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Conserved domains on  [gi|260763885|ref|NP_083902|]
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glycosyltransferase 8 domain-containing protein 1 isoform 1 [Mus musculus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 10157674)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 66-351 1.72e-107

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


:

Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 315.48  E-value: 1.72e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  66 IPVVIAASEdRLGGTIAAINSVHQNTR-SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPD-- 142
Cdd:cd06429    1 IHVVIFSDN-RLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSLmq 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 143 -------------QGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEdcdsastkvii 209
Cdd:cd06429   80 leseadtsnlkqrKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 210 rgagnqynyigyldykkerirklsmkastcSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGlysRTLAGSITTPPLL 289
Cdd:cd06429  149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEEE---VTLWKLITLPPGL 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260763885 290 IVFYQQHSTIDPMWNVRHLGSSAGKRysPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKWYI 351
Cdd:cd06429  196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAipSYKELWEKYLS 257
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 66-351 1.72e-107

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 315.48  E-value: 1.72e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  66 IPVVIAASEdRLGGTIAAINSVHQNTR-SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPD-- 142
Cdd:cd06429    1 IHVVIFSDN-RLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSLmq 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 143 -------------QGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEdcdsastkvii 209
Cdd:cd06429   80 leseadtsnlkqrKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 210 rgagnqynyigyldykkerirklsmkastcSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGlysRTLAGSITTPPLL 289
Cdd:cd06429  149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEEE---VTLWKLITLPPGL 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260763885 290 IVFYQQHSTIDPMWNVRHLGSSAGKRysPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKWYI 351
Cdd:cd06429  196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAipSYKELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 67-340 5.95e-77

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 237.61  E-value: 5.95e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885   67 PVVIAASEDRLGGTIAAINSVHQNT-RSNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPDQGE 145
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  146 SMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDcdsastkviirgagnqyNYIGYLDYK 225
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  226 KERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVeeglySRTLAGSITTPPLLIVFYQQHSTIDPMWNV 305
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNE-----NRTLWKLGDQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 260763885  306 RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTA 340
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPWLDIA 252
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 63-350 2.35e-24

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 101.20  E-value: 2.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  63 QEEIPVVIAASEDRLGGTIAAINSVHQNTRS-NVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLegkvkQDP 141
Cdd:COG1442    3 KNTINIVFAIDDNYLPGLGVSIASLLENNPDrPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVDDELL-----KDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 142 DQGESMKPLTFARFYLPILVPSA-KKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSAStkviirgagnqynyig 220
Cdd:COG1442   78 PVSKHISKATYYRLLIPELLPDDyDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG---------------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 221 yldYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYsrtlagsittpP----LLIVFYQQH 296
Cdd:COG1442  141 ---SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGGKV 206

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260763885 297 STIDPMWNV-----RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPW--GRTASYADVWEKWY 350
Cdd:COG1442  207 KFLPPRYNYqyslyYELKDKSNKKELLEARKNPVIIHYTGPTKPWhkWCTHPYADLYWEYL 267
PLN02742 PLN02742
Probable galacturonosyltransferase
 75-349 1.78e-22

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 98.69  E-value: 1.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  75 DRLGGTIAAINSVHQNTR--SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDT-KLLEG------KVKQDPD--- 142
Cdd:PLN02742 235 DNILATSVVVNSTVSNAKhpDQLVFHLVTDEVNYGAMQAWFAMNDFKGVTVEVQKIEEfSWLNAsyvpvlKQLQDSDtqs 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 143 ------QGESMKPLTFA-----------RFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASt 205
Cdd:PLN02742 315 yyfsgsQDDGKTEIKFRnpkylsmlnhlRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETCLETF- 392

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 206 kviirgagnqYNYIGYLDYKKERIRKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITT 285
Cdd:PLN02742 393 ----------HRYHKYLNFSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVD-----RTLWKLGTL 456

