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Conserved domains on  [gi|262076594|gb|ACY12567|]
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Intercellular adhesion protein R [Staphylococcus aureus subsp. aureus ED98]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_37 super family cl39982
Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor ...
 72-182 1.54e-30

Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.


The actual alignment was detected with superfamily member pfam18665:

Pssm-ID: 408446  Cd Length: 117  Bit Score: 107.75  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262076594   72 YSIDALYQFL-------FEFIFDIEERYIrmYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMT-KEDFQN 143
Cdd:pfam18665   1 YSIDDLYQFIerlfsrkWNLLFDDGVFYS--CYALVFREKAIKSKYKKILDSLRETLSDILKECNDEGLIKLKnPDDTAN 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 262076594  144 LILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNI 182
Cdd:pfam18665  79 LIFVLLDGAYYYLSLEEDKEAYEERLNQYKDQAYSLLGI 117
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
2-104 3.47e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 74.55  E-value: 3.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYS--IDALYQ 79
Cdd:COG1309    8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRerLRALLR 87

                         90       100
                 ....*....|....*....|....*
gi 262076594  80 FLFEFIFDIEERYIRMYVQLSNTPE 104
Cdd:COG1309   88 AYLEFLAENPALARLLLAEAAELPE 112
 
Name Accession Description Interval E-value
TetR_C_37 pfam18665
Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor ...
 72-182 1.54e-30

Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.


Pssm-ID: 408446  Cd Length: 117  Bit Score: 107.75  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262076594   72 YSIDALYQFL-------FEFIFDIEERYIrmYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMT-KEDFQN 143
Cdd:pfam18665   1 YSIDDLYQFIerlfsrkWNLLFDDGVFYS--CYALVFREKAIKSKYKKILDSLRETLSDILKECNDEGLIKLKnPDDTAN 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 262076594  144 LILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNI 182
Cdd:pfam18665  79 LIFVLLDGAYYYLSLEEDKEAYEERLNQYKDQAYSLLGI 117
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
2-104 3.47e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 74.55  E-value: 3.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYS--IDALYQ 79
Cdd:COG1309    8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRerLRALLR 87

                         90       100
                 ....*....|....*....|....*
gi 262076594  80 FLFEFIFDIEERYIRMYVQLSNTPE 104
Cdd:COG1309   88 AYLEFLAENPALARLLLAEAAELPE 112
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
5-49 1.40e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 62.04  E-value: 1.40e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 262076594    5 IIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYE 49
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 2-50 8.02e-10

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 55.61  E-value: 8.02e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQ 50
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEY 49
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
5-44 8.38e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 52.60  E-value: 8.38e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 262076594   5 IIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSK 44
Cdd:NF041196  11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSK 50
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 5-48 4.91e-07

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 47.81  E-value: 4.91e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 262076594   5 IIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIY 48
Cdd:PRK09975  16 LIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLF 59
 
Name Accession Description Interval E-value
TetR_C_37 pfam18665
Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor ...
 72-182 1.54e-30

Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.


Pssm-ID: 408446  Cd Length: 117  Bit Score: 107.75  E-value: 1.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262076594   72 YSIDALYQFL-------FEFIFDIEERYIrmYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMT-KEDFQN 143
Cdd:pfam18665   1 YSIDDLYQFIerlfsrkWNLLFDDGVFYS--CYALVFREKAIKSKYKKILDSLRETLSDILKECNDEGLIKLKnPDDTAN 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 262076594  144 LILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNI 182
Cdd:pfam18665  79 LIFVLLDGAYYYLSLEEDKEAYEERLNQYKDQAYSLLGI 117
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
2-104 3.47e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 74.55  E-value: 3.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYS--IDALYQ 79
Cdd:COG1309    8 RERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRerLRALLR 87

                         90       100
                 ....*....|....*....|....*
gi 262076594  80 FLFEFIFDIEERYIRMYVQLSNTPE 104
Cdd:COG1309   88 AYLEFLAENPALARLLLAEAAELPE 112
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
5-49 1.40e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 62.04  E-value: 1.40e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 262076594    5 IIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYE 49
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLE 45
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 2-50 8.02e-10

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 55.61  E-value: 8.02e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQ 50
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQGLLEY 49
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
5-44 8.38e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 52.60  E-value: 8.38e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 262076594   5 IIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSK 44
Cdd:NF041196  11 ILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSK 50
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 5-48 4.91e-07

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 47.81  E-value: 4.91e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 262076594   5 IIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIY 48
Cdd:PRK09975  16 LIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLF 59
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 5-51 6.66e-06

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 44.61  E-value: 6.66e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 262076594   5 IIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSK----KSIYEQS 51
Cdd:PRK10668  16 ILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKsdlfSEIWELS 66
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 2-48 4.37e-05

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 42.61  E-value: 4.37e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIY 48
Cdd:PRK15008  20 KKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALY 66
PRK13756 PRK13756
TetR family transcriptional regulator;
2-47 6.81e-05

TetR family transcriptional regulator;


Pssm-ID: 172294 [Multi-domain]  Cd Length: 205  Bit Score: 41.80  E-value: 6.81e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSI 47
Cdd:PRK13756   6 KEKVIDSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRAL 51
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 2-48 3.65e-03

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 36.95  E-value: 3.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 262076594   2 KDKIIDNAITLFSEKGYDGTTlDDIAKSVNIKKASLYYHFDSKKSIY 48
Cdd:PRK11552  15 KQQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLY 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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