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Conserved domains on  [gi|261878481|ref|NP_001159773|]
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probable ATP-dependent RNA helicase DHX40 isoform 2 [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
65-647 1.83e-116

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 369.02  E-value: 1.83e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  65 AETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAF 144
Cdd:COG1643   99 AATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 145 FGNCPIFDIPGRLYPVREKFCnligPRDRENTAYIQAIVKVTMDIhLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdy 224
Cdd:COG1643  175 LGDAPVIESSGRTYPVEVRYR----PLPADERDLEDAVADAVREA-LAEEPGDILVFLPGEREIRRTAEAL--------- 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 225 dydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILE 304
Cdd:COG1643  241 ----RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLP 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 305 VVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLIL 384
Cdd:COG1643  317 TERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIA 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 385 EALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSvenvfirpvdpeyqkeaEQRHR 464
Cdd:COG1643  396 DARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLS-----------------ERDPR 458

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 465 ELAAKAggfnDFATLAVIFEQCKSsgapaswCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQsdfpketfEGPKHEVLRR 544
Cdd:COG1643  459 RGAAGS----DLLARLNLWRRLRE-------QQREFLSYLRLREWRDLARQLRRLLGEGANE--------EPADYEAIGL 519

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 545 CLCAGYFKNVA-RRSVGRTFCTMDGRGspVHIHPSSALHeqetKLEWIIFHEvLVTTKVYARI--VCPIRYEWVRDLLPK 621
Cdd:COG1643  520 LLALAYPDRIArRRGEGGRYLLARGRG--AALFPGSPLA----KKEWLVAAE-LVGGAAEARIrlAAPIDPEWLEELAAH 592

                        570       580
                 ....*....|....*....|....*...
gi 261878481 622 L--HEFNAHdlSSVARREVRedARRRWT 647
Cdd:COG1643  593 LikRYSEPH--WDKKRGRVV--ARERVR 616
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
65-647 1.83e-116

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 369.02  E-value: 1.83e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  65 AETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAF 144
Cdd:COG1643   99 AATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 145 FGNCPIFDIPGRLYPVREKFCnligPRDRENTAYIQAIVKVTMDIhLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdy 224
Cdd:COG1643  175 LGDAPVIESSGRTYPVEVRYR----PLPADERDLEDAVADAVREA-LAEEPGDILVFLPGEREIRRTAEAL--------- 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 225 dydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILE 304
Cdd:COG1643  241 ----RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLP 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 305 VVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLIL 384
Cdd:COG1643  317 TERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIA 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 385 EALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSvenvfirpvdpeyqkeaEQRHR 464
Cdd:COG1643  396 DARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLS-----------------ERDPR 458

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 465 ELAAKAggfnDFATLAVIFEQCKSsgapaswCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQsdfpketfEGPKHEVLRR 544
Cdd:COG1643  459 RGAAGS----DLLARLNLWRRLRE-------QQREFLSYLRLREWRDLARQLRRLLGEGANE--------EPADYEAIGL 519

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 545 CLCAGYFKNVA-RRSVGRTFCTMDGRGspVHIHPSSALHeqetKLEWIIFHEvLVTTKVYARI--VCPIRYEWVRDLLPK 621
Cdd:COG1643  520 LLALAYPDRIArRRGEGGRYLLARGRG--AALFPGSPLA----KKEWLVAAE-LVGGAAEARIrlAAPIDPEWLEELAAH 592

                        570       580
                 ....*....|....*....|....*...
gi 261878481 622 L--HEFNAHdlSSVARREVRedARRRWT 647
Cdd:COG1643  593 LikRYSEPH--WDKKRGRVV--ARERVR 616
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 25-628 1.35e-85

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 293.60  E-value: 1.35e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481    25 QEERLSAVCIADR--EEKGctsQEGGTTPTFPIQKQRKkiIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 102
Cdd:TIGR01967  118 QPRRLAARTVAQRiaEELG---TPLGEKVGYKVRFHDQ--VSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERS 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   103 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAI 182
Cdd:TIGR01967  193 LNIDFLLGYLKQLLP-----RRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPLVEEQEDDDLDQLEAI 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   183 VKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPgiR 262
Cdd:TIGR01967  268 LD-AVDELFAEGPGDILIFLPGEREIRDAAEIL-------------RKRNLRHTEILPLYARLSNKEQQRVFQPHSG--R 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   263 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMP 342
Cdd:TIGR01967  332 RIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS-RP 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   343 DHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDR---SGHVTRLGLSMVEFPLPPHLT 419
Cdd:TIGR01967  411 EFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDdeaEPQLTPIGRQLAQLPVDPRLA 490

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   420 CAVIKAASLDCEDLLLPIAAMLSVENVFIRPvdPEYQKEAEQRHRELAAKAGGFNDFATLAVIFE---QCKSSGAPASWC 496
Cdd:TIGR01967  491 RMLLEAHRLGCLQEVLIIASALSIQDPRERP--MEKQQAADQAHARFKDPRSDFLSRVNLWRHIEeqrQALSANQFRNAC 568

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   497 QKHWIH------WRCLFSafrveaQLRELIRKLK-QQSDFPKEtfegpkHEVLRRCLCAGYFKNVARRSVGRTFctmDG- 568
Cdd:TIGR01967  569 RKQYLNylrvreWQDIYR------QLTQVVKELGlKLNEEPAD------YDAIHKALLSGLLSQIGMKDEKHEY---DGa 633

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261878481   569 RGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL---HEFNAH 628
Cdd:TIGR01967  634 RGRKFHIFPGSPLFKKPPK--WVMAAELVETSKLYARLVAKIEPEWVEPVAGHLikkNYFEPH 694
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 25-622 2.82e-76

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 267.31  E-value: 2.82e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   25 QEERLSAVCIADREEKGCTSQEGGTTP---TFPIQkqrkkiIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHER 101
Cdd:PRK11131  125 QPRRLAARTVANRIAEELETELGGCVGykvRFNDQ------VSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHER 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  102 TLTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQA 181
Cdd:PRK11131  199 SLNIDFILGYLKELL----PRRPD-LKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQA 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  182 IVKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMaesvdydyDVQDTTldgllILPCYGSMTTDQQRRIFlpPPPGI 261
Cdd:PRK11131  274 IFD-AVDELGREGPGDILIFMSGEREIRDTADALNKL--------NLRHTE-----ILPLYARLSNSEQNRVF--QSHSG 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  262 RKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSK-DFWNQc 340
Cdd:PRK11131  338 RRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEdDFLSR- 416

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  341 mPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAI--DRSGHVTRL---GLSMVEFPLP 415
Cdd:PRK11131  417 -PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAIttDEQASAYKLtplGRQLAQLPVD 495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  416 PHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPeyQKEAEQRHRELAAKAGGFNDFATL-AVIFEQCK--SSGAP 492
Cdd:PRK11131  496 PRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDK--QQASDEKHRRFADKESDFLAFVNLwNYLQEQQKalSSNQF 573

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  493 ASWCQKHWIHWrclfsaFRVE------AQLRELIRKLkqqsDFPKETFEGPKHEVlRRCLCAGYFKNVARRSVGRTFCTm 566
Cdd:PRK11131  574 RRLCRTDYLNY------LRVRewqdiyTQLRQVVKEL----GIPVNSEPAEYREI-HTALLTGLLSHIGMKDAEKQEYT- 641

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 261878481  567 DGRGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL 622
Cdd:PRK11131  642 GARNARFSIFPGSGLFKKPPK--WVMVAELVETSRLWGRIAARIEPEWIEPLAQHL 695
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 158-332 9.29e-71

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 227.80  E-value: 9.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 158 YPVREKFCNLIGPR-----DRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDydydvqdtt 232
Cdd:cd18791    1 FPVEVYYLEDILELlgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPD--------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 233 LDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSE 312
Cdd:cd18791   72 LGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151