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 260763885 286 PPLLIVFYQQHSTIDPMWNVRHLGSSAgkRYSPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKW 349
Cdd:PLN02742 457 PPGLLTFYGLTEPLDRRWHVLGLGYDT--NIDPRLIESAAVLHFNGNMKPWLKLAieRYKPLWERY 520
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 66-351 1.72e-107

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 315.48  E-value: 1.72e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  66 IPVVIAASEdRLGGTIAAINSVHQNTR-SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPD-- 142
Cdd:cd06429    1 IHVVIFSDN-RLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSLmq 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 143 -------------QGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEdcdsastkvii 209
Cdd:cd06429   80 leseadtsnlkqrKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 210 rgagnqynyigyldykkerirklsmkastcSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGlysRTLAGSITTPPLL 289
Cdd:cd06429  149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEEE---VTLWKLITLPPGL 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260763885 290 IVFYQQHSTIDPMWNVRHLGSSAGKRysPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKWYI 351
Cdd:cd06429  196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAipSYKELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 67-340 5.95e-77

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 237.61  E-value: 5.95e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885   67 PVVIAASEDRLGGTIAAINSVHQNT-RSNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPDQGE 145
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  146 SMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDcdsastkviirgagnqyNYIGYLDYK 225
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  226 KERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVeeglySRTLAGSITTPPLLIVFYQQHSTIDPMWNV 305
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNE-----NRTLWKLGDQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 260763885  306 RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTA 340
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPWLDIA 252
Glyco_transf_8 cd00505
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ...
 68-338 2.26e-61

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.


Pssm-ID: 132996 [Multi-domain]  Cd Length: 246  Bit Score: 197.28  E-value: 2.26e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  68 VVIAASEDRLGGTIAAINSVHQNTRSNVMFYIVTFNstadhlRSWLNSGSLKSIRYK---IVNFDTKLLEGKVKQDPdQG 144
Cdd:cd00505    4 VIVATGDEYLRGAIVLMKSVLRHRTKPLRFHVLTNP------LSDTFKAALDNLRKLynfNYELIPVDILDSVDSEH-LK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 145 ESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSASTKViirgagnqynyigyldy 224
Cdd:cd00505   77 RPIKIVTLTKLHLPNLVPDYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGDRREGKY----------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 225 kkeRIRKLSMKASTCSFNPGVFVANLTEWKR-QNVTNQLEKWMKLNVeeglysrtlAGSITTPPLLIVFYQQ----HSTI 299
Cdd:cd00505  140 ---YRQKRSHLAGPDYFNSGVFVVNLSKERRnQLLKVALEKWLQSLS---------SLSGGDQDLLNTFFKQvpfiVKSL 207

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 260763885 300 DPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGR 338
Cdd:cd00505  208 PCIWNVRLTGCYRSLNCFKAFVKNAKVIHFNGPTKPWNK 246
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 63-350 2.35e-24

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 101.20  E-value: 2.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  63 QEEIPVVIAASEDRLGGTIAAINSVHQNTRS-NVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLegkvkQDP 141
Cdd:COG1442    3 KNTINIVFAIDDNYLPGLGVSIASLLENNPDrPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVDDELL-----KDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 142 DQGESMKPLTFARFYLPILVPSA-KKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSAStkviirgagnqynyig 220
Cdd:COG1442   78 PVSKHISKATYYRLLIPELLPDDyDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG---------------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 221 yldYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYsrtlagsittpP----LLIVFYQQH 296
Cdd:COG1442  141 ---SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGGKV 206

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260763885 297 STIDPMWNV-----RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPW--GRTASYADVWEKWY 350
Cdd:COG1442  207 KFLPPRYNYqyslyYELKDKSNKKELLEARKNPVIIHYTGPTKPWhkWCTHPYADLYWEYL 267
PLN02742 PLN02742
Probable galacturonosyltransferase
 75-349 1.78e-22

