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Conserved domains on  [gi|261271711|gb|ACX58683|]
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adenylate kinase, partial [Vibrio sp. 9ZA146]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11478412)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0050145|GO:0016310|GO:0046872
PubMed:  2841070
SCOP:  3002021

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-135 4.04e-86

adenylate kinase; Reviewed


:

Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 250.07  E-value: 4.04e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGL----KENGVSIDYVLE 76
Cdd:PRK00279  33 DMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVIE 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261271711  77 FDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:PRK00279 113 IDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKR 171
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-135 4.04e-86

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 250.07  E-value: 4.04e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGL----KENGVSIDYVLE 76
Cdd:PRK00279  33 DMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVIE 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261271711  77 FDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:PRK00279 113 IDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKR 171
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-135 1.77e-80

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 235.79  E-value: 1.77e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGL----KENGVSIDYVLE 76
Cdd:COG0563   33 DMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261271711  77 FDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:COG0563  113 LDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKR 171
ADK pfam00406
Adenylate kinase;
1-135 5.43e-75

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 220.64  E-value: 5.43e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711    1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKEN---GVSIDYVLEF 77
Cdd:pfam00406  29 DLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELlerGIKLDYVIEF 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 261271711   78 DVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:pfam00406 109 DVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKR 166
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-135 1.30e-62

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 190.52  E-value: 1.30e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711    1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQE-DCAKGFLLDGFPRTIPQADGLKE-NGVSIDYVLEFD 78
Cdd:TIGR01351  32 DLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNdDNENGFILDGFPRTLSQAEALDAlLEEPIDAVIELD 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 261271711   79 VADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:TIGR01351 112 VPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKR 168
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-135 1.61e-58

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 1.61e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKEN---GVSIDYVLEF 77
Cdd:cd01428   32 DLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELldeGIKPDKVIEL 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 261271711  78 DVADEVIVERMSGRRAHLPSGRTYHVvynppkeeGKDDETGEPLVIREDDKPETVLAR 135
Cdd:cd01428  112 DVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKR 161
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-135 4.04e-86

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 250.07  E-value: 4.04e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGL----KENGVSIDYVLE 76
Cdd:PRK00279  33 DMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVIE 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261271711  77 FDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:PRK00279 113 IDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKR 171
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-135 1.77e-80

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 235.79  E-value: 1.77e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGL----KENGVSIDYVLE 76
Cdd:COG0563   33 DMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261271711  77 FDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:COG0563  113 LDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKR 171
ADK pfam00406
Adenylate kinase;
1-135 5.43e-75

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 220.64  E-value: 5.43e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711    1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKEN---GVSIDYVLEF 77
Cdd:pfam00406  29 DLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELlerGIKLDYVIEF 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 261271711   78 DVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:pfam00406 109 DVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKR 166
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-135 1.30e-62

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 190.52  E-value: 1.30e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711    1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQE-DCAKGFLLDGFPRTIPQADGLKE-NGVSIDYVLEFD 78
Cdd:TIGR01351  32 DLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNdDNENGFILDGFPRTLSQAEALDAlLEEPIDAVIELD 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 261271711   79 VADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:TIGR01351 112 VPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKR 168
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-135 1.61e-58

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 1.61e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKEN---GVSIDYVLEF 77
Cdd:cd01428   32 DLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELldeGIKPDKVIEL 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 261271711  78 DVADEVIVERMSGRRAHLPSGRTYHVvynppkeeGKDDETGEPLVIREDDKPETVLAR 135
Cdd:cd01428  112 DVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKR 161
PLN02674 PLN02674
adenylate kinase
 1-135 5.51e-45

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 146.57  E-value: 5.51e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKE----NGVSIDYVLE 76
Cdd:PLN02674  64 DMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVVQAQKLDEmlakQGAKIDKVLN 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261271711  77 FDVADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:PLN02674 144 FAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKDDTAAVLKSR 202
PLN02842 PLN02842
nucleotide kinase
 1-135 6.90e-33

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 120.35  E-value: 6.90e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQED-CAKGFLLDGFPRTIPQADGLKENGVSIDYVLEFDV 79
Cdd:PLN02842  30 DLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDaKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDV 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 261271711  80 ADEVIVERMSGRRAHLPSGRTYHVVYNPPkeegKDDETGEPLVIREDDKPETVLAR 135
Cdd:PLN02842 110 PDEILIDRCVGRRLDPVTGKIYHIKNFPP----ESEEIKARLITRPDDTEEKVKAR 161
adk PRK02496
adenylate kinase; Provisional
 1-91 1.23e-31

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 110.61  E-value: 1.23e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADG----LKENGVSIDYVLE 76
Cdd:PRK02496  34 DILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFldelLQEIGQSGERVVN 113

                         90
                 ....*....|....*
gi 261271711  77 FDVADEVIVERMSGR 91
Cdd:PRK02496 114 LDVPDDVVVERLLAR 128
PRK14528 PRK14528
adenylate kinase; Provisional
 1-91 5.51e-29

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 103.94  E-value: 5.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADG----LKENGVSIDYVLE 76
Cdd:PRK14528  34 DILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADAldalLKNEGKSIDKAIN 113

                         90
                 ....*....|....*
gi 261271711  77 FDVADEVIVERMSGR 91
Cdd:PRK14528 114 LEVPDGELLKRLLGR 128
PRK14532 PRK14532
adenylate kinase; Provisional
 1-126 1.12e-28

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 103.36  E-value: 1.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKE----NGVSIDYVLE 76
Cdd:PRK14532  33 DMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGGAIFDGFPRTVAQAEALDKmlasRGQKIDVVIR 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 261271711  77 FDVADEVIVERMSGRRAhlpsgrtyhvvynppkEEGKDDETGEPLVIRED 126
Cdd:PRK14532 113 LKVDDEALIERIVKRFE----------------EQGRPDDNPEVFVTRLD 146
PRK13808 PRK13808
adenylate kinase; Provisional
 1-135 5.26e-26

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 99.58  E-value: 5.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADG----LKENGVSIDYVLE 76
Cdd:PRK13808  33 DMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANGFILDGFPRTVPQAEAldalLKDKQLKLDAVVE 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261271711  77 FDVADEVIVERMSGRRAHLpsgrtyhvvynppkeegkdDETGEPlvIREDDKPETVLAR 135
Cdd:PRK13808 113 LRVNEGALLARVETRVAEM-------------------RARGEE--VRADDTPEVLAKR 150
PRK14530 PRK14530
adenylate kinase; Provisional
 18-135 2.15e-25

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 95.63  E-value: 2.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711  18 KSVIDAGQLVSDEIILGLVKERIAQEDcakGFLLDGFPRTIPQADGLkENGVSIDYVLEFDVADEVIVERMSGRRAHLPS 97
Cdd:PRK14530  57 GEYMDAGELVPDAVVNEIVEEALSDAD---GFVLDGYPRNLEQAEYL-ESITDLDVVLYLDVSEEELVDRLTGRRVCPDC 132

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 261271711  98 GRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:PRK14530 133 GANYHVEFNQPEEEGVCDECGGELIQRDDDTEETVRER 170
PLN02459 PLN02459
probable adenylate kinase
 1-135 7.03e-23

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 89.91  E-value: 7.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERI--AQEDCAKGFLLDGFPRTIPQADGLKENgVSIDYVLEFD 78
Cdd:PLN02459  62 DLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLeaGEEEGESGFILDGFPRTVRQAEILEGV-TDIDLVVNLK 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261271711  79 VADEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEP-----------LVIREDDKPETVLAR 135
Cdd:PLN02459 141 LREEVLVEKCLGRRICSECGKNFNVADIDLKGEDGRPGIVMPpllpppecaskLITRADDTEEVVKAR 208
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1-134 1.52e-22

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 88.32  E-value: 1.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQ--EDCAKGFLLDGFPRTIPQADGLKENgVSIDYVLEFD 78
Cdd:PTZ00088  39 NILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvtDDCFKGFILDGFPRNLKQCKELGKI-TNIDLFVNIY 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261271711  79 VADEVIVERMSGRRAHLPSGRTYHVV------YN-PPKEEGKDDET--GEPLVIREDDKPETVLA 134
Cdd:PTZ00088 118 LPRNILIKKLLGRRICNTCNRNFNIAhirsdpYDmPPILPPADCEGckGNPKLQKRSDDTEEIVA 182
PRK14529 PRK14529
adenylate kinase; Provisional
 2-92 5.74e-22