                        170       180
                 ....*....|....*....|
gi 261878481 313 ALQRSGRAGRTSSGKCFRIY 332
Cdd:cd18791  152 AEQRAGRAGRTRPGKCYRLY 171
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 542-622 7.31e-19

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 81.53  E-value: 7.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  542 LRRCLCAGYFKNVARR-SVGRTFCTMDGrGSPVHIHPSSAL-HEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLL 619
Cdd:pfam07717   1 LRAALAAGLYPNVARRdPKGKGYTTLSD-NQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFA 79


                  ...
gi 261878481  620 PKL 622
Cdd:pfam07717  80 PHI 82
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 392-480 3.45e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.54  E-value: 3.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   392 QCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRpvdpEYQKEAEQRHRELAAKAG 471
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK----EKREDADAARRRFADPES 76


                   ....*....
gi 261878481   472 gfnDFATLA 480
Cdd:smart00847  77 ---DHLTLL 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
65-647 1.83e-116

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 369.02  E-value: 1.83e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  65 AETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAF 144
Cdd:COG1643   99 AATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 145 FGNCPIFDIPGRLYPVREKFCnligPRDRENTAYIQAIVKVTMDIhLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdy 224
Cdd:COG1643  175 LGDAPVIESSGRTYPVEVRYR----PLPADERDLEDAVADAVREA-LAEEPGDILVFLPGEREIRRTAEAL--------- 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 225 dydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILE 304
Cdd:COG1643  241 ----RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLP 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 305 VVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLIL 384
Cdd:COG1643  317 TERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIA 395

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 385 EALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSvenvfirpvdpeyqkeaEQRHR 464
Cdd:COG1643  396 DARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLS-----------------ERDPR 458

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 465 ELAAKAggfnDFATLAVIFEQCKSsgapaswCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQsdfpketfEGPKHEVLRR 544
Cdd:COG1643  459 RGAAGS----DLLARLNLWRRLRE-------QQREFLSYLRLREWRDLARQLRRLLGEGANE--------EPADYEAIGL 519

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 545 CLCAGYFKNVA-RRSVGRTFCTMDGRGspVHIHPSSALHeqetKLEWIIFHEvLVTTKVYARI--VCPIRYEWVRDLLPK 621
Cdd:COG1643  520 LLALAYPDRIArRRGEGGRYLLARGRG--AALFPGSPLA----KKEWLVAAE-LVGGAAEARIrlAAPIDPEWLEELAAH 592

                        570       580
                 ....*....|....*....|....*...
gi 261878481 622 L--HEFNAHdlSSVARREVRedARRRWT 647
Cdd:COG1643  593 LikRYSEPH--WDKKRGRVV--ARERVR 616
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 25-628 1.35e-85

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 293.60  E-value: 1.35e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481    25 QEERLSAVCIADR--EEKGctsQEGGTTPTFPIQKQRKkiIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 102
Cdd:TIGR01967  118 QPRRLAARTVAQRiaEELG---TPLGEKVGYKVRFHDQ--VSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERS 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   103 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAI 182
Cdd:TIGR01967  193 LNIDFLLGYLKQLLP-----RRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPLVEEQEDDDLDQLEAI 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   183 VKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPgiR 262
Cdd:TIGR01967  268 LD-AVDELFAEGPGDILIFLPGEREIRDAAEIL-------------RKRNLRHTEILPLYARLSNKEQQRVFQPHSG--R 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   263 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMP 342
Cdd:TIGR01967  332 RIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS-RP 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   343 DHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDR---SGHVTRLGLSMVEFPLPPHLT 419
Cdd:TIGR01967  411 EFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDdeaEPQLTPIGRQLAQLPVDPRLA 490

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   420 CAVIKAASLDCEDLLLPIAAMLSVENVFIRPvdPEYQKEAEQRHRELAAKAGGFNDFATLAVIFE---QCKSSGAPASWC 496
Cdd:TIGR01967  491 RMLLEAHRLGCLQEVLIIASALSIQDPRERP--MEKQQAADQAHARFKDPRSDFLSRVNLWRHIEeqrQALSANQFRNAC 568

