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Conserved domains on  [gi|260100460|gb|ACX31471|]
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zinc finger protein, partial [Tanygnathus megalorynchos]

Protein Classification

C2H2-type zinc finger protein; zinc finger and BTB domain-containing protein( domain architecture ID 12112566)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 291-381 8.34e-21

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


:

Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 86.31  E-value: 8.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460  291 EKAAPVSTASPVSAYSSSVTTSYPSSIATTYPSPVRTVYSSPAPSSYPSPAHTTFPSPSIATTYPSGTAAFQTQVATSFS 370
Cdd:pfam11914   1 EKVAPASAVSSISSYSSSVTTSYPSPITTSYPSPVSTSYSSPVPSSYPSPVHTSFPSPSIATTYPSVTTTFQTQVASSFP 80

                          90
                  ....*....|.
gi 260100460  371 SPGVTNNFSSQ 381
Cdd:pfam11914  81 SSVVTNSYSSQ 91
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 3-101 4.72e-17

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 76.03  E-value: 4.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460    3 GRFSLEPAPNSSNTLWPEPLFSLVSGLVGMANAPPTSTPSSSSPSSSQS-----PPLSCSVQASETSPIYSAAPTFPNSS 77
Cdd:pfam11928   1 GKFSIDPQYPGGGSLWPEGLISLVSGLVGMANPPSSSSSSSPSSSSSPNssgplCTMSCSVQSSEMEHIYSAPPPYPSSG 80

                          90       100
                  ....*....|....*....|....*
gi 260100460   78 -TDIFPEPPTQSfPNPSGAPIQYPP 101
Cdd:pfam11928  81 cGDLYQDPSAFL-STPSGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-271 7.35e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 7.35e-07
                          10        20
                  ....*....|....*....|....*.
gi 260100460  246 HLTTHIRTHTGEKPFACDICGRKFAR 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-243 8.58e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 8.58e-06
                          10        20
                  ....*....|....*....|....*.
gi 260100460  218 ELTRHIRIHTGQKPFQCRICMRNFSR 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 202-226 1.09e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*
gi 260100460  202 YACPVesCDRRFSRSDELTRHIRIH 226
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 291-381 8.34e-21

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 86.31  E-value: 8.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460  291 EKAAPVSTASPVSAYSSSVTTSYPSSIATTYPSPVRTVYSSPAPSSYPSPAHTTFPSPSIATTYPSGTAAFQTQVATSFS 370
Cdd:pfam11914   1 EKVAPASAVSSISSYSSSVTTSYPSPITTSYPSPVSTSYSSPVPSSYPSPVHTSFPSPSIATTYPSVTTTFQTQVASSFP 80

                          90
                  ....*....|.
gi 260100460  371 SPGVTNNFSSQ 381
Cdd:pfam11914  81 SSVVTNSYSSQ 91
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 3-101 4.72e-17

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 76.03  E-value: 4.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460    3 GRFSLEPAPNSSNTLWPEPLFSLVSGLVGMANAPPTSTPSSSSPSSSQS-----PPLSCSVQASETSPIYSAAPTFPNSS 77
Cdd:pfam11928   1 GKFSIDPQYPGGGSLWPEGLISLVSGLVGMANPPSSSSSSSPSSSSSPNssgplCTMSCSVQSSEMEHIYSAPPPYPSSG 80

                          90       100
                  ....*....|....*....|....*
gi 260100460   78 -TDIFPEPPTQSfPNPSGAPIQYPP 101
Cdd:pfam11928  81 cGDLYQDPSAFL-STPSGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-271 7.35e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 7.35e-07
                          10        20
                  ....*....|....*....|....*.
gi 260100460  246 HLTTHIRTHTGEKPFACDICGRKFAR 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-243 8.58e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 8.58e-06
                          10        20
                  ....*....|....*....|....*.
gi 260100460  218 ELTRHIRIHTGQKPFQCRICMRNFSR 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 202-226 1.09e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*
gi 260100460  202 YACPVesCDRRFSRSDELTRHIRIH 226
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 161-280 1.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460 161 TQTGSQELKTLNTNYQSQLIKPSRMRKYPNrpsktpphERPYACPVESCDRRFSRSDELTRHiRIHTGQKPFQCR----I 236
Cdd:COG5189  317 PCTNSSSNGKLAHGGERNIDTPSRMLKVKD--------GKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHEnpspE 387

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 260100460 237 CMRNFSRSDhltthirthtgeKPFACDICGRKFARSDERKRHTK 280
Cdd:COG5189  388 KMNIFSAKD------------KPYRCEVCDKRYKNLNGLKYHRK 419
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 230-295 2.86e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 2.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460 230 KPFqCRICMRNFSRSDHLTTHIRTHTgekpFACDICGRKFArsdeRKRHTKIHLRQ--KDK--KVEKAAP 295
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLY----TAGGLAVHCLQvhKETltKVPNALP 61
ZnF_C2H2 smart00355
zinc finger;
202-226 7.99e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 7.99e-03
                           10        20
                   ....*....|....*....|....*
gi 260100460   202 YACPVesCDRRFSRSDELTRHIRIH 226
Cdd:smart00355   1 YRCPE--CGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
232-254 8.23e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 8.23e-03
                           10        20
                   ....*....|....*....|...
gi 260100460   232 FQCRICMRNFSRSDHLTTHIRTH 254
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 201-251 9.70e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 260100460 201 PYACPVesCDRRFSRSDELTRHIRIHTGQKpfQCRICMRNFSRSDHLTTHI 251
Cdd:PHA00733  73 PYVCPL--CLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 291-381 8.34e-21

