDRNGLPVEIYTEKKHKIRMRQTHREEFLNLCRISLDDLEKEMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTFLY 159
Cdd:PRK13208 81 PQGWDDNGLPTERKVEKYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 160 LWKKGLVYSSNRPNNYCPSCGTTIADAEITYEEKKTILVYLKFKLKnENGYLIVATTRPELIFACQCIIVNPSDSRYENL 239
Cdd:PRK13208 161 LYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVE-DGEEIEIATTRPELLPACVAVVVHPDDERYKHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 240 HNNEVILPIFNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGGNYANLSIDNARKK 319
Cdd:PRK13208 240 VGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 320 IIDDLKNNDYVEKEETILHRIPMCERSKSPVEIVPMQDYYIKQLEFLPKLREFSSTLKFYPEAHRQILFNWLDSVAIDWP 399
Cdd:PRK13208 320 IVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRVRLENWIEGLNWDWC 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 400 VSRRRFYGTEIPIWYCDNCKEPILPEPGKY-YRPWKDKAPVDKCVKCGFDKFTGDERTFDTWMDSSISPLFITKYNRDED 478
Cdd:PRK13208 400 ISRQRYFGTPIPVWYCKDCGHPILPDEEDLpVDPTKDEPPGYKCPQCGSPGFEGETDVMDTWATSSITPLIVTGWERDED 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 479 FFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFW 558
Cdd:PRK13208 480 LFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYW 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 559 SATeANHGQDFRCSEQKIVEAQKFLTKLWNIGRFVSSFE--FIPSHESDLLPSDKWILAELSNLITECMRGYKEYNFFIP 636
Cdd:PRK13208 560 AAS-ARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSadPEPDKAEVLEPLDRWILAKLAKVVEKATEALENYDFAKA 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 637 ASHIREFTWNIFASHYLELVKSRAYNDNDSDSRNSALYALHKCFSVILLLLAPICPFITDKLWTTIYDKeSIHLNKLPDE 716
Cdd:PRK13208 639 LEEIESFFWHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG-SVHRASWPEP 717
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262089308 717 NND--YEDMRKYTKDIIDFNSLIWTKKREslnedgKRYSLRDPIK------TEVPIQLSQFKDDLTQMHNIQD 781
Cdd:PRK13208 718 DEEliDEEDEELGELAKEILSAVRKYKSE------AGLSLNAPLKkvevygPADLELLEAAEEDLKAAGNIEE 784
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
12-722 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 576.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 12 SNIENEVSKKWDEGRIYDFKV-SDKNNFVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPV 90
Cdd:TIGR00422 8 HEVEKKWYKKWEKSGFFKPDGnSNKPPFCIDIPPPNVTGS-LHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 91 EIYTEKKHKIRMRQTH---REEFLNLCrISLDDLEKEMIQ-IMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLV 166
Cdd:TIGR00422 87 QVKVEKKLGAEGKTKHdlgREEFREKI-WEWKEESGGTIKnQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 167 YSSNRPNNYCPSCGTTIADAEITYEEKKTILVYLKFKLKN-ENGYLIVATTRPELIFACQCIIVNPSDSRYENLHNNEVI 245
Cdd:TIGR00422 166 YRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANgSKDYLVVATTRPETMFGDTAVAVHPEDERYKHLIGKKVI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 246 LPIFNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGGNYANLSIDNARKKIIDDLK 325
Cdd:TIGR00422 246 LPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLK 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 326 NNDYVEKEETILHRIPMCERSKSPVEIVPMQDYYIKQLEFLPKLRE--FSSTLKFYPEAHRQILFNWLDSVAiDWPVSRR 403
Cdd:TIGR00422 326 EEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEaaEEGEIKFVPKRMEKRYLNWLRNIK-DWCISRQ 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 404 RFYGTEIPIWYCDNCkepilpepGKYYRPWKDKAPVDKCVKCGFDKFTGDERTFDTWMDSSISPLFITKYNRDEDFFVKT 483
Cdd:TIGR00422 405 LIWGHRIPVWYCKEC--------GEVYVAKEEPLPDDKTNTGPSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKF 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 484 FPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEA 563
Cdd:TIGR00422 477 YPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLV 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 564 NHGQDFRCSEQKIVEAQKFLTKLWNIGRFV----SSFEFIPSHESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASH 639
Cdd:TIGR00422 557 TPGDDINFDWKRVESARNFLNKLWNASRFVlmnlSDDLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKA 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 640 IREFTWNIFASHYLELVKSRAYNDNdSDSRNSALYALHKCFSVILLLLAPICPFITDKLWTTIYDK-ESIHLNKLPDENN 718
Cdd:TIGR00422 637 LYEFIWNDFCDWYIELVKYRLYNGN-EAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGaDSIMLQSYPVVDA 715
|
....
gi 262089308 719 DYED 722
Cdd:TIGR00422 716 EFVD 719
|
|
| alt_ValS |
NF000540 |
valine--tRNA ligase; |
14-699 |
1.93e-131 |
|
valine--tRNA ligase;
Pssm-ID: 467949 [Multi-domain] Cd Length: 827 Bit Score: 410.85 E-value: 1.93e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 14 IENEVSKKWDEGRIYDFKVSDKNN--FVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVE 91
Cdd:NF000540 9 LEAKWAARWEEDGTYAFDRPAAREevFSIDTPPPTVSGS-LHVGHVFSYTHTDVVARYQRMRGKEVFYPMGWDDNGLPTE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 92 -------------------IYTEKKHKIRMRQTH--REEFLNLC-RISLDDlEKEMIQIMKSIGLSANFEEYYRTDSIEY 149
Cdd:NF000540 88 rrvqnyygvrcdpslpydpDFTPPEKPGPKDQVPisRRNFIELCeRLTAED-EKAFEDLWRRLGLSVDWSLTYRTIGDRA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 150 RTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAEItyEEKKTILVYLKFKLKNENGY-LIVATTRPELIFACQCII 228
Cdd:NF000540 167 RRVSQRAFLRNLARGEAYQAEAPTLWDVTFQTAVAQAEL--EDREYPGAYHRLAFHGADGGpVHIETTRPELLPACVALV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 229 VNPSDSRYENLHNNEVILPIFNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKI------- 301
Cdd:NF000540 245 AHPDDERYQPLFGTTVTSPLFGVEVPVLAHPLAEPDKGSGIAMCCTFGDLTDVTWWRELQLPTRAIIGRDGRLlaetpew 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 302 ---SENGGNYANL---SIDNARKKIIDDLK-NNDYVEKEETILHRIPMCERSKSPVEIVPMQDYYIKQLEFLPKLRE--- 371
Cdd:NF000540 325 itsEAGRAAYAELagkTVFSAREAVVELLReSGDLDGEPRPIQHPVKFYEKGDKPLEIVSTRQWYIRNGGRDADLREall 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 372 -FSSTLKFYPEAHRQILFNWLDSVAIDWPVSRRRFYGTEIPIWY-CDNCKEPILPEPgkyYRPWKDKAPVDKCVKC--GF 447
Cdd:NF000540 405 aRGRELAWHPEHMRVRYENWVEGLNGDWLISRQRFFGVPFPVWYpLDADGEPDYDAP---IVPAEDQLPVDPSSDVppGY 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 448 DK--------FTGDERTFDTWMDSSISPLFITKYNRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEV 519
Cdd:NF000540 482 TEdqrgvpggFIGDPDVMDTWATSSLTPQIAGGWERDPDLFARVFPMDLRPQGHDIIRTWLFSTVVRAHLEHGSLPWRHA 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 520 WIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATeANHGQDFRCSEQKIVEAQKFLTKLWNIGRFVSSFefi 599
Cdd:NF000540 562 AISGWILDPDRKKMSKSKGNVVTPTGLLEQHGSDAVRYWAAS-ARPGTDTAFDETQMKVGRRLAIKLLNASKFVLGF--- 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 600 PSHESDL----LPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNiFASHYLELVKSRAYNDNDSDSRNSALYA 675
Cdd:NF000540 638 GAPAGDPaavtEPLDRAMLAALAEVVEQATAAFEAYDYTRALEVTESFFWT-FCDDYLELVKERAYGADGEAAAASARAA 716
|
730 740
....*....|....*....|....
gi 262089308 676 LHKCFSVILLLLAPICPFITDKLW 699
Cdd:NF000540 717 LATALSVLLRLFAPFLPFATEEVW 740
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
7-717 |
8.83e-120 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 381.38 E-value: 8.83e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 7 EKIWN-SNIENEVSKKWDEGRIYDFKVSDKNNFVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDR 85
Cdd:PRK05729 6 PKTYDpKEVEAKWYQKWEEKGYFKPDDNSKKPFSIVIPPPNVTGS-LHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDH 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 86 NGLPVEIYTEKK---HKIRMRQTHREEFLNLC---------RIslddlekemIQIMKSIGLSANFEeyyRtdsiEYRTL- 152
Cdd:PRK05729 85 AGIATQMVVERQlaaEGKSRHDLGREKFLEKVwewkeesggTI---------TNQLRRLGASCDWS---R----ERFTMd 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 153 ------TQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAEITYEEKKTILVYLKFKLKNENGYLIVATTRPELIFACQC 226
Cdd:PRK05729 149 eglskaVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDYLVVATTRPETMLGDTA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 227 IIVNPSDSRYENLHNNEVILPIFNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGG 306
Cdd:PRK05729 229 VAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPG 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 307 NYANLSIDNARKKIIDDLKNNDYVEKEETILHRIPMCERSKSPVEivPM---QdYYIKQLEFLPKLREF--SSTLKFYPE 381
Cdd:PRK05729 309 EYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIE--PYlsdQ-WFVKMKPLAKPALEAveNGEIKFVPE 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 382 AHRQILFNWLDSVAiDWPVSRRRFYGTEIPIWYCDNCKEpilpepgkyyrpWKDKAPVDKCVKCgfdKFTGDERTFDTWM 461
Cdd:PRK05729 386 RWEKTYFHWMENIQ-DWCISRQLWWGHRIPAWYDEDGEV------------YVGREEPEAREKA---LLTQDEDVLDTWF 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 462 DSSISPlFITKYNRDEDFFVKTF-PTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNV 540
Cdd:PRK05729 450 SSALWP-FSTLGWPEKTEDLKRFyPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNV 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 541 IDPFPIITKHGADTFRFWSATEANHGQDFRCSEQKIVEAQKFLTKLWNIGRFV------SSFEFIPsHESDLLPSDKWIL 614
Cdd:PRK05729 529 IDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWNASRFVlmnlegADVGELP-DPEELSLADRWIL 607
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 615 AELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYNDNDSDSRNSALYALhkcfSVILLLLAPICPFI 694
Cdd:PRK05729 608 SRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEAAKRATRATLAYVL----EQILRLLHPFMPFI 683
|
730 740
....*....|....*....|....*.
gi 262089308 695 TDKLWTTIYD---KESIHLNKLPDEN 717
Cdd:PRK05729 684 TEELWQKLAPlgiEESIMLAPWPEAD 709
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
16-722 |
3.69e-116 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 372.08 E-value: 3.69e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 16 NEVSKKWD----EGRIYD-------FK---VSDKNNFVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPI 81
Cdd:COG0525 1 MELPKTYDpkevEAKWYQyweengyFKadpDSDKEPFTIVIPPPNVTGS-LHMGHALNNTLQDILIRYKRMQGYNTLWQP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 82 GIDRNGlpveIYTE-------KKHKIRMRQTHREEFLNLC---------RIslddlekemIQIMKSIGLSANFEeyyRtd 145
Cdd:COG0525 80 GTDHAG----IATQavverqlAEEGKSRHDLGREKFLERVwewkeesggTI---------TNQLRRLGASCDWS---R-- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 146 siEYRTL-------TQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAEITYEEKKTILVYLKFKLKNENGYLIVATTRP 218
Cdd:COG0525 142 --ERFTMdeglskaVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGYIVVATTRP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 219 ELIFACQCIIVNPSDSRYENLHNNEVILPIFNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHY 298
Cdd:COG0525 220 ETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDED 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 299 GKISENGGNYANLSIDNARKKIIDDLKNNDYVEKEETILHRIPMCERSKSPVEivPM---QdYYIKQLEFLPKLREF--S 373
Cdd:COG0525 300 GTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIE--PYlsdQ-WFVKMKPLAKPAIEAveD 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 374 STLKFYPEAHRQILFNWLDSVAiDWPVSRRRFYGTEIPIWYCDNckepilpepGKYY--RPwkdkaPVDKCVKCGFDKFT 451
Cdd:COG0525 377 GEIKFVPERWEKTYFHWMENIR-DWCISRQLWWGHRIPAWYCPD---------GEVYvaRT-----EPEACAKAGSVNLT 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 452 GDERTFDTWMDSSISPlFIT----KYNRDEDFFvktFPTQIRPQAKDIVRTW--------LYYTmlrcyqltENLAWSEV 519
Cdd:COG0525 442 QDEDVLDTWFSSALWP-FSTlgwpEKTEDLKYF---YPTSVLVTGFDIIFFWvarmimmgLHFT--------GEVPFKDV 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 520 WIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQDFRCSEQKIVEAQKFLTKLWNIGRFV------ 593
Cdd:COG0525 510 YIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWNASRFVlmnleg 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 594 SSFEFIPSHEsDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRaYNDNDSDSRNSAL 673
Cdd:COG0525 590 FDPGLDPDPE-ELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPR-LYGGDEAAKRETR 667
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|..
gi 262089308 674 YALHKCFSVILLLLAPICPFITDKLWTTIY---DKESIHLNKLPDENNDYED 722
Cdd:COG0525 668 ATLVYVLEQILRLLHPFMPFITEEIWQKLPprkEGESIMLAPWPEADEELID 719
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
33-699 |
2.31e-100 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 333.88 E-value: 2.31e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 33 SDKNNFVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKK-HKIRMRQTH---RE 108
Cdd:PRK14900 45 RTRPPFSIVLPPPNVTGS-LHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKElKKTEKKSRHdlgRE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 109 EFLNLCRISLDDLEKEMIQIMKSIGLSANFE-EYYRTDSIEYRTLtQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAE 187
Cdd:PRK14900 124 AFLERVWAWKEQYGSRIGEQHKALGASLDWQrERFTMDEGLSRAV-REVFVRLHEEGLIYREKKLINWCPDCRTALSDLE 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 188 ITYEEKKT-ILVYLKFKLKNENGYLIVATTRPELIFACQCIIVNPSDSRYENLHNNEVILPIFNREVKILPHHS-AKSDF 265
Cdd:PRK14900 203 VEHEEAHQgELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAIlVDPKF 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 266 GSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGGNYANLSIDNARKKIIDDLKNNDYVEKEETilHRIPM--C 343
Cdd:PRK14900 283 GTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKP--HVLPLgrC 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 344 ERSKSPVEIVPMQDYYIKqLEFLPK----LREFSSTlKFYPEAHRQILFNWLDSVAiDWPVSRRRFYGTEIPIWYCDNcK 419
Cdd:PRK14900 361 QRSATILEPLLSDQWYVR-IEPLARpaieAVEQGRT-RFIPEQWTNTYMAWMRNIH-DWCISRQLWWGHQIPAWYCPD-G 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 420 EPILPEpgkyyrpwkdKAPvDKCVKCGFDKFTGDERTFDTWMDSSISPLFITKYNRDEDFFVKTFPTQIRPQAKDIVRTW 499
Cdd:PRK14900 437 HVTVAR----------ETP-EACSTCGKAELRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFW 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 500 LYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQDFRCSEQKIVEA 579
Cdd:PRK14900 506 VARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGY 585
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 580 QKFLTKLWNIGRF----VSSFEF--IPSHESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYL 653
Cdd:PRK14900 586 RAFANKLWNASRFalmnLSGYQErgEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYI 665
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 262089308 654 ELVKSRAYNDnDSDSRNSALYALHKCFSVILLLLAPICPFITDKLW 699
Cdd:PRK14900 666 ELAKEALASE-DPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELW 710
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
20-558 |
9.03e-97 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 313.19 E-value: 9.03e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 20 KKWDEGRIYD---FKVSDKNNFVIDTPPPYPSGRPwHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEK 96
Cdd:pfam00133 4 EFWDEQGYFKpelEKRKGKPSFTIHDGPPNATGSL-HIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 97 KHKIRMRQTH----REEFLNLCRISLDDLEKEMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRP 172
Cdd:pfam00133 83 KLGIKEKKTRhkygREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 173 NNYCPSCGTTIADAEITYEEKKTILVYLKFKLK-NENGYLIVATTRPELIFACQCIIVNP-------------------- 231
Cdd:pfam00133 163 VNWSPALNTALSNLEVEYKDVKGPSIHVAFPLAdDEGASLVIWTTTPWTLPGNTAVAVNPefdyvitgegyilaeallks 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 232 -----------SDSRYENLHNNEVILPIFNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGK 300
Cdd:pfam00133 243 lykkgtdkkilEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGT 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 301 ISENGGNYANLSIDNARKKIIDDLKNNDYVEKEETILHRIPMCERSKSPVEIVPMQDYYIKQLEFLPKLREFSSTLKFYP 380
Cdd:pfam00133 323 FTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEKVQFVP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 381 EAHRQILFNWLDSVAiDWPVSRRRFYGTEIPIWYCDNCKEPILPEPGKYY----------RPWKDKAPVDKcVKCGFDKF 450
Cdd:pfam00133 403 KSGEKRYFNWLANIQ-DWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELvagrfeeegsIKWLHREAKDK-LGYGKGTL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 451 TGDERTFDTWMDSSISPLFITKY-NRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEY 529
Cdd:pfam00133 481 EQDEDVLDTWFSSGSWPFSTLGWpFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQ 560
|
570 580
....*....|....*....|....*....
gi 262089308 530 GEKMSKSKGNVIDPFPIITKHGADTFRFW 558
Cdd:pfam00133 561 GRKMSKSLGNVIDPLDVIDKYGADALRLW 589
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
13-722 |
4.84e-96 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 319.33 E-value: 4.84e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 13 NIENEVSKKWDEGRIYDfKV----SDKNNFV-IDTPPpYPSGRPwHIGAAahYAQI--DMIARTARMFGKNVFFPIGIDR 85
Cdd:COG0060 20 KREPEILKFWEENDIYE-KSrearAGRPKFVlHDGPP-YANGDI-HIGHA--LNKIlkDIIVRYKTMRGFDVPYVPGWDC 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 86 NGLPVEIYTEKKHKIRMRQTHR---EEFLNLCRISLDDLEKEMIQIMKSIGLSANFEEYYRTDSIEY-----RTLTQstf 157
Cdd:COG0060 95 HGLPIELKVEKELGIKKKDIEKvgiAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYeesiwWALKK--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 158 lyLWKKGLVYSSNRPNNYCPSCGTTIADAEITYEEKKTILVYLKFKLKN-------ENGYLIVATTRPELIFACQCIIVN 230
Cdd:COG0060 172 --LYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKDekallllEDAYLVIWTTTPWTLPANLAVAVH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 231 P----------SDSRY---ENL----------HNNEVI-------------------LPIFNREVKILPhhsakSDF--- 265
Cdd:COG0060 250 PdidyvlvevtGGERLilaEALveavlkelgiEDYEVLatfkgaeleglryehpfyyVVGYDRAHPVIL-----GDYvtt 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 266 --GSGAV-MVCSYGDlNDVQVFRELGLKEIVSVNHYGKISENGGNYANLSIDNARKKIIDDLKNNDYVEKEETILHRIPM 342
Cdd:COG0060 325 edGTGIVhTAPGHGE-DDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPH 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 343 CERSKSPVeI---VPmQdYYIKqlefLPKLREfsSTLK------FYPEAHRQILFNWLDSvAIDWPVSRRRFYGTEIPIW 413
Cdd:COG0060 404 CWRCKTPL-IyraTP-Q-WFIS----MDKLRD--RALEaiekvnWIPEWGEGRFGNMLEN-RPDWCISRQRYWGVPIPIW 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 414 YCDNCKEPILP------------EPGKyyRPWKDKAP----VD---KCVKCGfDKFTGDERTFDTWMDSSISPlFITKYN 474
Cdd:COG0060 474 VCEDCGELHRTeevigsvaelleEEGA--DAWFELDLhrpfLDetlKCPKCG-GTMRRVPDVLDVWFDSGSMH-FAVLEN 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 475 RDEdffvKTFPtqirpqAKDIV------RTWlYYTMLRC---------YQ--LTenlawsevwiMGYGVDEYGEKMSKSK 537
Cdd:COG0060 550 REE----LHFP------ADFYLegsdqtRGW-FYSSLLTstalfgrapYKnvLT----------HGFVLDEDGRKMSKSL 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 538 GNVIDPFPIITKHGADTFRFWSATeANHGQDFRCSEQKIVEAQKFLTKLWNIGRFVSS--FEFIPSHES----DLLPSDK 611
Cdd:COG0060 609 GNVVDPQEVIDKYGADILRLWVAS-SDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLAnlDDFDPAEDAvpyeDLPELDR 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 612 WILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYND-NDSDSRNSALYALHKCFSVILLLLAPI 690
Cdd:COG0060 688 WILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEaADSLDRRAAQTTLYEVLETLVRLLAPI 767
|
810 820 830
....*....|....*....|....*....|....
gi 262089308 691 CPFITDKLWTTI--YDKESIHLNKLPDENNDYED 722
Cdd:COG0060 768 LPFTAEEIWQNLpgEAEESVHLADWPEVDEELID 801
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
38-570 |
1.37e-95 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 302.63 E-value: 1.37e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 38 FVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKKHKIRMRQTH---REEFLNLC 114
Cdd:cd00817 3 FVIDTPPPNVTGS-LHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHdlgREEFLEKC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 115 RISLDDLEKEMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAEItyeekk 194
Cdd:cd00817 82 WEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 195 tilvylkfklknengylivattrpelifacqciivnpsdsryenlhnnevilpifnrevkilphhsaksdfgsgavmvcs 274
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 275 ygdlndvqvfrelglkeivsvnhygkisenggnyanlsidnarkkiiddlknndyvekeetilhripmCERSKSPVEIVP 354
Cdd:cd00817 156 --------------------------------------------------------------------CSRSGDVIEPLL 167
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 355 MQDYYIKQLEFLPKLREF--SSTLKFYPEAHRQILFNWLDSVAiDWPVSRRRFYGTEIPIWYCDNCKEPIlpePGKYYRP 432
Cdd:cd00817 168 KPQWFVKVKDLAKKALEAvkEGDIKFVPERMEKRYENWLENIR-DWCISRQLWWGHRIPAWYCKDGGHWV---VAREEDE 243
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 433 WKDKAPVDKCVKCGFDKFTGDERTFDTWMDSSISPLFITKYNRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTE 512
Cdd:cd00817 244 AIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTG 323
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 262089308 513 NLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQDFR 570
Cdd:cd00817 324 KLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDIN 381
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
35-722 |
1.79e-88 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 300.38 E-value: 1.79e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 35 KNNFVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKK-----HKIRmRQTHREE 109
Cdd:PTZ00419 59 GKKFVIVLPPPNVTGY-LHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKlmkeeNKTR-HDLGREE 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 110 FLNlcRIsLDDLEKEMIQI---MKSIGLSANFEEYYRT-DsiEYRTLT-QSTFLYLWKKGLVYSSNRPNNYCPSCGTTIA 184
Cdd:PTZ00419 137 FLK--KV-WEWKDKHGNNIcnqLRRLGSSLDWSREVFTmD--EQRSKAvKEAFVRLYEDGLIYRDTRLVNWCCYLKTAIS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 185 DAEITYEE-----KKTI-----------LVYLKFKLKN-ENGYLIVATTRPELIFACQCIIVNPSDSRYENLHNNEVILP 247
Cdd:PTZ00419 212 DIEVEFEEiekptKITIpgydkkvevgvLWHFAYPLEDsGQEEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 248 IFN-REVKIL--PHHsAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGGNYANLSIDNARKKIIDDL 324
Cdd:PTZ00419 292 FIPdRKIPIIadDEL-VDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEEL 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 325 KN-NDYVEKEETILhRIPMCERSKSPVEIVPMQDYYIKQLEFLPKLREF--SSTLKFYPEAHRQILFNWLDSVAiDWPVS 401
Cdd:PTZ00419 371 KEmGLLRDKVPNPM-RLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSSHENVWYHWLENIQ-DWCIS 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 402 RRRFYGTEIPIWycdNCKEPILPEPGKYYRPWKDKAPVDKCVKCGFDKF---------TGDERTFDTWMDSSISPLFITK 472
Cdd:PTZ00419 449 RQLWWGHRIPAY---RVISKGPETDPSDEEPWVVARSEEEALEKAKKKFglseedfelEQDEDVLDTWFSSGLFPFSTLG 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 473 YNRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPII----- 547
Cdd:PTZ00419 526 WPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIegisl 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 548 -------------TKH-------------------GADTFRFWSATEANHGQDFRCSEQKIVEAQKFLTKLWNIGRFV-- 593
Cdd:PTZ00419 606 qdlnqklyegnlpEKEikraielqkkefpngipecGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFAlm 685
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 594 ---------SSFEFIPSHESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYNDN 664
Cdd:PTZ00419 686 kllkdfnlpNSTLFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQS 765
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262089308 665 DSDSRNSALYALHKCFSVILLLLAPICPFITDKLWTTI----YDKESIHLNKLPDENNDYED 722
Cdd:PTZ00419 766 DGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLpnylRKSESISIAKYPQPNPGWNN 827
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
17-736 |
2.45e-81 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 279.90 E-value: 2.45e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 17 EVSKKWD---EGRIYDFKVSD---KNN-------FVIDTPPPYPSGrPWHIGAAAHYAQIDMIARTARMFGKNVFFPIGI 83
Cdd:PLN02943 56 ETAKSFDftsEERIYNWWESQgyfKPNfdrggdpFVIPMPPPNVTG-SLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 84 DRNGLPVEIYTEK---KHKIRMRQTHREEFLNLCRISLDDLEKEMIQIMKSIGLSANF-EEYYRTDSIEYRTLTQStFLY 159
Cdd:PLN02943 135 DHAGIATQLVVEKmlaSEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWsRERFTLDEQLSRAVVEA-FVR 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 160 LWKKGLVYSSNRPNNYCPSCGTTIADAEITYEEKKTILVYLKFKLK-NENGYLIVATTRPELIFACQCIIVNPSDSRYEN 238
Cdd:PLN02943 214 LHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAgGSEDFLTIATTRPETLFGDVAIAVNPEDDRYSK 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 239 LHNNEVILPI-FNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGGNYANlsidNAR 317
Cdd:PLN02943 294 YIGKMAIVPMtYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAGLYWF----EAR 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 318 KKIIDDLKNNDYVEKEETILHRIPMCERSKSPVE-------IVPMQDYYIKQLEFLPKlrefsSTLKFYPEAHRQILFNW 390
Cdd:PLN02943 370 EKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEplvskqwFVTMEPLAEKALKAVEN-----GELTIIPERFEKIYNHW 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 391 LDSVAiDWPVSRRRFYGTEIPIWYC--DNCKEPILPEPGKYYRPWKDKAPVDKCVKcgfdkFTGDERTFDTWMDSSISPL 468
Cdd:PLN02943 445 LSNIK-DWCISRQLWWGHRIPVWYIvgKDCEEDYIVARSAEEALEKAREKYGKDVE-----IYQDPDVLDTWFSSALWPF 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 469 FITKY-NRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPII 547
Cdd:PLN02943 519 STLGWpDVSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTI 598
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 548 TKHGADTFRFWSATeANHGQDFRCSEQKIVEAQKFLTKLWNIGRFV----------SSFEFIPSHESDL------LP-SD 610
Cdd:PLN02943 599 KEFGTDALRFTLAL-GTAGQDLNLSTERLTSNKAFTNKLWNAGKFVlqnlpsqsdtSAWEHILACKFDKeesllsLPlPE 677
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 611 KWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYNDNDSDSRNSALYALHKCFSVILLLLAPI 690
Cdd:PLN02943 678 CWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPF 757
|
730 740 750 760
....*....|....*....|....*....|....*....|....*..
gi 262089308 691 CPFITDKLWTTI-YDKESIHLNKLPDENndyedMRKYTKDIIDFNSL 736
Cdd:PLN02943 758 MPFVTEELWQALpYRKEALIVSPWPQTS-----LPKDLKSIKRFENL 799
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
33-714 |
5.72e-59 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 217.07 E-value: 5.72e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 33 SDKNNFVIDTPPPYPSGrPWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKKhkiRMRQTH------ 106
Cdd:PLN02381 125 SSKPPFVIVLPPPNVTG-ALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKK---LMRERHltrhdi 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 107 -REEFLNLCRISLDDLEKEMIQIMKSIGLSANF-EEYYRTDSIEYRTLTQStFLYLWKKGLVYSSNRPNNYCPSCGTTIA 184
Cdd:PLN02381 201 gREEFVSEVWKWKDEYGGTILNQLRRLGASLDWsRECFTMDEQRSKAVTEA-FVRLYKEGLIYRDIRLVNWDCTLRTAIS 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 185 DAEITYEEKKT----------------ILVYLKFKLKNENGYLIVATTRPELIFACQCIIVNPSDSRYENLHNNEVILPI 248
Cdd:PLN02381 280 DVEVDYIDIKErtllkvpgydkpvefgVLTSFAYPLEGGLGEIVVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPF 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 249 FNREVKILPHHS-AKSDFGSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGG-NYANLSIDNARKKIIDDLKN 326
Cdd:PLN02381 360 NGRKLPIICDAIlVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGsEFAGMPRFAAREAVIEALQK 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 327 NDYVEKEETILHRIPMCERSKSPVEIVPMQDYYI------KQ-LEFLPKLRefSSTLKFYPEAHRQILFNWLDSVAiDWP 399
Cdd:PLN02381 440 KGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVncssmaKQaLDAAIDGE--NKKLEFIPKQYLAEWKRWLENIR-DWC 516
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 400 VSRRRFYGTEIPIWYCdNCKEPILPEPGKYYRPW-----KDKAPVDKCVKCGFDKF--TGDERTFDTWMDSSISPLFITK 472
Cdd:PLN02381 517 ISRQLWWGHRIPAWYV-TLEDDQLKELGSYNDHWvvarnESDALLEASQKFPGKKFelSQDPDVLDTWFSSGLFPLSVLG 595
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 473 YNRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDP--------- 543
Cdd:PLN02381 596 WPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPlevingisl 675
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 544 ---------------------------FPI-ITKHGADTFRFWSATEANHGQDFRCSEQKIVEAQKFLTKLWNIGRFVSS 595
Cdd:PLN02381 676 eglhkrleegnldpkelvvakegqkkdFPNgIAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMS 755
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 596 ---FEFIPS---HESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYNDNDS--D 667
Cdd:PLN02381 756 klgDDYTPPatlSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPEfaS 835
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|...
gi 262089308 668 SRNSALYALHKCFSVILLLLAPICPFITDKLWTTI------YDKESIHLNKLP 714
Cdd:PLN02381 836 ERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLpqpkdhTRKDSIMISEYP 888
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
38-570 |
9.06e-46 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 166.05 E-value: 9.06e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 38 FVIDTPPPYPSGRPwHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKKHKIRMRQTHREEFLNLCRIS 117
Cdd:cd00668 2 FYVTTPPPYANGSL-HLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIWIEEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 118 LDDLEKEMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYssnrpnnycpscgttiadaeityeekktil 197
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIY------------------------------ 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 198 vylkfklkneNGYlivattrpelifacqciivnpsdsryenlhnnevilpifnREVKILPHhsaksdfgsgavmvcsygd 277
Cdd:cd00668 131 ----------RGT----------------------------------------HPVRITEQ------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 278 lndvqvfrelglkeivsvnhygkisenggnyanlsidnarkkiiddlknndyvekeetilhripmcerskspveivpmqd 357
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 358 YYIKQLEFLPKLREFSSTLKFYPEAHRQILFNWLDSVaIDWPVSRRRFYGTEIPIWYcdnckepilpepgkyyrpwkdka 437
Cdd:cd00668 142 WFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESL-LDWAISRQRYWGTPLPEDV----------------------- 197
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 438 pvdkcvkcgfdkftgdertFDTWMDSSISPLFITKYNRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWS 517
Cdd:cd00668 198 -------------------FDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPK 258
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 262089308 518 EVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQDFR 570
Cdd:cd00668 259 NLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIR 311
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
572-702 |
5.16e-45 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 157.72 E-value: 5.16e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 572 SEQKIVEAQKFLTKLWNIGRFVSSF----EFIPSHESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNI 647
Cdd:cd07962 2 DEKRVEGGRNFCNKLWNAARFVLMNleddDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWND 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 262089308 648 FASHYLELVKSRAYNDnDSDSRNSALYALHKCFSVILLLLAPICPFITDKLWTTI 702
Cdd:cd07962 82 FCDWYLELVKPRLYGE-DEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
52-722 |
5.61e-41 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 161.96 E-value: 5.61e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 52 WHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKkhkIRMRQTHR-EEFLNLCRISLDDLEK------- 123
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAER---IARGDPETiELYKSLYGIPEEELEKfkdpeyi 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 124 ------EMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAEITYEEKKTIL 197
Cdd:PRK12300 78 veyfseEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEEPEIV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 198 VY--LKFKlKNENGYLIVATTRPELIFACQCIIVNP----------------SDSRYENL----HNNEVI---------- 245
Cdd:PRK12300 158 EYtlIKFE-ESEDLILPAATLRPETIFGVTNLWVNPdatyvkaevdgekwivSKEAAEKLsfqdRDVEIIeeikgselig 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 246 ----LPIFNREVKILPHHSAKSDFGSGAVM---------------------------------VCSYGDLNDVQVFRELG 288
Cdd:PRK12300 237 kkvkNPVTGKEVPILPADFVDPDNGTGVVMsvpahapydyvalrdlkknkelldviepiplieVEGYGEFPAKEVVEKLG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 289 LK------------EIVSVNHY-GKISENGGNYANLSIDNARKKIIDDLKNNDYVEKEETILHRIPMCeRSKSP--VEIV 353
Cdd:PRK12300 317 IKsqedpeleeatkEVYRAEFHkGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMYEFSNRPVYC-RCGTEcvVKVV 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 354 PMQdYYIK--QLEFLPKLREFSSTLKFYPEAHRQILFN---WLDsvaiDWPVSRRRFYGTEIPiWycDncKEPILpEP-- 426
Cdd:PRK12300 396 KDQ-WFIDysDPEWKELAHKALDNMEIIPEEYRKEFENtidWLK----DRACARRRGLGTRLP-W--D--EEWII-ESls 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 427 -----------GKYYRPWKDKApvDKCVKCGFDK-FTGDERTFDTWMDSSIsPLFITKYNRDEdfFVKTFPTQIRPQAKD 494
Cdd:PRK12300 465 dstiymayytiAHKIREYGIKP--EQLTPEFFDYvFLGKGDPEEVSKKTGI-PKEILEEMREE--FLYWYPVDWRHSGKD 539
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 495 IVRTWL-YYTMLRCYQLTENLawsevW-----IMGYGVDEyGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQD 568