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   497 QKHWIH------WRCLFSafrveaQLRELIRKLK-QQSDFPKEtfegpkHEVLRRCLCAGYFKNVARRSVGRTFctmDG- 568
Cdd:TIGR01967  569 RKQYLNylrvreWQDIYR------QLTQVVKELGlKLNEEPAD------YDAIHKALLSGLLSQIGMKDEKHEY---DGa 633

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261878481   569 RGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL---HEFNAH 628
Cdd:TIGR01967  634 RGRKFHIFPGSPLFKKPPK--WVMAAELVETSKLYARLVAKIEPEWVEPVAGHLikkNYFEPH 694
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 25-622 2.82e-76

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 267.31  E-value: 2.82e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   25 QEERLSAVCIADREEKGCTSQEGGTTP---TFPIQkqrkkiIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHER 101
Cdd:PRK11131  125 QPRRLAARTVANRIAEELETELGGCVGykvRFNDQ------VSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHER 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  102 TLTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQA 181
Cdd:PRK11131  199 SLNIDFILGYLKELL----PRRPD-LKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQA 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  182 IVKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMaesvdydyDVQDTTldgllILPCYGSMTTDQQRRIFlpPPPGI 261
Cdd:PRK11131  274 IFD-AVDELGREGPGDILIFMSGEREIRDTADALNKL--------NLRHTE-----ILPLYARLSNSEQNRVF--QSHSG 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  262 RKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSK-DFWNQc 340
Cdd:PRK11131  338 RRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEdDFLSR- 416

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  341 mPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAI--DRSGHVTRL---GLSMVEFPLP 415
Cdd:PRK11131  417 -PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAIttDEQASAYKLtplGRQLAQLPVD 495

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  416 PHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPeyQKEAEQRHRELAAKAGGFNDFATL-AVIFEQCK--SSGAP 492
Cdd:PRK11131  496 PRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDK--QQASDEKHRRFADKESDFLAFVNLwNYLQEQQKalSSNQF 573

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  493 ASWCQKHWIHWrclfsaFRVE------AQLRELIRKLkqqsDFPKETFEGPKHEVlRRCLCAGYFKNVARRSVGRTFCTm 566
Cdd:PRK11131  574 RRLCRTDYLNY------LRVRewqdiyTQLRQVVKEL----GIPVNSEPAEYREI-HTALLTGLLSHIGMKDAEKQEYT- 641

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 261878481  567 DGRGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL 622
Cdd:PRK11131  642 GARNARFSIFPGSGLFKKPPK--WVMVAELVETSRLWGRIAARIEPEWIEPLAQHL 695
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 158-332 9.29e-71

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 227.80  E-value: 9.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 158 YPVREKFCNLIGPR-----DRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDydydvqdtt 232
Cdd:cd18791    1 FPVEVYYLEDILELlgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPD--------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 233 LDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSE 312
Cdd:cd18791   72 LGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151

                        170       180
                 ....*....|....*....|
gi 261878481 313 ALQRSGRAGRTSSGKCFRIY 332
Cdd:cd18791  152 AEQRAGRAGRTRPGKCYRLY 171
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 65-471 2.82e-56

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 205.54  E-value: 2.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  65 AETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfQEkspNRKEHLKVVVMSATMELAKLSAF 144
Cdd:PRK11664  92 PNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDV-QQ---GLRDDLKLLIMSATLDNDRLQQL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 145 FGNCPIFDIPGRLYPVREKFCNLiGPRDRENTAYIQAIVKVtmdihLNEMAGDILVFLTGQFEIEKSCELLfqmAESVDY 224
Cdd:PRK11664 168 LPDAPVIVSEGRSFPVERRYQPL-PAHQRFDEAVARATAEL-----LRQESGSLLLFLPGVGEIQRVQEQL---ASRVAS 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 225 DYDvqdttldgllILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILE 304
Cdd:PRK11664 239 DVL----------LCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLV 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 305 VVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLIL 384
Cdd:PRK11664 309 TQRISQASMTQRAGRAGRLEPGICLHLYSKEQAER-AAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALA 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 385 EALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDceDLLLPIAAML-------------SVENVFIRPv 451
Cdd:PRK11664 388 AAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKLaaileepprsgssDLGVALSRK- 464

                        410       420
                 ....*....|....*....|
gi 261878481 452 DPEYQKEAEQRHRELAAKAG 471
Cdd:PRK11664 465 QPHWQQRAQQLLKRLNVRGG 484
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 25-153 1.40e-53

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 182.36  E-value: 1.40e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCTSQEggttpTFPIQKQRKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 102
Cdd:cd17984   53 QPRRVAAISVAQRvaEEMKCTLGS-----KVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERS 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 261878481 103 LTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17984  128 LTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 28-153 9.67e-38

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 137.98  E-value: 9.67e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  28 RLSAVCIADR--EEKGCTS-QEGGTTPTFpiqkqrKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLT 104
Cdd:cd17917   42 RIAAISVAERvaEERGEKLgEEVGYQIRF------ESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLD 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 261878481 105 TDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17917  116 TDFLLGLLKDLLR-----KRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 16-154 3.50e-35

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 131.45  E-value: 3.50e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  16 EEGERSRDL----QEERLSAVCIADR--EEKGC-TSQEGGTTPTFpiqkqrKKIIQAETAIKYMTDGCLLKHILGDPNLT 88
Cdd:cd17971   45 EAGYTSRGKigctQPRRVAAMSVAKRvaEEFGCcLGQEVGYTIRF------EDCTSPETVIKYMTDGMLLRECLIDPDLS 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261878481  89 KFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIP 154
Cdd:cd17971  119 QYSVIMLDEAHERTIHTDVLFGLLKKTVQ-----KRPDLKLIVTSATLDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 25-153 2.53e-33

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 125.93  E-value: 2.53e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCT-SQEGGTTPTFpiqkqrKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHER 101
Cdd:cd17978   53 QPRRVAAVSVAKRvaEEMGVElGQLVGYSVRF------DDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHER 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 261878481 102 TLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17978  127 TVHTDVLFGLVKSAQRRRKEQKLSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 25-153 1.18e-32

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 124.11  E-value: 1.18e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCT-SQEGGTTPTFpiqkqrKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHER 101
Cdd:cd17983   53 QPRRVAAMSVAKRvsEEMGVElGEEVGYAIRF------EDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHER 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 261878481 102 TLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17983  127 SLNTDVLFGLLREVVA-----RRRDLKLIVTSATMDADKFADFFGNVPIFTI 173
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 65-153 2.12e-28

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 112.51  E-value: 2.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  65 AETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAF 144
Cdd:cd17973  104 AKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVR-----RRPDLKLIVMSATLDAGKFQKY 178


                 ....*....
gi 261878481 145 FGNCPIFDI 153
Cdd:cd17973  179 FDNAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 25-153 4.19e-27

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 108.36  E-value: 4.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCT-SQEGGTTPTFpiqkqrKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHER 101
Cdd:cd17974   54 QPRRVAAMSVAARvaEEMGVKlGNEVGYSIRF------EDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHER 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 261878481 102 TLTTDILFGLLKKLfqekSPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17974  128 TLHTDILFGLVKDI----ARFRPD-LKLLISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 25-145 6.81e-27

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 107.94  E-value: 6.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCT-SQEGGTTPTFpiqkqRKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHER 101
Cdd:cd17980   54 QPRRVAAVTVAGRvaEEMGAVlGHEVGYCIRF-----DDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHER 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 261878481 102 TLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFF 145
Cdd:cd17980  129 TLYTDILIGLLKKIQK-----KRGDLRLIVASATLDAEKFRDFF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 25-154 9.29e-23