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 98.69  E-value: 1.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  75 DRLGGTIAAINSVHQNTR--SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDT-KLLEG------KVKQDPD--- 142
Cdd:PLN02742 235 DNILATSVVVNSTVSNAKhpDQLVFHLVTDEVNYGAMQAWFAMNDFKGVTVEVQKIEEfSWLNAsyvpvlKQLQDSDtqs 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 143 ------QGESMKPLTFA-----------RFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASt 205
Cdd:PLN02742 315 yyfsgsQDDGKTEIKFRnpkylsmlnhlRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETCLETF- 392

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 206 kviirgagnqYNYIGYLDYKKERIRKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITT 285
Cdd:PLN02742 393 ----------HRYHKYLNFSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVD-----RTLWKLGTL 456

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 260763885 286 PPLLIVFYQQHSTIDPMWNVRHLGSSAgkRYSPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKW 349
Cdd:PLN02742 457 PPGLLTFYGLTEPLDRRWHVLGLGYDT--NIDPRLIESAAVLHFNGNMKPWLKLAieRYKPLWERY 520
PLN02829 PLN02829
Probable galacturonosyltransferase
 150-336 8.48e-21

Probable galacturonosyltransferase


Pssm-ID: 215443 [Multi-domain]  Cd Length: 639  Bit Score: 93.76  E-value: 8.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSastkviirgagNQYNYIGYLDYKKERI 229
Cdd:PLN02829 443 LNHLRFYLPEIFPKLNKVLFLDDDIVVQKDLTGLWSIDLK-GNVNGAVETCGE-----------SFHRFDRYLNFSNPLI 510

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 230 RKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNveeglYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLG 309
Cdd:PLN02829 511 SK-NFDPHACGWAYGMNVFDLDEWKRQNITEVYHSWQKLN-----HDRQLWKLGTLPPGLITFWKRTYPLDRSWHVLGLG 584

                        170       180       190
                 ....*....|....*....|....*....|.
gi 260763885 310 ssagkrYSPQF----VKAAKLLHWNGHFKPW 336
Cdd:PLN02829 585 ------YNPNVnqrdIERAAVIHYNGNMKPW 609
PLN02910 PLN02910
polygalacturonate 4-alpha-galacturonosyltransferase
 150-353 9.38e-21

polygalacturonate 4-alpha-galacturonosyltransferase


Pssm-ID: 215493 [Multi-domain]  Cd Length: 657  Bit Score: 93.86  E-value: 9.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSAStkviirgagnqYNYIGYLDYKKERI 229
Cdd:PLN02910 461 LNHLRFYLPEVYPKLEKILFLDDDIVVQKDLTPLWSIDMQ-GMVNGAVETCKESF-----------HRFDKYLNFSNPKI 528

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 230 RKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLG 309
Cdd:PLN02910 529 SE-NFDPNACGWAFGMNMFDLKEWRKRNITGIYHYWQDLNED-----RTLWKLGSLPPGLITFYNLTYPLDRSWHVLGLG 602

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 260763885 310 ssagkrYSPQF----VKAAKLLHWNGHFKPWGRTA--SYADVWEKWYIPD 353
Cdd:PLN02910 603 ------YDPALnqteIENAAVVHYNGNYKPWLDLAiaKYKPYWSRYVQYD 646
GT8_A4GalT_like cd04194
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ...
 66-336 1.16e-20

A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.


Pssm-ID: 133037 [Multi-domain]  Cd Length: 248  Bit Score: 89.97  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  66 IPVVIAASEDRLGGTIAAINS-VHQNTRSNVMFYIVTFNstadhlrswLNSGSLKSIRYKIVNFDTKLL-----EGKVKQ 139
Cdd:cd04194    1 MNIVFAIDDNYAPYLAVTIKSiLANNSKRDYDFYILNDD---------ISEENKKKLKELLKKYNSSIEfikidNDDFKF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 140 DPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCdsastkviirgagnqynyi 219
Cdd:cd04194   72 FPATTDHISYATYYRLLIPDLLPDYDKVLYLDADIIVLGDLSELFDIDLG-DNLLAAVRDP------------------- 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 220 gYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYsrtlagsittpP----LLIVFYQQ 295
Cdd:cd04194  132 -FIEQEKKRKRRLGGYDDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIY-----------PdqdiLNAVLKDK 199

