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Conserved domains on  [gi|260177239|gb|ACX33959|]
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putative acyl carrier protein phosphopantetheine-binding [uncultured bacterium RM35]

Protein Classification

acyl carrier protein( domain architecture ID 10000754)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

CATH:  1.10.1200.10
Gene Ontology:  GO:0009245|GO:0006633|GO:0000036|GO:0000035
PubMed:  18059524|30543875|20662770
SCOP:  4000857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 5-70 1.08e-09

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 49.85  E-value: 1.08e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 260177239  5 TEPEIQGWILERIGEIVK-GTSKIELQRPF-AEMGLGSVDVVTLIGKLEDWLGIEIELTLALDFPTVE 70
Cdd:COG0236   2 PREELEERLAEIIAEVLGvDPEEITPDDSFfEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVA 69
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 5-70 1.08e-09

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 49.85  E-value: 1.08e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 260177239  5 TEPEIQGWILERIGEIVK-GTSKIELQRPF-AEMGLGSVDVVTLIGKLEDWLGIEIELTLALDFPTVE 70
Cdd:COG0236   2 PREELEERLAEIIAEVLGvDPEEITPDDSFfEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVA 69
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 2-70 3.43e-09

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 48.79  E-value: 3.43e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260177239    2 PPPTEPEIQGWILERIGEIVK--GTSKIELQRPFAEMGLGSVDVVTLIGKLEDWLGIEIELTLALDFPTVE 70
Cdd:smart00823  6 PAERRRLLLDLVREQVAAVLGhaAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPA 76
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 12-70 7.68e-09

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.17  E-value: 7.68e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177239  12 WILERIGEIVK-GTSKIELQRPFAEMGLGSVDVVTLIGKLEDWLGIEIELTLALDFPTVE 70
Cdd:pfam00550  2 RLRELLAEVLGvPAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLA 61
 
Name Accession Description Interval E-value
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 5-70 1.08e-09

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 49.85  E-value: 1.08e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 260177239  5 TEPEIQGWILERIGEIVK-GTSKIELQRPF-AEMGLGSVDVVTLIGKLEDWLGIEIELTLALDFPTVE 70
Cdd:COG0236   2 PREELEERLAEIIAEVLGvDPEEITPDDSFfEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVA 69
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 2-70 3.43e-09

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 48.79  E-value: 3.43e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260177239    2 PPPTEPEIQGWILERIGEIVK--GTSKIELQRPFAEMGLGSVDVVTLIGKLEDWLGIEIELTLALDFPTVE 70
Cdd:smart00823  6 PAERRRLLLDLVREQVAAVLGhaAAEAIDPDRPFRDLGLDSLMAVELRNRLEAATGLRLPATLVFDHPTPA 76
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 12-70 7.68e-09

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 47.17  E-value: 7.68e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 260177239  12 WILERIGEIVK-GTSKIELQRPFAEMGLGSVDVVTLIGKLEDWLGIEIELTLALDFPTVE 70
Cdd:pfam00550  2 RLRELLAEVLGvPAEEIDPDTDLFDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLA 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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