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 96.27  E-value: 9.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCTSQEGGttptfpIQKQRKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 102
Cdd:cd17982   58 QPRRVAAVSMAKRvaEELNVFGKEVS------YQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERS 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261878481 103 LTTDILFGLL-------KKLFqeKSPNRKEHLKVVVMSATMelaKLSAFFGNCPIFDIP 154
Cdd:cd17982  132 VNTDILIGMLsrivplrAKLY--LQDQTVKPLKLVIMSATL---RVEDFTENKLLFPRP 185
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 25-153 1.69e-20

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 89.52  E-value: 1.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR-EEKGCTSQEGGTTPTFPIQKQRKKIiQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTL 103
Cdd:cd17981   57 QPRRISAISVAERvAAERAESCGLGNSTGYQIRLESRKP-RKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNL 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 261878481 104 TTDILFGLLKKLFqekspNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17981  136 QSDVLMGIVKDLL-----PFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 5-151 1.89e-20

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 88.93  E-value: 1.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   5 PAVAGRAprrQEEGERSRDLQEERLSAVCIADREEKgCTSQEGGTTPTFPIQKQRKkiIQAETAIKYMTDGCLLKHILGD 84
Cdd:cd17990   36 LALLAEL---WIAGGKIIVLEPRRVAARAAARRLAT-LLGEAPGETVGYRVRGESR--VGRRTRVEVVTEGVLLRRLQRD 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261878481  85 PNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEkspnRKEHLKVVVMSATMELAKLSAFFGNCPIF 151
Cdd:cd17990  110 PELSGVGAVILDEFHERSLDADLALALLLEVQQL----LRDDLRLLAMSATLDGDGLAALLPEAPVV 172
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 542-622 7.31e-19

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 81.53  E-value: 7.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  542 LRRCLCAGYFKNVARR-SVGRTFCTMDGrGSPVHIHPSSAL-HEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLL 619
Cdd:pfam07717   1 LRAALAAGLYPNVARRdPKGKGYTTLSD-NQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFA 79


                  ...
gi 261878481  620 PKL 622
Cdd:pfam07717  80 PHI 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 386-470 7.44e-19

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 82.29  E-value: 7.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  386 ALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRE 465
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRR 80


                  ....*
gi 261878481  466 LAAKA 470
Cdd:pfam04408  81 RRAAD 85
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 25-153 7.61e-18

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 81.73  E-value: 7.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEkgcTSQEGGTTPTFPIQKQRKkiIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 102
Cdd:cd17989   53 QPRRLAARSVAERiaEE---LKTELGGAVGYKVRFTDQ--TSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERS 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 261878481 103 LTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17989  128 LNIDFLLGYLKQLL----PRRPD-LKVIITSATIDAERFSRHFNNAPIIEV 173
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 25-153 9.04e-18

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 81.88  E-value: 9.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCTSQEGGTTPTFPIQKQRKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 102
Cdd:cd17975   58 QPRRISAMSLATRvcEELGCESGPGGKNSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERS 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 261878481 103 LTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17975  138 VQSDFLLIILKEILHKRS-----DLHLILMSATVDCEKFSSYFTHCPILRI 183
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 392-480 3.45e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.54  E-value: 3.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   392 QCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRpvdpEYQKEAEQRHRELAAKAG 471
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK----EKREDADAARRRFADPES 76


                   ....*....
gi 261878481   472 gfnDFATLA 480
Cdd:smart00847  77 ---DHLTLL 82
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 25-153 7.70e-17

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 78.64  E-value: 7.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADREEKGCTSQEGGTTpTFPIQKQRKKiiQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLT 104
Cdd:cd17979   50 QPRRIACISLAKRVAFESLNQYGSKV-AYQIRFERTR--TLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLH 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 261878481 105 TDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17979  127 GDFLLGVLRCLLR-----LRPDLKLILMSATINIELFSGYFEGAPVVQV 170
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 25-153 2.23e-16

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 77.57  E-value: 2.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADREEKGCTSQEGGTTpTFPIQKQRKKiiQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLT 104
Cdd:cd17985   57 QPRRISAISVAERVAQERAERVGQSV-GYQIRLESVK--SSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEE 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 261878481 105 TDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17985  134 SDFLLLVLKDLMVQRP-----DLKVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 25-146 2.47e-15

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 74.46  E-value: 2.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGCTSqegGTTPTFpiQKQRKKIIQAETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 102
Cdd:cd17988   55 QPRRIAAISIARRvsQEREWTL---GSLVGY--QVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERD 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 261878481 103 LTTDILFGLLKKLFQEKSpnrkEHLKVVVMSATMELAKLSAFFG 146
Cdd:cd17988  130 QELDFLLLVVRRLLRTNS----RHVKIILMSATISCKEFADYFT 169
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 66-153 4.59e-15

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 73.71  E-value: 4.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  66 ETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEkspnRKEhLKVVVMSATMELAKLSAFF 145
Cdd:cd17977   94 ETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLS----RPE-LKLVIITCPHLSSKLLSYY 168


                 ....*...
gi 261878481 146 GNCPIFDI 153
Cdd:cd17977  169 GNVPLIEV 176
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 25-150 1.37e-14

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 72.52  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADReekgcTSQEGGTTptfpIQKQRKKIIQAET-------AIKYMTDGCLLKHILGDPNLTKFSVIILDE 97
Cdd:cd17976   57 QPRRISAVSVAQR-----VAHELGPN----LRRNVGYQVRLESrppprggALLFCTVGVLLKKLQSNPRLEGVSHVIVDE 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 261878481  98 AHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPI 150
Cdd:cd17976  128 VHERDVNTDFLLILLKGVLQLNP-----ELRVVLMSATGDNQRLSRYFGGCPV 175
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 42-153 3.62e-12

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 65.30  E-value: 3.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  42 CTSQEGGTTPtfpiqkqrkkiiqaETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEksp 121
Cdd:cd17986   85 SIPQEDCTGP--------------NTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQ--- 147

                         90       100       110
                 ....*....|....*....|....*....|..
gi 261878481 122 nRKEHLKVVVMSATMElAKLSAFFGNCPIFDI 153
Cdd:cd17986  148 -RPELRVVVVTSPALE-PKLRAFWGNPPVVHV 177
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 25-153 1.01e-11

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 64.08  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGctsQEGGTTPTFPIQKQRKkiIQAETAIKYMTDGCLLKHIL-GDPNLTKFSVIILDEAHER 101
Cdd:cd17987   55 QPRRLAAIAVAERvaAERG---EKIGQTVGYQIRLESR--VSPKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHER 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 261878481 102 TLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17987  130 DRFSDFLLTKLRDILQKHP-----NLKLILSSAALDVNLFIRYFGSCPVIYI 176
DEXDc smart00487
DEAD-like helicases superfamily;
55-159 1.15e-11

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 64.44  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481    55 IQKQRKKIIQAETAIKYMTDGCLLKHILGDP-NLTKFSVIILDEAHERT--LTTDILFGLLKKLfqekspnrKEHLKVVV 131
Cdd:smart00487  94 KREQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL--------PKNVQLLL 165

                           90       100       110
                   ....*....|....*....|....*....|
gi 261878481   132 MSATM--ELAKLSAFFGNCPIFDIPGRLYP 159
Cdd:smart00487 166 LSATPpeEIENLLELFLNDPVFIDVGFTPL 195
HELICc smart00490
helicase superfamily c-terminal domain;
235-322 3.63e-11

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 59.53  E-value: 3.63e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   235 GLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFvkqlnhnprlgldilevvPISKSEAL 314
Cdd:smart00490  11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPASYI 72


                   ....*...
gi 261878481   315 QRSGRAGR 322
Cdd:smart00490  73 QRIGRAGR 80
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 25-153 9.62e-10

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 59.46  E-value: 9.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  25 QEERLSAVCIADR--EEKGctsQEGGTTPTFPIQKQrKKIIQAETAIKYMTDGCLLKHIlgDPNLTKFSVIILDEAHERT 102
Cdd:cd17972  115 QPRRISAVSVAERvaFERG---EEVGKSCGYSVRFE-SVLPRPHASILFCTVGVLLRKL--EAGIRGISHVIVDEIHERD 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 261878481 103 LTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 153
Cdd:cd17972  189 INTDFLLVVLRDVVQAYP-----DLRVILMSATIDTSMFCEYFFNCPVIEV 234
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 86-335 1.19e-09

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 61.53  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  86 NLTKFSVIILDEAHERTLTTDILFGLLKKLfqeksPNRKEHLkvVVMSATME--LAKLSAFFGNcPIF-DIPG-RLYPVR 161
Cdd:PHA02653 288 KLFDYGTVIIDEVHEHDQIGDIIIAVARKH-----IDKIRSL--FLMTATLEddRDRIKEFFPN-PAFvHIPGgTLFPIS 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 162 EKFC-NLIGPRDR------ENTAYIQAIVKVTMDihlNEMAGDILVFLTGQfeieksCELLFQMAESVDYDYDV-----Q 229
Cdd:PHA02653 360 EVYVkNKYNPKNKrayieeEKKNIVTALKKYTPP---KGSSGIVFVASVSQ------CEEYKKYLEKRLPIYDFyiihgK 430

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481 230 DTTLDGLLilpcygsmttdqqRRIFLPPPPGIrkcVISTNISATSLTIDGIRYVVDGG--FVKQlnhnPRLGLDILevvp 307
Cdd:PHA02653 431 VPNIDEIL-------------EKVYSSKNPSI---IISTPYLESSVTIRNATHVYDTGrvYVPE----PFGGKEMF---- 486

                        250       260
                 ....*....|....*....|....*...
gi 261878481 308 ISKSEALQRSGRAGRTSSGKCFRIYSKD 335
Cdd:PHA02653 487 ISKSMRTQRKGRVGRVSPGTYVYFYDLD 514
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 183-322 5.94e-08

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 51.44  E-value: 5.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  183 VKVTMDIHLNEMAGDILVFLTGQFEIEksCELLFQmaesvdydydvqdttLDGLLILPCYGSMTTDQQRRIFLPPPPGIR 262
Cdd:pfam00271   3 LEALLELLKKERGGKVLIFSQTKKTLE--AELLLE---------------KEGIKVARLHGDLSQEEREEILEDFRKGKI 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  263 KCVISTNISATSLTIDGIRYVVDGGFvkqlnhnprlgldilevvPISKSEALQRSGRAGR 322
Cdd:pfam00271  66 DVLVATDVAERGLDLPDVDLVINYDL------------------PWNPASYIQRIGRAGR 107
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 54-136 9.71e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 43.39  E-value: 9.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481   54 PIQKQRKKIIQAEtaIKYMTDGCLLKHILGDPNLTKFSVIILDEAHErtlTTDILFG-LLKKLFQEKSPNRkehlKVVVM 132
Cdd:pfam00270  84 SRKEQLEKLKGPD--ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpDLEEILRRLPKKR----QILLL 154


                  ....
gi 261878481  133 SATM 136
Cdd:pfam00270 155 SATL 158
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 89-214 5.89e-03

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 39.82  E-value: 5.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261878481  89 KFSVIILDEAH----ERTLTTDILFGLlkklfqeKSPNRkehlkvVVMSAT-MELaKLSAFFGncpIFDI--PGRLYPV- 160
Cdd:COG0553  358 DWDLVILDEAQhiknPATKRAKAVRAL-------KARHR------LALTGTpVEN-RLEELWS---LLDFlnPGLLGSLk 420

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 261878481 161 --REKFCNLIGPRDRENTAYIQAIVKVTMdihLNEMAGDILVFLTGQFEIEKSCEL 214
Cdd:COG0553  421 afRERFARPIEKGDEEALERLRRLLRPFL---LRRTKEDVLKDLPEKTEETLYVEL 473
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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