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 260763885 296 HSTIDPMWNV------RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPW 336
Cdd:cd04194  200 ILYLPPRYNFqtgfyyLLKKKSKEEQELEEARKNPVIIHYTGSDKPW 246
PLN02523 PLN02523
galacturonosyltransferase
 150-349 1.73e-20

galacturonosyltransferase


Pssm-ID: 215286 [Multi-domain]  Cd Length: 559  Bit Score: 93.02  E-value: 1.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCdsastkviirgAGNQYNYIGYLDYKKERI 229
Cdd:PLN02523 363 LNHLRFYLPEMYPKLHRILFLDDDVVVQKDLTGLWKIDMD-GKVNGAVETC-----------FGSFHRYAQYLNFSHPLI 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 230 R-KLSMKAstCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHL 308
Cdd:PLN02523 431 KeKFNPKA--CAWAYGMNIFDLDAWRREKCTEQYHYWQNLNEN-----RTLWKLGTLPPGLITFYSTTKPLDKSWHVLGL 503

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 260763885 309 GssagkrYSPQF----VKAAKLLHWNGHFKPWGRTA--SYADVWEKW 349
Cdd:PLN02523 504 G------YNPSIsmdeIRNAAVIHFNGNMKPWLDIAmnQFKPLWTKY 544
PLN02659 PLN02659
Probable galacturonosyltransferase
 154-336 5.82e-20

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 91.25  E-value: 5.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 154 RFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASTKVIIRGAGNqynyigYLDYKKERIRKlS 233
Cdd:PLN02659 334 RIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GKVNGAVETCRGEDKFVMSKKLKS------YLNFSHPLIAK-N 405

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 234 MKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYSRTLAgsiTTPPLLIVFYQQHSTIDPMWNVRHLGSSAG 313
Cdd:PLN02659 406 FDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKSDLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQEN 482

                        170       180
                 ....*....|....*....|...
gi 260763885 314 KRYSPqfVKAAKLLHWNGHFKPW 336
Cdd:PLN02659 483 TSLAD--AESAGVVHFNGRAKPW 503
PLN02870 PLN02870
Probable galacturonosyltransferase
 150-336 1.06e-19

Probable galacturonosyltransferase


Pssm-ID: 215468 [Multi-domain]  Cd Length: 533  Bit Score: 90.38  E-value: 1.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASTKVIIRGAGNQYNYIGYLDYKkeri 229
Cdd:PLN02870 329 LNHLRIYLPELFPNLDKVVFLDDDVVIQRDLSPLWDIDLG-GKVNGAVETCRGEDEWVMSKRFRNYFNFSHPLIAK---- 403

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 230 rklSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLysrTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLG 309
Cdd:PLN02870 404 ---NLDPEECAWAYGMNIFDLRAWRKTNIRETYHSWLKENLKSNL---TMWKLGTLPPALIAFKGHVHPIDPSWHMLGLG 477

                        170       180
                 ....*....|....*....|....*..
gi 260763885 310 SSagKRYSPQFVKAAKLLHWNGHFKPW 336
Cdd:PLN02870 478 YQ--SKTNIESVKKAAVIHYNGQSKPW 502
PLN02867 PLN02867
Probable galacturonosyltransferase
 69-370 4.26e-18

