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Conserved domains on  [gi|262072996|ref|NP_081337|]
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zona pellucida-binding protein 2 isoform 1 precursor [Mus musculus]

Protein Classification

Sp38 domain-containing protein( domain architecture ID 10538336)

Sp38 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sp38 pfam07354
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 149-326 2.31e-110

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


:

Pssm-ID: 336682  Cd Length: 177  Bit Score: 318.35  E-value: 2.31e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262072996  149 FTTGSCVGRHNDLLFRVLKKILDNLISDLLCHVIEPSYKCHFVKLPERDFLYELFIAFQVNPFAPGWRSLCNRSADCEDI 228
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPGWKDLCNRSLDCEDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262072996  229 TNHNVLKARDRMEEFFRKQAHILHHHFNrTVPAMHFVDHSFQVTRIDNCRPGFGKNEGLHSNCATCCVVCSPGTFSPDVD 308
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFE-TLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVVCSPGTYSPDSG 159

                         170
                  ....*....|....*...
gi 262072996  309 VTCQICVSVHIYGAKACP 326
Cdd:pfam07354 160 IHCLQCVSSLTYGAKSCP 177
 
Name Accession Description Interval E-value
Sp38 pfam07354
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 149-326 2.31e-110

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


Pssm-ID: 336682  Cd Length: 177  Bit Score: 318.35  E-value: 2.31e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262072996  149 FTTGSCVGRHNDLLFRVLKKILDNLISDLLCHVIEPSYKCHFVKLPERDFLYELFIAFQVNPFAPGWRSLCNRSADCEDI 228
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPGWKDLCNRSLDCEDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262072996  229 TNHNVLKARDRMEEFFRKQAHILHHHFNrTVPAMHFVDHSFQVTRIDNCRPGFGKNEGLHSNCATCCVVCSPGTFSPDVD 308
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFE-TLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVVCSPGTYSPDSG 159

                         170
                  ....*....|....*...
gi 262072996  309 VTCQICVSVHIYGAKACP 326
Cdd:pfam07354 160 IHCLQCVSSLTYGAKSCP 177
TNFRSF1B cd10577
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2; TNFRSF1B ...
 277-321 4.50e-03

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2; TNFRSF1B (also known as TNFR2, type 2 TNFR, TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b) binds TNF-alpha, but lacks the death domain (DD) that is associated with the cytoplasmic domain of TNFRSF1A (TNFR1). It is inducible and expressed exclusively by oligodendrocytes, astrocytes, T cells, thymocytes, myocytes, endothelial cells, and in human mesenchymal stem cells. TNFRSF1B protects oligodendrocyte progenitor cells (OLGs) against oxidative stress, and induces the up-regulation of cell survival genes. While pro-inflammatory and pathogen-clearing activities of TNF are mediated mainly through activation of TNFRSF1A, a strong activator of NF-kappaB, TNFRSF1B is more responsible for suppression of inflammation. Although the affinities of both receptors for soluble TNF are similar, TNFRSF1B is sometimes more abundantly expressed and thought to associate with TNF, thereby increasing its concentration near TNFRSF1A receptors, and making TNF available to activate TNFRSF1A (a ligand-passing mechanism).


Pssm-ID: 276903 [Multi-domain]  Cd Length: 163  Bit Score: 37.45  E-value: 4.50e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 262072996 277 CRPGFGKNEGLHSNCATCCVVCSPGTFSPDV--DVTC---QICVSVHIYG 321
Cdd:cd10577  105 CGPGFGVARPGTASSDVECKPCAPGTFSDTTssTDTCrphRICSSVAIPG 154
 
Name Accession Description Interval E-value
Sp38 pfam07354
Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding ...
 149-326 2.31e-110

Zona-pellucida-binding protein (Sp38); This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilization to occur.


Pssm-ID: 336682  Cd Length: 177  Bit Score: 318.35  E-value: 2.31e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262072996  149 FTTGSCVGRHNDLLFRVLKKILDNLISDLLCHVIEPSYKCHFVKLPERDFLYELFIAFQVNPFAPGWRSLCNRSADCEDI 228
Cdd:pfam07354   1 FTAAPCNSRYNDSFFRELKKILSKLISDLSCEVSLPSYECHSVKMPRRGLQSELFFTFQVNPFAPGWKDLCNRSLDCEDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262072996  229 TNHNVLKARDRMEEFFRKQAHILHHHFNrTVPAMHFVDHSFQVTRIDNCRPGFGKNEGLHSNCATCCVVCSPGTFSPDVD 308
Cdd:pfam07354  81 TNHRLLKAKDRIERFFRSQVYILKHQFE-TLPEIHYVEGSLQVVWIDRCRPGFGKNEILHPNCAECCVVCSPGTYSPDSG 159

                         170
                  ....*....|....*...
gi 262072996  309 VTCQICVSVHIYGAKACP 326
Cdd:pfam07354 160 IHCLQCVSSLTYGAKSCP 177
TNFRSF1B cd10577
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2; TNFRSF1B ...
 277-321 4.50e-03

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2; TNFRSF1B (also known as TNFR2, type 2 TNFR, TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b) binds TNF-alpha, but lacks the death domain (DD) that is associated with the cytoplasmic domain of TNFRSF1A (TNFR1). It is inducible and expressed exclusively by oligodendrocytes, astrocytes, T cells, thymocytes, myocytes, endothelial cells, and in human mesenchymal stem cells. TNFRSF1B protects oligodendrocyte progenitor cells (OLGs) against oxidative stress, and induces the up-regulation of cell survival genes. While pro-inflammatory and pathogen-clearing activities of TNF are mediated mainly through activation of TNFRSF1A, a strong activator of NF-kappaB, TNFRSF1B is more responsible for suppression of inflammation. Although the affinities of both receptors for soluble TNF are similar, TNFRSF1B is sometimes more abundantly expressed and thought to associate with TNF, thereby increasing its concentration near TNFRSF1A receptors, and making TNF available to activate TNFRSF1A (a ligand-passing mechanism).


Pssm-ID: 276903 [Multi-domain]  Cd Length: 163  Bit Score: 37.45  E-value: 4.50e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 262072996 277 CRPGFGKNEGLHSNCATCCVVCSPGTFSPDV--DVTC---QICVSVHIYG 321
Cdd:cd10577  105 CGPGFGVARPGTASSDVECKPCAPGTFSDTTssTDTCrphRICSSVAIPG 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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