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 86.70  E-value: 5.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   2 MLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIaQEDCAKGFLLDGFPRTIPQA----DGLKENGVSIDYVLEF 77
Cdd:PRK14529  34 IFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL-KQDGKNGWLLDGFPRNKVQAeklwEALQKEGMKLDYVIEI 112

                         90
                 ....*....|....*
gi 261271711  78 DVADEVIVERMSGRR 92
Cdd:PRK14529 113 LLPREVAKNRIMGRR 127
PRK14531 PRK14531
adenylate kinase; Provisional
 1-91 2.31e-21

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 84.48  E-value: 2.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIaQEDCAKGFLLDGFPRTIPQADGLK----ENGVSIDYVLE 76
Cdd:PRK14531  35 DLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL-KALNSGGWLLDGFPRTVAQAEALEplleELKQPIEAVVL 113

                         90
                 ....*....|....*
gi 261271711  77 FDVADEVIVERMSGR 91
Cdd:PRK14531 114 LELDDAVLIERLLAR 128
PRK14526 PRK14526
adenylate kinase; Provisional
 1-135 6.09e-21

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 83.75  E-value: 6.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKENGVSIDyVLEFDVA 80
Cdd:PRK14526  33 DLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFILDGFPRNINQAKALDKFLPNIK-IINFLID 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 261271711  81 DEVIVERMSGRRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIREDDKPETVLAR 135
Cdd:PRK14526 112 EELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKEESLKTR 166
PRK14527 PRK14527
adenylate kinase; Provisional
 1-91 2.02e-20

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 82.15  E-value: 2.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKgFLLDGFPRTIPQADG----LKENGVSIDYVLE 76
Cdd:PRK14527  39 DILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVR-VIFDGFPRTLAQAEAldrlLEELGARLLAVVL 117

                         90
                 ....*....|....*
gi 261271711  77 FDVADEVIVERMSGR 91
Cdd:PRK14527 118 LEVPDEELIRRIVER 132
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 91-126 4.00e-17

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 69.41  E-value: 4.00e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 261271711   91 RRAHLPSGRTYHVVYNPPKEEGKDDETGEPLVIRED 126
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1-99 3.79e-16

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 71.00  E-value: 3.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711    1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERI-AQEDCAKGFLLDGFPRTIPQADGLKENGVSIDYVLEFDV 79
Cdd:TIGR01360  36 DLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMvAALGTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDC 115

                          90       100
                  ....*....|....*....|
gi 261271711   80 ADEVIVERMSGRRAhlPSGR 99
Cdd:TIGR01360 116 SEDTMVKRLLKRAE--TSGR 133
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1-100 6.70e-15

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 67.40  E-value: 6.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711    1 DMLRAAIKA-GTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADG---LKENGVSIDYVLE 76
Cdd:TIGR01359  32 DLLRAEIKReGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLIDGFPRNEENLEAwekLMDNKVNFKFVLF 111

                          90       100
                  ....*....|....*....|....
gi 261271711   77 FDVADEVIVERMSGRRAhlPSGRT 100
Cdd:TIGR01359 112 FDCPEETMIKRLLKRGQ--TSGRV 133
AAA_17 pfam13207
AAA domain;
1-101 5.13e-13

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 61.49  E-value: 5.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711    1 DMLRAAIKAGTelGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKGFLLDGFPRTIPQADGLKE------NGVSIDYV 74
Cdd:pfam13207  28 DLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAI 105

                          90       100
                  ....*....|....*....|....*..
gi 261271711   75 LEFDVADEVIVERMSGRRAhlpSGRTY 101
Cdd:pfam13207 106 ILLEADPEEILERRLKDRT---RGRDD 129
PLN02200 PLN02200
adenylate kinase family protein
 1-91 1.37e-07

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 48.35  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261271711   1 DMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLVKERIAQEDCAKgFLLDGFPRTipqadglKEN--------GVSID 72
Cdd:PLN02200  76 DLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK-FLIDGFPRT-------EENriaferiiGAEPN 147

                         90
                 ....*....|....*....
gi 261271711  73 YVLEFDVADEVIVERMSGR 91
Cdd:PLN02200 148 VVLFFDCPEEEMVKRVLNR 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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