Cdd:PRK12300 540 LIPNHLtFFIFNHVAIFPEEK-----WprgivVNGFVLLE-GKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQD 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 569 FRCSEQKIVEAQKFLTKLWNigrFVSSFEFIPSHESDLLPsDKWILAELSNLITECMRGYKEYNFfipashiREFTWNIF 648
Cdd:PRK12300 614 ADWREKEVESVRRQLERFYE---LAKELIEIGGEEELRFI-DKWLLSRLNRIIKETTEAMESFQT-------RDAVQEAF 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 649 ------ASHYLELVKsrayndndsdsrNSALYALHKCFSVILLLLAPICPFITDKLWTTIYDKESIHLNKLPDENNDYED 722
Cdd:PRK12300 683 yellndLRWYLRRVG------------EANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDESKID 750
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
14-716 |
5.32e-40 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 158.68 E-value: 5.32e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 14 IENEVSKKWDEGRIydFKVSDKNN---------FvidtppPYPSGRPwHIGaaaH---YAQIDMIARTARMFGKNVFFPI 81
Cdd:COG0495 10 IEKKWQKYWEENGT--FKADEDSSkpkyyvldmF------PYPSGRL-HMG---HvrnYTIGDVVARYKRMQGYNVLHPM 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 82 GIDRNGLPVEIYTeKKHKIRMRQTHREeflNlcrIslddleKEMIQIMKSIGLSANFE--------EYYRTdsieyrtlT 153
Cdd:COG0495 78 GWDAFGLPAENAA-IKNGVHPAEWTYE---N---I------ANMRRQLKRLGLSYDWSreiatcdpEYYKW--------T 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 154 QSTFLYLWKKGLVYSSNRPNNYCPSCGTTIA------------DAE------------IT-YEEK-------------KT 195
Cdd:COG0495 137 QWIFLQLYEKGLAYRKEAPVNWCPVDQTVLAneqvidgrcwrcGAPvekkelpqwflkITdYADEllddldkldgwpeKV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 196 IL-----------VYLKFKLKNENGYLIVATTRPELIFACQCIIVNP---------------------------SDS--- 234
Cdd:COG0495 217 KTmqrnwigrsegAEVDFPVEGSDEKITVFTTRPDTLFGATFMVLAPehplvkelatpeqnaavaafieeakkkSEIert 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 235 ------------RYenlhnneVILPIFNREVKI------LphhsakSDFGSGAVMVCSYGDLNDvqvF---RELGLkEIV 293
Cdd:COG0495 297 setkektgvftgLY-------AINPLTGEKIPIwiadyvL------MDYGTGAVMAVPAHDQRD---FefaKKYGL-PIK 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 294 SV-----NHYGKISE----------NGGNYANLSIDNARKKIIDDLKNNDYVEKEETilhripmcerskspveivpmqdY 358
Cdd:COG0495 360 QViapedGDDPDILEeaytgdgvliNSGEFDGLDSEEAKEAIIEWLEEKGLGKRKVN----------------------Y 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 359 yikqleflpKLRefsstlkfypeahrqilfnwldsvaiDWPVSRRRFYGTEIPIWYCDNCKE--------PI-LPEpGKY 429
Cdd:COG0495 418 ---------RLR--------------------------DWLISRQRYWGEPIPIIHCEDCGVvpvpedqlPVeLPE-DVD 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 430 YRPwKDKAPVDK--------CVKCGfdkftGDER----TFDTWMDSS------ISPlfitkyNRDEDFFvktfptqirpq 491
Cdd:COG0495 462 FDP-TGGSPLARapewvnvtCPKCG-----GPARretdTMDTFVDSSwyylryTDP------HNDEAPF----------- 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 492 AKDIVRTW-----------------LY---YTM-LRcyqltenlawsevwIMGY-GVDE--------------------- 528
Cdd:COG0495 519 DPEAANYWlpvdqyiggiehailhlLYarfFTKvLR--------------DLGLvSFDEpfkrlltqgmvlevgkdgvvi 584
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 529 -YGEKMSKSKGNVIDPFPIITKHGADTFR----FWSATEanhgQDFRCSEQKIVEAQKFLTKLWnigRFVSSF-EFIPSH 602
Cdd:COG0495 585 gGIEKMSKSKGNVVDPDEIIEKYGADTLRlfemFAGPPE----RDLEWSDSGVEGAYRFLNRVW---RLVVDEaEALKLD 657
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 603 ESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTwNifashylELVKSRAYNDNDSDsrnsalyALHKCFSV 682
Cdd:COG0495 658 VADLSEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELV-N-------ALYKAKDSGEADRA-------VLREALET 722
|
890 900 910
....*....|....*....|....*....|....*.
gi 262089308 683 ILLLLAPICPFITDKLWTTIYDKESIHLNKLP--DE 716
Cdd:COG0495 723 LVLLLAPFAPHIAEELWERLGHEGSVADAPWPeaDE 758
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
15-743 |
6.12e-40 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 158.78 E-value: 6.12e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 15 ENEVSKKWDEGRIYDfKVSDKNN---FVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVE 91
Cdd:PLN02843 9 EPEIQKLWEENQVYK-RVSDRNNgesFTLHDGPPYANGD-LHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 92 IytekKHKIRMRQTHREEFLNL------CRISLDDLEKEMIQiMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGL 165
Cdd:PLN02843 87 L----KVLQSLDQEARKELTPIklrakaAKFAKKTVDTQRES-FKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 166 VYSSNRPNNYCPSCGTTIADAEITYEE-KKTILVYLKFKLKN-------------ENGYLIVATTRPELIFACQCIIVNP 231
Cdd:PLN02843 162 IYRGRKPVHWSPSSRTALAEAELEYPEgHVSKSIYVAFPVVSpsetspeeleeflPGLSLAIWTTTPWTMPANAAVAVND 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 232 ----------------------SDSRYEN--------------------------------------LHNNEVILPIFNR 251
Cdd:PLN02843 242 klqysvvevqsfsedestsggnKKKRPGNvlkeqqklflivatdlvpaleakwgvklvvlktfpgsdLEGCRYIHPLYNR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 252 EVKILphhsAKSDF-----GSGAVMVCSYGDLNDVQVFRELGLKEIVSVNHYGKISENGGNYANLSI-DNARKKIIDDLK 325
Cdd:PLN02843 322 ESPVV----IGGDYittesGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVlGEGNAAVVEALD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 326 NNDYVEKEETILHRIPMCERSKSPVeIVPMQDYYIKQLE-FLPKLREFSSTLKFYPEAHRQILFNWLDSVAiDWPVSRRR 404
Cdd:PLN02843 398 EAGSLLMEEAYGHKYPYDWRTKKPT-IFRATEQWFASVEgFRQAALDAIDKVKWIPAQGENRIRAMVSGRS-DWCISRQR 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 405 FYGTEIPIWYCDNCKEPILPE---------------------------PGKYyrpwKDKApvdkcvkcgfDKFTGDERTF 457
Cdd:PLN02843 476 TWGVPIPVFYHVETKEPLMNEetiahvksivaqkgsdawwymdvedllPEKY----RDKA----------SDYEKGTDTM 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 458 DTWMDSSISPLFITKyNRDEdffvKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSK 537
Cdd:PLN02843 542 DVWFDSGSSWAGVLG-SREG----LSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSL 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 538 GNVIDPFPIIT---------KHGADTFRFWSATeANHGQDFRCSEQKIVEAQKFLTKLWNIGRFVSS--FEFIPSH--ES 604
Cdd:PLN02843 617 GNVVDPRLVIEggknqkqepAYGADVLRLWVAS-VDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGnlHDWKPDNavPY 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 605 DLLPS-DKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYNDNDSD-SRNSALYALHKCFSV 682
Cdd:PLN02843 696 EDLPSiDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSfTRRSCQTVLAAHLLS 775
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 262089308 683 ILLLLAPICPFITDKLWTTI------YDKESIHLNKLPDENNDYEDMRkytkdiiDFNSLIWTKKRE 743
Cdd:PLN02843 776 LLRAIAPILPHLAEDAWQNLpfqedgSAAESVFEAGWPTPNEEWLSFP-------AEDVDFWSLLLE 835
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
15-774 |
6.39e-36 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 146.41 E-value: 6.39e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 15 ENEVSKKWDEGRIYDFKVS---DKNNFVIDTPPPYPSGRPwhigaaaHYAQI------DMIARTARMFGKNVFFPIGIDR 85
Cdd:PLN02882 14 EEKILSLWSEIDAFKTQLKrteGLPEYIFYDGPPFATGLP-------HYGHIlagtikDIVTRYQSMTGHHVTRRFGWDC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 86 NGLPVEIYTEKKHKIrmrqTHREEFLNL--------CRISLDDLEKEMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTF 157
Cdd:PLN02882 87 HGLPVEYEIDKKLGI----KRRDDVLKMgidkyneeCRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 158 LYLWKKGLVYSSNRPNNYCPSCGTTIADAE--ITYEEKKTILVYLKFKL--KNENGYLIVATTRPELIFACQCIIVNPS- 232