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 86.31  E-value: 8.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460  291 EKAAPVSTASPVSAYSSSVTTSYPSSIATTYPSPVRTVYSSPAPSSYPSPAHTTFPSPSIATTYPSGTAAFQTQVATSFS 370
Cdd:pfam11914   1 EKVAPASAVSSISSYSSSVTTSYPSPITTSYPSPVSTSYSSPVPSSYPSPVHTSFPSPSIATTYPSVTTTFQTQVASSFP 80

                          90
                  ....*....|.
gi 260100460  371 SPGVTNNFSSQ 381
Cdd:pfam11914  81 SSVVTNSYSSQ 91
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 3-101 4.72e-17

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 76.03  E-value: 4.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460    3 GRFSLEPAPNSSNTLWPEPLFSLVSGLVGMANAPPTSTPSSSSPSSSQS-----PPLSCSVQASETSPIYSAAPTFPNSS 77
Cdd:pfam11928   1 GKFSIDPQYPGGGSLWPEGLISLVSGLVGMANPPSSSSSSSPSSSSSPNssgplCTMSCSVQSSEMEHIYSAPPPYPSSG 80

                          90       100
                  ....*....|....*....|....*
gi 260100460   78 -TDIFPEPPTQSfPNPSGAPIQYPP 101
Cdd:pfam11928  81 cGDLYQDPSAFL-STPSGPPLAYPP 104
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-271 7.35e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 7.35e-07
                          10        20
                  ....*....|....*....|....*.
gi 260100460  246 HLTTHIRTHTGEKPFACDICGRKFAR 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-243 8.58e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 8.58e-06
                          10        20
                  ....*....|....*....|....*.
gi 260100460  218 ELTRHIRIHTGQKPFQCRICMRNFSR 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 202-226 1.09e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*
gi 260100460  202 YACPVesCDRRFSRSDELTRHIRIH 226
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 161-280 1.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460 161 TQTGSQELKTLNTNYQSQLIKPSRMRKYPNrpsktpphERPYACPVESCDRRFSRSDELTRHiRIHTGQKPFQCR----I 236
Cdd:COG5189  317 PCTNSSSNGKLAHGGERNIDTPSRMLKVKD--------GKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHEnpspE 387

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 260100460 237 CMRNFSRSDhltthirthtgeKPFACDICGRKFARSDERKRHTK 280
Cdd:COG5189  388 KMNIFSAKD------------KPYRCEVCDKRYKNLNGLKYHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 232-254 2.52e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.52e-04
                          10        20
                  ....*....|....*....|...
gi 260100460  232 FQCRICMRNFSRSDHLTTHIRTH 254
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-287 4.40e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260100460 229 QKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFAC--DICGRKFARSDERKRHTKIHLRQKD 287
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 260-282 6.66e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 6.66e-04
                          10        20
                  ....*....|....*....|...
gi 260100460  260 FACDICGRKFARSDERKRHTKIH 282
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 232-254 8.00e-04

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 36.47  E-value: 8.00e-04
                          10        20
                  ....*....|....*....|...
gi 260100460  232 FQCRICMRNFSRSDHLTTHIRTH 254
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 230-295 2.86e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 2.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460 230 KPFqCRICMRNFSRSDHLTTHIRTHTgekpFACDICGRKFArsdeRKRHTKIHLRQ--KDK--KVEKAAP 295
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLY----TAGGLAVHCLQvhKETltKVPNALP 61
ZnF_C2H2 smart00355
zinc finger;
202-226 7.99e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 7.99e-03
                           10        20
                   ....*....|....*....|....*
gi 260100460   202 YACPVesCDRRFSRSDELTRHIRIH 226
Cdd:smart00355   1 YRCPE--CGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
232-254 8.23e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 8.23e-03
                           10        20
                   ....*....|....*....|...
gi 260100460   232 FQCRICMRNFSRSDHLTTHIRTH 254
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-268 8.56e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260100460 170 TLNTNYQSQLIKPSRMRKYPNRPSK-TPPHERPYACPveSCDRRFSRSDELTRHIRIHTGQKPFQCRICMR--NFSRSDH 246
Cdd:COG5048    1 ATLTSSQSSSSNNSVLSSTPKSTLKsLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLE 78

                         90       100
                 ....*....|....*....|..
gi 260100460 247 LTTHIRTHTGEKPFACDICGRK 268
Cdd:COG5048   79 LSRHLRTHHNNPSDLNSKSLPL 100
PHA00733 PHA00733
hypothetical protein
 201-251 9.70e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 260100460 201 PYACPVesCDRRFSRSDELTRHIRIHTGQKpfQCRICMRNFSRSDHLTTHI 251
Cdd:PHA00733  73 PYVCPL--CLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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