Probable galacturonosyltransferase


Pssm-ID: 178458 [Multi-domain]  Cd Length: 535  Bit Score: 85.72  E-value: 4.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  69 VIAASedrlggtiAAINSVHQNTRS--NVMFYIVTFNSTADHLRSWLNSGSLKSIRYKI-----------VNFDTK---- 131
Cdd:PLN02867 221 VLAAS--------VVISSTVQNAANpeKLVFHIVTDKKTYTPMHAWFAINSIKSAVVEVkglhqydwsqeVNVGVKemle 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 132 ------------------LLEGKVKQDPdqgESMKP-----LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPL 188
Cdd:PLN02867 293 ihrliwshyyqnlkesdfQFEGTHKRSL---EALSPsclslLNHLRIYIPELFPDLNKIVFLDDDVVVQHDLSSLWELDL 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 189 -KPGHAAAFSEDCDSASTkviirgAGNQYNyiGYLDYKKERIRKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMK 267
Cdd:PLN02867 370 nGKVVGAVVDSWCGDNCC------PGRKYK--DYLNFSHPLISS-NLDQERCAWLYGMNVFDLKAWRRTNITEAYHKWLK 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 268 LNVEEGLysrTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKrYSPQFVKAAKLLHWNGHFKPWgRTASYADVWE 347
Cdd:PLN02867 441 LSLNSGL---QLWQPGALPPALLAFKGHVHPIDPSWHVAGLGSRPPE-VPREILESAAVLHFSGPAKPW-LEIGFPEVRS 515

                        330       340
                 ....*....|....*....|...
gi 260763885 348 KWYipdptgkfslirRHMDTSNI 370
Cdd:PLN02867 516 LWY------------RHVNFSDK 526
PLN02718 PLN02718
Probable galacturonosyltransferase
 95-336 2.93e-16

Probable galacturonosyltransferase


Pssm-ID: 178320 [Multi-domain]  Cd Length: 603  Bit Score: 80.32  E-value: 2.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885  95 VMFYIVT--FNSTADHLRSWLNSGSLKSIRYK-IVNFD---TKLLEGKVKQDPDQGESMKPLTFARFYLPILVPSAKKAI 168
Cdd:PLN02718 343 IVFHVVTdsLNYPAISMWFLLNPPGKATIQILnIDDMNvlpADYNSLLMKQNSHDPRYISALNHARFYLPDIFPGLNKIV 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 169 YMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASTKViirgaGNQYNYIGYLDykKERIRKLSMKASTCSFNPGVFva 248
Cdd:PLN02718 423 LFDHDVVVQRDLSRLWSLDMK-GKVVGAVETCLEGEPSF-----RSMDTFINFSD--PWVAKKFDPKACTWAFGMNLF-- 492

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 249 NLTEWKRQNVTNQLEKWMKLNVEEGLYSrtlAGSIttPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPqfVKAAKLLH 328
Cdd:PLN02718 493 DLEEWRRQKLTSVYHKYLQLGVKRPLWK---AGSL--PIGWLTFYNQTVALDKRWHVLGLGHESGVGASD--IEQAAVIH 565


                 ....*...
gi 260763885 329 WNGHFKPW 336
Cdd:PLN02718 566 YDGVMKPW 573
PLN02769 PLN02769
Probable galacturonosyltransferase
 155-336 4.99e-11

Probable galacturonosyltransferase


Pssm-ID: 215412 [Multi-domain]  Cd Length: 629  Bit Score: 63.95  E-value: 4.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 155 FYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpghaaafsedcdsasTKVIirGA--------GNQYNYIGyldykk 226
Cdd:PLN02769 443 FLLPEIFKKLKKVVVLDDDVVVQRDLSFLWNLDMG---------------GKVN--GAvqfcgvrlGQLKNYLG------ 499

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260763885 227 erirKLSMKASTCSFNPGVFVANLTEWKRQNVTN---QLEKWMKLNVEEGLYSRTLAGSittpplLIVFYQQHSTIDPMW 303
Cdd:PLN02769 500 ----DTNFDTNSCAWMSGLNVIDLDKWRELDVTEtylKLLQKFSKDGEESLRAAALPAS------LLTFQDLIYPLDDRW 569

                        170       180       190
                 ....*....|....*....|....*....|...
gi 260763885 304 NVRHLGSSAGkrYSPQFVKAAKLLHWNGHFKPW 336
Cdd:PLN02769 570 VLSGLGHDYG--IDEQAIKKAAVLHYNGNMKPW 600
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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