Cdd:PLN02882 163 KQLFEKGLVYKGFKVMPYSTACKTPLSNFEagLNYKDVSDPAVMVSFPIvgDPDNASFVAWTTTPWTLPSNLALCVNPNf 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 233 -----------------DSRYENL----------HNNEVILPIFNREVKIL----------PHHSAKSDFGSGAVMVCS- 274
Cdd:PLN02882 243 tyvkvrnkytgkvyivaESRLSALptakpkskkgSKPENAAEGYEVLAKVPgsslvgkkyePLFDYFSEFSDTAFRVVAd 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 275 -----------------YGDlNDVQVFRELGLKE-----IVSVNHYGKISENGGNYANLSIDNARKKIIDDLKNNDYVEK 332
Cdd:PLN02882 323 dyvtddsgtgvvhcapaFGE-DDYRVCLANGIIEkggnlPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVK 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 333 EETILHRIPMCERSKSPV--EIVPmqDYYIKQLEFLPKLREFSSTLKFYPEAHRQILF-NWLDSvAIDWPVSRRRFYGTE 409
Cdd:PLN02882 402 SGSITHSYPFCWRSDTPLiyRAVP--SWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFhNWLEN-ARDWAVSRSRFWGTP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 410 IPIWYCDNCKEPI-------LPE-PGK----YYRPWKDKAPVDKCVKCGFDKFTGDERTFDTWMDSSISPLFITKYN-RD 476
Cdd:PLN02882 479 LPIWISDDGEEVVvigsiaeLEKlSGVkvtdLHRHFIDHITIPSSRGPEFGVLRRVDDVFDCWFESGSMPYAYIHYPfEN 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 477 EDFFVKTFPTQIRPQAKDIVRTWLYYTMLRCYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFR 556
Cdd:PLN02882 559 KELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALR 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 557 FWSA-TEANHGQDFRCSEQKIVEAQK--FLtKLWNIGRFV----------SSFEFIPSHESDLLPS----DKWILAELSN 619
Cdd:PLN02882 639 LYLInSPVVRAEPLRFKEEGVFGVVKdvFL-PWYNAYRFLvqnakrleveGGAPFVPLDLAKLQNSanvlDRWINSATQS 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 620 LIT---ECMRGYKEYNfFIPA--SHIREFTwNIFASHYLELVKSRaynDNDSDSRNsALYALHKCFSVILLLLAPICPFI 694
Cdd:PLN02882 718 LVKfvrEEMGAYRLYT-VVPYlvKFIDNLT-NIYVRFNRKRLKGR---TGEEDCRT-ALSTLYNVLLTSCKVMAPFTPFF 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 695 TDKLWTTIY-----DKESIHLNKLPDENNDYEDMR-----KYTKDIIDFNSLIwtkkRESLNEdgkrySLRDPIKTEVPI 764
Cdd:PLN02882 792 TEVLYQNLRkvlpgSEESIHYCSFPQVDEGELDERieqsvSRMQTVIELARNI----RERHNK-----PLKTPLKEMVVV 862
|
890
....*....|.
gi 262089308 765 QL-SQFKDDLT 774
Cdd:PLN02882 863 HPdAEFLDDIT 873
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
44-570 |
2.41e-31 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 125.42 E-value: 2.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 44 PPYPSGRPwHIGAAahYAQI--DMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKKHKIRMRQTHR----EEFLNLCRIS 117
Cdd:cd00818 9 PPYANGLP-HYGHA--LNKIlkDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEkmgiAEFNAKCREF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 118 LDDLEKEMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYcpscgttiadaeityeekktil 197
Cdd:cd00818 86 ALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW---------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 198 vylkfklknengylivattrpelifacqciivnpsdsryenlhnnevilPIFNREVKilphhsaksdfgsgavmvcsygd 277
Cdd:cd00818 144 -------------------------------------------------PLIYRATP----------------------- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 278 lndvQVFrelglkeivsvnhygkisenggnyanLSIDNARKKIiddLKNNDYVekeetilhripmcerskspveivpmqd 357
Cdd:cd00818 152 ----QWF--------------------------IRVTKIKDRL---LEANDKV--------------------------- 171
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 358 yyikqleflpklrefsstlKFYPEAHRQILFNWLDSvAIDWPVSRRRFYGTEIPIWYCDNCKEPIlpepgkyyrpwkdka 437
Cdd:cd00818 172 -------------------NWIPEWVKNRFGNWLEN-RRDWCISRQRYWGTPIPVWYCEDCGEVL--------------- 216
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 438 pvdkCVKCgfdkftgdERTFDTWMDSSISPLFITKYNRDEDFFVKTFPTQIRPQAKDIVRTWlYYTMLRCYQLTENLA-W 516
Cdd:cd00818 217 ----VRRV--------PDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGW-FYSLLLLSTALFGKApY 283
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 262089308 517 SEVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQDFR 570
Cdd:cd00818 284 KNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLR 337
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
610-731 |
3.38e-29 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 113.27 E-value: 3.38e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 610 DKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYNDNDSDsrnSALYALHKCFSVILLLLAP 689
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 262089308 690 ICPFITDKLWTtiydKESIHLNKLP----DENNDYEDMRKYTKDII 731
Cdd:pfam08264 78 FMPFITEELWQ----KESIHLAPWPedaeLEEAELEEAFELRQEIV 119
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
11-699 |
8.22e-29 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 123.92 E-value: 8.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 11 NSNI---ENEVSKKWDEgrIYDFKVSD-----KNNFVIDTPPPYPSGRPwhigaaaHYAQI------DMIARTARMFGKN 76
Cdd:PTZ00427 71 NPNIveeEEKVLKYWKS--IDAFNTSNklaknKKAYIFYDGPPFATGLP-------HYGHLlagiikDCVTRYFYQCGFS 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 77 VFFPIGIDRNGLPVEIYTEKKHKIrmrqTHREEFLNL--------CRISLDDLEKEMIQIMKSIGLSANFEEYYRTDSIE 148
Cdd:PTZ00427 142 VERKFGWDCHGLPIEYEIEKENNI----NKKEDILKMgidvynekCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKT 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 149 YRTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAEITYEEKKT-----ILVYL----------------------- 200
Cdd:PTZ00427 218 FMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTpdpsiIISFVlcsdfpkveeecnieedkqllge 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 201 KFKL----KNENGY-----------------LIVATTRPELIFACQCIIVNPSDS--RYENLHNNEVIL----------- 246
Cdd:PTZ00427 298 KYSVlynnKRENSNngnnnstnnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTylRIHHVKSNRVVIvgecrlewimk 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 247 --------------------------PIFN----------REVKILPHHSAKSDFGSGAVMVC-SYGDlNDVQVFRELGL 289
Cdd:PTZ00427 378 elkwnvedlkivnrfkgkelkglrykPLFTnfyekynfkeRAYKILADDFVTDDAGTGIVHCApTYGE-DDFRVCKKNGV 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 290 KE------IVSVNHYGKISENGGNYANLSIDNARKKIIDDLKNNDYVEKEETILHRIPMCERSKSPVEIVPMQDYYIKQL 363
Cdd:PTZ00427 457 IDpeknifIDPLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVS 536
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 364 EFLPKLREFSSTLKFYPEAHRQILF-NWLdSVAIDWPVSRRRFYGTEIPIWyCDN------CKEPI--------LPEPGK 428
Cdd:PTZ00427 537 NSTNELVKNNETTYWIPAHIKEKKFhNWI-KDAKDWCISRNRYWGTPIPIW-ADEkmetviCVESIkhleelsgVKNIND 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 429 YYRPWKDKAPVDKCVKCGFDKFTGDERTFDTWMDSSISPLFITKY--NRDEDFFVKTFPTQIRPQAKDIVRTWLYYTMLR 506
Cdd:PTZ00427 615 LHRHFIDHIEIKNPKGKTYPKLKRIPEVFDCWFESGSMPYAKVHYpfSTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVI 694
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 507 CYQLTENLAWSEVWIMGYGVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATE-ANHGQDFRCSEQKIVEAQK-FLT 584
Cdd:PTZ00427 695 STLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSvAVRAENLKFQEKGVNEVVKsFIL 774
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 585 KLWNIGRFVSS--------------FEFIPSHESDLLpSDKWILAELSNLITEC---MRGYKEYNFFipaSHIREFTWNI 647
Cdd:PTZ00427 775 PFYHSFRFFSQevtryeclnkkqflFNTDYIYKNDNI-MDQWIFSSVQSLTKSVhteMKAYKLYNVL---PKLLQFIENL 850
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|..
gi 262089308 648 fASHYLELVKSRAYNDNDSDSRNSALYALHKCFSVILLLLAPICPFITDKLW 699
Cdd:PTZ00427 851 -TNWYIRLNRDRMRGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIY 901
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
36-700 |
5.25e-24 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 106.74 E-value: 5.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 36 NNFVIDTPPPYPSGRPwHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIyTEKKHKI-------RMRQTHRE 108
Cdd:COG0143 1 KKFLVTTAIPYANGPP-HIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIEL-AAEKEGItpqelvdRIHAEFKE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 109 EFlNLCRISLDDlekemiqimksiglsanfeeYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADaei 188
Cdd:COG0143 79 LF-EKLGISFDN--------------------FIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPD--- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 189 TYEEKKtilvylkfklknengylivattrpelifaCqciivnpsdsryenlhnnevilpifnrevkilPHhsaksdfgsg 268
Cdd:COG0143 135 RYVEGT-----------------------------C--------------------------------PK---------- 143
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 269 avmvCSYGDlndvqvfrelglkeivsvnHYGKISENGGNYANLSidnarkkiidDLKNndyvekeetilhriPMCERSKS 348
Cdd:COG0143 144 ----CGAED-------------------AYGDQCENCGATLEPT----------ELIN--------------PRSAISGA 176
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 349 PVEIVPMQDYYIKQLEFLPKLREFSSTLK-FYPEAHRQILfNWLDSVAIDWPVSRRRFYGTEIPIWycdnckepilpePG 427
Cdd:COG0143 177 PPELREEEHYFFRLSKYQDRLLEWIEENPdIQPEVRNEVL-SWLKEGLQDLSISRDFDWGIPVPGD------------PG 243
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 428 KYYRPWKDkAPV-----------DKCVKCGFDKFtgdertfdtWMDSSISPL-FItkynrdedffvktfptqirpqAKDI 495
Cdd:COG0143 244 KVFYVWFD-ALIgyisatkgyadDRGLPEDFEKY---------WPAPDTELVhFI---------------------GKDI 292
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 496 VRtwlYYT-----MLRC--YQLTENLAWSEVWIMGygvdeyGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQD 568
Cdd:COG0143 293 IR---FHAiiwpaMLMAagLPLPKKVFAHGFLTVE------GEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQD 363
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 569 FRCSEQKIVE------AQKFltklwniGRFVSS--------FEFIPSHESDLLPSDKWILAELSNLITECMRGYKEYNFf 634
Cdd:COG0143 364 GDFSWEDFVArvnsdlANDL-------GNLASRtlsmihkyFDGKVPEPGELTEADEELLAEAEAALEEVAEAMEAFEF- 435
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262089308 635 ipASHIREfTWNI--FASHYLE------LVKsraynDNDSDSRNSALYALHKCFSVILLLLAPICPFITDKLWT 700
Cdd:COG0143 436 --RKALEE-IMALarAANKYIDetapwkLAK-----DEDPERLATVLYTLLEALRILAILLKPFLPETAEKILE 501
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
14-720 |
4.45e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 95.66 E-value: 4.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 14 IENEVSKKWDEGRIY----DFKVSDKNNFVIDTPPpYPSGRPWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLP 89
Cdd:PLN02563 85 IEPKWQRYWEENRTFrtpdDVDTSKPKFYVLDMFP-YPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 90 VEIY---TEKKHKIrmrQTHReeflNLCRISLDdlekemiqiMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLV 166
Cdd:PLN02563 164 AEQYaieTGTHPKI---TTLK----NIARFRSQ---------LKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLA 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 167 YSSNRPNNYCPSCGTTIADAE------------------------IT-YEEK-----------------------KTILV 198
Cdd:PLN02563 228 YQAEVPVNWCPALGTVLANEEvvdglsergghpvirkpmrqwmlkITaYADRlledlddldwpesikemqrnwigRSEGA 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 199 YLKFKLKNENGY-----LIVATTRPELIFACQCIIVNP----------------------SDSRYENLHNNEV------- 244
Cdd:PLN02563 308 ELDFSVLDGEGKerdekITVYTTRPDTLFGATYLVVAPehpllsslttaeqkeaveeyvdAASRKSDLERTELqkektgv 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 245 ------ILPIFNREVKILPHHSAKSDFGSGAVMVCSYGDLNDVQVFRELGL--KEIVSVNH------------YGKI--- 301
Cdd:PLN02563 388 ftgsyaINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLpiKWVVKPADgneddaekaytgEGVIvns 467
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 302 SENGGNYANLSIDNARKKIIDDLKNNDYVEKEETILHRIPMCERSK---SPVEIVPMQDY----YIKQLEF---LPKLRE 371
Cdd:PLN02563 468 SSSGLDINGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRywgEPIPVVFLEDSgepvPVPESDLpltLPELDD 547
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 372 FSSTLKfyPEAHRQILFNWLDSV-AIDWPVSRRRfyGTEIPIW---------YCD--NCKEPILPEPGKYYRP------- 432
Cdd:PLN02563 548 FTPTGT--GEPPLAKAVSWVNTVdPSSGKPARRE--TNTMPQWagscwyylrFMDpkNSNALVDKEKEKYWMPvdlyvgg 623
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 433 -------------W----------KDKAPVDKCVKCGFdkFTGdERTFDTWMDSSisplfiTKYNRDEDFFVKTFPTQIR 489
Cdd:PLN02563 624 aehavlhllyarfWhkvlydigvvSTKEPFQCLVNQGM--ILG-EVEYTAFKDSD------GEYVSADTADRLGELQQEK 694
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 490 PQAKDIVRTWLYYTMlrcyQLTENLAwsevwimgygVDEYGEKMSKSKGNVIDPFPIITKHGADTFRFWsatEANHG--Q 567
Cdd:PLN02563 695 IPEEKVIKSGDSFVL----KDDPSIR----------LIARAHKMSKSRGNVVNPDDVVSEYGADSLRLY---EMFMGplR 757
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 568 DFRCSEQKIVEA-QKFLTKLWNIgrFVSSFEFIPSHESDLLPSDKWILAELSNLITECMRGYKEynffipasHIREFTWN 646
Cdd:PLN02563 758 DSKTWSTSGVEGvHRFLGRTWRL--VVGAPLPDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTE--------EIESTRFN 827
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262089308 647 IFASHYLELVKsrAYNDNDSDSRnSALYALhkcfsviLLLLAPICPFITDKLWTTIYDKESIHLNKLPDENNDY 720
Cdd:PLN02563 828 TAISAMMEFTN--AAYKWDKVPR-EAIEPF-------VLLLSPYAPHLAEELWFRLGHSNSLAYEPWPEANPSY 891
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
572-722 |
4.98e-20 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 88.38 E-value: 4.98e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 572 SEQKIVEAQK-FLTKLWNIGRF----VSSFEFIPSHESDLLPS----DKWILAELSNLI---TECMRGYKEYNFfipASH 639
Cdd:cd07961 2 SEKGVREVVRkVLLPLWNAYRFfvtyANLDGFDPGKDDDAVASlnvlDRWILSRLNSLIkevTEEMEAYDLYTA---VRA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 640 IREFT-----WnifashYLELVKSRAYNDNDSDSRNSALYALHKCFSVILLLLAPICPFITDKLWTT-----IYDKESIH 709
Cdd:cd07961 79 LLEFIdeltnW------YIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNlrrelGDAPESVH 152
|
170
....*....|...
gi 262089308 710 LNKLPDENNDYED 722
Cdd:cd07961 153 LLDWPEVDESLID 165
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
38-578 |
9.56e-19 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 88.89 E-value: 9.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 38 FVIDTPPPYPSGRPwHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIyTEKKHKI-------RMRQTHREEF 110
Cdd:pfam09334 1 ILVTTALPYANGPP-HLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIEL-KAEKEGItpeelvdRYHEIHREDF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 111 LNlCRISLDDlekemiqimksiglsanfeeYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIADAEITy 190
Cdd:pfam09334 79 KK-FNISFDD--------------------YGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 191 eekktilvylkfklknengylivattrpelifacqciivnpsdsryenlhnnevilpifnrevkilphhsaksdfgsGAV 270
Cdd:pfam09334 137 -----------------------------------------------------------------------------GTC 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 271 MVCSYGDlndvqvfrelglkeivsvnHYGKISENGGnyANLSidnarkkiIDDLKNndyvekeetilhriPMCERSKSPV 350
Cdd:pfam09334 140 PHCGSED-------------------ARGDQCENCG--RHLE--------PTELIN--------------PKCVICGTTP 176
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 351 EIVPMQDYYIKQLEFLPKLREF-SSTLKFYPEAHRQILFNWLDSVAIDWPVSRRRFYGTEIPiwycdnckepilPEPGKY 429
Cdd:pfam09334 177 EVKETEHYFFDLSKFQDKLREWiEENNPEWPENVKNMVLEWLKEGLKDRAISRDLDWGIPVP------------GAEGKV 244
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 430 YRPWKDkAPVDKCvkCGFDKFTGDERTFDT-WMDSSISPL--FItkynrdedffvktfptqirpqAKDIVR--TWLYYTM 504
Cdd:pfam09334 245 FYVWLD-APIGYI--SATKELSGNEEKWKEwWPNDPDTELvhFI---------------------GKDIIYfhTIFWPAM 300
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262089308 505 LRCYQLT--ENLAWSEVWIMgygvdeYGEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQDFRCSEQKIVE 578
Cdd:pfam09334 301 LLGAGYRlpTTVFAHGYLTY------EGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWEDFVE 370
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
38-176 |
2.21e-18 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 86.92 E-value: 2.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 38 FVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKkhkirmRQTHREEFlnlcris 117
Cdd:cd00812 2 FYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK------IGRDPEDW------- 67
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 262089308 118 LDDLEKEMIQIMKSIGLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYC 176
Cdd:cd00812 68 TEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
604-722 |
6.01e-18 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 82.19 E-value: 6.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 604 SDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIFASHYLELVKSRAYNDN-DSDSRNSALYALHKCFSV 682
Cdd:cd07960 40 EELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDIIKDRLYCDAkDSLERRSAQTVLYHILDA 119
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 262089308 683 ILLLLAPICPFITDKLWTTIYDK---ESIHLNKLPDENNDYED 722
Cdd:cd07960 120 LLKLLAPILPFTAEEVWEHLPGEkkeESVFLEDWPELPEEWKD 162
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
530-700 |
1.87e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 76.84 E-value: 1.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 530 GEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQDFRCSEQKIVE------AqkfltklWNIGRFVS--------S 595
Cdd:PRK11893 297 GEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINrinadlA-------NDLGNLAQrtlsmiakN 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 596 FEFIPSHESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTwnIFASHYLELVKSRAYNDNDSDSRNSALYA 675
Cdd:PRK11893 370 FDGKVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYIDEQAPWSLAKTDPERLATVLYT 447
|
170 180
....*....|....*....|....*
gi 262089308 676 LHKCFSVILLLLAPICPFITDKLWT 700
Cdd:PRK11893 448 LLEVLRGIAVLLQPVMPELAAKILD 472
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
37-192 |
7.88e-14 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 73.33 E-value: 7.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 37 NFVIDTPPPYPSGRPwHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKKHKirmrqTHREeflnLCri 116
Cdd:cd00814 1 KVLITTALPYVNGVP-HLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGV-----TPQE----LC-- 68
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262089308 117 slDDLEKEMIQIMKSIGLSanFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIadAEITYEE 192
Cdd:cd00814 69 --DKYHEIFKDLFKWLNIS--FDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFL--PEWREEE 138
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
318-568 |
1.11e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 69.87 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 318 KKIIDDLKNNDYVEKEETILHRIPMCERSKSpvEIVPMQDYYIKQLEFLPKLREF--SSTLKFYPEAHRQILFNWLDSVA 395
Cdd:cd00814 102 QEFFKKLYENGYIYEGEYEGLYCVSCERFLP--EWREEEHYFFRLSKFQDRLLEWleKNPDFIWPENARNEVLSWLKEGL 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 396 IDWPVSRRRFY-GTEIPIwycdnckepilpEPGKyyrpwkdkapvdkcvkcgfdkftgderTFDTWMDSSISPLFITKY- 473
Cdd:cd00814 180 KDLSITRDLFDwGIPVPL------------DPGK---------------------------VIYVWFDALIGYISATGYy 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 474 ---NRDEDFFVKTFPTQIRPQAKDIVR--TWLYYTMLRCYQLT--ENLAWSEVWIMgygvdeYGEKMSKSKGNVIDPFPI 546
Cdd:cd00814 221 neeWGNSWWWKDGWPELVHFIGKDIIRfhAIYWPAMLLGAGLPlpTRIVAHGYLTV------EGKKMSKSRGNVVDPDDL 294
|
250 260
....*....|....*....|..
gi 262089308 547 ITKHGADTFRFWSATEANHGQD 568
Cdd:cd00814 295 LERYGADALRYYLLRERPEGKD 316
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
530-568 |
7.82e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 55.96 E-value: 7.82e-08
10 20 30
....*....|....*....|....*....|....*....
gi 262089308 530 GEKMSKSKGNVIDPFPIITKHGADTFRFWSATEANHGQD 568
Cdd:PRK12267 297 DGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSD 335
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
45-185 |
1.04e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 55.54 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 45 PYPSGrPWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIyTEKKHKI-------RMRQTHREEFlnlcris 117
Cdd:PRK00133 11 PYANG-PIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIML-KAEKEGItpeeliaRYHAEHKRDF------- 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262089308 118 lddlekemiqimKSIGLSanFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYCPSCGTTIAD 185
Cdd:PRK00133 82 ------------AGFGIS--FDNYGSTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLPD 135
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
33-99 |
2.14e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 51.34 E-value: 2.14e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262089308 33 SDKNNFVIDTPPPYPSGRPwHIGAAahYAQI--DMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKKHK 99
Cdd:PRK12267 1 MMKKTFYITTPIYYPNGKP-HIGHA--YTTIaaDALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGK 66
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
573-690 |
3.02e-06 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 46.73 E-value: 3.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 573 EQKIVEAQKFLTKLWNIGRFVSSFEFIPSHESD---LLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTWNIfa 649
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGGTQPKWDnelLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-- 78
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 262089308 650 SHYLELVKSRAYNDNDsdsRNSALYALHKCFSVILLLLAPI 690
Cdd:cd07375 79 NWYLDELKPALQTEEL---REAVLAVLRAALVVLTKLLAPF 116
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
579-702 |
5.13e-06 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 46.04 E-value: 5.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 579 AQKFLTKLWNIGRFVSSFEFIPSHESDLlpsDKWILAELSNLITECMRGYKEYNFfipashiREFTWNIF------ASHY 652
Cdd:cd07959 9 AILRLERFYELAEELIETEGELEELTFI---DRWLLSRLNRLIKETTEAYENMQF-------REALKEGLyelqndLDWY 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 262089308 653 LELVKSRAYNDndsdsrnsalyALHKCFSVILLLLAPICPFITDKLWTTI 702
Cdd:cd07959 79 RERGGAGMNKD-----------LLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
420-578 |
5.83e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 46.63 E-value: 5.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 420 EPILPEPGKYYRPWKDKAPVDKCVKCGFDKFT--------------GDERTFDTWMDSSISPL-FITKYNRDEDFFVKT- 483
Cdd:PLN02224 238 EDILAQNPRFVQPSYRLNEVQSWIKSGLRDFSisralvdwgipvpdDDKQTIYVWFDALLGYIsALTEDNKQQNLETAVs 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 484 --FPTQIRPQAKDIVRTWLYY--TMLrcyqLTENLAWSEVwIMGYG-VDEYGEKMSKSKGNVIDPFPIITKHGADTFRFW 558
Cdd:PLN02224 318 fgWPASLHLIGKDILRFHAVYwpAML----MSAGLELPKM-VFGHGfLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYF 392
|
170 180
....*....|....*....|
gi 262089308 559 SATEANHGQDFRCSEQKIVE 578
Cdd:PLN02224 393 FLREVEFGNDGDYSEDRFIK 412
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
530-588 |
1.34e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 45.09 E-value: 1.34e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262089308 530 GEKMSKSKGNVIDPFPIITKHGADTFRFW--SAteanH---GQDFrcSEQKIVEAQKFLTKLWN 588
Cdd:COG0215 263 GEKMSKSLGNFFTVRDLLKKYDPEVLRFFllSA----HyrsPLDF--SEEALEEAEKALERLYN 320
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
32-179 |
1.92e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 44.70 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 32 VSDKNNFVIDTPPPYPSGRPwHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNGLPVEIYTEKKHKirmrqtHREEFL 111
Cdd:PLN02224 65 VDEADTFVLTTPLYYVNAPP-HMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGR------NPPEHC 137
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262089308 112 NLCRISLDDLEKEmiqimksigLSANFEEYYRTDSIEYRTLTQSTFLYLWKKGLVYSSNRPNNYCPSC 179
Cdd:PLN02224 138 DIISQSYRTLWKD---------LDIAYDKFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNC 196
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
572-702 |
4.62e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 40.67 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 572 SEQKIVEAQKFLTKLWNIGRFVSSFEFIPSHESDLLPSDKWILAELSNLITECMRGYKEYNFFIPASHIREFTwNifash 651
Cdd:cd07958 2 SDSGVEGAYRFLNRVWRLVTELAEALAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELV-N----- 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 262089308 652 ylELVKSRAYNDNDSDsrnsalyALHKCFSVILLLLAPICPFITDKLWTTI 702
Cdd:cd07958 76 --ALYKYKKKDAQHAA-------VLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
13-90 |
1.42e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 42.36 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262089308 13 NIENEVSKKWDEGRIYDFKVSDK-----NNFVIDTPPPYPSGRpWHIGAAAHYAQIDMIARTARMFGKNVFFPIGIDRNG 87
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAEAGDEppkpgEKFFGNFPYPYMNGL-LHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTG 95
|
...
gi 262089308 88 LPV 90
Cdd:PLN02959 96 MPI 98
|
|
| |
