NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|261197099|ref|XP_002624952|]
View 

NADH dehydrogenase [Blastomyces gilchristii SLH14081]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NuzM cd22849
NuzM subunit of NADH:Ubiquinone Oxidoreductase; The NuzM subunit is a fungal specific subunit ...
 26-190 5.25e-52

NuzM subunit of NADH:Ubiquinone Oxidoreductase; The NuzM subunit is a fungal specific subunit of NADH:ubiquinone oxidoreductase (respiratory complex I) which is a redox-driven proton pump that plays a central role in aerobic energy metabolism. Redox-linked proton translocation by complex I creates the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Loss of NuzM leads to disassembly of fungal complex I, thus making it a potential antifungal drug target.


:

Pssm-ID: 439366  Cd Length: 159  Bit Score: 163.95  E-value: 5.25e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261197099  26 STGVWERIRRFLAVDPNRSNGVPLNPQFRNPTPGALAPqsYDDPVTLPAGDIADNPYWKRDGRRNYARPSVLRQADVVGL 105
Cdd:cd22849    1 SSGFWEKIRKLLVVNPNRSSGLPLVPLYRNPPPGSRPE--YYDPPATPASDIAENPYWKRDVRRNYPRLSVVTQSDLAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261197099 106 LTVGSEASPKADvlqIGDAGAQQLVEVrqKGEAHGLAAFFekEKNVQGVLDSQGLPPMAPNLNPaSRYELGTEHGYPSS- 184
Cdd:cd22849   79 LLAGSAAAPRIA---KGEAGTKALAAV--KESPPSLTEVL--KSLPKLYSASKLLPPLPPSLKK-YKWKISTDEMYPHDp 150


                 ....*...
gi 261197099 185 --YPCRTF 190
Cdd:cd22849  151 hyYPMRNF 158
 
Name Accession Description Interval E-value
NuzM cd22849
NuzM subunit of NADH:Ubiquinone Oxidoreductase; The NuzM subunit is a fungal specific subunit ...
 26-190 5.25e-52

NuzM subunit of NADH:Ubiquinone Oxidoreductase; The NuzM subunit is a fungal specific subunit of NADH:ubiquinone oxidoreductase (respiratory complex I) which is a redox-driven proton pump that plays a central role in aerobic energy metabolism. Redox-linked proton translocation by complex I creates the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Loss of NuzM leads to disassembly of fungal complex I, thus making it a potential antifungal drug target.


Pssm-ID: 439366  Cd Length: 159  Bit Score: 163.95  E-value: 5.25e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261197099  26 STGVWERIRRFLAVDPNRSNGVPLNPQFRNPTPGALAPqsYDDPVTLPAGDIADNPYWKRDGRRNYARPSVLRQADVVGL 105
Cdd:cd22849    1 SSGFWEKIRKLLVVNPNRSSGLPLVPLYRNPPPGSRPE--YYDPPATPASDIAENPYWKRDVRRNYPRLSVVTQSDLAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261197099 106 LTVGSEASPKADvlqIGDAGAQQLVEVrqKGEAHGLAAFFekEKNVQGVLDSQGLPPMAPNLNPaSRYELGTEHGYPSS- 184
Cdd:cd22849   79 LLAGSAAAPRIA---KGEAGTKALAAV--KESPPSLTEVL--KSLPKLYSASKLLPPLPPSLKK-YKWKISTDEMYPHDp 150


                 ....*...
gi 261197099 185 --YPCRTF 190
Cdd:cd22849  151 hyYPMRNF 158
 
Name Accession Description Interval E-value
NuzM cd22849
NuzM subunit of NADH:Ubiquinone Oxidoreductase; The NuzM subunit is a fungal specific subunit ...
 26-190 5.25e-52

NuzM subunit of NADH:Ubiquinone Oxidoreductase; The NuzM subunit is a fungal specific subunit of NADH:ubiquinone oxidoreductase (respiratory complex I) which is a redox-driven proton pump that plays a central role in aerobic energy metabolism. Redox-linked proton translocation by complex I creates the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Loss of NuzM leads to disassembly of fungal complex I, thus making it a potential antifungal drug target.


Pssm-ID: 439366  Cd Length: 159  Bit Score: 163.95  E-value: 5.25e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261197099  26 STGVWERIRRFLAVDPNRSNGVPLNPQFRNPTPGALAPqsYDDPVTLPAGDIADNPYWKRDGRRNYARPSVLRQADVVGL 105
Cdd:cd22849    1 SSGFWEKIRKLLVVNPNRSSGLPLVPLYRNPPPGSRPE--YYDPPATPASDIAENPYWKRDVRRNYPRLSVVTQSDLAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261197099 106 LTVGSEASPKADvlqIGDAGAQQLVEVrqKGEAHGLAAFFekEKNVQGVLDSQGLPPMAPNLNPaSRYELGTEHGYPSS- 184
Cdd:cd22849   79 LLAGSAAAPRIA---KGEAGTKALAAV--KESPPSLTEVL--KSLPKLYSASKLLPPLPPSLKK-YKWKISTDEMYPHDp 150


                 ....*...
gi 261197099 185 --YPCRTF 190
Cdd:cd22849  151 hyYPMRNF 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH